Effects of PEGylation on the preservation of cationic lipid/DNA complexes during freeze-thawing and lyophilization

Journal of Pharmaceutical Sciences

Volumn 91, Issue 12, 2002, Pages 2549-2558

  Armstrong, Taylor K C ^a   Girouard, Lorinda G ^a   Anchordoquy, Thomas J ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Agitation; Formulation; Freezing; Gene delivery; Lyophilization; Nonviral vectors; PEGylation; Stabilization

Indexed keywords

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; DIOLEOYLPHOSPHATIDYLETHANOLAMINE; DNA; EXCIPIENT; LIPID; MACROGOL; MACROGOL 2000; MACROGOL 5000; PHOSPHATIDYLETHANOLAMINE; SUCROSE; UNCLASSIFIED DRUG; 1,2 DIOLEOYL GLYCERO 3 PHOSPHATIDYL ETHANOLAMINE; 1,2 DIOLEOYLOXY 3 (TRIMETHYLAMMONIUM)PROPANE; 1,2-DIOLEOYL-GLYCERO-3-PHOSPHATIDYL ETHANOLAMINE; 1,2-DIOLEOYLOXY-3-(TRIMETHYLAMMONIUM)PROPANE; MACROGOL DERIVATIVE; MONOUNSATURATED FATTY ACID; QUATERNARY AMMONIUM DERIVATIVE;

ANIMAL CELL; COMPLEX FORMATION; CONFERENCE PAPER; DNA LIPID COMPLEX; DRUG FORMULATION; FREEZE DRYING; GENE DELIVERY SYSTEM; GENETIC TRANSFECTION; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PRESERVATION; STORAGE; THAWING; ANIMAL; ARTICLE; CELL STRAIN COS1; CERCOPITHECUS; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECT; FREEZING; GENETICS; METHODOLOGY; PHYSIOLOGY;

ANIMALS; CERCOPITHECUS AETHIOPS; CHEMISTRY, PHARMACEUTICAL; COS CELLS; DNA; DRUG DELIVERY SYSTEMS; FATTY ACIDS, MONOUNSATURATED; FREEZING; PHOSPHATIDYLETHANOLAMINES; POLYETHYLENE GLYCOLS; QUATERNARY AMMONIUM COMPOUNDS; TRANSFECTION;

EID: 0036892708     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10255     Document Type: Conference Paper

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