Redistribution of neuroactive amino acids in hippocampus and striatum during hypoglycemia: A quantitative immunogold study

Journal of Cerebral Blood Flow and Metabolism

Volumn 21, Issue 1, 2001, Pages 41-51

  Gundersen, Vidar ^a   Fonnum, Frode ^b   Ottersen, Ole Petter ^a   Storm Mathisen, Jon ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b Division for Environmental Toxicology   (Norway)

Author keywords

Aspartate; Electron microscopy; GABA; Glutamate; Glutamine; Hypoglycemia; Immunocytochemistry

Indexed keywords

4 AMINOBUTYRIC ACID; ASPARTIC ACID; GLUTAMIC ACID; GLUTAMINE; NEURAMINIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY LABELING; ARTICLE; BRAIN REGION; CONTROLLED STUDY; CORPUS STRIATUM; ELECTRON MICROSCOPY; GABAERGIC SYSTEM; HIPPOCAMPUS; HYPOGLYCEMIA; IMMUNOCYTOCHEMISTRY; IMMUNOGOLD STAINING; IMMUNOREACTIVITY; MYELINATED NERVE; NERVE CELL NECROSIS; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SENSORY NERVE; SYNAPSE VESICLE; TISSUE DISTRIBUTION;

EID: 0035192655     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200101000-00006     Document Type: Article

References (36)

1. Light- and electron microscopic distribution of taurine, an organic osmolyte, in rat renal tubule cells
2. The distribution of hypoglycemic brain damage
3. Distribution of glutamate-like immunoreactivity in excitatory hippocampal pathways: A semiquantitative electron microscopic study in rats
4. Enrichment of glutamate-like immunoreactivity in primary afferent terminals throughout the spinal cord dorsal horn
5. Cellular origins of endogenous amino acids released into the extracellular fluid of the rat striatum during severe insulin-induced hypoglycemia
6. Inhibition of gamma-aminobutyrate and glycine uptake into synaptic vesicles
7. Excitatory amino acid receptors in the vertebrate central nervous system
8. Selectivity of amino acid transmitters acting at N-methyl-D-aspartate and amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors
9. Effect of insulin-induced hypoglycemia on the concentrations of glutamate and related amino acids and energy metabolites in the intact and decorticated rat neostriatum
10. Cerebral aspartate utilization: Near-equilibrium relationships in aspartate aminotransferase reaction
11. Aspartate and glutamate mediate excitatory synaptic transmission in area CA1 of the hippocampus
12. Demonstration of glutamate/aspartate uptake activity in nerve endings by use of antibodies recognizing exogenous D-aspartate
13. Quantification of excitatory amino acid uptake at intact glutamatergic synapses by immunocytochemistry of exogenous D-aspartate
14. Selective excitatory amino acid uptake in glutamatergic nerve terminals and in glia in the rat striatum: Quantitative electron microscopic immunocytochemistry of exogenous (D)-aspartate and endogenous glutamate and GABA
15. Synaptic vesicular localization and exocytosis of L-aspartate in excitatory nerve terminals: A quantitative immunogold analysis in rat hippocampus
16. Synaptosomal bioenergetics: The role of glycolysis, pyruvate oxidation and response to hypoglycemia
17. LTP of AMPA and NMDA receptor-mediated signals: Evidence for presynaptic expression and extrasynaptic glutamate spill-over
18. Glutamine from glial cells is essential for the maintenance of the nerve terminal pool of glutamate: Immunogold evidence from hippocampal slice cultures
19. Identification and characterization of the vesicular GABA transporter
20. The release and uptake of excitatory amino acids
21. Excitotoxin-mediated neuron death in youth and old age
22. Glutamate- and GABA-containing neurons in the mouse and rat brain, as demonstrated with a new immunocytochemical technique
23. Postembedding light- and electron microscopic immunocytochemistry of amino acids: Description of a new model system allowing identical conditions for specificity testing and tissue processing
24. Postembedding immunogold labeling of fixed glutamate: An electron microscopic analysis of the relationship between gold particle density and antigen concentration
25. Glutamate release in severe brain ischemia is mainly by reversed uptake
26. Extracellular overflow of neuroactive amino acids during severe insulin-induced hypoglycemia: In vivo dialysis of the rat hippocampus
27. Distinct roles of synaptic and extrasynaptic NMDA receptors in excitotoxicity
28. Occurrence of a large Ca2+-independent release of glutamate during anoxia in isolated nerve terminals (synaptosomes)
29. Glutamate producing aspartate aminotransferase in glutamatergic perforant path terminals of the rat hippocampus. Cytochemical and lesion studies
30. First visualization of glutamate and GABA in neurones by immunocytochemistry
31. Reversible shifts in the Ca2+-dependent release of aspartate and glutamate from hippocampal slices with changing glucose concentrations
32. Changes in the relative amounts of aspartate and glutamate released and retained in hippocampal slices during stimulation
33. Different modes of expression of AMPA and NMDA receptors in hippocampal synapses
34. Cellular and subcellular redistribution of glutamate-, glutamine- and taurine-like immunoreactivities during forebrain ischemia: A semiquantitative electron microscopic study in rat hippocampus
35. Effect of ischemia and reperfusion on the extra- and intracellular distribution of glutamate, glutamine, aspartate and GABA in the rat hippocampus, with a note on the effect of the sodium channel blocker BW1003C87
36. Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist