Effect of formulation factors on the trans-scleral iontophoretic and post-iontophoretic transports of a 40 kDa dextran in vitro

European Journal of Pharmaceutical Sciences

Volumn 42, Issue 5, 2011, Pages 503-508

  Pescina, Silvia ^a   Padula, Cristina ^a   Santi, Patrizia ^a   Nicoli, Sara ^a  

^a UNIVERSITY OF PARMA   (Italy)

Author keywords

Electroosmosis; Macromolecule; Ocular barriers; Ocular delivery; Post iontophoretic transport; Trans scleral iontophoresis

Indexed keywords

DEXTRAN 40;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRUCH MEMBRANE; CONTROLLED STUDY; DRUG FORMULATION; DRUG TRANSPORT; IN VITRO STUDY; IONTOPHORESIS; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; SCLERA;

ANIMALS; BIOLOGICAL TRANSPORT; BRUCH MEMBRANE; CELL MEMBRANE PERMEABILITY; CHEMISTRY, PHARMACEUTICAL; CHOROID; DEXTRANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IONTOPHORESIS; MOLECULAR WEIGHT; PHARMACEUTICAL PREPARATIONS; SCLERA; SWINE;

EID: 79954631233     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.02.008     Document Type: Article

References (31)

1. S. Ahuja, and M.I. Jimidar Capillary Electrophoresis Methods for Pharmaceutical Analysis 2008 Academic Press
2. V.H. Barocas, and R.K. Balachandran Sustained transscleral drug delivery Expert Opin. Drug Deliv. 5 2008 1 10 (Pubitemid 351234106)
3. N.P. Cheruvu, and U.B. Kompella Bovine and porcine transscleral solute transport: influence of lipophilicity and the Choroid-Bruch's layer Invest. Ophthalmol. Vis. Sci. 47 2006 4513 4522 (Pubitemid 46579380)
4. P. Chopra, J. Hao, and S.K. Li Iontophoretic transport of charged macromolecules across human sclera Int. J. Pharm. 388 2010 107 113
5. J.B. Davies, V.T. Ciavatta, J.H. Boatright, and J.M. Nickerson Delivery of several forms of DNA, DNA-RNA hybrids, and dyes across human sclera by electrical fields Mol. Vis. 9 2003 569 578 (Pubitemid 38097624)
6. E.M. Del Amo, and A. Urtti Current and future ophthalmic drug delivery systems. A shift to the posterior segment Drug Discov. Today 13 2008 135 143
7. E. Eljarrat-Binstock, and A.J. Domb Iontophoresis: a non-invasive ocular drug delivery J. Control. Release 110 2006 479 489 (Pubitemid 43163439)
8. E. Eljarrat-Binstock, A.J. Domb, F. Orucov, J. Frucht-Pery, and J. Pe'er Methotrexate delivery to the eye using transscleral hydrogel iontophoresis Curr. Eye Res. 32 2007 639 646 (Pubitemid 47400678)
9. E. Eljarrat-Binstock, A.J. Domb, F. Orucov, A. Dagan, J. Frucht-Pery, and J. Pe'er In vitro and in vivo evaluation of carboplatin delivery to the eye using hydrogel-iontophoresis Curr. Eye Res. 33 2008 269 275
10. R. Gaudana, J. Jwala, S.H. Boddu, and A.K. Mitra Recent perspectives in ocular drug delivery Pharm. Res. 26 2009 1197 1216
11. S. Gungor, M.B. Delgado-Charro, B. Ruiz-Perez, W. Schubert, P. Isom, P. Moslemy, M.A. Patane, and R.H. Guy Trans-scleral iontophoretic delivery of low molecular weight therapeutics J. Control. Release 147 2010 225 231
12. B. Hayden, M.E. Jockovich, T.G. Murray, M.T. Kralinger, M. Voigt, E. Hernandez, W. Feuer, and J.M. Parel Iontophoretic delivery of carboplatin in a murine model of retinoblastoma Invest. Ophthalmol. Vis. Sci. 47 2006 3717 3721 (Pubitemid 46044280)
13. G. Hecht, R.E. Roehrs, E.R. Cooper, J.W. Hiddemen, and B.F. Van Duzee Design and evaluation of opthalmic pharmaceutical products G.S. Banker, C.T. Rhodes, Modern Pharmaceutics 1990 Marcel Dekker, Inc. New York/Basel
14. K.G. Janoria, S. Gunda, S.H. Boddu, and A.K. Mitra Novel approaches to retinal drug delivery Expert Opin. Drug Deliv. 4 2007 371 388 (Pubitemid 47260195)
15. Y.N. Kalia, A. Naik, J. Garrison, and R.H. Guy Iontophoretic drug delivery Adv. Drug Deliv. Rev. 56 2004 619 658 (Pubitemid 38326937)
16. A. Kim, P.G. Green, G. Rao, and R.H. Guy Convective solvent flow across the skin during iontophoresis Pharm. Res. 10 1993 1315 1320 (Pubitemid 23261832)
17. K. Kobuch, W.A. Herrmann, C. Framme, H.G. Sachs, V.P. Gabel, and J. Hillenkamp Maintenance of adult porcine retina and retinal pigment epithelium in perfusion culture: characterisation of an organotypic in vitro model Exp. Eye Res. 86 2008 661 668
18. S.K. Li, Y. Zhang, H. Zhu, W.I. Higuchi, and H.S. White Influence of asymmetric donor-receiver ion concentration upon transscleral iontophoretic transport J. Pharm. Sci. 94 2005 847 860 (Pubitemid 40577317)
19. A. Luzardo-Alvarez, M. Rodriguez-Fernandez, J. Blanco-Mendez, R.H. Guy, and M.B. Delgado-Charro Iontophoretic permselectivity of mammalian skin: characterization of hairless mouse and porcine membrane models Pharm. Res. 15 1998 984 987 (Pubitemid 28356911)
20. S.A. Molokhia, E.K. Jeong, W.I. Higuchi, and S.K. Li Transscleral iontophoretic and intravitreal delivery of a macromolecule: study of ocular distribution in vivo and postmortem with MRI Exp. Eye Res. 88 2009 418 425
21. M.E. Myles, D.M. Neumann, and J.M. Hill Recent progress in ocular drug delivery for posterior segment disease: emphasis on transscleral iontophoresis Adv. Drug Deliv. Rev. 57 2005 2063 2079 (Pubitemid 41740797)
22. S. Nicoli, G. Ferrari, M. Quarta, C. Macaluso, and P. Santi In vitro transscleral iontophoresis of high molecular weight neutral compounds Eur. J. Pharm. Sci. 36 2009 486 492
23. T.W. Olsen, H.F. Edelhauser, J.I. Lim, and D.H. Geroski Human scleral permeability. Effects of age, cryotherapy, transscleral diode laser, and surgical thinning Invest. Ophthalmol. Vis. Sci. 36 1995 1893 1903
24. M.J. Pikal The role of electroosmotic flow in transdermal iontophoresis Adv. Drug Deliv. Rev. 46 2001 281 305
25. L. Pitkanen, V.P. Ranta, H. Moilanen, and A. Urtti Permeability of retinal pigment epithelium: effects of permeant molecular weight and lipophilicity Invest. Ophthalmol. Vis. Sci. 46 2005 641 646 (Pubitemid 40270347)
26. Y.B. Schuetz, P.A. Carrupt, A. Naik, R.H. Guy, and Y.N. Kalia Structure-permeation relationships for the non-invasive transdermal delivery of cationic peptides by iontophoresis Eur. J. Pharm. Sci. 29 2006 53 59 (Pubitemid 44294860)
27. S.G. Schultz Basic Principles of Membrane Transport 1980 Cambridge University Press
28. N.A. Sharif, and P. Klimko Ophtalmic agents D. Triggle, J. Taylor, Comprehensive Medicinal Chemistry II vol. 6 2006 Elsevier Oxford, UK 297 320
29. Sigma-Aldrich. Fluorescein isothiocyanate-dextran - Product Information. Sigma-Aldrich Inc., St. Louis, USA.
30. H. Steuer, A. Jaworski, D. Stoll, and B. Schlosshauer In vitro model of the outer blood-retina barrier Brain Res. Brain Res. Protoc. 13 2004 26 36 (Pubitemid 38519596)
31. J.A. Tamada, and K. Comyns Effect of formulation factors on electroosmotic glucose transport through human skin in vivo J. Pharm. Sci. 94 2005 1839 1849 (Pubitemid 41360877)