메뉴 건너뛰기




Volumn 19, Issue 1, 2010, Pages 26-31

Targeting bone morphogenetic protein signaling on renal and vascular diseases

Author keywords

Bone morphogenetic protein; Kidney; Pathophysiology; Vasculature

Indexed keywords

BONE MORPHOGENETIC PROTEIN;

EID: 73849131053     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/MNH.0b013e328332fc13     Document Type: Review
Times cited : (12)

References (72)
  • 1
    • 66349137029 scopus 로고    scopus 로고
    • Finding partners: How BMPs select their targets
    • Blitz IL, Cho KW. Finding partners: how BMPs select their targets. Dev Dyn 2009; 238:1321-1331.
    • (2009) Dev Dyn , vol.238 , pp. 1321-1331
    • Blitz, I.L.1    Cho, K.W.2
  • 2
    • 0346996450 scopus 로고    scopus 로고
    • Signal transduction of bone morphogenetic protein receptors
    • Nohe A, Keating E, Knaus P, et al. Signal transduction of bone morphogenetic protein receptors. Cell Signal 2004; 16:291-299.
    • (2004) Cell Signal , vol.16 , pp. 291-299
    • Nohe, A.1    Keating, E.2    Knaus, P.3
  • 3
    • 21244479759 scopus 로고    scopus 로고
    • Fine tuning and cross-talking of TGF-beta signal by inhibitory Smads
    • Park SH. Fine tuning and cross-talking of TGF-beta signal by inhibitory Smads. J Biochem Molec Biol 2005; 38:9-16.
    • (2005) J Biochem Molec Biol , vol.38 , pp. 9-16
    • Park, S.H.1
  • 4
    • 33846004405 scopus 로고    scopus 로고
    • Bone morphogenetic proteins and their antagonists
    • Gazzerro E, Canalis E. Bone morphogenetic proteins and their antagonists. Rev Endocr Metab Disord 2006; 7 (1-2):51-65.
    • (2006) Rev Endocr Metab Disord , vol.7 , Issue.1-2 , pp. 51-65
    • Gazzerro, E.1    Canalis, E.2
  • 5
    • 0037040197 scopus 로고    scopus 로고
    • Matrix GLA protein, a regulatory protein for bone morphogenetic protein-2
    • Zebboudj AF, Imura M, Bostrom K. Matrix GLA protein, a regulatory protein for bone morphogenetic protein-2. J Biological Chem 2002; 277:4388-4394.
    • (2002) J Biological Chem , vol.277 , pp. 4388-4394
    • Zebboudj, A.F.1    Imura, M.2    Bostrom, K.3
  • 6
    • 43149095145 scopus 로고    scopus 로고
    • Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor
    • Kirkbride KC, Townsend TA, Bruinsma MW, et al. Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor. J Biol Chem 2008; 283:7628-7637.
    • (2008) J Biol Chem , vol.283 , pp. 7628-7637
    • Kirkbride, K.C.1    Townsend, T.A.2    Bruinsma, M.W.3
  • 7
    • 66749165207 scopus 로고    scopus 로고
    • DRAGON, a GPI-anchored membrane protein, inhibits BMP signaling in C2C12 myoblasts
    • Kanomata K, Kokabu S, Nojima J, et al. DRAGON, a GPI-anchored membrane protein, inhibits BMP signaling in C2C12 myoblasts. Genes Cells 2009; 14:695-702.
    • (2009) Genes Cells , vol.14 , pp. 695-702
    • Kanomata, K.1    Kokabu, S.2    Nojima, J.3
  • 8
    • 68849095265 scopus 로고    scopus 로고
    • Generation and functional characterization of mice with a conditional BMP7 allele
    • Zouvelou V, Passa O, Segklia K, et al. Generation and functional characterization of mice with a conditional BMP7 allele. Int J Develop Biol 2009; 53:597-603.
    • (2009) Int J Develop Biol , vol.53 , pp. 597-603
    • Zouvelou, V.1    Passa, O.2    Segklia, K.3
  • 9
    • 33845971522 scopus 로고    scopus 로고
    • Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis
    • Bandyopadhyay A, Tsuji K, Cox K, et al. Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis. PLoS Genet 2006; 2:e216.
    • (2006) PLoS Genet , vol.2
    • Bandyopadhyay, A.1    Tsuji, K.2    Cox, K.3
  • 10
    • 50849113091 scopus 로고    scopus 로고
    • Real time monitoring of BMP Smads transcriptional activity during mouse development
    • Monteiro RM, de Sousa Lopes SM, Bialecka M, et al. Real time monitoring of BMP Smads transcriptional activity during mouse development. Genesis 2008; 46:335-346.
    • (2008) Genesis , vol.46 , pp. 335-346
    • Monteiro, R.M.1    De Sousa Lopes, S.M.2    Bialecka, M.3
  • 11
    • 53249101499 scopus 로고    scopus 로고
    • An in vivo reporter of BMP signaling in organogenesis reveals targets in the developing kidney
    • Blank U, Seto ML, Adams DC, et al. An in vivo reporter of BMP signaling in organogenesis reveals targets in the developing kidney. BMC Dev Biol 2008; 8:86.
    • (2008) BMC Dev Biol , vol.8 , pp. 86
    • Blank, U.1    Seto, M.L.2    Adams, D.C.3
  • 12
    • 37249010753 scopus 로고    scopus 로고
    • Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
    • Yu PB, Hong CC, Sachidanandan C, et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nature Chem Biol 2008; 4:33-41.
    • (2008) Nature Chem Biol , vol.4 , pp. 33-41
    • Yu, P.B.1    Hong, C.C.2    Sachidanandan, C.3
  • 13
    • 34347375050 scopus 로고    scopus 로고
    • Renal fibrosis and glomerulosclerosis in a new mouse model of diabetic nephropathy and its regression by bone morphogenic protein-7 and advanced glycation end product inhibitors
    • Sugimoto H, Grahovac G, Zeisberg M, et al. Renal fibrosis and glomerulosclerosis in a new mouse model of diabetic nephropathy and its regression by bone morphogenic protein-7 and advanced glycation end product inhibitors. Diabetes 2007; 56:1825-1833.
    • (2007) Diabetes , vol.56 , pp. 1825-1833
    • Sugimoto, H.1    Grahovac, G.2    Zeisberg, M.3
  • 14
    • 36749101547 scopus 로고    scopus 로고
    • Bone morphogenetic protein-7 delays podocyte injury due to high glucose
    • De Petris L, Hruska KA, Chiechio S, et al. Bone morphogenetic protein-7 delays podocyte injury due to high glucose. Nephrol Dial Transplant 2007; 22:3442-3450.
    • (2007) Nephrol Dial Transplant , vol.22 , pp. 3442-3450
    • De Petris, L.1    Hruska, K.A.2    Chiechio, S.3
  • 15
    • 0034758712 scopus 로고    scopus 로고
    • Loss of tubular bone morphogenetic protein-7 in diabetic nephropathy
    • Wang SN, Lapage J, Hirschberg R. Loss of tubular bone morphogenetic protein-7 in diabetic nephropathy. J Am Soc Nephrol 2001; 12:2392-2399.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 2392-2399
    • Wang, S.N.1    Lapage, J.2    Hirschberg, R.3
  • 16
    • 67651149607 scopus 로고    scopus 로고
    • BMP signaling and podocyte markers are decreased in human diabetic nephropathy in association with CTGF overexpression
    • Turk T, Leeuwis JW, Gray J, et al. BMP signaling and podocyte markers are decreased in human diabetic nephropathy in association with CTGF overexpression. J Histochem Cytochem 2009; 57:623-631.
    • (2009) J Histochem Cytochem , vol.57 , pp. 623-631
    • Turk, T.1    Leeuwis, J.W.2    Gray, J.3
  • 17
    • 33748062324 scopus 로고    scopus 로고
    • Renal bone morphogenetic protein-7 protects against diabetic nephropathy
    • Wang S, de Caestecker M, Kopp J, et al. Renal bone morphogenetic protein-7 protects against diabetic nephropathy. J Am Soc Nephrol 2006; 17:2504-2512.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 2504-2512
    • Wang, S.1    De Caestecker, M.2    Kopp, J.3
  • 18
    • 70349568517 scopus 로고    scopus 로고
    • Decrease of bone morphogenetic protein-7 (BMP-7) and its type II receptor (BMP-RII) in kidney of type 1-like diabetic rats
    • Yeh CH, Chang CK, Cheng MF, et al. Decrease of bone morphogenetic protein-7 (BMP-7) and its type II receptor (BMP-RII) in kidney of type 1-like diabetic rats. Horm Metab Res 2009; 41:605-611.
    • (2009) Horm Metab Res , vol.41 , pp. 605-611
    • Yeh, C.H.1    Chang, C.K.2    Cheng, M.F.3
  • 19
    • 36049022526 scopus 로고    scopus 로고
    • BMP7 is a podocyte survival factor and rescues podocytes from diabetic injury
    • Mitu GM, Wang S, Hirschberg R. BMP7 is a podocyte survival factor and rescues podocytes from diabetic injury. Am J Physiol Renal Physiol 2007; 293:F1641-1648.
    • (2007) Am J Physiol Renal Physiol , vol.293
    • Mitu, G.M.1    Wang, S.2    Hirschberg, R.3
  • 20
    • 63549125875 scopus 로고    scopus 로고
    • The antioxidative effect of bone morphogenetic protein-7 against high glucose-induced oxidative stress in mesangial cells
    • Yeh CH, Chang CK, Cheng MF, et al. The antioxidative effect of bone morphogenetic protein-7 against high glucose-induced oxidative stress in mesangial cells. Biochem Biophys Res Commun 2009; 382:292-297.
    • (2009) Biochem Biophys Res Commun , vol.382 , pp. 292-297
    • Yeh, C.H.1    Chang, C.K.2    Cheng, M.F.3
  • 21
    • 0034616419 scopus 로고    scopus 로고
    • IHG-2, a mesangial cell gene induced by high glucose, is human gremlin. Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta1
    • McMahon R, Murphy M, Clarkson M, et al. IHG-2, a mesangial cell gene induced by high glucose, is human gremlin. Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta1. J Biological Chem 2000; 275:9901-9904.
    • (2000) J Biological Chem , vol.275 , pp. 9901-9904
    • McMahon, R.1    Murphy, M.2    Clarkson, M.3
  • 22
    • 20444364531 scopus 로고    scopus 로고
    • Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy
    • Dolan V, Murphy M, Sadlier D, et al. Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy. Am J Kidney Dis 2005; 45:1034-1039.
    • (2005) Am J Kidney Dis , vol.45 , pp. 1034-1039
    • Dolan, V.1    Murphy, M.2    Sadlier, D.3
  • 23
    • 39149086711 scopus 로고    scopus 로고
    • Co-regulation of Gremlin and Notch signalling in diabetic nephropathy
    • Walsh DW, Roxburgh SA, McGettigan P, et al. Co-regulation of Gremlin and Notch signalling in diabetic nephropathy. Biochim Biophys Acta 2008; 1782:10-21.
    • (2008) Biochim Biophys Acta , vol.1782 , pp. 10-21
    • Walsh, D.W.1    Roxburgh, S.A.2    McGettigan, P.3
  • 24
    • 67650239578 scopus 로고    scopus 로고
    • Allelic depletion of grem1 attenuates diabetic kidney disease
    • Roxburgh SA, Kattla JJ, Curran SP, et al. Allelic depletion of grem1 attenuates diabetic kidney disease. Diabetes 2009; 58:1641-1650.
    • (2009) Diabetes , vol.58 , pp. 1641-1650
    • Roxburgh, S.A.1    Kattla, J.J.2    Curran, S.P.3
  • 25
    • 33744830851 scopus 로고    scopus 로고
    • Temporal expression profile and distribution pattern indicate a role of connective tissue growth factor (CTGF/CCN-2) in diabetic nephropathy in mice
    • Roestenberg P, van Nieuwenhoven FA, Joles JA, et al. Temporal expression profile and distribution pattern indicate a role of connective tissue growth factor (CTGF/CCN-2) in diabetic nephropathy in mice. Am J Physiol Renal Physiol 2006; 290:F1344-F1354.
    • (2006) Am J Physiol Renal Physiol , vol.290
    • Roestenberg, P.1    Van Nieuwenhoven, F.A.2    Joles, J.A.3
  • 26
    • 0036051343 scopus 로고    scopus 로고
    • Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta
    • Abreu JG, Ketpura NI, Reversade B, et al. Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta. Nat Cell Biol 2002; 4:599-604.
    • (2002) Nat Cell Biol , vol.4 , pp. 599-604
    • Abreu, J.G.1    Ketpura, N.I.2    Reversade, B.3
  • 28
    • 69449084178 scopus 로고    scopus 로고
    • BMP-7 counteracts TGF-beta1-induced epithelialto-mesenchymal transition in human renal proximal tubular epithelial cells
    • Xu Y, Wan J, Jiang D, et al. BMP-7 counteracts TGF-beta1-induced epithelialto- mesenchymal transition in human renal proximal tubular epithelial cells. J Nephrol 2009; 22:403-410.
    • (2009) J Nephrol , vol.22 , pp. 403-410
    • Xu, Y.1    Wan, J.2    Jiang, D.3
  • 29
    • 0037405422 scopus 로고    scopus 로고
    • BMP7 antagonizes TGF-beta-dependent fibrogenesis in mesangial cells
    • Wang S, Hirschberg R. BMP7 antagonizes TGF-beta-dependent fibrogenesis in mesangial cells. Am J Physiol Renal Physiol 2003; 284:F1006-F1013.
    • (2003) Am J Physiol Renal Physiol , vol.284
    • Wang, S.1    Hirschberg, R.2
  • 30
    • 51649117133 scopus 로고    scopus 로고
    • BMP-7 and proximal tubule epithelial cells: Activation of multiple signaling pathways reveals a novel antifibrotic mechanism
    • Motazed R, Colville-Nash P, Kwan JT, et al. BMP-7 and proximal tubule epithelial cells: activation of multiple signaling pathways reveals a novel antifibrotic mechanism. Pharm Res 2008; 25:2440-2446.
    • (2008) Pharm Res , vol.25 , pp. 2440-2446
    • Motazed, R.1    Colville-Nash, P.2    Kwan, J.T.3
  • 31
    • 0032128140 scopus 로고    scopus 로고
    • Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat
    • Vukicevic S, Basic V, Rogic D, et al. Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat. J Clin Invest 1998; 102:202-214.
    • (1998) J Clin Invest , vol.102 , pp. 202-214
    • Vukicevic, S.1    Basic, V.2    Rogic, D.3
  • 32
    • 0038717407 scopus 로고    scopus 로고
    • BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
    • Zeisberg M, Hanai J, Sugimoto H, et al. BMP-7 counteracts TGF-beta1- induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 2003; 9:964-968.
    • (2003) Nat Med , vol.9 , pp. 964-968
    • Zeisberg, M.1    Hanai, J.2    Sugimoto, H.3
  • 33
    • 17544379605 scopus 로고    scopus 로고
    • Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction
    • Hruska KA, Guo G, Wozniak M, et al. Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction. Am J Physiol Renal Physiol 2000; 279:F130-143.
    • (2000) Am J Physiol Renal Physiol , vol.279
    • Hruska, K.A.1    Guo, G.2    Wozniak, M.3
  • 34
    • 59649093679 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 antagonizes renal interstitial fibrosis by promoting catabolism of type i transforming growth factor-beta receptors
    • Yang YL, Liu YS, Chuang LY, et al. Bone morphogenetic protein-2 antagonizes renal interstitial fibrosis by promoting catabolism of type I transforming growth factor-beta receptors. Endocrinology 2009; 150:727-740.
    • (2009) Endocrinology , vol.150 , pp. 727-740
    • Yang, Y.L.1    Liu, Y.S.2    Chuang, L.Y.3
  • 35
    • 53049094210 scopus 로고    scopus 로고
    • BMP-7 protects mesangial cells from injury by polymeric IgA
    • Chan WL, Leung JC, Chan LY, et al. BMP-7 protects mesangial cells from injury by polymeric IgA. Kidney Int 2008; 74:1026-1039.
    • (2008) Kidney Int , vol.74 , pp. 1026-1039
    • Chan, W.L.1    Leung, J.C.2    Chan, L.Y.3
  • 36
    • 63349084498 scopus 로고    scopus 로고
    • BMP6 attenuates oxidant injury in HK-2 cells via Smad-dependent HO-1 induction
    • Yan J, Yang S, Zhang J, et al. BMP6 attenuates oxidant injury in HK-2 cells via Smad-dependent HO-1 induction. Free Radic Biol Med 2009; 46:1275-1282.
    • (2009) Free Radic Biol Med , vol.46 , pp. 1275-1282
    • Yan, J.1    Yang, S.2    Zhang, J.3
  • 37
    • 42949143822 scopus 로고    scopus 로고
    • Gremlin: A novel mediator of epithelial mesenchymal transition and fibrosis in chronic allograft nephropathy
    • Carvajal G, Droguett A, Burgos ME, et al. Gremlin: a novel mediator of epithelial mesenchymal transition and fibrosis in chronic allograft nephropathy. Transplant Proc 2008; 40:734-739.
    • (2008) Transplant Proc , vol.40 , pp. 734-739
    • Carvajal, G.1    Droguett, A.2    Burgos, M.E.3
  • 38
    • 34547851691 scopus 로고    scopus 로고
    • Expression of gremlin, a bone morphogenetic protein antagonist, in glomerular crescents of pauci-immune glomerulonephritis
    • Mezzano S, Droguett A, Burgos ME, et al. Expression of gremlin, a bone morphogenetic protein antagonist, in glomerular crescents of pauci-immune glomerulonephritis. Nephrol Dial Transplant 2007; 22:1882-1890.
    • (2007) Nephrol Dial Transplant , vol.22 , pp. 1882-1890
    • Mezzano, S.1    Droguett, A.2    Burgos, M.E.3
  • 39
    • 35748957452 scopus 로고    scopus 로고
    • Balance between bone morphogenetic proteins and their antagonists in kidney injury
    • Yanagita M. Balance between bone morphogenetic proteins and their antagonists in kidney injury. Ther Apher Dial 2007; 11(Suppl 1):S38-S43.
    • (2007) Ther Apher Dial , vol.11 , Issue.SUPPL. 1
    • Yanagita, M.1
  • 40
    • 37549033870 scopus 로고    scopus 로고
    • Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury
    • Tanaka M, Endo S, Okuda T, et al. Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury. Kidney Int 2008; 73:181-191.
    • (2008) Kidney Int , vol.73 , pp. 181-191
    • Tanaka, M.1    Endo, S.2    Okuda, T.3
  • 41
    • 65649093071 scopus 로고    scopus 로고
    • Chordin-like 1 and twisted gastrulation 1 regulate BMP signaling following kidney injury
    • Larman BW, Karolak MJ, Adams DC, et al. Chordin-like 1 and twisted gastrulation 1 regulate BMP signaling following kidney injury. J Am Soc Nephrol 2009; 20:1020-1031.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 1020-1031
    • Larman, B.W.1    Karolak, M.J.2    Adams, D.C.3
  • 42
    • 33751092502 scopus 로고    scopus 로고
    • Inhibitory Smad transcription factors protect arterial endothelial cells from apoptosis induced by BMP4
    • Kiyono M, Shibuya M. Inhibitory Smad transcription factors protect arterial endothelial cells from apoptosis induced by BMP4. Oncogene 2006; 25:7131-7137.
    • (2006) Oncogene , vol.25 , pp. 7131-7137
    • Kiyono, M.1    Shibuya, M.2
  • 43
    • 0031470417 scopus 로고    scopus 로고
    • Inhibition of rat vascular smooth muscle proliferation in vitro and in vivo by bone morphogenetic protein-2
    • Nakaoka T, Gonda K, Ogita T, et al. Inhibition of rat vascular smooth muscle proliferation in vitro and in vivo by bone morphogenetic protein-2. J Clin Invest 1997; 100:2824-2832.
    • (1997) J Clin Invest , vol.100 , pp. 2824-2832
    • Nakaoka, T.1    Gonda, K.2    Ogita, T.3
  • 44
    • 43049092988 scopus 로고    scopus 로고
    • An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension
    • Hansmann G, de Jesus Perez VA, Alastalo TP, et al. An antiproliferative BMP- 2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension. J Clin Invest 2008; 118:1846-1857.
    • (2008) J Clin Invest , vol.118 , pp. 1846-1857
    • Hansmann, G.1    De Jesus Perez, V.A.2    Alastalo, T.P.3
  • 45
    • 37549065952 scopus 로고    scopus 로고
    • Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardinrelated transcription factors
    • Lagna G, Ku MM, Nguyen PH, et al. Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardinrelated transcription factors. J Biol Chem 2007; 282:37244-37255.
    • (2007) J Biol Chem , vol.282 , pp. 37244-37255
    • Lagna, G.1    Ku, M.M.2    Nguyen, P.H.3
  • 46
    • 0034074899 scopus 로고    scopus 로고
    • Bone morphogenetic protein-7 (osteogenic protein-1) inhibits smooth muscle cell proliferation and stimulates the expression of markers that are characteristic of SMC phenotype in vitro
    • Dorai H, Vukicevic S, Sampath TK. Bone morphogenetic protein-7 (osteogenic protein-1) inhibits smooth muscle cell proliferation and stimulates the expression of markers that are characteristic of SMC phenotype in vitro. J Cell Physiol 2000; 184:37-45.
    • (2000) J Cell Physiol , vol.184 , pp. 37-45
    • Dorai, H.1    Vukicevic, S.2    Sampath, T.K.3
  • 47
    • 42949178711 scopus 로고    scopus 로고
    • Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells
    • Yu PB, Deng DY, Beppu H, et al. Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells. J Biol Chem 2008; 283:3877-3888.
    • (2008) J Biol Chem , vol.283 , pp. 3877-3888
    • Yu, P.B.1    Deng, D.Y.2    Beppu, H.3
  • 48
    • 58149361392 scopus 로고    scopus 로고
    • The bone morphogenetic protein antagonist gremlin promotes vascular smooth muscle cell apoptosis
    • Maciel TT, Melo RS, Campos AH. The bone morphogenetic protein antagonist gremlin promotes vascular smooth muscle cell apoptosis. J Vasc Res 2009; 46:325-332.
    • (2009) J Vasc Res , vol.46 , pp. 325-332
    • MacIel, T.T.1    Melo, R.S.2    Campos, A.H.3
  • 49
    • 39149099992 scopus 로고    scopus 로고
    • Gremlin promotes vascular smooth muscle cell proliferation and migration
    • Maciel TT, Melo RS, Schor N, et al. Gremlin promotes vascular smooth muscle cell proliferation and migration. J Mol Cell Cardiol 2008; 44:370-379.
    • (2008) J Mol Cell Cardiol , vol.44 , pp. 370-379
    • MacIel, T.T.1    Melo, R.S.2    Schor, N.3
  • 50
    • 33751227533 scopus 로고    scopus 로고
    • Pulmonary hypertension due to BMPR2 mutation: A new paradigm for tissue remodeling?
    • Morrell NW. Pulmonary hypertension due to BMPR2 mutation: a new paradigm for tissue remodeling? Proc Am Thorac Soc 2006; 3:680-686.
    • (2006) Proc Am Thorac Soc , vol.3 , pp. 680-686
    • Morrell, N.W.1
  • 51
    • 34447542025 scopus 로고    scopus 로고
    • Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH
    • Tada Y, Majka S, Carr M, et al. Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH. Am J Physiol Lung Cell Mol Physiol 2007; 292:L1556-1563.
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.292
    • Tada, Y.1    Majka, S.2    Carr, M.3
  • 52
    • 57049159708 scopus 로고    scopus 로고
    • Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions
    • West J, Harral J, Lane K, et al. Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions. Am J Physiol Lung Cell Mol Physiol 2008; 295:L744-755.
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.295
    • West, J.1    Harral, J.2    Lane, K.3
  • 53
    • 20344362689 scopus 로고    scopus 로고
    • Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension
    • Yang X, Long L, Southwood M, et al. Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension. Circ Res 2005; 96:1053-1063.
    • (2005) Circ Res , vol.96 , pp. 1053-1063
    • Yang, X.1    Long, L.2    Southwood, M.3
  • 54
    • 45149132191 scopus 로고    scopus 로고
    • Mutations in bone morphogenetic protein type II receptor cause dysregulation of Id gene expression in pulmonary artery smooth muscle cells: Implications for familial pulmonary arterial hypertension
    • Yang J, Davies RJ, Southwood M, et al. Mutations in bone morphogenetic protein type II receptor cause dysregulation of Id gene expression in pulmonary artery smooth muscle cells: implications for familial pulmonary arterial hypertension. Circ Res 2008; 102:1212-1221.
    • (2008) Circ Res , vol.102 , pp. 1212-1221
    • Yang, J.1    Davies, R.J.2    Southwood, M.3
  • 55
    • 35348967735 scopus 로고    scopus 로고
    • BMP4 induces HO-1 via a Smad-independent, p38MAPK-dependent pathway in pulmonary artery myocytes
    • Yang X, Lee PJ, Long L, et al. BMP4 induces HO-1 via a Smad-independent, p38MAPK-dependent pathway in pulmonary artery myocytes. Am J Respir Cell Mol Biol 2007; 37:598-605.
    • (2007) Am J Respir Cell Mol Biol , vol.37 , pp. 598-605
    • Yang, X.1    Lee, P.J.2    Long, L.3
  • 56
    • 33745946837 scopus 로고    scopus 로고
    • Bone morphogenic protein-4 induces hypertension in mice: Role of noggin, vascular NADPH oxidases, and impaired vasorelaxation
    • Miriyala S, Gongora Nieto MC, Mingone C, et al. Bone morphogenic protein-4 induces hypertension in mice: role of noggin, vascular NADPH oxidases, and impaired vasorelaxation. Circulation 2006; 113:2818-2825.
    • (2006) Circulation , vol.113 , pp. 2818-2825
    • Miriyala, S.1    Gongora Nieto, M.C.2    Mingone, C.3
  • 57
    • 0043234315 scopus 로고    scopus 로고
    • Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress stimulates an inflammatory response
    • Sorescu GP, Sykes M, Weiss D, et al. Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress stimulates an inflammatory response. J Biol Chem 2003; 278:31128-31135.
    • (2003) J Biol Chem , vol.278 , pp. 31128-31135
    • Sorescu, G.P.1    Sykes, M.2    Weiss, D.3
  • 58
    • 52449102202 scopus 로고    scopus 로고
    • Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cells
    • Csiszar A, Labinskyy N, Jo H, et al. Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cells. Am J Physiol Heart Circ Physiol 2008; 295:H569-H577.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295
    • Csiszar, A.1    Labinskyy, N.2    Jo, H.3
  • 59
    • 0027285583 scopus 로고
    • Bone morphogenetic protein expression in human atherosclerotic lesions
    • Bostrom K, Watson KE, Horn S, et al. Bone morphogenetic protein expression in human atherosclerotic lesions. J Clin Invest 1993; 91:1800-1809.
    • (1993) J Clin Invest , vol.91 , pp. 1800-1809
    • Bostrom, K.1    Watson, K.E.2    Horn, S.3
  • 60
    • 34047095329 scopus 로고    scopus 로고
    • Activin-like kinase receptor 1 (ALK1) in atherosclerotic lesions and vascular mesenchymal cells
    • Yao Y, Zebboudj AF, Torres A, et al. Activin-like kinase receptor 1 (ALK1) in atherosclerotic lesions and vascular mesenchymal cells. Cardiovasc Res 2007; 74:279-289.
    • (2007) Cardiovasc Res , vol.74 , pp. 279-289
    • Yao, Y.1    Zebboudj, A.F.2    Torres, A.3
  • 61
    • 34948907257 scopus 로고    scopus 로고
    • Bone morphogenic protein antagonists are coexpressed with bone morphogenic protein 4 in endothelial cells exposed to unstable flow in vitro in mouse aortas and in human coronary arteries: Role of bone morphogenic protein antagonists in inflammation and atherosclerosis
    • Chang K, Weiss D, Suo J, et al. Bone morphogenic protein antagonists are coexpressed with bone morphogenic protein 4 in endothelial cells exposed to unstable flow in vitro in mouse aortas and in human coronary arteries: role of bone morphogenic protein antagonists in inflammation and atherosclerosis. Circulation 2007; 116:1258-1266.
    • (2007) Circulation , vol.116 , pp. 1258-1266
    • Chang, K.1    Weiss, D.2    Suo, J.3
  • 62
    • 34948874100 scopus 로고    scopus 로고
    • Endothelium-derived bone morphogenic protein antagonists may counteract the proatherogenic vascular effects of bone morphogenic protein 4
    • Ungvari ZI. Endothelium-derived bone morphogenic protein antagonists may counteract the proatherogenic vascular effects of bone morphogenic protein 4. Circulation 2007; 116:1221-1223.
    • (2007) Circulation , vol.116 , pp. 1221-1223
    • Ungvari, Z.I.1
  • 63
    • 57549104510 scopus 로고    scopus 로고
    • High-density lipoproteins affect endothelial BMP-signaling by modulating expression of the activin-like kinase receptor 1 and 2
    • Yao Y, Shao ES, Jumabay M, et al. High-density lipoproteins affect endothelial BMP-signaling by modulating expression of the activin-like kinase receptor 1 and 2. Arterioscler Thromb Vasc Biol 2008; 28:2266-2274.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 2266-2274
    • Yao, Y.1    Shao, E.S.2    Jumabay, M.3
  • 64
    • 0037835949 scopus 로고    scopus 로고
    • BMP-7 is an efficacious treatment of vascular calcification in a murine model of atherosclerosis and chronic renal failure
    • Davies MR, Lund RJ, Hruska KA. BMP-7 is an efficacious treatment of vascular calcification in a murine model of atherosclerosis and chronic renal failure. J Am Soc Nephrol 2003; 14:1559-1567.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 1559-1567
    • Davies, M.R.1    Lund, R.J.2    Hruska, K.A.3
  • 65
    • 36348963624 scopus 로고    scopus 로고
    • Aortic Msx2-Wnt calcification cascade is regulated by TNF-alpha-dependent signals in diabetic Ldlr/mice
    • Al-Aly Z, Shao JS, Lai CF, et al. Aortic Msx2-Wnt calcification cascade is regulated by TNF-alpha-dependent signals in diabetic Ldlr-/- mice. Arterioscler Thromb Vasc Biol 2007; 27:2589-2596.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 2589-2596
    • Al-Aly, Z.1    Shao, J.S.2    Lai, C.F.3
  • 66
    • 33744741007 scopus 로고    scopus 로고
    • Osteogenic regulation of vascular calcification
    • Towler DA, Shao JS, Cheng SL, et al. Osteogenic regulation of vascular calcification. Ann N Y Acad Sci 2006; 1068:327-333.
    • (2006) Ann N y Acad Sci , vol.1068 , pp. 327-333
    • Towler, D.A.1    Shao, J.S.2    Cheng, S.L.3
  • 67
    • 64249102107 scopus 로고    scopus 로고
    • Vascular smooth muscle cells in the pathogenesis of vascular calcification
    • Hruska KA. Vascular smooth muscle cells in the pathogenesis of vascular calcification. Circ Res 2009; 104:710-711.
    • (2009) Circ Res , vol.104 , pp. 710-711
    • Hruska, K.A.1
  • 68
    • 64249157371 scopus 로고    scopus 로고
    • Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries
    • Speer MY, Yang HY, Brabb T, et al. Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries. Circ Res 2009; 104:733-741.
    • (2009) Circ Res , vol.104 , pp. 733-741
    • Speer, M.Y.1    Yang, H.Y.2    Brabb, T.3
  • 69
    • 40949158527 scopus 로고    scopus 로고
    • BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells
    • Li X, Yang HY, Giachelli CM. BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells. Atherosclerosis 2008; 199:271-277.
    • (2008) Atherosclerosis , vol.199 , pp. 271-277
    • Li, X.1    Yang, H.Y.2    Giachelli, C.M.3
  • 70
    • 33751074163 scopus 로고    scopus 로고
    • BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells
    • Lagna G, Nguyen PH, Ni W, et al. BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2006; 291:L1059-L1067.
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.291
    • Lagna, G.1    Nguyen, P.H.2    Ni, W.3
  • 71
    • 65349196385 scopus 로고    scopus 로고
    • Expression of gremlin, a bone morphogenetic protein antagonist, is associated with vascular calcification in uraemia
    • Jara A, Chacon C, Burgos ME, et al. Expression of gremlin, a bone morphogenetic protein antagonist, is associated with vascular calcification in uraemia. Nephrol Dial Transplant 2009; 24:1121-1129.
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 1121-1129
    • Jara, A.1    Chacon, C.2    Burgos, M.E.3
  • 72
    • 33845921834 scopus 로고    scopus 로고
    • Regulation of bone morphogenetic protein-4 by matrix GLA protein in vascular endothelial cells involves activin-like kinase receptor 1
    • Yao Y, Zebboudj AF, Shao E, et al. Regulation of bone morphogenetic protein-4 by matrix GLA protein in vascular endothelial cells involves activin-like kinase receptor 1. J Biol Chem 2006; 281:33921-33930.
    • (2006) J Biol Chem , vol.281 , pp. 33921-33930
    • Yao, Y.1    Zebboudj, A.F.2    Shao, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.