Inhibition of a bacterial O-GlcNAcase homologue by lactone and lactam derivatives: Structural, kinetic and thermodynamic analyses

Amino Acids

Volumn 40, Issue 3, 2011, Pages 829-839

  He, Yuan ^a   Bubb, Abigail K ^a   Stubbs, Keith A ^c   Gloster, Tracey M ^a,b   Davies, Gideon J ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b SIMON FRASER UNIVERSITY   (Canada)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Carbohydrate; Diabetes; Enzyme; Neurodegeneration; O GlcNAc; X ray structure

Indexed keywords

ACETYLGLUCOSAMINIDASE; LACTAM DERIVATIVE; LACTONE DERIVATIVE; LACTONE OXIME; N ACETYLGLUCONOLACTAM; N ACETYLGLUCOSAMINE; O (2 ACETAMIDO 2 DEOXY DEXTRO GLUCOPYRANOSYLIDENE)AMINO N PHENYL CARBAMATE; UNCLASSIFIED DRUG;

ARTICLE; BACTEROIDES THETAIOTAOMICRON; CONTROLLED STUDY; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; THERMODYNAMICS;

BACTERIAL PROTEINS; BACTEROIDES; ENZYME INHIBITORS; KINETICS; LACTAMS; LACTONES; MODELS, MOLECULAR; N-ACETYLGLUCOSAMINYLTRANSFERASES; PROTEIN BINDING; THERMODYNAMICS;

BACTERIA (MICROORGANISMS); BACTEROIDES THETAIOTAOMICRON;

EID: 79954439629     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-010-0700-6     Document Type: Article

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