Treatment efficacy in a soman-poisoned guinea pig model: Added value of physostigmine?

Archives of Toxicology

Volumn 85, Issue 3, 2011, Pages 227-237

  Joosen, Marloes J A ^a   Smit, August B ^b   Van Helden, Herman P M ^a  

^a TNO   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Obidoxime; Organophosphate; Physostigmine; Seizures; Soman

Indexed keywords

ACETYLCHOLINESTERASE; ATROPINE; OBIDOXIME; PHYSOSTIGMINE; SOMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; BREATHING RATE; CLINICAL FEATURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; ELECTROENCEPHALOGRAM; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME INHIBITION; GUINEA PIG; HEART RATE; INTOXICATION; LOW DRUG DOSE; MALE; NONHUMAN; PRIORITY JOURNAL; SEIZURE;

ANIMALS; ATROPINE; BRAIN; CARBAMATES; CHEMICAL WARFARE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; ELECTROENCEPHALOGRAPHY; GUINEA PIGS; MALE; MODELS, ANIMAL; OBIDOXIME CHLORIDE; PARASYMPATHOLYTICS; PHYSOSTIGMINE; SEIZURES; SOMAN; TIME FACTORS; TREATMENT OUTCOME;

CAVIA;

EID: 79954415344     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-010-0571-3     Document Type: Article

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