Sildenafil (Viagra) ameliorates clinical symptoms and neuropathology in a mouse model of multiple sclerosis

Acta Neuropathologica

Volumn 121, Issue 4, 2011, Pages 499-508

  Pifarre, Paula ^a   Prado, Judith ^a   Baltrons, María Antonia ^a   Giralt, Merce ^b   Gabarro, Pere ^a   Feinstein, Douglas L ^c   Hidalgo, Juan ^b   Garcia, Agustina ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b INSTITUT DE NEUROCIÈNCIES   (Spain)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; SILDENAFIL; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL LOSS; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE MODEL; FEMALE; MACROPHAGE ACTIVATION; MICROGLIA; MOUSE; MULTIPLE SCLEROSIS; NERVE CELL; NEUROPATHOLOGY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REMYELINIZATION; SPINAL CORD; SPLEEN CELL; SYMPTOM; T LYMPHOCYTE; TH1 CELL; TH2 CELL; TREATMENT OUTCOME;

ANIMALS; ANTIGENS, CD3; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOSIS; GLYCOPROTEINS; INTERCELLULAR ADHESION MOLECULE-1; MICE; MICE, INBRED C57BL; NEUROFILAMENT PROTEINS; PEPTIDE FRAGMENTS; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; PURINES; SPINAL CORD; SULFONES; TIME FACTORS;

EID: 79954610434     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-010-0795-6     Document Type: Article

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