Emodin suppression of ocular surface inflammatory reaction

Investigative Ophthalmology and Visual Science

Volumn 48, Issue 11, 2007, Pages 5013-5022

  Kitano, Ai ^a   Saika, Shizuya ^a   Yamanaka, Osamu ^a   Ikeda, Kazuo ^b   Okada, Yuka ^a   Shirai, Kumi ^a   Reinach, Peter S ^c  

^a WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; EMODIN; FIBRONECTIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; SMAD2 PROTEIN; SMAD3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN; CCL2 PROTEIN, HUMAN; HERBACEOUS AGENT; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOASSAY; CELL MIGRATION; CELL PROLIFERATION; CHINESE MEDICINE; COCULTURE; COLLAGEN SYNTHESIS; COLORIMETRY; CONJUNCTIVA; CONTROLLED STUDY; CORNEA BURN; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME IMMUNOASSAY; EXTRACELLULAR MATRIX; EYE INFLAMMATION; EYE INJURY; FIBROBLAST CULTURE; FIBROGENESIS; GENE; HERBAL MEDICINE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MEDIATOR; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; OCULAR FIBROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ALLERGIC CONJUNCTIVITIS; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL MOTION; CYTOLOGY; DISEASE MODEL; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; METABOLISM;

ANIMALS; BLOTTING, WESTERN; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; CHEMOKINE CCL2; COCULTURE TECHNIQUES; COLLAGEN TYPE I; CONJUNCTIVA; CONJUNCTIVITIS, ALLERGIC; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; EMODIN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLASTS; FIBRONECTINS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; MAP KINASE KINASE 4; MICE; MICE, INBRED C57BL; NF-KAPPA B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA1;

EID: 38449089687     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.07-0393     Document Type: Article

References (41)

1. Leask A, Abraham DJ. TGF-β signaling and the fibrotic response. FASEB J. 2004;18:816-827.
2. Desmouliere A, Chaponnier C, Gabbiani G. Tissue repair, contraction, and the myofibroblast. Wound Repair Regen. 2005;13:7-12.
3. Tsai RJ, Li LM, Chen JK. Reconstruction of damaged corneas by transplantation of autologous limbal epithelial cells. N Engl J Med. 2000;343:86-93.
4. Kinoshita S, Adachi W, Sotozono C, et al. Characteristics of the human ocular surface epithelium. Prog Retin Eye Res. 2001;20:639-673.
5. Shoda J, Miura T, Utsunomiya H, et al. Genipin enhances Mrp2 (Abcc2)-mediated bile formation and organic anion transport in rat liver. Hepatology. 2004;39:167-178.
6. Arai M, Yokosuka O, Fukai K, et al. A case of severe acute hepatitis of unknown etiology treated with the Chinese herbal medicine Inchinko-to. Hepatol Res. 2004;28:161-165.
7. Sakaida I, Tsuchiya M, Kawaguchi K, et al. Herbal medicine Inchinko-to (TJ-135) prevents liver fibrosis and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. J Hepatol. 2003;38:762-769.
8. Yim JS, Kim YS, Moon SK, et al. Metabolic activities of ginsenoside RbI, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora. Biol Pharm Bull. 2004; 27:1580-1583.
9. Inao M, Mochida S, Matsui A, et al. Japanese herbal medicine Inchinko-to as a therapeutic drug for liver fibrosis. J Hepatol. 2004;41:584-591.
10. Imanishi Y, Maeda N, Otogawa K, et al. Herb medicine Inchinko-to (TJ-135) regulates PDGF-BB-dependent signaling pathways of hepatic stellate cells in primary culture and attenuates development of liver fibrosis induced by thioacetamide administration in rats. J Hepatol. 2004;41:242-250.
11. Woo SW, Nan JX, Lee SH, et al. Aloe emodin suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture. Pharmacol Toxicol. 2002;90:193-198.
12. Yeh FT, Wu CH, Lee HZ. Signaling pathway for aloe-emodin-induced apoptosis in human H460 lung nonsmall carcinoma cell. Int J Cancer. 2003;106:26-33.
13. Lee HZ. Effects and mechanisms of emodin on cell death in human lung squamous cell carcinoma. Br J Pharmacol. 2001;134:11-20.
14. Wasserman L, Avigad S, Beery E, et al. The effect of aloe emodin on the proliferation of a new Merkel carcinoma cell line. Am J Dermatopathol. 2002;24:17-22.
15. Lin JG, Chen GW, Li TM, et al. Aloe-emodin induces apoptosis in T24 human bladder cancer cells through the p53 dependent apoptotic pathway. J Urol. 2006;175:343-347.
16. Kitano A, Saika S, Yamanaka O, et al. Genipin suppresses fibrogenic behaviors of α-TN4 lens cell line. J Cat Refract Surg. 2006;38:355-360.
17. Yamanaka O, Saika S, Okada Y, et al. Effects of interferon-gamma on human subconjunctival fibroblasts in the presence of TGF-β1: reversal of TGF-β-stimulated collagen production. Graefes Arch Clin Exp Ophthalmol. 2003;241:116-124.
18. Arguello F, Sterry JA, Zhao YZ, et al. Two serologic markers to monitor the engraftment, growth, and treatment response of human leukemias in severe combined immunodeficient mice. Blood. 1996;87:4325-4332.
19. Hamid R, Rotshteyn Y, Rabadi L, et al. Comparison of Alamar blue and MTT assays for high through-put screening. Toxicol In Vitro. 2004;18:703-710.
20. Saika S, Ooshima A, Hashizume N, et al. Effect of lysyl hydroxylase inhibitor, minoxidil, on ultrastructure and behavior of cultured rabbit subconjunctival fibroblasts. Graefes Arch Clin Exp Ophthalmol. 1995;233:347-353.
21. Saika S, Yamanaka O, Ikeda K, et al. Inhibition of p38MAP kinase suppresses fibrotic reaction of retinal pigment epithelial cells. Lab Invest. 2005;85:838-850.
22. Saika S, Ikeda K, Yamanaka O, et al. Adenoviral gene transfer of BMP-7, Id2 or Id3 suppresses injury-induced epithelial-mesenchymal transition of lens epithelium in mice. Am J Physiol Cell Physiol. 2006;290:C282-C289.
23. Saika S, Ooshima A, Yamanaka O, et al. Effect of fibrostatin C, an inhibitor of prolyl 4-hydroxylase, on collagen secretion by human Tenon's capsule fibroblasts in vitro. Graefes Arch Clin Exp Ophthalmol. 1996;234:214-222.
24. Tanaka T, Saika S, Ohnishi Y, et al. Fibroblast growth factor 2: roles of regulation of lens cell proliferation and epithelial-mesenchymal transition in response to injury. Mol Vis. 2004;10:462-467.
25. Saika S, Ikeda K, Yamanaka O, et al. Expression of Smad7 in mouse eyes accelerates healing of corneal tissue after exposure to alkali. Am J Pathol. 2005;166:1405-1418.
26. Saika S, Miyamoto T, Yamanaka O, et al. Therapeutic effect of topical administration of SN50, an inhibitor of nuclear factor-κB, in treatment of corneal alkali burns in mice. Am J Pathol. 2005;166:1393-1403.
27. Saika S, Miyamoto T, Kawashima Y, et al. Immunolocalization of TGF-β1, - β2, and - β3, and TGF-β receptors in human lens capsules with lens implants. Graefes Arch Clin Exp Ophthalmol. 2000;238:283-293.
28. Nishida K, Sotozono C, Adachi W, et al. Transforming growth factor-β1, -β2 and -β3 mRNA expression in human cornea. Curr Eye Res. 1995;14:235-241.
29. Wajant H, Pfizenmaier K, Scheurich P. Tumor necrosis factor signaling. Cell Death Differ. 2003;10:45-65.
30. Cha TL, Qiu L, Chen CT, et al. Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth. Cancer Res. 2005;65:2287-2295.
31. Huang C, Jacobson K, Schaller MD. MAP kinases and cell migration. J Cell Sci. 2004;117:4619-4628.
32. Hocevar BA, Brown TL, Howe PH. TGF-β induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway. EMBO J. 1999;18:1345-1356.
33. Tomasek JJ, Gabbiani G, Hinz B, et al. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol. 2002;3:349-363.
34. Evans RA, Tian YC, Steadman R, et al. TGF-β1-mediated fibroblastmyofibroblast terminal differentiation-the role of Smad proteins. Exp Cell Res. 2003;282:90-100.
35. Serini G, Bochaton-Piallat ML, Ropraz P, et al. The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1. J Cell Biol. 1998;142:873-881.
36. Dugina V, Fontao L, Chaponnier C, et al. Focal adhesion features during myofibroblastic differentiation are controlled by intracellular and extracellular factors. J Cell Sci. 2001;114:3285-3296.
37. Dooley S, Hamzavi J, Breitkopf K, et al. Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats. Gastroenterology. 2003;125:178-191.
38. Yamanaka O, Ikeda K, Saika S, Miyazaki K, Ooshima A, Ohnishi Y. Gene transfer of Smad7 modulates injury-induced conjunctival wound healing in mice. Mol Vis. 2006;12:841-851.
39. Moustakas A, Heldin CH. Non-Smad TGF-β signals. J Cell Sci. 2005;118:3573-3584.
40. Yoshida K, Matsuzaki K, Mori S, et al. Transforming growth factor-β and platelet-derived growth factor signal via c-Jun N-terminal kinase-dependent Smad2/3 phosphorylation in rat hepatic stellate cells after acute liver injury. Am J Pathol. 2005;166:1029-1039.
41. Mori S, Matsuzaki K, Yoshida K, et al. TGF-β and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regions. Oncogene. 2004;23:7416-7429.