Albumin causes increased myosin light chain kinase expression in astrocytes via p38 mitogen-activated protein kinase

Journal of Neuroscience Research

Volumn 89, Issue 6, 2011, Pages 852-861

  Rossi, Janet L ^a   Ralay Ranaivo, Hantamalala ^a   Patel, Fatima ^a   Chrzaszcz, Maryann ^a   Venkatesan, Charu ^a   Wainwright, Mark S ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Astrocyte; Blood brain barrier; Myosin light chain kinase; Transforming growth factor; Traumatic brain injury

Indexed keywords

ALBUMIN; MITOGEN ACTIVATED PROTEIN KINASE P38; MYOSIN LIGHT CHAIN KINASE; RHO KINASE; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRAUMATIC BRAIN INJURY;

ALBUMINS; ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BRAIN INJURIES; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; MICE; MICE, INBRED C57BL; MYOSIN-LIGHT-CHAIN KINASE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION; STATISTICS, NONPARAMETRIC; TIME FACTORS;

EID: 79954595957     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22600     Document Type: Article

References (38)

1. Abbott N. 2002. Astrocyte-endothelial interactions and blood-brain barrier permeability. J Anat 200: 629-638.
2. Afonso P, Ozden S, Prevost M, Schmitt C, Seilhean D, Weksler D, Couraud P, Gessain A, Romero I, Ceccaldi P. 2007. Human blood-brain barrier disruption by retroviral-infected lymphocytes: role of myosin light chain kinase in endothelial tight-junction disorganization. J Immunol 179: 2576-2583.
3. Amano M, Itol M, Kimura K, Fukata Y, Chihara K, Nakano T, Matsuura Y, Kaibuchi K. 1996. Phosphorylation and activation of myosin by rho-associated kinase. J Biol Chem 271: 20246-20249.
4. Baorto D, Mellado W, Shelanksi M. 1992. Astrocyte process growth induction by actin breakdown. J Cell Biol 117: 357-367.
5. Bazzoni G, Dejana E, Lampugnani M. 1999. Endothelial adhesion molecules in the development of the vascular tree: the garden of forking paths. Curr Opin Cell Biol 11: 573-591.
6. Cacheaux L, Ivens S, David Y, Lakhter A, Bar-Klein G, Shapira M, Heinemann U, Friedman A, Kaufer D. 2009. Transcriptome profiling reveals TGF-β signaling involvement in epileptogenesis. J Neurosci 29: 8927-8935.
7. Chrzaszcz M, Venkatesan C, Dragisic T, Watterson D, Wainwright M. 2010. Minozac treatment prevents increased seizure susceptibility in a mouse "two-hit" model of closed skull traumatic brain injury and electroconvulsive shock-induced seizure. J Neurotrauma 27: 1283-1295.
8. Clements R, Minnear F, Singer H, Keller R, Vincent P. 2005. RhoA and Rho kinase dependent and independent signals mediate TGF-β-induced pulmonary endothelial cytoskeletal reorganization and permeability. Am J Physiol 288: L294-L306.
9. Drexler H, Horning B. 1999. Endothelial dysfunction in human disease. J Mol Cell Cardiol 31: 51-60.
10. Edelman A, Higgins D, Bowman C, Habar S, Rabin R, Cho-Lee J. 1992. Myosin light chain kinase is expressed in neurons and glia: immunoblotting and immunocytochemical studies. Brain Res Mol Brain Res 14: 27-43.
11. Eiznhamer D, Flavin M, Jesmok G, Borgia J, Nelson D, Burhop K, Xu Z. 2004. Effective attenuation of endotoxin-induced acute lung injury by 2, 3-diacetyloxybenzoic acid in two independent animal models. Pulm Pharmacol Ther 17: 105-110.
12. Garcia J, Davis H, Patterson C. 1995. Regulation of endothelial cell gap formation and barrier dysfunction role of myosin light chain phosphorylation. J Cell Physiol 163: 510-522.
13. Haorah J, Heilman D, Knipe B, Chrastil J, Leibhart J, Ghorpade A, Miller D, Persidsky Y. 2005. Ethanol-Induced activation of myosin light chain kinase leads to dysfunction of tight junctions and blood-brain barrier compromise. Alcohol Clin Exp Res 29: 999-1009.
14. Hooper C, Pinteaux-Jones F, Fry V, Sevastou I, Baker D, Heales S, Pocock J. 2009. Differential effects of albumin on microglia and macrophages; implications for neurodegeneration following blood-brain barrier damage. J Neurochem 109: 694-705.
15. Ivens S, Kaufer D, Flores L, Bechmann I, Zumsteg D, Tomkins O, Seiffert E, Heinemann U, Friedman A. 2007. TGF-β receptor mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis. Brain Res 130: 535-547.
16. Kudryashov D, Stepanova O, Vilitkevich E, Nikonenko T, Nadezhdina E, Shanina N, Lukas T, Van Eldik L, Watterson D, Shirinsky V. 2004. Myosin light chain kinase (210 kDa) is a potential cytoskeleton integrator through its unique N-terminal domain. Exp Cell Res 298: 407-417.
17. Kuhlmann C, Lessmann V, Luhmann H. 2006. Fluvastatin stablizes the blood brain barrier in vitro by nitric oxide-dependent dephosphorylation of myosin light chains. Neuropharmacology 51: 907-913.
18. Kuhlmann C, Tamaki R, Garmerdinger M, Lessmann V, Behl C, Kempski O, Luhmann H. 2007. Inhibition of the myosin light chain kinase prevents hypoxia-induced blood-brain barrier disruption. J Neurochem 102: 501-507.
19. Kuhlmann C, Librizzi L, Closhen D, Pflanzner T, Lessmann V, Pietrzik C, de Curtis M, Luhmann H. 2009. Mechanisms of C-reactive protein-induced blood-brain barrier disruption. Stroke 40: 1458-1466.
20. Luh C, Kuhlmann C, Ackermann B, Timaru-Kast R, Luhmann H, Behl C, Werner C, Engelhard K, Thal S. 2010. Inhibition of myosin light chain kinase reduces brain edema formation after traumatic brain injury. J Neurochem 112: 1015-1025.
21. Mihaescu A, Santen S, Jeppsson B, Thorlacius H. 2010. p38 Mitogen-activated protein kinase signalling regulates vascular inflammation and epithelial barrier dysfunction in an experimental model of radiation-induced colitis. Br J Surg 97: 226-234.
22. Mirzapoiazova T, Moita J, Moreno-Vinasco L, Sammani S, Turner J, Evenoski C, Wang T, Singleton P, Huang Y, Lussier Y, Watterson D, Dudek S, Garcia J. 2011. The nonmuscle myosin light chain kinase isoform is a variable molecular target in acute inflammatory lung injury. Am J Respir Cell Mol Biol 44: 40-52.
23. Padmanabhan J, Shelanski M. 1998. Process formation in astrocytes: modulation of cytoskeletal proteins. Neurochem Res 23: 377-384.
24. Park S, Shim J, Kim M, Sun Y, Kwak S, Yan X, Choi B, Im C, Sim S, Jeong J, Kim I, Min Y, Sohn U. 2010. MLCK and PKC involvement via Gi and rho A protein in contraction by the electrical field stimulation in feline esophageal smooth muscle. Korean J Physiol Pharmacol 14: 29-35.
25. Parker J. 2000. Inhibitors of myosin light chain kinase and phosphodiesterase reduce ventilator-induced lung injury. J Appl Physiol 89: 2241-2248.
26. Ralay Ranaivo H, Wainwright M. 2010. Albumin activates astrocytes and microglia through mitogen activated protein kinase pathways. Brain Res 1313: 222-231.
27. Ralay Ranaivo H, Patel F, Wainwright M. 2010. Albumin activates the canonical TGF receptor-smad signaling pathway but this is not required for activation of astrocytes. Exp Neurol 226: 310-319.
28. Reynoso R, Perrin R, Breslin J, Daines D, Watson K, Watterson D, Wu M, Yuan S. 2007. A role for long chain myosin light chain kinase (MLCK-210) in microvascular hyperpermeability during severe burns. Shock 28: 589-595.
29. Rossi J, Velentza A, Steinhorn D, Watterson D, Wainwright M. 2007. MLCK210 gene knockout or kinase inhibition preserves lung function following endotoxin induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol 292: L1327-L1334.
30. Schmidt O, Infanger M, Heyde C, Ertel W, Stahel P. 2003. The role of neuroinflammation in traumatic brain injury. Eur J Trauma 30: 135-149.
31. Shen Q, Rigor R, Pivetti C, Wu M, Yuan S. 2010. Myosin light chain kinase in microvascular endothelial barrier function. Cardiovasc Res 87: 272-280.
32. Sinpitaksakul S, Pimkhaokham A, Sanchavanakit N, Pavasant P. 2008. TGF-beta1 induced MMP-9 expression in HNSCC cell lines via SMAD/MLCK. Biochem Biophys Res Commun 371: 713-718.
33. Somera-Molina K, Robin B, Somera C, Anderson C, Stine C, Koh S, Behanna H, Van Eldik L, Watterson D, Wainwright M. 2007. Glial activation links early-life seizures and long-term neurologic dysfunction: Evidence using a small molecule inhibitor of pro-inflammatory cytokine up-regulation. Epilepsia 48: 1785-1800.
34. Totsukawa G, Yamakita Y, Yamashiro S, Hartshorne D, Yasyharau S. 2000. Distinct roles of ROCK (rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts. J Cell Biol 150: 797-806.
35. Wainwright M, Rossi J, Schavocky J, Crawford S, Steinhorn D, Velentza A, Zasadski M, Shirinsky V, Jia Y, Haiech J, Van Eldik L, Watterson D. 2003. Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment. Proc Natl Acad Sci U S A 100: 6233-6238.
36. Wang F, Graham W, Wang Y, Witkowski E, Schwarz B, Turner J. 2005. Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal interstial epithelial barrier dysfunction by upregulating myosin light chain kinase. Am J Pathol 166: 409-419.
37. Yu C, Yezierski R, Joshi A, Raza K, Geddes J. 2010. Involvement of ERK2 in traumatic spinal cord injury. J Neurochem 113: 131-142.
38. Yurchenco P, Schittny J. 1990. Molecular architecture of basement membranes. FASEB J 4: 1577-1590.