In vitro and in vivo evaluation of carboplatin delivery to the eye using hydrogel-iontophoresis

Current Eye Research

Volumn 33, Issue 3, 2008, Pages 269-275

  Eljarrat Binstock, Esther ^a   Domb, Abraham J ^a   Orucov, Faik ^b   Dagan, Amir ^b   Frucht Pery, Joseph ^b   Pe'Er, Jacob ^b  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Carboplatin; Eye; Hydrogel; Iontophoresis; Retinoblastoma

Indexed keywords

2 HYDROXYETHYL METHACRYLATE; AGAR; ANTINEOPLASTIC AGENT; CARBOPLATIN; METHACRYLIC ACID DERIVATIVE;

ANIMAL; ARTICLE; DRUG DELIVERY SYSTEM; IONTOPHORESIS; MALE; METABOLISM; METHODOLOGY; RABBIT; SCLERA;

AGAR; ANIMALS; ANTINEOPLASTIC AGENTS; CARBOPLATIN; DRUG DELIVERY SYSTEMS; IONTOPHORESIS; MALE; METHACRYLATES; RABBITS; SCLERA;

EID: 44049088856     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.1080/02713680701871140     Document Type: Article

References (53)

1. Baeyens V, Percicot C, Zignani M, Deshpande AA, Kaltsatos V, Gurny R. Ocular drug delivery in veterinary medicine. Adv Drug Deliv Rev. 1997;28: 335-361.
2. Guy RH, Kalia YN, Delgado-Charro MB, Merino V, Lopez A, Marro D. Iontophoresis: Electrorepulsion and electroosmosis. J Control Release. 2000;64: 129-132.
3. Eljarrat-Binstock E, Domb AJ. Iontophoresis: A non-invasive ocular drug delivery. J Control Release. 2006;110: 479-489.
4. BridgerMW, Keene M, Graham JM, Healey R, Ammar MM. A device for iontophoretic anesthesia of the tympanic membrane. J Med Eng Technol. 1982;6: 62-64.
5. Zempsky WT, Sullivan J, Paulson DM, Hoath SB. Evaluation of a low-dose lidocaine iontophoresis system for topical anesthesia in adults and children: A randomized controlled trial. Clin Ther. 2004;26: 1110-1119.
6. Moppett IK, Szypula K, Yeoman PM. Comparison of EMLA and lidocaine iontophoresis for cannulation analgesia. Eur J Anaesthesiol. 2004;21: 210-213.
7. DeCou JM, Abrams RS, Hammond JH, Lowder LR, Gauderer MWL. Iontophoresis: A needle-free electrical system of local anesthesia delivery for pediatric surgical office procedures. J Pediatr Surg. 1999;34: 946-949.
8. Gibson LE, Cooke RE. A test for concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilizing pilocarpine by iontophoresis. Pediatrics. 1959;23: 545-549.
9. Carter EP, Barrett AD, Heeley AF, Kuzemko JA. Improved sweat test method for the diagnosis of cystic fibrosis. Arch Dis Child. 1984;59: 919-922.
10. Gangarosa LP, Hill JM, Thompson BL, Leggett C, Rissing JP. Iontophoresis of vidarabine monophosphate for herpes orolabialis. J Infect Dis. 1986;154: 930-934.
11. Gangarosa LP, Park NH. Practical considerations in iontophoresis of fluoride for desensitizing dentine. J Prosthet Dent. 1978;39:173- 178.
12. Krauser JT. Hypersensitive teeth. Part II: Treatment. J Prosthet Dent. 1986;56: 307-311.
13. Barza M, Peckman C, Baum J. Transscleral iontophoresis of cefazolin, ticarcillin, and gentamicin in the rabbit. Ophthalmology. 1986;93: 133-139.
14. Frucht-Pery J, Goren D, Solomon A, et al. The distribution of gentamicin in the rabbit cornea following iontophoresis to the central cornea. J Ocul Pharmacol Ther. 1999;15: 251-256.
15. Rootman DS, Hobden JA, Jantzen JA, Gonzalez JR, Ocallaghan RJ, Hill JM. Iontophoresis of tobramycin for the treatment of experimental pseudomonas keratitis in the rabbit. Arch Ophthalmol. 1988;106: 262-265.
16. Yoshizumi MO, Cohen D, Verbukh I, Leinwand M, Kim J, Lee DA. Experimental transscleral iontophoresis of ciprofloxacin. J Ocular Pharmacol. 1991;7: 163-167.
17. Eljarrat-Binstock E, Raiskup F, Stepensky D, Domb AJ, Frucht-Pery J. Delivery of gentamicin to the rabbit eye by drug-loaded hydrogel iontophoresis. Invest Ophthalmol Vis Sci. 2004;45: 2543-2548.
18. Lam TT, Fu J, Chu R, Stojack K, Siew E, Tso MOM. Intravitreal delivery of ganciclovir in rabbits by transscleral iontophoresis. J Ocul Pharmacol. 1994;10: 571-575.
19. Behar-Cohen FF, El Aouni A, Gautier S, et al. Transscleral coulombcontrolled iontophoresis of methylprednisolone into the rabbit eye: Influence of duration of treatment, current intensity and drug concentration on ocular tissue and fluid levels. Exp Eye Res. 2002;74:51- 59.
20. Behar-Cohen FF, Parel JM, Pouliquen Y, et al. Iontophoresis of dexamethasone in the treatment of endotoxin-induced uveitis in rats. Exp Eye Res. 1997;65: 533-545.
21. Eljarrat-Binstock E, Raiskup F, Frucht-Pery J, Domb AJ. Transcorneal and transscleral iontophoresis of dexamethasone phosphate using drug-loaded hydrogel. J Control Release. 2005;106: 386-390.
22. Hayden BC, Jockovich ME, Murray TG, et al. Pharmacokinetics of systemic versus focal carboplatin chemotherapy in the rabbit eye: Possible implication in the treatment of retinoblastoma. Invest Ophthalmol Vis Sci. 2004;45: 3644-3649.
23. Kondo M, Araie M. Iontophoresis of 5-fluorouracil into the conjunctiva and sclera. Invest Ophthalmol Vis Sci. 1989;30: 583-585.
24. Asahara T, Shinomiya K, Naito T, Shiota H. Induction of gene into the rabbit eye by iontophoresis: Preliminary report. Jpn J Ophthalmol. 2001;45: 31-39.
25. Abramson DH, Frank CM, Chantada GL, et al. Intraocular carboplatin concentrations following intravenous administration for human intraocular retinoblastoma. Ophthalmic Genet. 1999;20:31- 36.
26. Harbour JW, Murray TG, Hamasaki D, et al. Local carboplatin therapy in transgenic murine retinoblastoma. Invest Ophthalmol Vis Sci. 1996;37: 1892-1898.
27. Murray TG, Roth DB, O'Brien JM, et al. Local carboplatin and radiation therapy in the treatment of murine transgenic retinoblastoma. Arch Ophthalmol. 1996;114: 1385-1389.
28. Murray TG, Cicciarelli N, Obrien JM, et al. Subconjunctival carboplatin therapy and cryotherapy in the treatment of transgenic murine retinoblastoma. Arch Ophthalmol. 1997;115: 1286-1290.
29. Mendelsohn ME, Abramson DH, Madden T, TongW, Tran HT, Dunkel IJ. Intraocular concentrations of chemotherapeutic agents after systemic or local administration. Arch Ophthalmol. 1998;116:1209- 1212.
30. Hayden BH, Murray TG, Scott IU, et al. Subconjunctival carboplatin in retinoblastoma - impact of tumor burden and dose schedule. Arch Ophthalmol. 2000;118: 1549-1554.
31. Abramson DH, Frank CM, Dunkel IJ. A phase I/II study of subconjunctival carboplatin for intraocular retinoblastoma. Ophthalmology. 1999;106: 1947-1950.
32. Pardue MT, Hejny C, Gilbert JA, Phillips MJ, Geroski DH, Edelhauser HF. Retinal function after subconjunctival injection of carboplatin in fibrin sealant. Retin - J Retin Vitr Dis. 2004;24: 776-782.
33. Van Quill KR, Dioguardi PK, Tong CT, et al. Subconjunctival carboplatin in fibrin sealant in the treatment of transgenic murine retinoblastoma. Ophthalmology. 2005;112: 1151-1158.
34. Mulvihill A, Budning A, Jay V, et al. Ocular motility changes after subtenon carboplatin chemotherapy for retinoblastoma. Arch Ophthalmol. 2003;121: 1120-1124.
35. Hayden B, Jockovich ME, Murray TG, et al. Iontophoretic delivery of carboplatin in a murine model of retinoblastoma. Invest Ophthalmol Vis Sci. 2006;47: 3717-3721.
36. Alvarez-Figueroa MJ, Blanco-Mendez J. Transdermal delivery of methotrexate: Iontophoretic delivery from hydrogels and passive delivery from microemulsions. Int J Pharm. 2001;215: 57-65.
37. Banga AK, Chien YW. Hydrogel-based iontotherapeutic delivery devices for transdermal delivery of peptide/protein drugs. Pharm Res. 1993;10: 697-702.
38. Fischer GA, Parkinson TM, Szlek MA. OcuPhor - The future of ocular drug delivery. Drug Delivery Tech. 2002;2: 50-52.
39. Vollmer DL, Szlek MA, Kolb K, Lloyd LB, Parkinson TM. In vivo transscleral iontophoresis of amikacin to rabbit eyes. J Ocul Pharmacol Ther. 2002;18: 549-558.
40. Hastings MS, Li SK, Miller DJ, Bernstein PS, Mufson D. Visulex: Advancing iontophoresis for effective noninvasive back-to-the-eye therapeutics. Drug Delivery Tech. 2004;4: 53-57.
41. Eljarrat-Binstock E, Raiskup F, Frucht-Pery J, Domb AJ. Hydrogel probe for iontophoresis drug delivery to the eye. J Biomater Sci Polym Ed. 2004;15: 397-413.
42. Frucht-Pery J, Mechoulam H, Siganos CS, Ever-Hadani P, Shapiro M, Domb A. Iontophoresis-gentamicin delivery into the rabbit cornea using a hydrogel delivery probe. Exp Eye Res. 2004;78:745- 749.
43. Pohlen U, Rieger H, Meyer BT, et al. Chemoembolization of lung metastases - pharmacokinetic behaviour of carboplatin in a rat model. Anticancer Res. 2007;27: 809-815.
44. Brouneus F, Karami K, Beronius P, Sundelof LO. Diffusive transport properties of some local anesthetics applicable for iontophoretic formulation of the drugs. Int J Pharm. 2001;218:57- 62.
45. Anderson CR, Morris RL, Boeh SD, Panus PC, Sembrowich WL. Effects of iontophoresis current magnitude and duration on dexamethasone deposition and localized drug retention. Phys Ther. 2003;83: 161-170.
46. Wilson TW, Chan HSL, Moselhy GM, Heydt DD, Frey CM, Gallie BL. Penetration of chemotherapy into vitreous is increased by cryotherapy and cyclosporine rabbits. Arch Ophthalmol. 1996;114:1390- 1395.
47. Zlioba A, Peyman GA, Nikoleit J. Retinal toxicity study of intravitreal carboplatin and iproplatin. Ann Ophthalmol. 1988;20: 71-72.
48. Eljarrat-Binstock E, Domb AJ, Orucov F, Frucht-Pery J, Pe'er J. Methotrexate delivery to the eye using transscleral hydrogel iontophoresis. Curr Eye Res. 2007;32: 639-646.
49. Eljarrat-Binstock E, Orucov F, Frucht-Pery J, Pe'er J, Domb AJ. Methylprednisolone delivery to the back of the eye using hydrogel iontophoresis. J Ocular Pharm Ther. 2008. In press.
50. Eljarrat-Binstock E, Orucov F, Aldouby, Y, Frucht-Pery J, Domb AJ. Charged nonoparticles delivery to the eye using hydrogel iontophoresis. J Control Release. 2008;126: 156-161.
51. Eljarrat-Binstock E, Bentolila A, Kumar N, Harel H, Domb A. Preparation, characterization and sterilization of hydrogel sponges for iontophoretic drug-delivery use. Polym Adv Tech. 2007;18:720- 730.
52. Simpson AE, Gilbert JA, Rudnick DE, Geroski DH, Aberg TM, Edelhauser HF. Transscleral diffusion of carboplatin - an in vitro and in vivo study. Arch Ophthalmol. 2002;120: 1069-1074.
53. Boulikas T, Vougiouka M. Cisplatin and platinum drugs at the molecular level. Oncology Reports. 2003;10: 1663-1682.