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Bioorganic and Medicinal Chemistry

Volumn 19, Issue 8, 2011, Pages 2508-2516

Fluorescent phosphoinositide 3-kinase inhibitors suitable for monitoring of intracellular distribution

(5) Kim, Donghee a Lee, Hyunseung b Jun, Hwiseok a Hong, Soon Sun b Hong, Sungwoo a

a Korea Advanced Institute of Science and Technology (KAIST) (South Korea)

b Inha University School of Medicine (South Korea)

Author keywords

Anticancer; Drug design; Fluorescent PI3K inhibitor; Intracellular distribution

Indexed keywords

1 [4 [7 (3 FLUORO 4 METHOXYPHENYL) 1,3 DIMETHYL 2,6 DIOXO 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL]PHENYL] 3 METHYLUREA; 7 (3,4 DIFLUOROPHENYL) 8 [4 (DIMETHYLAMINO)PHENYL] 1,3 DIMETHYL 1H PURINE 2,6(3H,7H)DIONE; 7 (3,4 DIMETHOXYPHENYL) 8 [4 (DIMETHYLAMINO)PHENYL] 1,3 DIMETHYL 1H PURINE 2,6(3H,7H)DIONE; 7 (3,5 DIFLUOROPHENYL) 8 [4 (DIMETHYLAMINO)PHENYL] 1,3 DIMETHYL 1H PURINE 2,6(3H,7H)DIONE; 8 [4 (DIMETHYLAMINO) 2 METHOXYPHENYL] 7 (3 FLUOROPHENYL) 1,3 DIMETHYL 1H PURINE 2,6(3H,7H)DIONE; 8 [4 (DIMETHYLAMINO)PHENYL] 7 (3 FLUORO 4 METHOXYPHENYL) 1,3 DIMETHYL 1H PURINE 2,6(3H,7H)DIONE; 8 [4 (DIMETHYLAMINO)PHENYL] 7 (3 FLUOROPHENYL) 1,3 DIMETHYL 1H PURINE 2,6(3H,7H)DIONE; 8 [4 (DIMETHYLAMINO)PHENYL] 7 (4 METHOXYPHENYL) 1,3 DIMETHYL 1H PURINE 2,6(3H,7H)DIONE; METHYL 4 [7 (4 METHOXYPHENYL) 1,3 DIMETHYL 2,6 DIOXO 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL]PHENYLCARBAMATE; N [3 [7 (4 METHOXYPHENYL) 1,3 DIMETHYL 2,6 DIOXO 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL]PHENYL]METHANESULFONAMIDE; N [4 (1,3 DIMETHYL 2,6 DIOXO 7 PHENYL 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL)PHENYL]ACETAMIDE; N [4 [7 (3 FLUORO 4 METHOXYPHENYL) 1,3 DIMETHYL 2,6 DIOXO 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL] 2 METHOXYPHENYL]ACETAMIDE; N [4 [7 (3 FLUORO 4 METHOXYPHENYL) 1,3 DIMETHYL 2,6 DIOXO 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL]PHENYL]ACETAMIDE; N [4 [7 (3 FLUOROPHENYL) 1,3 DIMETHYL 2,6 DIOXO 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL]PHENYL]ACETAMIDE; N [4 [7 (3,4 DICHLOROPHENYL) 1,3 DIMETHYL 2,6 DIOXO 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL] 3 METHOXYPHENYL]ACETAMIDE; N [4 [7 (3,4 DICHLOROPHENYL) 1,3 DIMETHYL 2,6 DIOXO 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL]PHENYL]ACETAMIDE; N [4 [7 (3,4 DIMETHOXYPHENYL) 1,3 DIMETHYL 2,6 DIOXO 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL]PHENYL]ACETAMIDE; N [4 [7 (4 METHOXYPHENYL) 1,3 DIMETHYL 2,6 DIOXO 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL]PHENYL]ACETAMIDE; N [5 [7 (4 METHOXYPHENYL) 1,3 DIMETHYL 2,6 DIOXO 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL]PYRIDIN 2 YL]METHANESULFONAMIDE; N [5 [7 (4 METHOXYPHENYL) 1,3 DIMETHYL 2,6 DIOXO 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL]PYRIDIN 3 YL]BENZENESULFONAMIDE; N [5 [7 (4 METHOXYPHENYL) 1,3 DIMETHYL 2,6 DIOXO 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL]PYRIDIN 3 YL]METHANESULFONAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE ALPHA INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE;

ARTICLE; CANCER CELL; CELL LEVEL; CELL PROLIFERATION; CELL STRAIN; CELL STRAIN T47D; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG MONITORING; DRUG SCREENING; ENZYME INHIBITION; FLUORESCENCE ANALYSIS; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IC 50; PHARMACOPHORE;

1-PHOSPHATIDYLINOSITOL 4-KINASE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; FLUORESCENT DYES; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR PROBE TECHNIQUES; NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASE; PROTEIN KINASE INHIBITORS; XANTHINE;

EID: 79954420332 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/j.bmc.2011.03.025 Document Type: Article

Times cited : (16)

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