Tumor cells induce COX-2 and mPGES-1 expression in microvascular endothelial cells mainly by means of IL-1 receptor activation

Microvascular Research

Volumn 81, Issue 3, 2011, Pages 261-268

  Casós, Kelly ^a   Siguero, Laura ^a   Fernández Figueras, María Teresa ^b   León, Xavier ^a   Sardá, María Pilar ^a   Vila, Luis ^a   Camacho, Mercedes ^a  

^a BIOMEDICAL RESEARCH INSTITUTE SANT PAU IIB SANT PAU   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Cyclooxygenase 2; FaDu; Microsomal PGE synthase 1; Microvascular endothelial cells; PGE2; SCC 25

Indexed keywords

ARACHIDONIC ACID; CYCLOOXYGENASE 2; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; MESSENGER RNA; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2; RECOMBINANT INTERLEUKIN 1BETA;

ADULT; ARTICLE; CANCER CELL CULTURE; CELL INTERACTION; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOSOL; DRUG TARGETING; GENE EXPRESSION; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MICROVASCULAR ENDOTHELIAL CELL; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROSTAGLANDIN SYNTHESIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INDUCTION; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA;

CARCINOMA, PAPILLARY; CARCINOMA, SQUAMOUS CELL; CELL COMMUNICATION; CELL LINE, TUMOR; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; CYCLOOXYGENASE 2; CYTOKINES; DINOPROSTONE; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; HEAD AND NECK NEOPLASMS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1ALPHA; INTRAMOLECULAR OXIDOREDUCTASES; MALE; NEOPLASMS; PROSTAGLANDINS; RECEPTORS, INTERLEUKIN-1; THYROID NEOPLASMS;

EID: 79954596638     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2011.01.006     Document Type: Article

References (42)

1. Bhowmick N.A., Moses H.L. Tumor-stroma interactions. Curr. Opin. Genet. Dev. 2005, 15:97-101.
2. Brú A., Souto J.C., Alcolea S., Antón R., Remacha A., Camacho M., Soler M., Brú I., Porres A., Vila L. Tumour cell lines HT-29 and FaDu produce proinflammatory cytokines and activate neutrophils in vitro. Possible applications for neutrophil-based anti-tumour treatment. Mediat. Inflamm. 2009, (Article ID 817498, 13 pages).
3. 2 from human dermal microvascular endothelial cells. Br. J. Dermatol. 1990, 122:153-164.
4. 2 in mixed incubations of endothelial cells and aspirin-treated platelets strongly depends on the prostaglandin I-synthase activity. Thromb. Res. 2000, 99:155-164.
5. Camacho M., Godessart N., Anton R., García M., Vila L. Interleukin-1 enhances the ability of cultured umbilical vein endothelial cells to oxidize linoleic acid. J. Biol. Chem. 1995, 270:17279-17286.
6. Camacho M., López-Belmonte J., Vila L. Rate of vasoconstrictor prostanoids released by endothelial cells depends on cyclooxygenase-2 expression and PGI-synthase activity. Circ. Res. 1998, 83:353-365.
7. 2 biosynthesis in vascular smooth muscle cells. J. Thromb. Haemost. 2007, 5:1411-1419.
8. 2 pathway in head and neck squamous cell carcinoma (HNSCC). Head Neck 2008, 30:1175-1181.
9. 2 is not a major metabolite of arachidonic acid in cultured endothelial cells from human foreskin microvessels. J. Clin. Invest. 1984, 74:914-919.
10. 2 synthesis blocks interstitial collagenase and 92-kDa type IV collagenase/gelatinase production by human monocytes. J. Biol. Chem. 1992, 267:515-519.
11. Dinarello C.A. Why not treat human cancer with interleukin-1 blockade?. Cancer Metastasis Rev. 2010, 29:317-329.
12. Dohadwala M., Batra R.K., Luo J., Lin Y., Krysan K., Pold M., Sharma S., Dubinett S.M. Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates matrix metalloproteinase-2 and CD44 in cyclooxygenase-2-dependent invasion. J. Biol. Chem. 2002, 277:50828-50833.
13. Gallo O., Franchi A., Magnelli L., Sardi I., Vannacci A., Boddi V., Chiarugi V., Masini E. Cyclooxygenase-2 pathway correlates with VEGF expression in head and neck cancer. Implications for tumor angiogenesis and metastasis. Neoplasia 2001, 3:53-61.
14. Gerritsen M.E., Cheli C.D. Arachidonic acid and prostaglandin endoperoxide metabolism in isolated rabbit and coronary microvessels and isolated and cultivated coronary microvessel endothelial cells. J. Clin. Invest. 1983, 72:1658-1671.
15. Godessart N., Camacho M., López-Belmonte J., Antón R., García M., de Moragas J.M., Vila L. Prostaglandin H-synthase-2 is the main enzyme involved in the biosynthesis of octadecanoids from linoleic acid in human dermal fibroblasts stimulated with IL-1β. J. Invest. Dermatol. 1996, 107:726-732.
16. 2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. Carcinogenesis 2009, 30:377-386.
17. Griffiths R. Prostaglandins and Inflammation. Inflammation: basic principles and clinical correlates 1999, 349-360. Lippincott Williams and Wilkins, Philadelphia, Pennsylvania. J. Gallin, R. Snyderman (Eds.).
18. Harris S.G., Padilla J., Koumas L., Ray D., Phipps R.P. Prostaglandins as modulators of immunity. Trends Immunol. 2002, 23:144-150.
19. Hu M., Polyak K. Microenvironmental regulation of cancer development. Curr. Opin. Genet. Dev. 2008, 18:27-34.
20. Iñiguez M.A., Rodriguez A., Volpert O.V., Fresno M., Redondo J.M. Cyclooxygenase-2: a therapeutic target in angiogenesis. Trends Mol. Med. 2003, 9:73-78.
21. Jabbour H.N., Milne S.A., Williams A.R., Anderson R.A., Boddy S.C. Expression of COX-2 and PGE synthase and synthesis of PGE2 in endometrial adenocarcinoma: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors. Br. J. Cancer 2001, 85:1023-1031.
22. Lewis A.M., Varghese S., Xu H., Alexander H.R. Interleukin-1 and cancer progression: the emerging role of interleukin-1 receptor antagonist as a novel therapeutic agent in cancer treatment. J. Transl. Med. 2006, 4:48. (Nov 10).
23. Liu C.H., Chang S.H., Narko K., Trifan O.C., Wu M.T., Smith E., Haudenschild C., Lane T.F., Hla T. Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice. J. Biol. Chem. 2001, 276:18563-18569.
24. McAdam B.F., Castella-Lawson F., Mardini I.A., Kapoor S., Lawson J.A., Fitzgerald G.A. Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2. Proc. Natl Acad. Sci. USA 1999, 96:272-277.
25. Murakami M., Kudo I. Prostaglandin E synthase: a novel drug target for inflammation and cancer. Curr. Pharm. Des. 2006, 12:943-954.
26. 2 synthase that acts in concert with cyclooxygenase-2. J. Biol. Chem. 2000, 275:32783-32792.
27. Murakami M., Nakatani Y., Tanioka T., Kudo I. Prostaglandin E synthase. Prostaglandins Other Lipid Mediat. 2002, 68-69:383-399.
28. Pai R., Soreghan B., Szabo I.L., Pavelka M., Baatar D., Tarnawski A.S. Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy. Nat. Med. 2002, 8:289-293.
29. Phipps R.P., Stein S.H., Roper R.L. A new view of prostaglandin E regulation of the immune response. Immunol. Today 1991, 12:349-352.
30. Romano M., Claria J. Cyclooxygenase-2 and 5-lipoxygenase converging functions on cell proliferation and tumor angiogenesis: implications for cancer therapy. FASEB J. 2003, 17:1986-1995.
31. 2 by tumor cells. Arterioscler. Thromb. Vasc. Biol. 2009, 29:1131-1137.
32. Seno H., Oshima M., Ishikawa T.O., Oshima H., Takaku K., Chiba T., Narumiya S., Taketo M.M. Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps. Cancer Res. 2002, 62:506-511.
33. 2 induction, mainly through the PI3-K/mTOR pathway in renal mesangial cells. Kidney Int. 2006, 70:1935-1941.
34. Soler M., Camacho M., Escudero J.R., Iñiguez M.A., Vila L. Human vascular smooth muscle cells but not endothelial cells express prostaglandin E synthase. Circ. Res. 2000, 87:504-507.
35. Sonoshita M., Takaku K., Sasaki N., Sugimoto Y., Ushikubi F., Narumiya S., Oshima M., Taketo M.M. Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice. Nat. Med. 2001, 7:1048-1051.
36. 4. Eur. J. Biochem. 2000, 267:6428-6434.
37. Tlsty T.D., Coussens L.M. Tumor stroma and regulation of cancer development. Annu. Rev. Pathol. 2006, 1:119-150.
38. Vila L. Cyclooxygenase and 5-lipoxygenase pathways in the vessel wall: role in atherosclerosis. Med. Res. Rev. 2004, 24:399-424.
39. West R.B., van de Rijn M. Experimental approaches to the study of cancer-stroma interactions: recent findings suggest a pivotal role for stroma in carcinogenesis. Lab. Invest. 2007, 87:967-970.
40. Williams C.S., Tsujii M., Reese J., Dey S.K., DuBois R.N. Host cyclooxygenase-2 modulates carcinoma growth. J. Clin. Invest. 2000, 105:1589-1594.
41. Yoshimatsu K., Golijanin D., Paty P.B., Soslow R.A., Jakobsson P.J., DeLellis R.A., Subbaramaiah K., Dannenberg A.J. Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer. Clinical Cancer Res. 2001, 7:3971-3976.
42. Ziche M., Jones J., Gullino P.M. Role of prostaglandin E1 and copper in angiogenesis. J. Natl Cancer Inst. 1982, 69:475-482.