The identification of the 2-phenylphthalazin-1(2 H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A 3 adenosine receptor antagonists

Journal of Medicinal Chemistry

Volumn 54, Issue 7, 2011, Pages 2102-2113

  Poli, Daniela ^a   Catarzi, Daniela ^a   Colotta, Vittoria ^a   Varano, Flavia ^a   Filacchioni, Guido ^a   Daniele, Simona ^b   Trincavelli, Letizia ^b   Martini, Claudia ^b   Paoletta, Silvia ^c   Moro, Stefano ^c  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 PHENYLPHTHALAZIN 1(2H) ONE DERIVATIVE; 2,5 DIMETHOXYPHENYLPHTHALAZIN 1(2H) ONE; ADENOSINE A3 RECEPTOR; ADENOSINE A3 RECEPTOR ANTAGONIST; PHTHALAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG DESIGN; DRUG IDENTIFICATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; HUMAN; MOLECULAR DOCKING; NONHUMAN; RECEPTOR AFFINITY; STRUCTURE ANALYSIS;

ADENOSINE A3 RECEPTOR ANTAGONISTS; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DRUG DESIGN; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INHIBITORY CONCENTRATION 50; LIGANDS; MODELS, MOLECULAR; PIPERAZINES; PROTEIN CONFORMATION; RECEPTOR, ADENOSINE A3; STATIC ELECTRICITY; SUBSTRATE SPECIFICITY;

EID: 79953830526     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101328n     Document Type: Article

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