IKr vs. IKs blockade and arrhythmogenicity in normoxic rabbit Purkinje fibers: Does it really make a difference?

Fundamental and Clinical Pharmacology

Volumn 25, Issue 3, 2011, Pages 304-312

  Puddu, Paolo Emilio ^a   Legrand, Jean Christophe ^b   Sallé, Laurent ^c   Rouet, René ^c   Ducroq, Joffrey ^c,d  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b Dohme Chibret Centre de Recherche Riom   (France)

^c UNIVERSITÉ DE CAEN   (France)

^d PhysioStim   (France)

Author keywords

Class III anti arrhythmic drugs; Early after depolarizations; Rabbit Purkinje fibers

Indexed keywords

ADRENALIN; AZIMILIDE; CHROMANOL 293B; DELAYED RECTIFIER POTASSIUM CHANNEL; DOFETILIDE; N [3 HYDROXY 2,2 DIMETHYL 6 (4,4,4 TRIFLUOROBUTOXY)CHROMAN 4 YL] N METHYLMETHANESULFONAMIDE; SOTALOL;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARRHYTHMOGENESIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLARIZATION; ELECTROPHYSIOLOGY; HEART ARRHYTHMIA; INCIDENCE; MICROELECTRODE; NONHUMAN; PRIORITY JOURNAL; PURKINJE FIBER; RABBIT;

EID: 79954734112     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2010.00920.x     Document Type: Article

References (35)

1. Waldo A.L., Camm A.J., De Ruyter H. et al.; for the SWORD investigators. Effect of sotalol on mortality in patients with left myocardial infarction. Lancet (1996) 348 7-12.
2. Køber L., Bloch Thomsen P.E., Møller M. et al.; Danish Investigations of Arrhythmia and Mortality on Dofetilide (DIAMOND) Study Group. Effect of dofetilide in patients with recent myocardial infarction and left-ventricular dysfunction: a randomised trial. Lancet (2000) 356 2052-2058.
3. Camm A.J., Pratt C.M., Schwartz P.J. et al.; AzimiLide post Infarct surVival Evaluation (ALIVE) Investigators. Mortality in patients after a recent myocardial infarction: a randomized, placebo-controlled trial of azimilide using heart rate variability for risk stratification. Circulation (2004) 109 990-996.
4. Elming H., Brendorp B., Pehrson S., Pedersen O.D., Køber L., Torp-Petersen C. A benefit-risk assessment of class III antiarrhythmic agents. Expert Opin. Drug Saf. (2004) 3 559-577.
5. Ks. Br. J. Pharmacol. (2010) 159 93-101.
6. Thomsen M.B., Matz J., Volders P.G., Vos M.A. Assessing the proarrhythmic potential of drugs: current status of models and surrogate parameters of torsades de pointes arrhythmias. Pharmacol. Ther. (2006) 112 150-170.
7. Patterson E., Scherlag B.J., Szabo B., Lazzara R. Facilitation of epinephrine-induced afterdepolarizations by class III antiarrhythmic drugs. J. Electrocardiol. (1997) 30 217-224.
8. Zeng J., Rudy Y. Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence. Biophys. J. (1995) 68 949-964.
9. + current. J. Gen. Physiol. (1990) 96 195-215.
10. Ducroq J., Rouet R., Puddu P.E. et al. Electrophysiological effects of azimilide in an in vitro model of simulated-ischemia and reperfusion in guinea-pig ventricular myocardium. Eur. J. Pharmacol. (2005) 518 165-174.
11. o in an in vitro model of simulated-ischemia and reperfusion in guinea-pig ventricular myocardium. Eur. J. Pharmacol. (2006) 532 279-289.
12. Picard S., Rouet R., Monti F. et al. Proarrhythmic effects of dl- and d-sotalol on the "border zone" between normal and ischemic regions of isolated ventricular myocardium and antiarrhythmic effects on reperfusion. J. Cardiovasc. Pharmacol. (1998) 31 126-139.
13. Rouet R., Picard S., Libersa C., Ghadanfar M., Alabaster C., Gerard J.L. Electrophysiological effects of dofetilide in an in vitro model of "border zone" between normal and ischaemic/reperfused myocardium. Circulation (2000) 101 86-93.
14. Sun Z.Q., Thomas G.P., Antzelevitch C. Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes. J. Cardiovasc. Electrophysiol. (2001) 12 472-478.
15. Ks channels by HMR 1556. Naunyn Schmiedebergs Arch. Pharmacol. (2000) 362 480-488.
16. Singh B.N. Antiarrhythmic drugs: a reorientation in light of recent developments in the control of disorders of rhythms. Am. J. Cardiol. (1998) 81 3D-13D.
17. Lu H.R., Marien R., Saels A., De Clerck F. Species plays an important role in drug-induced prolongation of action potential duration and early afterdepolarizations in isolated Purkinje fibres. J. Cardiovasc. Electrophysiol. (2001) 12 93-102.
18. Rouet R., Ducroq J., Picard S. The action potential in Purkinje fibre: an in vitro model for evaluation of the proarrhythmic potential of cardiac and noncardiac drugs, in: Enna S.J., Williams M., Ferkany J.W., Kenakin T., Porsolt R.D., Sullivan J.P. (Eds), Current protocols in pharmacology, John Wiley & Sons, New York, 2001, pp. 11.3.1-11.3.17.
19. 2+ current enhanced by isoprenaline in rat atrial myocytes. J. Cardiovasc. Pharmacol. (1997) 29 136-143.
20. Kr: implications for torsade de pointes and reverse use-dependent. Circulation (1996) 93 407-411.
21. Carmeliet E. Electrophysiologic and voltage clamp analysis of the effects of sotalol on isolated cardiac muscle and Purkinje fibres. J. Pharmacol. Exp. Ther. (1985) 232 817-825.
22. Salata J.J., Brooks R.R. Pharmacology of azimilide dihydrochloride (NE-10064), a class III antiarrhythmic agent. Cardiovasc. Drug Rev. (1997) 15 137-156.
23. Bril A., Forest M.C., Cheval B., Faivre J.F. Combined potassium and calcium channel antagonistic activities as a basis for neutral frequency dependent increase in action potential duration: comparison between BRL-32872 and azimilide. Cardiovasc. Res. (1998) 37 130-140.
24. Fermini B., Jurkiewicz N.K., Jow B. et al. Use dependent effects of the class III antiarrhythmic agent NE-10064 (azimilide) on cardiac repolarization: block of delayed rectifier potassium and L-type calcium currents. J. Cardiovasc. Pharmacol. (1995) 26 259-271.
25. Van Opstal J., Leunissen J., Wellens H., Vos M. Azimilide and dofetilide produce similar electrophysiological effects in a canine model of torsade de pointes arrhythmias. Eur. J. Pharmacol. (2001) 412 67-76.
26. Ks in dog ventricular muscle and Purkinje fibre repolarization. J. Physiol. (2000) 523 67-81.
27. Ks blockade at high heart rate in guinea pig and rabbit. Circulation (2001) 104 951-956.
28. Burashnikov A., Antzelevitch C. Block of I(Ks) does not induce early afterdepolarization activity but promotes beta-adrebergic agonist-induced delayed afterdepolarization activity. J. Cardiovasc. Electrophysiol. (2000) 11 458-465.
29. Burashnikov A., Antzelevitch C. Prominente I(Ks) in epicardium and endocardium contributes to development of transmural dispersion of repolarization but protects against development of early afterdepolarization. J. Cardiovasc. Electrophysiol. (2002) 13 172-177.
30. Ks. Am. J. Physiol. (1996) 271 H2477-H2489.
31. Jost N., Papp J.G., Varró A. Slow delayed rectifier potassium current (IKs) and the repolarization reserve. Ann. Noninvasive Electrocardiol. (2007) 12 64-78.
32. So P.P., Backx P.H., Dorian P. Slow delayed rectifier K+ current block by HMR 1556 increases dispersion of repolarization and promotes Torsades de Pointes in rabbit ventricles. Br. J. Pharmacol. (2008) 155 1185-1194.
33. Cheng H.C., Incardona J. Models of torsades de pointes: effects of FPL64176, DPI201106, dofetilide, and chromanol 293B in isolated rabbit and guinea pig hearts. J. Pharmacol. Toxicol. Methods (2009) 60 174-184.
34. Puddu P.E., Criniti A., Monti F. Screening for drug-induced (acquired) long QT syndrome: is it time to apply new methods? (Editorial). Eur. Heart J. (2001) 22 363-369.
35. Weissenburger J., Funck-Brentano C., Jaillon P., Charbit B. Droperidol and ondansetron in vitro electrophysiological drug interaction study. Fundam. Clin. Pharmacol. (2009) 23 719-726.