Improvement in insulin sensitivity by weight loss does not affect hyperinsulinemia-mediated reduction in total and high molecular weight adiponectin: A MONET study

Applied Physiology, Nutrition and Metabolism

Volumn 36, Issue 2, 2011, Pages 191-200

  Drapeau, Sophie ^a   Doucet, Éric ^a   Rabasa Lhoret, Remi ^b   Brochu, Martin ^c   Prud'homme, Denis ^a   Imbeault, Pascal ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

^b CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^c UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

Caloric restriction; Hyperinsulinemic euglycemic clamp; Menopause; Obesity; Resistance training

Indexed keywords

ADIPONECTIN; BIOLOGICAL MARKER; INSULIN; LIPID;

ABDOMINAL FAT; AGED; ANALYSIS OF VARIANCE; ARTICLE; BLOOD; CALORIC RESTRICTION; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GLUCOSE CLAMP TECHNIQUE; HUMAN; HYPERINSULINISM; INSULIN RESISTANCE; INTRAABDOMINAL FAT; METHODOLOGY; MIDDLE AGED; OBESITY; OXYGEN CONSUMPTION; POSTMENOPAUSE; RADIOGRAPHY; RANDOMIZED CONTROLLED TRIAL; RESISTANCE TRAINING; WEIGHT REDUCTION;

ABDOMINAL FAT; ADIPONECTIN; AGED; ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; CALORIC RESTRICTION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLUCOSE CLAMP TECHNIQUE; HUMANS; HYPERINSULINISM; INSULIN; INSULIN RESISTANCE; INTRA-ABDOMINAL FAT; LIPIDS; MIDDLE AGED; OBESITY; OXYGEN CONSUMPTION; POSTMENOPAUSE; RESISTANCE TRAINING; TOMOGRAPHY, X-RAY COMPUTED; WEIGHT LOSS;

EID: 79954574445     PISSN: 17155312     EISSN: 17155320     Source Type: Journal    
DOI: 10.1139/h10-106     Document Type: Article

References (36)

1. Abbasi, F., Chu, J.W., Lamendola, C., McLaughlin, T., Hayden, J., Reaven, G.M., and Reaven, P.D. 2004. Discrimination between obesity and insulin resistance in the relationship with adiponectin. Diabetes, 53(3): 585-590. doi:10.2337/diabetes.53.3.585. PMID:14988241.
2. Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J., et al. 1999. Paradoxical decrease of an adiposespecific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun. 257(1): 79-83. doi:10.1006/bbrc.1999.0255. PMID:10092513.
3. Berg, A.H., Combs, T.P., Du, X., Brownlee, M., and Scherer, P.E. 2001. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat. Med. 7(8): 947-953. doi:10.1038/90992. PMID:11479628.
4. Blümer, R.M., van der Crabben, S.N., Stegenga, M.E., Tanck, M. W., Ackermans, M.T., Endert, E., et al. 2008. Hyperglycemia prevents the suppressive effect of hyperinsulinemia on plasma adiponectin levels in healthy humans. Am. J. Physiol. Endocrinol. Metab. 295(3): E613-E617. doi:10.1152/ajpendo.90288. 2008. PMID:18577692.
5. Bobbert, T., Weicht, J., Mai, K., Mohlig, M., Pfeiffer, A.F., and Spranger, J. 2009. Acute hyperinsulinaemia and hyperlipidaemia modify circulating adiponectin and its oligomers. Clin. Endocrinol. (Oxf.), 71(4): 507-511. doi:10.1111/j.1365-2265.2008.03519.x. PMID:19751297.
6. Brame, L.A., Considine, R.V., Yamauchi, M., Baron, A.D., and Mather, K.J. 2005. Insulin and endothelin in the acute regulation of adiponectin in vivo in humans. Obes. Res. 13(3): 582-588. doi:10.1038/oby.2005.62. PMID:15833944.
7. Brochu, M., Mathieu, M.E., Karelis, A.D., Doucet, E., Lavoie, M.E., Garrel, D., and Rabasa-Lhoret, R. 2008. Contribution of the lean body mass to insulin resistance in postmenopausal women with visceral obesity: a Monet study. Obesity (Silver Spring), 16(5): 1085-1093. doi:10.1038/oby.2008.23. PMID:18356851.
8. Brochu, M., Malita, M.F., Messier, V., Doucet, E., Strychar, I., Lavoie, J.M., et al. 2009. Resistance training does not contribute to improving the metabolic profile after a 6-month weight loss program in overweight and obese postmenopausal women. J. Clin. Endocrinol. Metab. 94(9): 3226-3233. doi:10.1210/jc.2008-2706. PMID:19567540.
9. Das, K., Lin, Y., Widen, E., Zhang, Y., and Scherer, P.E. 2001. Chromosomal localization, expression pattern, and promoter analysis of the mouse gene encoding adipocyte-specific secretory protein Acrp30. Biochem. Biophys. Res. Commun. 280(4): 1120-1129. doi:10.1006/bbrc.2001.4217. PMID:11162643.
10. Defronzo, R.A. 1979. Glucose intolerance and aging: evidence for tissue insensitivity to insulin. Diabetes, 28(12): 1095-1101. PMID:510806.
11. DeFronzo, R.A., Gunnarsson, R., Bjorkman, O., Olsson, M., and Wahren, J. 1985. Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J. Clin. Invest. 76(1): 149-155. doi:10.1172/JCI111938. PMID:3894418.
12. Elisha, B., Karelis, A.D., Imbeault, P., and Rabasa-Lhoret, R. 2010. Effects of acute hyperinsulinaemia on total and high-molecularweight adiponectin concentration in metabolically healthy but obese postmenopausal women: a Montreal-Ottawa New Emerging Team (MONET) study. Diabetes Metab. 36(4): 319-321. doi:10.1016/j.diabet.2010.03.004. PMID:20605505.
13. Faraj, M., Beauregard, G., Tardif, A., Loizon, E., Godbout, A., Cianflone, K., et al. 2008. Regulation of leptin, adiponectin and acylation-stimulating protein by hyperinsulinaemia and hyperglycaemia in vivo in healthy lean young men. Diabetes Metab. 34(4 Pt. 1): 334-342. doi:10.1016/j.diabet.2008.01.014. PMID: 18562232.
14. Fasshauer, M., Klein, J., Neumann, S., Eszlinger, M., and Paschke, R. 2002. Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes. Biochem. Biophys. Res. Commun. 290(3): 1084-1089. doi:10.1006/bbrc.2001.6307. PMID:11798186.
15. Fisher, F.F., Trujillo, M.E., Hanif, W., Barnett, A.H., McTernan, P.G., Scherer, P.E., and Kumar, S. 2005. Serum high molecular weight complex of adiponectin correlates better with glucose tolerance than total serum adiponectin in Indo-Asian males. Diabetologia, 48(6): 1084-1087. doi:10.1007/s00125-005-1758-7. PMID: 15902402.
16. Friedewald, W.T., Levy, R.I., and Fredrickson, D.S. 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18(6): 499-502. PMID:4337382.
17. Højlund, K., Frystyk, J., Levin, K., Flyvbjerg, A., Wojtaszewski, J.F., and Beck-Nielsen, H. 2006. Reduced plasma adiponectin concentrations may contribute to impaired insulin activation of glycogen synthase in skeletal muscle of patients with type 2 diabetes. Diabetologia, 49(6): 1283-1291. doi:10.1007/s00125-006-0240-5. PMID:16609880.
18. Hotta, K., Funahashi, T., Bodkin, N.L., Ortmeyer, H.K., Arita, Y., Hansen, B.C., and Matsuzawa, Y. 2001. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes, 50(5): 1126-1133. doi:10.2337/diabetes.50.5.1126. PMID:11334417.
19. Imbeault, P. 2007. Environmental influences on adiponectin levels in humans. Appl. Physiol. Nutr. Metab. 32(3): 505-511. doi:10.1139/ H07-017. PMID:17510690.
20. Imbeault, P., Pomerleau, M., Harper, M.E., and Doucet, E. 2004. Unchanged fasting and postprandial adiponectin levels following a 4-day caloric restriction in young healthy men. Clin. Endocrinol. (Oxf.), 60(4): 429-433. doi:10.1111/j.1365-2265.2004.01997.x. PMID:15049956.
21. Karelis, A.D., Tousignant, B., Nantel, J., Proteau-Labelle, M., Malita, F.M., St-Pierre, D.H., et al. 2007. Association of insulin sensitivity and muscle strength in overweight and obese sedentary postmenopausal women. Appl. Physiol. Nutr. Metab. 32(2): 297-301. doi:10.1139/H07-002. PMID:17486172.
22. Karelis, A.D., Lavoie, M.E., Messier, V., Mignault, D., Garrel, D., Prud'homme, D., and Rabasa-Lhoret, R. 2008. Relationship between the metabolic syndrome and physical activity energy expenditure: a MONET study. Appl. Physiol. Nutr. Metab. 33(2): 309-314. doi:10.1139/H07-193. PMID:18347686.
23. Krauss, R.M., Deckelbaum, R.J., Ernst, N., Fisher, E., Howard, B.V., Knopp, R.H., et al. 1996. Dietary guidelines for healthy American adults. A statement for health professionals from the Nutrition Committee, American Heart Association. Circulation, 94(7): 1795-1800. PMID:8840887.
24. Larson-Meyer, D.E., Heilbronn, L.K., Redman, L.M., Newcomer, B. R., Frisard, M.I., Anton, S., et al. 2006. Effect of calorie restriction with or without exercise on insulin sensitivity, b-cell function, fat cell size, and ectopic lipid in overweight subjects. Diabetes Care, 29(6): 1337-1344. doi:10.2337/dc05-2565. PMID:16732018.
25. Möhlig, M., Wegewitz, U., Osterhoff, M., Isken, F., Ristow, M., Pfeiffer, A.F., and Spranger, J. 2002. Insulin decreases human adiponectin plasma levels. Horm. Metab. Res. 34(11/12): 655-658. doi:10.1055/s-2002-38248. PMID:12660877.
26. Murdolo, G., Hammarstedt, A., Schmelz, M., Jansson, P.A., and Smith, U. 2009. Acute hyperinsulinemia differentially regulates interstitial and circulating adiponectin oligomeric pattern in lean and insulin-resistant, obese individuals. J. Clin. Endocrinol. Metab. 94(11): 4508-4516. doi:10.1210/jc.2009-0431. PMID: 19820029.
27. Ouchi, N., Kihara, S., Arita, Y., Maeda, K., Kuriyama, H., Okamoto, Y., et al. 1999. Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation, 100(25): 2473-2476. PMID:10604883.
28. Pajvani, U.B., Du, X., Combs, T.P., Berg, A.H., Rajala, M.W., Schulthess, T., et al. 2003. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications for metabolic regulation and bioactivity. J. Biol. Chem. 278(11): 9073-9085. doi:10.1074/jbc.M207198200. PMID:12496257.
29. Pajvani, U.B., Hawkins, M., Combs, T.P., Rajala, M.W., Doebber, T., Berger, J.P., et al. 2004. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J. Biol. Chem. 279(13): 12152-12162. doi:10.1074/jbc.M311113200. PMID:14699128.
30. Perseghin, G., Lattuada, G., Danna, M., Sereni, L.P., Maffi, P., De Cobelli, F., et al. 2003. Insulin resistance, intramyocellular lipid content, and plasma adiponectin in patients with type 1 diabetes. Am. J. Physiol. Endocrinol. Metab. 285(6): E1174-E1181. PMID:12933352.
31. Qiang, L., Wang, H., and Farmer, S.R. 2007. Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L a. Mol. Cell. Biol. 27(13): 4698-4707. doi:10.1128/MCB. 02279-06. PMID:17452443.
32. Ruge, T., Lockton, J.A., Renstrom, F., Lystig, T., Sukonina, V., Svensson, M.K., and Eriksson, J.W. 2009. Acute hyperinsulinemia raises plasma interleukin-6 in both nondiabetic and type 2 diabetes mellitus subjects, and this effect is inversely associated with body mass index. Metabolism, 58(6): 860-866. doi:10.1016/j.metabol. 2009.02.010. PMID:19375766.
33. Scherer, P.E. 2006. Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes, 55(6): 1537-1545. doi:10.2337/db06-0263. PMID:16731815.
34. Semple, R.K., Halberg, N.H., Burling, K., Soos, M.A., Schraw, T., Luan, J., et al. 2007. Paradoxical elevation of high-molecular weight adiponectin in acquired extreme insulin resistance due to insulin receptor antibodies. Diabetes, 56(6): 1712-1717. doi:10.2337/db06-1665. PMID:17325257.
35. Weinsier, R.L., Nagy, T.R., Hunter, G.R., Darnell, B.E., Hensrud, D. D., and Weiss, H.L. 2000. Do adaptive changes in metabolic rate favor weight regain in weight-reduced individuals? An examination of the set-point theory. Am. J. Clin. Nutr. 72(5): 1088-1094. PMID:11063433.
36. Yu, J.G., Javorschi, S., Hevener, A.L., Kruszynska, Y.T., Norman, R. A., Sinha, M., and Olefsky, J.M. 2002. The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. Diabetes, 51(10): 2968-2974. doi:10.2337/diabetes.51.10.2968. PMID:12351435.