Effects of diphenyl diselenide on lipid profile and hepatic oxidative stress parameters in ovariectomized female rats

Journal of Pharmacy and Pharmacology

Volumn 63, Issue 5, 2011, Pages 663-669

  Da Rocha, Juliana Trevisan ^a   Pinton, Simone ^a   Mazzanti, Alexandre ^b   Mazzanti, Cinthia Melazzo ^b   Beckemann, Diego Vilibaldo ^b   Nogueira, Cristina Wayne ^a   Zeni, Gilson ^a,b  

^a Reatividade e Avaliacao Farmacologica e Toxicologica de Organocalcogenios   (Brazil)

^b FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

cholesterol; menopause; ovariectomy; oxidative stress; selenium

Indexed keywords

ASCORBIC ACID; CATALASE; DIPHENYL DISELENIDE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; TRIACYLGLYCEROL;

ANIMAL EUTHANASIA; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; INTRAABDOMINAL FAT; LIPID BLOOD LEVEL; LIPID STORAGE; NONHUMAN; OVARIECTOMY; OXIDATIVE STRESS; PROTEIN CONTENT; RAT; SHAM PROCEDURE; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BENZENE DERIVATIVES; FEMALE; HORMONES; INTRA-ABDOMINAL FAT; LIPIDS; LIVER; MODELS, ANIMAL; OBESITY; ORGANOSELENIUM COMPOUNDS; OVARIECTOMY; OXIDATIVE STRESS; POSTMENOPAUSE; RATS; RATS, WISTAR; WEIGHT GAIN;

EID: 79954774062     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2011.01255.x     Document Type: Article

References (47)

1. Rachoń D, et al,. Effects of black cohosh extract on body weight gain, intra-abdominal fat accumulation, plasma lipids and glucose tolerance in ovariectomized Sprague-Dawley rats. Maturitas 2008; 60: 209-215.
2. El-Swefy SE, et al,. A novel concept to preserve the beneficial effects of hormone replacement therapy in bilaterally female ovariectomized rats: role of lovastatin therapy. Pharmacol Res 2002; 45: 167-173. (Pubitemid 35418357)
3. Cooke TS, Naaz A,. Role of estrogens in adipocyte development and function. Exp Biol Med 2004; 229: 1127-1135. (Pubitemid 39602255)
4. Ha BJ, et al,. The role of salicornia herbacea in ovariectomy-induced oxidative stress. Biol Pharm Bull 2006; 29: 1305-1309.
5. Akçay T, et al,. Effects of hormone replacement therapy on lipid peroxides and oxidation system in postmenopausal women. J Toxicol Environ Health A 2000; 59: 1-5. (Pubitemid 30060249)
6. Wojcicki J, et al,. Effect of selenium and vitamin E on the development of experimental atherosclerosis in rabbits. Atherosclerosis 1991; 87: 9-16.
7. Ewan RC,. Effect of selenium on rat growth, growth hormones and diet utilization. J Nutr 1976; 106: 102-109.
8. Nogueira CW, et al,. Organoselenium and organotellurium compounds: toxicology and pharmacology. Chem Rev 2004; 104: 6255-6286.
9. Nogueira CW, Rocha JBT,. Diphenyl diselenide a Janus-faced molecule. J Braz Chem Soc 2010; 21: 2055-2071.
10. Rossato JI, et al,. Antioxidant properties of new chalcogenides against lipid peroxidation in rat brain. Neurochem Res 2002; 27: 297-303. (Pubitemid 34273571)
11. Barbosa NBV, et al,. Diphenyl diselenide reduces temporarily hyperglycemia: possible relationship with oxidative stress. Chem Biol Interact 2006; 163: 230-238. (Pubitemid 44572228)
12. Savegnago L, et al,. Antinociceptive properties of diphenyl diselenide: evidences for the mechanism of action. Eur J Pharmacol 2007a; 555: 129-138. (Pubitemid 46048799)
13. Savegnago L, et al,. Monoaminergic agents modulate antidepressant-like effect caused by diphenyl diselenide in rats. Prog Neuropsychopharmacol 2007b; 31: 1261-1269. (Pubitemid 47081314)
14. Ghisleni G, et al,. Diphenyl diselenide exerts anxiolytic-like effect in Wistar rats: putative roles of GABAA and 5HT receptors. Prog Neuropsychopharmacol 2008; 32: 1508-1515.
15. Savegnago L, et al,. Diphenyl diselenide exerts antidepressant-like and anxiolyticlike effects in mice: involvement of l-arginine-nitric oxide-soluble guanylate cyclase pathway in its antidepressant-like action. Pharmacol Biochem Behav 2008; 88: 418-426. (Pubitemid 350266784)
16. De Bem AF, et al,. Diphenyl diselenide decreases serum levels of total cholesterol and tissue oxidative stress in cholesterol-fed rabbits. Basic Clin Pharmacol Toxicol 2009; 105: 17-23.
17. Da Rocha JT, et al,. Hypolipidaemic activity of orally administered diphenyl diselenide in Triton WR-1339-induced hyperlipidaemia in mice. J Pharm Pharmacol 2009; 61: 1673-1679.
18. Nogueira CW, et al,. Investigations into the potential neurotoxicity induced by diselenides in mice and rats. Toxicology 2003; 183: 29-37. (Pubitemid 36005387)
19. Prigol M, et al,. Convulsant effect of diphenyl diselenide in rats and mice and its relationship to plasma levels. Toxicol Lett 2009; 189: 35-39.
20. Paulmier C,. Selenium Reagents and Intermediates. Organic Synthesis. Oxford: Pergamon, 1986.
21. Baker HJ, et al,. The laboratory rat. In:, Baker HJ, Lindsey JR, Weisbroth SH, eds. Biology and Diseases, Vol. 1. New York: Academic Press, 1979: 153-168.
22. Ohkawa H, et al,. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95: 351-358. (Pubitemid 9194347)
23. Jacques-Silva MC, et al,. Diphenyl diselenide and ascorbic acid changes deposition of selenium and ascorbic acid in liver and brain of mice. Pharmacol Toxicol 2001; 88: 119-125.
24. Hissin PJ, Hilf R,. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 1976; 74: 214-226.
25. Aebi H,. Catalase in vitro. Methods Enzymol 1984; 105: 121-126.
26. Wendel A,. Glutathione peroxidase. Methods Enzymol 1981; 77: 325-333.
27. Habig WH, et al,. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 1974; 249: 7130-7139.
28. Bradford MM,. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principles of protein-dye binding. Anal Biochem 1976; 72: 248-254.
29. Shi H, Clegg DJ,. Sex differences in the regulation of body weight. Physiol Behav 2009; 97: 199-204.
30. Clegg DJ, et al,. Gonadal hormones determine sensitivity to central leptin and insulin. Diabetes 2006; 55: 978-987. (Pubitemid 44100172)
31. Hawkes WC, Keim NL,. Dietary selenium intake modulates thyroid hormone and energy metabolism in men. J Nutr 2003; 133: 3443-3448. (Pubitemid 37409471)
32. Jia X, et al,. A subchronic toxicity study of elemental nano-Se in Sprague-Dawley rats. Life Sci 2005; 76: 1989-2003. (Pubitemid 40222417)
33. Meotti FC, et al,. Toxicological evaluation of subchronic exposure to diphenyl diselenide in rats. J Appl Toxicol 2008; 28: 638-644. (Pubitemid 352009754)
34. Wakatsuki A, Sagara Y,. Lipoprotein metabolism in postmenopausal and oophorectomized women. Obstet Gynecol 1995; 85: 523-528 (6).
35. Van Lenten BJ, et al,. Lipoprotein metabolism in the ovariectomized rat. J Lipid Res 1983; 24: 1473-1484.
36. Kireev RA, et al,. Melatonin is able to prevent the liver of old castrated female rats from oxidative and pro-inflammatory damage. J Pineal Res 2008; 45: 394-402.
37. Prakash AK, Kumar A,. Effect of chronic treatment of carvedilol on oxidative stress in an intracerebroventricular streptozotocin induced model of dementia in rats. J Pharm Pharmacol 2009; 61: 1665-1672.
38. Mohanty IR, et al,. Bacopa monniera protects rat heart against ischaemia-reperfusion injury: role of key apoptotic regulatory proteins and enzymes. J Pharm Pharmacol 2010; 62: 1175-1184.
39. Sindhu ER, et al,. Carotenoid lutein protects rats from paracetamol-, carbon tetrachloride- and ethanol-induced hepatic damage. J Pharm Pharmacol 2010; 62: 1054-1060.
40. Carrasco-Pozo C, et al,. Protection by apple peel polyphenols against indometacin-induced oxidative stress, mitochondrial damage and cytotoxicity in Caco-2 cells. J Pharm Pharmacol 2010; 62: 943-950.
41. Li XB, et al,. Cardioprotective effect of matrine on isoproterenol- induced cardiotoxicity in rats. J Pharm Pharmacol 2010; 62: 514-520.
42. Massafra C, et al,. Effects of estradiol and medroxyprogesterone acetate treatment on erythrocyte antioxidant enzyme activities and malondialdehyde plasma levels in amenorrheic women. J Clin Endocrinol Metab 1997; 82: 173-175. (Pubitemid 27021291)
43. Kankofer M, et al,. Anti-oxidative/oxidative status of rat liver after ovariectomy. J Vet Med A 2007; 54: 225-229. (Pubitemid 46794212)
44. Topçuoglu A, et al,. Effects of estrogens on oxidative protein damage in plasma and tissues in ovariectomised rats. Clin Invest Med 2009; 32: E133-E143.
45. Oztekin E, et al,. Lipid peroxidation in liver tissue of ovariectomized and pinealectomized rats: effect of estradiol and progesterone supplementation. Cell Biochem Funct 2007; 25: 401-405. (Pubitemid 47066715)
46. Luchese C, et al,. Antioxidant effect of diphenyl diselenide on oxidative damage induced by smoke in rats: Involvement of glutathione. Ecotoxicol Environ Saf 2009; 72: 248-254.
47. Luchese C, Nogueira CW,. Diphenyl diselenide in its selenol form has dehydroascorbate reductase and glutathione S-transferase-like activity dependent on the glutathione content. J Pharm Pharmacol 2010; 62: 1146-1151.