Conditional β1-integrin-deficient mice display impaired pancreatic β cell function

Journal of Pathology

Volumn 224, Issue 1, 2011, Pages 45-55

  Riopel, M ^a   Krishnamurthy, M ^a   Li, J ^a   Liu, S ^a   Leask, A ^a   Wang, R ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b Victoria Research Laboratories   (Canada)

Author keywords

cell mass; 1 integrin; collagen I matrix; FAK MAPK ERK signalling pathway; glucose tolerance test

Indexed keywords

BETA1 INTEGRIN; CASPASE 3; COLLAGEN TYPE 1; CYCLIN D1; FOCAL ADHESION KINASE; GLUCOSE; INSULIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; TRANSCRIPTION FACTOR NKX6.1; TRANSCRIPTION FACTOR PDX 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; MALE; MORPHOMETRICS; MOUSE; NONHUMAN; ORGAN WEIGHT; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD29; CAPILLARIES; CELL PROLIFERATION; FEMALE; FOCAL ADHESION KINASE 1; GENE EXPRESSION REGULATION; GLUCOSE TOLERANCE TEST; HOMEODOMAIN PROTEINS; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; ORGAN SIZE; PANCREAS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANS-ACTIVATORS; WEIGHT LOSS;

EID: 79953783426     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2849     Document Type: Article

References (34)

1. Kaido T, Yebra M, Cirulli V, et al., Regulation of human β cell adhesion, motility, and insulin secretion by collagen IV and its receptor α1β1. J Biol Chem 2004; 279: 53762-53769. (Pubitemid 40051885)
2. Kaido T, Perez B, Yebra M, et al., αv-integrin utilization in human β cell adhesion, spreading, and motility. J Biol Chem 2004; 279: 17731-17737. (Pubitemid 38560539)
3. Juliano RL, Reddig P, Alahari S, et al., Integrin regulation of cell signalling and motility. Biochem Soc Trans 2004; 32 (3): 443-446. (Pubitemid 38813533)
4. French-Constant CF, Colognato H,. Integrins: versatile integrators of extracellular signals. Trends Cell Bio 2004; 14 (12): 678-695.
5. Bouvard D, Brakebusch C, Gustafsson E, et al., Functional consequences of integrin gene mutations in mice. Circ Res 2001; 89: 211-223. (Pubitemid 34132680)
6. Hynes RO,. Integrins: bidirectional, allosteric signaling molecules. Cell 2002; 110: 673-687. (Pubitemid 35283958)
7. Pozzi A, Zent R,. Integrins: sensors of extracellular matrix and modulators of cell function. Nephron Exp Nephrol 2003; 94: 77-84.
8. Bagutti C, Wobus AM, Fassler R, et al., Differentiation of embryonal stem cells into keratinocytes: comparison of wild-type and β1-integrin- deficient cells. Dev Biol 1996; 179: 184-196. (Pubitemid 26363256)
9. Fassler R, Pfaff M, Murphy J, et al., Lack of β1-integrin gene in embryonic stem cells affects morphology, adhesion, and migration but not integration into the inner cell mass of blastocysts. J Cell Biol 1995; 128: 979-988.
10. Kantengwa S, Beatens D, Sadoul K, et al., Identification and characterization of α3β1 on primary and transformed rat islet cells. Exp Cell Res 1997; 237: 394-402. (Pubitemid 28027934)
11. Bosco D, Meda P, Halban PA, et al., Importance of cell-matrix interactions in rat islet β-cell secretion in vitro: role of α6β1-integrin. Diabetes 2000; 49: 233-243. (Pubitemid 30071002)
12. Yashpal NK, Li J, Wheeler MB, et al., Expression of β1-integrin receptors during rat pancreas development-sites and dynamics. Endocrinology 2005; 146 (4): 1798-1807. (Pubitemid 40396889)
13. Wang R, Li J, Lyte K, et al., Role of β1-integrin and its associated α3, α5 and α6 subunits in the development of the human fetal pancreas. Diabetes 2005; 54: 2080-2089. (Pubitemid 40911271)
14. Krishnamurthy M, Li J, Al-Masri M, et al., Expression and function of αβ1-integrins in pancreatic β (INS-1) cells. J Cell Commun Signal 2008; 2 (3-4): 67-79.
15. Saleem S, Li J, Yee SP, et al., β1-integrin-FAK-ERK signalling pathway is essential for human fetal islet cell differentiation and survival. J Pathol 2009; 219 (2): 182-192.
16. Ponticos M, Abraham D, Alexakis C, et al., Col1a2 enhancer regulates collagen activity during development and in adult tissue repair. Matrix Biol 2004; 22 (8): 619-628. (Pubitemid 38520091)
17. Liu S, Kapoor M, Denton C, et al., Loss of β1-integrin in mouse fibroblasts results in resistance to skin scleroderma in a mouse model. Arthritis Rheum 2009; 60 (9): 2817-2821.
18. Krishnamurthy M, Ayazi F, Li J, et al., c-Kit in early onset of diabetes: a morphological and function analysis of pancreatic β-cells in c-KitW-v mutant mice. Endocrinology 2007; 148 (11): 5520-5530. (Pubitemid 350012638)
19. Allison DB, Paultre F, Maggio C, et al., The use of areas under curves in diabetes research. Diabetes Care 1995; 18: 245-250.
20. Junqueira LC, Bignolas G, Mourão PA, et al., Quantitation of collagen-proteoglycan interaction in tissue sections. Connect Tissue Res 1980; 7 (2): 91-96. (Pubitemid 10166718)
21. Wang R, Bouwens L, Kloppel G,. β-Cell proliferation in normal and streptozotocin-treated newborn rats: site, dynamics and capacity. Diabetologia 1994; 37: 1088-1096. (Pubitemid 24325552)
22. Papaccio G, Pisanti FA, Montefiano RD, et al., Th1 and Th2 cytokines exert regulatory effects upon islet microvascular areas in the NOD mouse. J Cell Biochem 2002; 86 (4): 651-664. (Pubitemid 34839967)
23. Humphries MJ, Travis MA, Clark K, et al., Mechanisms of integration of cells and extracellular matrices by integrins. Biochem Soc Trans 2004; 32: 822-825. (Pubitemid 39524388)
24. Bombardelli L, Carpenter ES, Wu AP, et al., Pancreas-specific ablation of β1-integrin induces tissue degeneration by disrupting acinar cell polarity. Gastroenterology 2010; 138 (7): 2531-2540.
25. Ahlgren U, Jonsson J, Edlund H,. The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice. Development 1996; 122: 1409-1416. (Pubitemid 26159631)
26. Ahlgren U, Jonsson J, Jonsson L, et al., β Cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β cell phenotype and maturity onset diabetes. Genes Dev 1998; 12: 1763-1768. (Pubitemid 28304328)
27. Henseleit KD, Nelson SB, Kuhlbordt K, et al., NKX6 transcription factor activity is required for α- and β-cell development in the pancreas. Development 2005; 132: 3139-3149. (Pubitemid 41086746)
28. Brissova M, Blaha M, Spear C, et al., Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis. Am J Physiol Endocrinol Metab 2005; 288 (4): 707-714.
29. Nikolova G, Jabs N, Konstantinova I, et al., The vascular basement membrane: a niche for insulin gene expression and β cell proliferation. Dev Cell 2006; 10 (3): 397-405.
30. Brissova M, Shostak A, Shiota M, et al., Pancreatic islet production of vascular endothelial growth factor-a is essential for islet vascularization, revascularization, and function. Diabetes 2006; 55 (11): 2974-2985. (Pubitemid 44923633)
31. Reddig PJ, Juliano RL,. Clinging to life: cell to matrix adhesion and cell survival. Cancer Metast Rev 2005; 24: 425-439. (Pubitemid 41569982)
32. Manohar A, Shome SG, Lamar J, et al., α3β1-integrin promotes keratinocyte cell survival through activation of a MEK-ERK signaling pathway. J Cell Sci 2004; 117: 4043-4054. (Pubitemid 39328293)
33. Hammar E, Parnaud G, Bosco D, et al., Extracellular matrix protects pancreatic β-cells against apoptosis: role of short- and long-term signaling pathways. Diabetes 2004; 53: 2034-2041. (Pubitemid 38970752)
34. Le May C, Chu K, Hu M, et al., Estrogens protect pancreatic β cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice. Proc Natl Acad Sci USA 2006; 103 (24): 9232-9237. (Pubitemid 43902561)