Aspartate release and signalling in the hippocampus

Neurochemical Research

Volumn 36, Issue 4, 2011, Pages 668-676

  Nadler, J Victor ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aspartate; Hippocampus; KB R7943; NMDA receptor; Sialin; Synaptic transmission

Indexed keywords

4 AMINOBUTYRIC ACID; ASPARTIC ACID; BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B;

4 AMINOBUTYRIC ACID RELEASE; AMINO ACID SYNTHESIS; ARTICLE; EXCITOTOXICITY; EXOCYTOSIS; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; HUMAN; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE CELL NECROSIS; NERVE ENDING; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SYNAPSE VESICLE; TRANSCRIPTION INITIATION;

ANIMALS; ASPARTIC ACID; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; HIPPOCAMPUS; HUMANS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 79954571300     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-010-0291-3     Document Type: Article

References (68)

1. TVP Bliss T Lømo 1973 Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path J Physiol 232 331 356 4727084 1:STN:280:DyaE3s3ktlersw%3D%3D
2. TVP Bliss AR Gardner-Medwin 1973 Long-lasting potentiation of the dentate area in the unanaesthetized rabbit following stimulation of the perforant path J Physiol 232 357 374 4727085 1:STN:280:DyaE3s3ktlersA%3D%3D
3. Cotman CW, Nadler JV (1978) Reactive synaptogenesis in the hippocampus. In: Cotman CW (ed) Neuronal plasticity. Raven, New York, pp 227-271
4. DR Curtis JW Phillis JC Watkins 1960 The chemical excitation of spinal neurones by certain acidic amino acids J Physiol 150 656 682 13813400 1:CAS:528:DyaF3cXot1WqtQ%3D%3D
5. DR Curtis JC Watkins 1960 The excitation and depression of spinal neurones by structurally related amino acids J Neurochem 6 117 141 13718948 10.1111/j.1471-4159.1960.tb13458.x 1:CAS:528:DyaF3MXns12nsw%3D%3D
6. JV Nadler KW Vaca WF White, et al. 1976 Aspartate and glutamate as possible transmitters of excitatory hippocampal afferents Nature 260 538 540 4735 10.1038/260538a0 1:CAS:528:DyaE28XksVCit7k%3D
7. JV Nadler WF White KW Vaca, et al. 1977 Characterization of putative amino acid transmitter release from slices of rat dentate gyrus J Neurochem 29 279 290 18560 10.1111/j.1471-4159.1977.tb09620.x 1:CAS:528:DyaE2sXlvVWnsro%3D (Pubitemid 8151965)
8. V Gundersen OP Ottersen J Storm-Mathisen 1991 Aspartate- and glutamate-like immunoreactivities in rat hippocampal slices: depolarization-induced redistribution and effects of precursors Eur J Neurosci 3 1281 1299 12106226 10.1111/j.1460-9568.1991.tb00061.x
9. V Gundersen FA Chaudhry JG Bjaalie, et al. 1998 Synaptic vesicular localization and exocytosis of L-aspartate in excitatory nerve terminals: a quantitative immunogold analysis in rat hippocampus J Neurosci 18 6059 6070 9698301 1:CAS:528:DyaK1cXlsVaht7g%3D (Pubitemid 28373215)
10. V Gundersen AT Holten J Storm-Mathisen 2004 GABAergic synapses in hippocampus exocytose aspartate on to NMDA receptors: quantitative immunogold evidence for co-transmission Mol Cell Neurosci 26 156 165 15121187 10.1016/j.mcn.2004.01.017 1:CAS:528:DC%2BD2cXjs1Chu78%3D (Pubitemid 38581031)
11. M Larsson S Persson OP Ottersen, et al. 2001 Quantitative analysis of immunogold labeling indicates low levels and non-vesicular localization of L-aspartate in rat primary afferent terminals J Comp Neurol 430 147 159 11135252 10.1002/1096-9861(20010205)430:2<147::AID-CNE1021>3.0.CO;2-5 1:CAS:528:DC%2BD3MXnvV2qsQ%3D%3D (Pubitemid 32052653)
12. S Persson J Broman 2004 Glutamate, but not aspartate, is enriched in trigeminothalamic tract terminals and associated with their synaptic vesicles in the rat nucleus submedius Exp Brain Res 157 152 161 14968283 10.1007/s00221-004-1837-x 1:CAS:528:DC%2BD2cXltVKmsLY%3D (Pubitemid 38916454)
13. V Gundersen F Fonnum OP Ottersen, et al. 2001 Redistribution of neuroactive amino acids in hippocampus and striatum during hypoglycemia: a quantitative immunogold study J Cereb Blood Flow Metab 21 41 51 11149667 10.1097/00004647-200101000-00006 1:CAS:528:DC%2BD3MXntFKjtbw%3D (Pubitemid 32016838)
14. SP Burke JV Nadler 1988 Regulation of glutamate and aspartate release from slices of the hippocampal CA1 area: effects of adenosine and baclofen J Neurochem 51 1541 1551 2902197 10.1111/j.1471-4159.1988.tb01123.x 1:CAS:528:DyaL1cXmt1eis74%3D (Pubitemid 18264377)
15. M Zhou CL Peterson Y-B Lu, et al. 1995 Release of glutamate and aspartate from CA1 synaptosomes: selective modulation of aspartate release by ionotropic glutamate receptor ligands J Neurochem 64 1556 1566 7891083 10.1046/j.1471-4159. 1995.64041556.x 1:CAS:528:DyaK2MXksVKisbo%3D
16. SE Bradford JV Nadler 2004 Aspartate release from rat hippocampal synaptosomes Neuroscience 128 751 765 15464283 10.1016/j.neuroscience.2004.06. 065 1:CAS:528:DC%2BD2cXotF2gsro%3D (Pubitemid 39298428)
17. D Nicholls D Attwell 1990 The release and uptake of excitatory amino acids Trends Pharmacol Sci 11 462 468 1980041 10.1016/0165-6147(90)90129-V (Pubitemid 20351933)
18. CL Peterson MA Thompson D Martin, et al. 1995 Modulation of glutamate and aspartate release from slices of hippocampal area CA1 by inhibitors of arachidonic acid metabolism J Neurochem 64 1152 1160 7861146 10.1046/j.1471-4159.1995.64031152.x 1:CAS:528:DyaK2MXjvVygtbo%3D
19. MT Herrero MJ Oset-Gasque C Cañadas, et al. 1998 Effect of various depolarizing agents on endogenous amino acid transmitter release in rat cortical neurons in culture Neurochem Int 32 257 264 9587919 10.1016/S0197-0186(97) 00088-0 1:CAS:528:DyaK1cXisFShsL8%3D (Pubitemid 28156445)
20. MW Fleck G Barrionuevo AM Palmer 2001 Synaptosomal and vesicular accumulation of L-glutamate, L-aspartate and D-aspartate Neurochem Int 39 217 225 11434980 10.1016/S0197-0186(01)00018-3 1:CAS:528:DC%2BD3MXkvVers70%3D (Pubitemid 32575262)
21. A Cavallero A Marte E Fedele 2009 L-Aspartate as an amino acid neurotransmitter: mechanisms of the depolarization-induced release from cerebrocortical synaptosomes J Neurochem 110 924 934 19549007 10.1111/j.1471-4159.2009.06187.x 1:CAS:528:DC%2BD1MXptlens7k%3D
22. 2+ exchange in cells expressing NCX1 J Biol Chem 271 22391 22397 8798401 10.1074/jbc.271.37.22391 1:CAS:528:DyaK28Xlslaitbw%3D (Pubitemid 26304672)
23. AT Holten C Morland K Nordengen, et al. 2008 Vesicular release of L- and D-aspartate from hippocampal nerve terminals: immunogold evidence Open Neurosci J 2 51 58 10.2174/1874082000802010051 1:CAS:528:DC%2BD1MXjt1Kitg%3D%3D
24. HT McMahon P Foran JO Dolly, et al. 1992 Tetanus toxin and botulinum toxins type A and B inhibit glutamate, γ-aminobutyric acid, aspartate, and met-enkephalin release from synaptosomes J Biol Chem 267 21338 21343 1356988 1:CAS:528:DyaK38Xls1GltLc%3D
25. MW Fleck G Barrionuevo AM Palmer 2001 Release of D-threo-β- hydroxyaspartate as a false transmitter from excitatory amino acid-releasing nerve terminals Neurochem Int 39 75 81 11311452 10.1016/S0197-0186(00)00111-X 1:CAS:528:DC%2BD3MXkslWqs7Y%3D (Pubitemid 32304458)
26. O Rossetto L Morbiato P Caccin, et al. 2006 Presynaptic enzymatic neurotoxins J Neurochem 97 1534 1545 16805767 10.1111/j.1471-4159.2006.03965.x 1:CAS:528:DC%2BD28Xnt1Onsrc%3D (Pubitemid 43873651)
27. G Schiavo M Matteoli C Montecucco 2000 Neurotoxins affecting neuroexocytosis Physiol Rev 80 717 766 10747206 1:CAS:528:DC%2BD3cXisFShu7c%3D (Pubitemid 30164948)
28. LL Simpson 2004 Identification of the major steps in botulinum neurotoxin action Annu Rev Pharmacol Toxicol 44 167 193 14744243 10.1146/annurev.pharmtox. 44.101802.121554 1:CAS:528:DC%2BD2cXhvVCkt7Y%3D (Pubitemid 38263838)
29. L Wang JV Nadler 2007 Reduced aspartate release from rat hippocampal synaptosomes loaded with Clostridial toxin light chain by electroporation: evidence for an exocytotic mechanism Neurosci Lett 412 239 242 17123709 10.1016/j.neulet.2006.11.006 1:CAS:528:DC%2BD2sXnsl2msw%3D%3D (Pubitemid 46109149)
30. 2+ exchange inhibitor KB-R7943 Neuropharmacology 38 1235 1242 10462135 10.1016/S0028- 3908(99)00040-4 1:CAS:528:DyaK1MXltVCgs7o%3D (Pubitemid 29292411)
31. 2+ entry in cultured neurons and astrocytes Biochem Biophys Res Comm 279 354 357 10.1006/bbrc.2000.3968 (Pubitemid 32016721)
32. 2+ exchange inhibitor KB-R7943 also blocks native and expressed neuronal nicotinic receptors Brit J Pharmacol 130 1893 1902 10.1038/sj.bjp.0703519 1:CAS:528:DC%2BD3cXmtFemsr0%3D (Pubitemid 30655802)
33. 2+ exchange inhibitor KB-R7943 potently blocks TRPC channels Biochem Biophys Res Comm 361 230 236 17658472 10.1016/j.bbrc.2007.07.019 1:CAS:528:DC%2BD2sXotlWrurw%3D (Pubitemid 47102290)
34. + channels in endothelial and vascular smooth muscle cells Eur J Pharmacol 582 35 41 18237728 10.1016/j.ejphar.2007.12.021 1:CAS:528:DC%2BD1cXitVeitLk%3D
35. YH Chung HS Ahn D Kim, et al. 2006 Immunohistochemical study on the distribution of TRPC channels in the rat hippocampus Brain Res 1085 132 137 16580647 10.1016/j.brainres.2006.02.087 1:CAS:528:DC%2BD28XkvVygs78%3D (Pubitemid 43728203)
36. J Zhou W Du K Zhou, et al. 2008 Critical role of TRPC6 channels in the formation of excitatory synapses Nat Neurosci 11 741 743 18516035 10.1038/nn.2127 1:CAS:528:DC%2BD1cXns1Onurk%3D (Pubitemid 351896670)
37. JC Szerb 1988 Changes in the relative amounts of aspartate and glutamate released and retained in hippocampal slices during stimulation J Neurochem 50 219 224 2891785 10.1111/j.1471-4159.1988.tb13252.x 1:CAS:528: DyaL1cXkvFyruw%3D%3D (Pubitemid 18023502)
38. EC McNay PE Gold 1999 Extracellular glucose concentrations in the rat hippocampus measured by zero-net-flux: effects of microdialysis flow rate, strain and age J Neurochem 72 785 790 9930754 10.1046/j.1471-4159.1999.720785.x 1:CAS:528:DyaK1MXmt1ylsQ%3D%3D (Pubitemid 29055244)
39. SP Burke JV Nadler 1989 Effects of glucose deficiency on glutamate/aspartate release and excitatory synaptic responses in the hippocampal CA1 area in vitro Brain Res 500 333 342 2575005 10.1016/0006-8993(89)90329-6 1:CAS:528:DyaL1MXmt1Grsbg%3D (Pubitemid 19257052)
40. MW Fleck DA Henze G Barrionuevo, et al. 1993 Aspartate and glutamate mediate excitatory synaptic transmission in area CA1 of the hippocampus J Neurosci 13 3944 3955 7690067 1:CAS:528:DyaK3sXmsVWrs7o%3D (Pubitemid 23264378)
41. RJ Reimer RH Edwards 2004 Organic anion transport is the primary function of the SLC17/type 1 phosphate transporter family Pflügers Arch 447 629 635 12811560 10.1007/s00424-003-1087-y 1:CAS:528:DC%2BD2cXhtVygsb0%3D (Pubitemid 38241447)
42. T Miyaji N Echigo M Hiasa, et al. 2008 Identification of a vesicular aspartate transporter Proc Natl Acad Sci USA 105 11720 11724 18695252 10.1073/pnas.0804015105 1:CAS:528:DC%2BD1cXhtVCnur3O
43. LM Prolo H Vogel RJ Reimer 2009 The lysosomal sialic acid transporter sialin is required for normal CNS myelination J Neurosci 29 15355 15365 20007460 10.1523/JNEUROSCI.3005-09.2009 1:CAS:528:DC%2BD1MXhsFOgsb%2FN
44. 2+-regulated exocytosis from cortical astrocytes J Neurosci 28 7648 7658 18650341 10.1523/JNEUROSCI.0744-08.2008 1:CAS:528:DC%2BD1cXpt12mur4%3D
45. N Aula O Kopra A Jalanko, et al. 2004 Sialin expression in the CNS implicates extralysosomal function in neurons Neurobiol Dis 15 251 261 15006695 10.1016/j.nbd.2003.11.017 1:CAS:528:DC%2BD2cXhvFSktLg%3D (Pubitemid 38296756)
46. +-dependent transporter in rat pinealocytes J Neurochem 69 340 347 9202328 10.1046/j.1471-4159.1997.69010340.x 1:CAS:528:DyaK2sXktV2msLk%3D (Pubitemid 27274190)
47. N Yarovaya R Schot L Fodero, et al. 2005 Sialin, an anion transporter defective in sialic acid storage diseases, shows highly variable expression in adult mouse brain, and is developmentally regulated Neurobiol Dis 19 351 365 16023578 10.1016/j.nbd.2004.12.020 1:CAS:528:DC%2BD2MXmt1aqtL8%3D (Pubitemid 40968049)
48. N Aula P Salomäki R Timonen, et al. 2000 The spectrum of SLC17A5-gene mutations resulting in free sialic acid-storage diseases indicates some genotype-phenotype correlation Am J Hum Genet 67 832 840 10947946 10.1086/303077 1:CAS:528:DC%2BD3cXnsVCgs7o%3D
49. P Morin C Sagné B Gasnier 2004 Functional characterization of wild-type and mutant human sialin EMBO J 23 4560 4570 15510212 10.1038/sj.emboj.7600464 1:CAS:528:DC%2BD2cXhtVWisr3E (Pubitemid 39657856)
50. CC Wreden M Wlizla RJ Reimer 2005 Varied mechanisms underlie the free sialic acid storage disorders J Biol Chem 280 1408 1416 15516337 10.1074/jbc.M411295200 1:CAS:528:DC%2BD2MXitFCluw%3D%3D
51. DK Patneau ML Mayer 1990 Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors J Neurosci 10 2385 2399 2165523 1:CAS:528:DyaK3cXls1Gmtrw%3D
52. MC Curras R Dingledine 1992 Selectivity of amino acid transmitters acting at N-methyl-D-aspartate and amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors Mol Pharmacol 41 520 526 1372086 1:CAS:528:DyaK38Xls1Clsr4%3D
53. M Frauli P Neuville C Vol, et al. 2006 Among the twenty classical L-amino acids, only glutamate directly activates metabotropic glutamate receptors Neuropharmacology 50 245 253 16310227 10.1016/j.neuropharm.2005.09.016 1:CAS:528:DC%2BD28XmsFCjsg%3D%3D (Pubitemid 43100010)
54. CG Thomas AJ Miller GL Westbrook 2006 Synaptic and extrasynaptic NMDA receptor NR2 subunits in cultured hippocampal neurons J Neurophysiol 95 1727 1734 16319212 10.1152/jn.00771.2005 1:CAS:528:DC%2BD28Xis1yhtLw%3D
55. K Erreger MT Geballe A Kristensen, et al. 2007 Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors Mol Pharmacol 72 907 920 17622578 10.1124/mol.107.037333 1:CAS:528:DC%2BD2sXhtFaiu7%2FI (Pubitemid 47481414)
56. Fonnum F, Paulsen RH, Fosse VM et al (1986) Synthesis and release of amino acid transmitters. In: Schwarcz R, Ben-Ari Y (eds) Excitatory amino acids and epilepsy. Advances in Experimental medicine and biology, 203. Plenum, New York, pp 285-293
57. 2+- dependent release of aspartate and glutamate from hippocampal slices with changing glucose concentrations Synapse 1 265 272 2905531 10.1002/syn.890010308 1:CAS:528:DyaL1cXks1Onu7k%3D (Pubitemid 17120920)
58. X Zhang JV Nadler 2009 Postsynaptic response to stimulation of the Schaffer collaterals with properties similar to those of synaptosomal aspartate release Brain Res 1295 13 20 19664606 10.1016/j.brainres.2009.07.104 1:CAS:528:DC%2BD1MXhtFyqsLfO
59. LEF Almeida PD Murray HR Zielke, et al. 2009 Autocrine activation of neuronal NMDA receptors by aspartate mediates dopamine- and cAMP-induced CREB-dependent gene transcription J Neurosci 29 12702 12710 19812345 10.1523/JNEUROSCI.1166-09.2009 1:CAS:528:DC%2BD1MXht12qt7fI
60. GE Hardingham Y Fukunaga H Bading 2002 Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways Nat Neurosci 5 405 414 11953750 1:CAS:528:DC%2BD38XjtFykurw%3D (Pubitemid 34454245)
61. P Vanhoutte H Bading 2003 Opposing roles of synaptic and extrasynaptic NMDA receptors in neuronal calcium signalling and BDNF gene regulation Curr Opinion Neurobiol 13 366 371 10.1016/S0959-4388(03)00073-4 1:CAS:528: DC%2BD3sXlt1entb8%3D (Pubitemid 36792249)
62. A-S Wahl B Buchthal F Rode, et al. 2009 Hypoxic/ischemic conditions induce expression of the putative pro-death gene Clca1 via activation of extrasynaptic N-methyl-D-aspartate receptors Neuroscience 158 344 352 18616988 10.1016/j.neuroscience.2008.06.018 1:CAS:528:DC%2BD1MXns1ynsA%3D%3D
63. DH Baird E Trenkner CA Mason 1996 Arrest of afferent axon extension by target neurons in vitro is regulated by the NMDA receptor J Neurosci 16 2642 2648 8786440 1:CAS:528:DyaK28XitFKhu70%3D (Pubitemid 26124351)
64. M Rocha M Sur 1995 Rapid acquisition of dendritic spines by visual thalamic neurons after blockade of N-methyl-D-aspartate receptors Proc Natl Acad Sci USA 92 8026 8030 7644532 10.1073/pnas.92.17.8026 1:CAS:528: DyaK2MXnsFOnurc%3D
65. J Nacher DR Rosell G Alonso-Llosa, et al. 2001 NMDA receptor antagonist treatment induces a long-lasting increase in the number of proliferating cells, PSA-NCAM-immunoreactive granule neurons and radial glia in the adult rat dentate gyrus Eur J Neurosci 13 512 520 11168558 10.1046/j.0953-816x.2000.01424.x 1:STN:280:DC%2BD3M3isFyhsQ%3D%3D (Pubitemid 32158783)
66. JV Nadler DA Evenson GJ Cuthbertson 1981 Comparative toxicity of kainic acid and other acidic amino acids toward rat hippocampal neurons Neuroscience 6 2505 2517 6275297 10.1016/0306-4522(81)90096-8 1:CAS:528:DyaL38XotlCmsQ%3D%3D (Pubitemid 12247040)
67. + homeostasis protects organotypic hippocampal slice cultures from hypoxic/hypoglycemic injury Neuropharmacology 39 1779 1787 10884559 10.1016/S0028-3908(00)00027-7 1:CAS:528:DC%2BD3cXksFCrtLc%3D (Pubitemid 30398482)
68. 2+ exchange inhibitor KB-R7943 protects CA1 neurons in rat hippocampal slices against hypoxic/hypoglycemic injury Neuropharmacology 38 319 321 10218875 10.1016/S0028-3908(98)00198-1 (Pubitemid 29073554)