The effect of cholesterol domains on PEGylated liposomal gene delivery in vitro

Therapeutic Delivery

Volumn 2, Issue 4, 2011, Pages 451-460

  Xu, Long ^a,b   Wempe, Michael F ^a   Anchordoquy, Thomas J ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; LIPOPLEX; PEGYLATED CHOLESTEROL; PEGYLATED DIACYLLIPID; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LINE; CELL TRANSPORT; CHEMICAL BINDING; DRUG FORMULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPOSOMAL GENE DELIVERY SYSTEM; MOUSE; NONHUMAN; PEGYLATION; PRIORITY JOURNAL;

EID: 79954486719     PISSN: 20415990     EISSN: 20416008     Source Type: Journal    
DOI: 10.4155/tde.11.13     Document Type: Article

References (36)

1. Zelphati O, Uyechi LS, Barron LG, Szoka FC Jr. Effect of serum components on the physico-chemical properties of cationic lipid/oligonucleotide complexes and on their interactions with cells. Biochim. Biophys. Acta. 1390(2), 119-133 (1998). (Pubitemid 28122331)
2. Thierry AR, Rabinovich P, Peng B, Mahan LC, Bryant JL, Gallo RC. Characterization of liposome-mediated gene delivery: expression, stability and pharmacokinetics of plasmid DNA. Gene Ther. 4(3), 226-237 (1997). (Pubitemid 27182076)
3. Yang JP, Huang L. Overcoming the inhibitory effect of serum on lipofection by increasing the charge ratio of cationic liposome to DNA. Gene Ther. 4(9), 950-960 (1997). (Pubitemid 27437721)
4. Yang JP, Huang L, Yang JP, Huang L. Time-dependent maturation of cationic liposome-DNA complex for serum resistance. Gene Ther. 5(3), 380-387 (1998). (Pubitemid 28138244)
5. Zhang Y, Anchordoquy TJ. The role of lipid charge density in the serum stability of cationic lipid/DNA complexes. Biochim. Biophys. Acta. 1663(1-2), 143-157 (2004). (Pubitemid 38625589)
6. Ogris M, Brunner S, Schuller S, Kircheis R, Wagner E. PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Ther. 6(4), 595-605 (1999). (Pubitemid 29192668)
7. Plank C, Mechtler K, Szoka FC Jr, Wagner E. Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery. Hum. Gene Ther. 7(12), 1437-1446 (1996). (Pubitemid 26293564)
8. Crook K, Stevenson BJ, Dubouchet M, Porteous DJ. Inclusion of cholesterol in DOTAP transfection complexes increases the delivery of DNA to cells in vitro in the presence of serum. Gene Ther. 5(1), 137-143 (1998). (Pubitemid 28045080)
9. Li S, Tseng WC, Stolz DB, Wu SP, Watkins SC, Huang L. Dynamic changes in the characteristics of cationic lipidic vectors after exposure to mouse serum: implications for intravenous lipofection. Gene Ther. 6(4), 585-594 (1999). (Pubitemid 29192667)
10. Wheeler JJ, Palmer L, Ossanlou M et al. Stabilized plasmid-lipid particles: construction and characterization. Gene Ther. 6(2), 271-281 (1999). (Pubitemid 29089926)
11. Wolff JA, Dowty ME, Jiao S et al. Expression of naked plasmids by cultured myotubes and entry of plasmids into T tubules and caveolae of mammalian skeletal muscle. J. Cell Sci. 103 (Pt 4), 1249-1259 (1992). (Pubitemid 23042268)
12. Torchilin VP, Omelyanenko VG, Papisov MI et al. Poly(ethylene glycol) on the liposome surface: on the mechanism of polymer-coated liposome longevity. Biochim. Biophys. Acta. 1195(1), 11-20 (1994). (Pubitemid 24318086)
13. Torchilin VP, Shtilman MI, Trubetskoy VS et al. Amphiphilic vinyl polymers effectively prolong liposome circulation time in vivo. Biochim. Biophys. Acta 1195(1), 181-184 (1994). (Pubitemid 24318108)
14. Harvie P, Wong FM, Bally MB. Use of poly(ethylene glycol)-lipid conjugates to regulate the surface attributes and transfection activity of lipid-DNA particles. J. Pharm. Sci. 89(5), 652-663 (2000).
15. Hyvonen Z, Ronkko S, Toppinen MR, Jaaskelainen I, Plotniece A, Urtti A. Dioleoyl phosphatidylethanolamine and PEG-lipid conjugates modify DNA delivery mediated by 1,4-dihydropyridine amphiphiles. J. Control. Release 99(1), 177-190 (2004). (Pubitemid 39165743)
16. Monck MA, Mori A, Lee D et al. Stabilized plasmid-lipid particles: pharmacokinetics and plasmid delivery to distal tumors following intravenous injection. J. Drug Target 7(6), 439-452 (2000). (Pubitemid 30184580)
17. Shi F, Wasungu L, Nomden A et al. Interference of poly(ethylene glycol)-lipid analogues with cationic-lipid-mediated delivery of oligonucleotides; role of lipid exchangeability and non-lamellar transitions. Biochem. J. 366(Pt 1), 333-341 (2002). (Pubitemid 34971834)
18. Tam P, Monck M, Lee D et al. Stabilized plasmid-lipid particles for systemic gene therapy. Gene Ther. 7(21), 1867-1874 (2000).
19. Armstrong TK, Girouard LG, Anchordoquy TJ. Effects of PEGylation on the preservation of cationic lipid/DNA complexes during freeze-thawing and lyophilization. J. Pharm. Sci. 91(12), 2549-2558 (2002). (Pubitemid 35379412)
20. Deshpande MC, Davies MC, Garnett MC et al. The effect of poly(ethylene glycol) molecular architecture on cellular interaction and uptake of DNA complexes. J. Control. Release 97(1), 143-156 (2004). (Pubitemid 38624517)
21. Li SD, Chono S, Huang L. Efficient gene silencing in metastatic tumor by siRNA formulated in surface-modified nanoparticles. J. Control. Release 126(1), 77-84 (2008).
22. Li W, Huang Z, MacKay JA, Grube S, Szoka FC Jr. Low-pH-sensitive poly(ethylene glycol) (PEG)-stabilized plasmid nanolipoparticles: effects of PEG chain length, lipid composition and assembly conditions on gene delivery. J. Gene Med. 7(1), 67-79 (2005).
23. Shin J, Shum P, Thompson DH. Acid-triggered release via dePEGylation of DOPE liposomes containing acid-labile vinyl ether PEG-lipids. J. Control. Release 91(1-2), 187-200 (2003) (Pubitemid 37288890)
24. Webb MS, Saxon D, Wong FM et al. Comparison of different hydrophobic anchors conjugated to poly(ethylene glycol): effects on the pharmacokinetics of liposomal vincristine. Biochim. Biophys. Acta 1372(2), 272-282 (1998). (Pubitemid 28451550)
25. Xu L, Anchordoquy TJ. Cholesterol domains in cationic lipid/DNA complexes improve transfection. Biochim. Biophys. Acta 1778(10), 2177-2181 (2008).
26. Zhao XB, Muthusamy N, Byrd JC, Lee RJ. Cholesterol as a bilayer anchor for PEGylation and targeting ligand in folate-receptor-targeted liposomes. J. Pharm. Sci. 96(9), 2424-2435 (2007). (Pubitemid 47477897)
27. Zhang Y, Bradshaw-Pierce EL, Delille A, Gustafson DL, Anchordoquy TJ. In vivo comparative study of lipid/DNA complexes with different in vitro serum stability: effects on biodistribution and tumor accumulation. J. Pharm. Sci. 97(1), 237-250 (2008).
28. Gabizon A, Papahadjopoulos D. Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors. Proc. Natl Acad. Sci. USA 85(18), 6949-6953 (1988)
29. Dos Santos N, Allen C, Doppen AM et al. Influence of poly(ethylene glycol) grafting density and polymer length on liposomes: relating plasma circulation lifetimes to protein binding. Biochim. Biophys. Acta 1768(6), 1367-1377 (2007). (Pubitemid 46782695)
30. Johnstone SA, Masin D, Mayer L, Bally MB. Surface-associated serum proteins inhibit the uptake of phosphatidylserine and poly(ethylene glycol) liposomes by mouse macrophages. Biochim. Biophys. Acta 1513(1), 25-37 (2001). (Pubitemid 32566372)
31. Allen C, Dos Santos N, Gallagher R et al. Controlling the physical behavior and biological performance of liposome formulations through use of surface grafted poly(ethylene glycol).Biosci. Rep. 22(2), 225-250 (2002). (Pubitemid 35222733)
32. Mamot C, Drummond DC, Noble CO et al. Epidermal growth factor receptor-targeted immunoliposomes significantly enhance the efficacy of multiple anticancer drugs in vivo. Cancer Res. 65(24), 11631-11638 (2005) (Pubitemid 41821723)
33. Choi JS, MacKay JA, Szoka FC Jr. Low-pH-sensitive PEG-stabilized plasmid-lipid nanoparticles: preparation and characterization. Bioconjug. Chem. 14(2), 420-429 (2003). (Pubitemid 36348666)
34. Masson C, Garinot M, Mignet N et al. pH-sensitive PEG lipids containing orthoester linkers: new potential tools for nonviral gene delivery. J. Control. Release 99(3), 423-434 (2004). (Pubitemid 39296911)
35. Xu L, Anchordoquy TJ. Effect of cholesterol nanodomains on the targeting of lipid-based gene delivery in cultured cells. Mol. Pharm. 7(4), 1311-1317 (2010).
36. Ishida T, Kiwada H. Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes. Int. J. Pharm. 354(1-2), 56-62 (2008).