Toxicodynamic analysis of the combined cholinesterase inhibition by paraoxon and methamidophos in human whole blood

Toxicology and Applied Pharmacology

Volumn 236, Issue 1, 2009, Pages 9-15

  Bosgra, Sieto ^a   van Eijkeren, Jan C H ^b   van der Schans, Marcel J ^c   Langenberg, Jan P ^c   Slob, Wout ^a,b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^c TNO   (Netherlands)

Author keywords

Cholinesterase inhibition; Dose addition; Interactions; Mixtures; Organophosphorus pesticides; Toxicodynamic

Indexed keywords

CHOLINESTERASE; METHAMIDOPHOS; ORGANOPHOSPHATE PESTICIDE; PARAOXON;

ACCURACY; ARTICLE; BLOOD; CHEMICAL INTERACTION; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DOSE ADDITION; DOSE RESPONSE; DYNAMICS; ENZYME ASSAY; HUMAN; IN VITRO STUDY; MATHEMATICAL MODEL; PREDICTION; RISK ASSESSMENT; SIMULATION; TECHNIQUE; TOXICODYNAMIC ANALYSIS;

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; HUMANS; INSECTICIDES; KINETICS; MODELS, BIOLOGICAL; ORGANOTHIOPHOSPHORUS COMPOUNDS; PARAOXON; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT;

EID: 61849124739     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.01.001     Document Type: Article

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