Molecular mechanisms involved in intervertebral disc degeneration and potential new treatment strategies

Bioscience Horizons

Volumn 2, Issue 1, 2009, Pages 83-89

  Ireland, Daniel ^a  

^a SHEFFIELD HALLAM UNIVERSITY   (United Kingdom)

Author keywords

Autologous disc cell transplantation; Cytokine; Gene therapy; Growth factor; Intervertebral disc degeneration; Mesenchymal stem cells

Indexed keywords

EID: 79954552097     PISSN: None     EISSN: 17547431     Source Type: Journal    
DOI: 10.1093/biohorizons/hzp005     Document Type: Article

References (55)

1. Kara SA, Toppare MF, Avsar F et al. (1999) Predictors of early improvement in low back pain amongst consulters to general practice: the influence of premorbid and episode-related factors. Pain 80: 113-119.
2. Maniadacis N, Gray A (2000) The economic burden of back pain in the UK. Pain 84: 95-103.
3. Dagenais S, Caro J, Haldeman S (2008) A systematic review of low back pain cost of illness studies in the United States and internationally. Spine J 8: 8-20. (Pubitemid 350299273)
4. Chadderdon RC, Shimer AL, Gilbertson LG et al. (2004) Advances in gene therapy for intervertebral disc degeneration. Spine J 4: 341S-347S. (Pubitemid 39497325)
5. Paesold G, Nerlich AG, Boos N (2007) Biological treatment strategies for disc degeneration: potentials and shortcomings. Eur Spine J 16: 447-468. (Pubitemid 46626252)
6. Le Maitre CL, Hoyland JA, Freemont AJ (2006) A preliminary in vitro study into the use of IL-1Ra gene therapy for the inhibition of intervertebral disc degeneration. Int J Exp Pathol 87: 17-28.
7. Luoma K, Riihimäki H, Luukkonen R et al. (2000) Low back pain in relation to lumbar disc degeneration. Spine 25: 487-492. (Pubitemid 30115569)
8. Adams M, Bogduk N, Burton K et al. (2002) The Biomechanics of Back Pain. 1st ed. Churchill Livingstone: Edinburgh.
9. Urban JPG, Roberts S (2003) Degeneration of the intervertebral disc. Arthritis Res Ther 5: 120-130. (Pubitemid 36849758)
10. Colombini A, Lombardi G, Corsi MM et al. (2008) Pathophysiology of the human intervertebral disc. Int J Biochem Cell Biol 40: 837-842.
11. Le Maitre CL, Pockert A, Buttle DJ et al. (2007) Matrix synthesis and degradation in human intervertebral disc degeneration. Biochem Soc Trans 35: 652-655. (Pubitemid 47310333)
12. Adams M (2004) The biomechanics of back pain. Acupunct Med 22: 178-188.
13. Zhao CQ, Wang LM, Jiang LS et al. (2007) The cell biology of intervertebral disc aging and degeneration. Ageing Res Rev 6: 247-261.
14. Cassinelli EH, Kang JD (2000) Current understanding of lumbar disc degeneration. Oper Tech Orthop 10: 254-262.
15. Le Maitre CL, Hoyland JA, Freemont AJ (2007) Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study. Arthritis Res Ther 9: R83.
16. Freemont AJ, Peacock TE, Goupille P et al. (1997) Nerve ingrowth into diseased intervertebral disc in chronic back pain. Lancet 350: 178-181. (Pubitemid 27303625)
17. Le Maitre CL, Freemont AJ, Hoyland JA (2004) Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc. J Pathol 204: 47-54. (Pubitemid 39214481)
18. Le Maitre CL, Freemont A, Hoyland J (2006) Human disc degeneration is associated with increased MMP 7 expression. Biotech Histochem 81: 125-131. (Pubitemid 44842203)
19. Le Maitre CL, Hoyland JA, Freemont AJ (2007) Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration. Arthritis Res Ther 9: R45.
20. Goupille P, Jayson MIV, Valat JP et al. (1998) Matrix metalloproteinases: the clue to intervertebral disc degeneration? Spine 23: 1612-1626. (Pubitemid 28459968)
21. Roberts S, Evans EH, Kletsas D et al. (2006) Senescence in human intervertebral discs. Eur Spine J 15: S312-S316. (Pubitemid 44371008)
22. Gruber HE, Ingram JA, Norton HJ et al. (2007) Senescence in cells of the aging and degenerating intervertebral disc: immunolocalization of senescence-associated beta-galactosidase in human and sand rat discs. Spine 32: 321-327. (Pubitemid 46197471)
23. Le Maitre CL, Freemont AJ, Hoyland JA (2005) The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration. Arthritis Res Ther 7: R732-R745.
24. Séguin CA, Bojarski M, Pilliar RM et al. (2005) Tumor necrosis factor-alpha modulates matrix production and catabolism in nucleus pulposus tissue. Spine 30: 1940-1948. (Pubitemid 41292217)
25. Le Maitre CL, Hoyland JA, Freemont AJ (2007) Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1b and TNFa expression profile. Arthritis Res Ther 9: R77.
26. Hoyland JA, Le Maitre CL, Freemont AJ (2008) Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc. Rheumatology 47: 809-814. (Pubitemid 351796365)
27. Kary S, Burmester GR (2003) Anakinra: the first interleukin-1 inhibitor in the treatment of rheumatoid arthritis. Int J Clin Pract 57: 231-234. (Pubitemid 36511784)
28. Nishida K, Kang JD, Suh JK et al. (1998) Adenovirus-mediated gene transfer to nucleus pulposus cells: implications for the treatment of intervertebral disc degeneration. Spine 23: 2437-2442.
29. Moon S, Nishida K, Gilbertson LG et al. (2000) Human intervertebral disc cells are genetically modifiable by adenovirus-mediated gene transfer. Spine 25: 2573-2579.
30. Wallach CJ, Kim JS, Sobajima S et al. (2006) Safety assessment of intradiscal gene transfer: a pilot study. Spine J 6: 107-112.
31. Raj PP (2008) Intervertebral disc: anatomy-physiology- pathophysiologytreatment. Pain Pract 8: 18-44.
32. Wallach CJ, Sobajima S, Watanabe Y et al. (2003) Gene transfer of the catabolic inhibitor TIMP-1 increases measured proteoglycans in cells from degenerated human intervertebral discs. Spine 28: 2331-2337. (Pubitemid 37271328)
33. Thompson JP, Oegema TRJr, Bradford DS (1991) Stimulation of mature canine intervertebral disc by growth factors. Spine 16: 253-260.
34. Osada R, Ohshima H, Ishihara H et al. (1996) Autocrine/paracrine mechanism of insulin-like growth factor-1 secretion, and the effect of insulin-like growth factor-1 on proteoglycan synthesis in bovine intervertebral discs. J Orthop Res 14: 690-699. (Pubitemid 26376511)
35. Takegami K, An HS, Kumano F et al. (2005) Osteogenic protein-1 is most effective in stimulating nucleus pulposus and annulus fibrosus cells to repair their matrix after chondroitinase ABC-induced chemonucleolysis. Spine 5: 231-238. (Pubitemid 40613662)
36. Shimer AL, Chadderdon RC, Gilbertson LG et al. (2004) Gene therapy approaches for intervertebral disc degeneration. Spine 29: 2770-2778. (Pubitemid 40353263)
37. Levicoff EA, Gilbertson LG, Kang JD (2005) Gene therapy for disc repair. Spine J 5: 287S-296S. (Pubitemid 41700073)
38. Wehling P, Schulitz KP, Robbins PD et al. (1997) Transfer of genes to chondrocytic cells of the lumbar spine: proposal for a treatment strategy of spinal disorders by local gene therapy. Spine 22: 1092-1097. (Pubitemid 27209350)
39. Moon SH, Nishida K, Gilbertson LG et al. (2002) Responsiveness of human intervertebral disc cells to adenovirus mediated transfer of TGF-1 cDNA in 2D and 3D culture systems: comparison to exogenous TGF-1. Presented at the International Society for the Study of the Lumbar Spine meeting, Adelaide, Australia, 2002.
40. Kim DJ, Moon SH, Kim H et al. (2003) Bone morphogenetic protein-2 facilitates expression of chondrogenic, not osteogenic, phenotype of human intervertebral disc cells. Spine 28: 2679-2684. (Pubitemid 37543473)
41. Le Maitre CL, Richardson SM, Baird P et al. (2005) Expression of receptors for putative anabolic growth factors in human intervertebral disc: implications for repair and regeneration of the disc. J Pathol 207: 445-452. (Pubitemid 43025693)
42. Freemont AJ, Peacock TE, Goupille P et al. (1997) Nerve ingrowth into diseased intervertebral disc in chronic back pain. Lancet 350: 178-181. (Pubitemid 27303625)
43. Paul R, Haydon RC, Cheng H et al. (2003) Potential use of Sox9 gene therapy for intervertebral degenerative disc disease. Spine 28: 755-763. (Pubitemid 36459290)
44. Behrens A, Haigh J, Mechta-Grigoriou F et al. (2003) Impaired intervertebral disc formation in the absence of Jun. Development 130: 103-109. (Pubitemid 36113947)
45. Boden SD, Liu Y, Hair GA et al. (1998) LMP-1, an LIM-domain protein, mediates BMP-6 effects on bone formation. Endocrinology 139: 5125-5134. (Pubitemid 28533461)
46. Yoon ST, Park JS, Kim KS et al. (2004) ISSLS prize winner: LMP-1 upregulates intervertebral disc cell production of proteoglycans and BMPs in vitro and in vivo. Spine 29: 2603-2611. (Pubitemid 40353245)
47. Meisel HJ, Ganey T, Hutton WC et al. (2006) Clinical experience in cell-based therapeutics: intervention and outcome. Eur Spine J 15: S397-S405. (Pubitemid 44371019)
48. Richardson SM, Hughes N, Hunt JA et al. (2008) Human mesenchymal stem cell differentiation to NP-like cells in chitosan-glycerophosphate hydrogels. Biomaterials 29: 85-93. (Pubitemid 47599659)
49. Leung VY, Chan D, Cheung KM (2006) Regeneration of intervertebral disc by mesenchymal stem cells: potentials, limitations, and future direction. Eur Spine J 15: S406-S413. (Pubitemid 44371020)
50. Richardson SM, Walker RV, Parker S et al. (2005) Intervertebral disc cell mediated mesenchymal stem cell differentiation. Stem Cells 24: 707-716.
51. Sobajima S, Vadala G, Shimer A et al. (2008) Feasibility of a stem cell therapy for intervertebral disc degeneration. Spine J 8: 888-896.
52. Sebastine IM, Williams DJ (2007) Current developments in tissue engineering of nucleus pulposus for the treatment of intervertebral disc degeneration. Proceedings of the 29th Annual International Conference of the IEEE EMBS, Cité Internationale, Lyon, France, 23-26 August 2007.
53. Risbud MV, Albert TJ, Guttapalli A et al. (2004) Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: implications for cell-based transplantation therapy. Spine 29: 2627-2632. (Pubitemid 40353248)
54. Ho G, Leung VY, Cheung KM et al. (2008) Effect of severity of intervertebral disc injury on mesenchymal stem cell-based regeneration. Connect Tissue Res 49: 15-21. (Pubitemid 351298150)
55. Vadala G, Sobajima S, Lee JY et al. (2007) In vitro interaction between muscle-derived stem cells and nucleus pulposus cells. Spine J 8: 804-809.