MLCK210 gene knockout or kinase inhibition preserves lung function following endotoxin-induced lung injury in mice

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 292, Issue 6, 2007, Pages

  Rossi, Janet L ^a,b   Velentza, Anastasia V ^a   Steinhorn, David M ^a   Watterson, D Martin ^a   Wainwright, Mark S ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Acute respiratory distress syndrome; Endothelium; Oxygenation; Protein kinase

Indexed keywords

ENDOTOXIN; MYOSIN LIGHT CHAIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; IN VIVO STUDY; KNOCKOUT GENE; LUNG FUNCTION; LUNG INJURY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ACID-BASE EQUILIBRIUM; ANIMALS; ENDOTOXEMIA; ENZYME INHIBITORS; FEMALE; LIPOPOLYSACCHARIDES; LUNG COMPLIANCE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOSIN-LIGHT-CHAIN KINASE; OXYGEN; POSITIVE-PRESSURE RESPIRATION; PULMONARY EDEMA; PULMONARY GAS EXCHANGE; PYRIDAZINES; RESPIRATORY DISTRESS SYNDROME, ADULT;

EID: 34447534215     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00380.2006     Document Type: Article

References (36)

1. Abdulnour R, Peng X, Finigan J, Han E, Hasan E, Birukov K, Reddy S, Watkins J, Kayyali U, Garcia J, Tuder R, Hassoun P. Mechanical stress activates xanthine oxidoreductase through MAP kinase-dependent pathways. Am J Physiol Lung Cell Mol Physiol 291: L345-L353, 2006.
2. Arid W. Endothelial cell dynamics and complexity theory. Crit Care Med 30: S180-S185, 2002.
3. Avecillas J, Freire A, Arroliga A. Clinical epidemiology of acute lung injury and respiratory distress syndrome: incidence, diagnosis and outcomes. Clin Chest Med 27: 549-557, 2006.
4. Birukov K, Shavocky J, Shirinsky V, Chibalina M, Van Eldik L, Watterson D. Organization of the genetic locus for chicken myosin light chain kinase is complex: multiple proteins are encoded and exhibit differential expression and localization. J Cell Biochem 70: 402-413, 1998.
5. Birukova A, Birukov K, Gorshkov B, Liu F, Garcia J. MAP kinases in lung endothelial permeability induced by microtubule disassembly. Am J Physiol Lung Cell Mol Physiol 289: L75-L84, 2005.
6. Brigham K, Bowers R, Haynes J. Increased sheep lung vascular permeability caused by Escherichia coli endotoxin. Circ Res 45: 292-297, 1979.
7. Brower R, Rubenfeld G. Lung protective ventilation strategies in acute lung injury. Crit Care Med 31: S312-S316, 2003.
8. Clayburgh D, Shen L, Turner J. A porous defense: the leaky epithelial barrier in intestinal disease. Lab Invest 84: 282-291, 2004.
9. Dhainaut J, Yan S, Cariou A, Mira J. Soluble thrombomodulin, plasma-derived unactivated protein C, and recombinant human activated protein C in sepsis. Crit Care Med 30: S318-S324, 2002.
10. Dudek S, Garcia J. Cytoskeletal regulation of pulmonary vascular permeability. J Appl Physiol 91: 1487-1500, 2001.
11. Dudek S, Peng X, Birukov K, Wang P, Zahn X, Wadgononkar R, McGillem L, Pearse D, Chaing E, Garcia J. Mechanisms of sphingosine 1-phosphate mediated lung vascular barrier enhancement in vivo and in vitro. J Biol Chem 279: 24692-24700, 2004.
12. Fink M, Delude R. Epithelial barrier dysfunction: a unifying theme to explain the pathogenesis of multiple organ dysfunction at the cellular level. Crit Care Clin 21: 177-196, 2005.
13. Garcia J, Davis H, Patterson C. Regulation of endothelial cell gap formation and barrier dysfunction: role of myosin light chain phosphorylation. J Cell Physiol 163: 510-522, 1995.
14. Groeneveld ABJ. Vascular pharmacology of acute lung injury and acute respiratory distress syndrome. Vasc Pharm 39: 247-256, 2002.
15. Kabir K, Gelinas M, Chen M, Chen D, Luo X, Yang J, Carter D, Rabinovici R. Characterization of a murine model of endotoxin-induced acute lung injury. Shock 17: 300-303, 2002.
16. Levi M, Cate H, Van der Poll T. Endothelium: interface between coagulation and inflammation. Crit Care Med 30: S220-S224, 2002.
17. McVerry B, Garcia J. Endothelial cell barrier regulation by sphinosine 1-phosphate. J Cell Biochem 92: 1075-1085, 2004.
18. Mirzoeva S, Sawkar A, Zasadzki M, Ling G, Velentza A, Dunlap V, Bourguingnon J, Ramstrom H, Jaiech J, Van Eldik L, Watterson D. Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound. J Med Chem 45: 563-566, 2002.
19. Murphy H, Bakopoulos N, Dame M, Varani J, Ward P. Heterogeneity of vascular endothelial cells: differences in susceptibility to neutrophil-mediated injury. Microvasc Res 56: 203-211, 1998.
20. Mustafa A, McKallip R, Fisher M, Duncan R, Nagarkatti R, Nagarkatti M. Regulation of interleukin-2-induced vascular leak syndrome by targeting CD44 using hyaluronic acid and anti-CD4 antibodies. J Immunotherapy 25: 476-488, 2002.
21. The ARDS Network. Ventilation with lower tidal volumes as compared to with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342: 1301-1308, 2000.
22. Parker J. Inhibitors of myosin light chain kinase and phosphodiesterase reduce ventilator-induced lung injury. J Appl Physiol 89: 2241-2248, 2000.
23. Parker J, Townsley M. Evaluation of lung injury in rats and mice. Am J Physiol Lung Cell Mol Physiol 286: L312-L316, 2004.
24. Peters J, Unger R, Brunner J, Kirkpatrick C. Molecular basis of endothelial dysfunction in sepsis. Cardiovasc Res 60: 49-57, 2003.
25. Stevens T, Garcia J, Shasby D, Bhattacharya J, Malik A. Mechanisms regulating endothelial cell barrier function. Am J Physiol Lung Cell Mol Physiol 279: L419-L422, 2000.
26. Tinsley J, De Lanerolle P, Wilson E, Ma W, Yuan S. Myosin light chain kinase transference induces light chain activation and endothelial hyperpermeability. Am J Physiol Lung Cell Mol Physiol 279: L1285-L1289, 2000.
27. Tinsley J, Teasdale N, Yuan S. Myosin light chain phosphorylation and pulmonary endothelial cell hyperpermeability in burns. Am J Physiol Lung Cell Mol Physiol 286: L841-L847, 2004.
28. 2+ channels and pulmonary endothelial permeability: insights from study of intact lung and chronic pulmonary hypertension. Microcirculation 13: 725-739, 2006.
29. Turner J. Molecular basis of epithelial barrier regulation: from basic mechanism to clinical application. Am J Pathol 169: 1901-1909, 2006.
30. Van Nieuw Amerongen G, Draijer R, Vermeer M, Van Hinsbergh V. Transient and prolonged increase in endothelial permeability induced by histamine and thrombin: role of protein kinases, calcium, and RhoA. Circ Res 83: 1115-1123, 1998.
31. Wainwright M, Rossi J, Schavocky J, Crawford S, Steinhorn D, Velentza A, Zasadski M, Shirinsky V, Jia Y, Haiech J, Van Eldik L, Watterson D. Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment. Proc Natl Acad Sci USA 100: 6233-6238, 2003.
32. Ware L. Pathophysiology of acute lung injury and the respiratory distress syndrome. Semin Respir Crit Care Med 27: 337-349, 2006.
33. Warfel J, Steele A, D'Agnillo F. Anthrax lethal toxin induced endothelial barrier dysfunction. Am J Pathol 166: 1871-1881, 2005.
34. Weinert C, Gross C, Marinelli W. Impact of randomized trial results on acute lung injury ventilator therapy in teaching hospitals. Am J Respir Crit Care Med 167: 1304-1309, 2003.
35. West JB, Mathieu-Costello O. Structure, strength, failure and remodeling of the pulmonary blood-gas barrier. Annu Rev Physiol 61: 543-572, 1999.
36. Whitehead T, Slutsky A. The pulmonary physician in critical care *7: ventilator induced lung injury. Thorax 57: 635-642, 2002.