Reprogramming of mouse fibroblasts to an intermediate state of differentiation by chemical induction

Cellular Reprogramming

Volumn 13, Issue 2, 2011, Pages 121-131

  Park, Joonghoon ^a   Kim, Chul ^a,b   Tang, Yong ^a   Amano, Tomokazu ^a,c   Lin, Chih Jen ^a   Tian, X Cindy ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; CARCINOGEN; FETAL ANTIGEN; SURFACE SPECIFIC EMBRYONIC ANTIGEN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER RESEARCH; CELL DIFFERENTIATION; CHEMICAL REACTION; COLONY FORMATION; COMPUTER MODEL; DOWN REGULATION; EMBRYONIC STEM CELL; FIBROBLAST; GENE EXPRESSION; GENOTOXICITY; HIGH THROUGHPUT SCREENING; IMMUNOCHEMISTRY; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; NUCLEOTIDE SEQUENCE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; UNINDEXED SEQUENCE; UPREGULATION;

ALKALINE PHOSPHATASE; ANIMALS; ANTIGENS, CD15; CARCINOGENS; CELL DEDIFFERENTIATION; CELL DIFFERENTIATION; CELL LINE; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MICE;

EID: 79953770015     PISSN: 21524971     EISSN: 21524998     Source Type: Journal    
DOI: 10.1089/cell.2010.0067     Document Type: Article

References (44)

1. Abdel-Aziz, H.O., Murai, Y., Takasaki, I., et al. (2008). Targeted disruption of the galectin-3 gene results in decreased susceptibility to NNK-induced lung tumorigenesis: an oligonu-cleotide microarray study. J. Cancer Res. Clin. Oncol. 134, 777-788.
2. Alimirah, F., Panchanathan, R., Davis, F.J., et al. (2007). Restoration of p53 expression in human cancer cell lines upre-gulates the expression of Notch1: implications for cancer cell fate determination after genotoxic stress. Neoplasia 9, 427-434. (Pubitemid 46799986)
3. Almstrup, K., Hoei-Hansen, C.E., Wirkner, U., et al. (2004). Embryonic stem cell-like features of testicular carcinoma in situ revealed by genome-wide gene expression profiling. Cancer Res. 64, 4736-4743. (Pubitemid 38924515)
4. Amabile, G., and Meissner, A. (2009). Induced pluripotent stem cells: current progress and potential for regenerative medicine. Trends Mol. Med. 15, 59-68.
5. Becker, K.G., Hosack, D.A., Dennis, G., Jr., et al. (2003). Pub-Matrix: a tool for multiplex literature mining. BMC Bioinfor-matics 4, 61.
6. Bleicher, K.H., Bohm, H.J., Muller, K., et al. (2003). Hit and lead generation: beyond high-throughput screening. Nat. Rev. Drug Discov. 2, 369-378. (Pubitemid 37361707)
7. Chen, S., Zhang, Q., Wu, X., et al. (2004a). Dedifferentiation of lineage-committed cells by a small molecule. J. Am. Chem. Soc. 126, 410-411. (Pubitemid 38084591)
8. Chen, Z.Y., Rex, S., and Tseng, C.C. (2004b). Kruppel-like factor 4 is transactivated by butyrate in colon cancer cells. J. Nutr. 134, 792-798. (Pubitemid 38456245)
9. Dennis, G., Jr., Sherman, B.T., Hosack, D.A., et al. (2003). DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 4, P3.
10. Faherty, S., Fitzgerald, A., Keohan, M., Quinlan, L.R. (2007). Self-renewal and differentiation of mouse embryonic stem cells as measured by Oct4 expression: the role of the cAMP/PKA pathway. In Vitro Cell Dev. Biol. Anim. 43, 37-47. (Pubitemid 47087328)
11. Greiner, D., Bonaldi, T., Eskeland, R., et al. (2005). Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Nat. Chem. Biol. 1, 143-145.
12. Hanna, J., Wernig, M., Markoulaki, S., et al. (2007). Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science 318, 1920-1923.
13. Hattori, N., Nishino, K., Ko, Y.G., et al. (2004). Epigenetic control of mouse Oct-4 gene expression in embryonic stem cells and trophoblast stem cells. J. Biol. Chem. 279, 17063-17069. (Pubitemid 38560461)
14. Hochedlinger, K., and Plath, K. (2009). Epigenetic reprogram-ming and induced pluripotency. Development 136, 509-623.
15. Huangfu, D., Maehr, R., Guo, W., et al. (2008). Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat. Biotechnol. 26, 795-797. (Pubitemid 351961456)
16. Inestrosa, N.C., Godoy, J.A., Quintanilla, R.A., et al. (2005). Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling. Exp. Cell Res. 304, 91-104. (Pubitemid 40227422)
17. Jonsson, M., Smith, K., and Harris, A.L. (1998). Regulation of Wnt5a expression in human mammary cells by protein kinase C activity and the cytoskeleton. Br. J. Cancer 78, 430-438. (Pubitemid 28360628)
18. Kim, C., Amano, T., Park, J., et al. (2009a). Improvement of embryonic stem cell line derivation efficiency with novel medium, glucose concentration, and epigenetic modifications. Cloning Stem Cells 11, 89-100.
19. Kim, D., Kim, C.H., Moon, J.I., et al. (2009b). Generation of human induced pluripotent stem cells by direct delivery of re-programming proteins. Cell Stem Cell 4, 472-476.
20. Kubicek, S., O'Sullivan, R.J., August, E.M., et al. (2007). Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol. Cell. 25, 473-481. (Pubitemid 46206139)
21. Liu, L., Luo, G.Z., Yang, W., et al. (2010). Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells. J. Biol. Chem. doi:10.1074/jbc.M110 .131995.
22. Lyssiotis, C.A., Foreman, R.K., Staerk, J., et al. (2009). Repro-gramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proc. Natl. Acad. Sci. USA. 106, 8912-8917.
23. Marson, A., Foreman, R., Chevalier, B., et al. (2008). Wnt signaling promotes reprogramming of somatic cells to plur-ipotency. Cell Stem Cell 3, 132-135.
24. Meissner, A., Wernig, M., and Jaenisch, R. (2007). Direct repro-gramming of genetically unmodified fibroblasts into pluripo-tent stem cells. Nat. Biotechnol. 25, 1177-1181. (Pubitemid 47538112)
25. Mikkelsen, T.S., Hanna, J., Zhang, X., et al. (2008). Dissecting direct reprogramming through integrative genomic analysis. Nature 454, 49-55. (Pubitemid 351931978)
26. Okita, K., Ichisaka, T., and Yamanaka, S. (2007). Generation of germline-competent induced pluripotent stem cells. Nature 448, 313-317. (Pubitemid 47080336)
27. Okita, K., Nakagawa, M., Hyenjong, H., et al. (2008). Generation of mouse induced pluripotent stem cells without viral vectors. Science 322, 949-953.
28. Page, R.L., Ambady, S., Holmes, W.F., et al. (2009). Induction of stem cell gene expression in adult human fibroblasts without transgenes. Cloning Stem Cells 11, 417-426.
29. Pardal, R., Clarke, M.F., and Morrison, S.J. (2003). Applying the principles of stem-cell biology to cancer. Nat. Rev. Cancer 3, 895-902. (Pubitemid 37500174)
30. Salins, P., Shawesh, S., He, Y., et al. (2007). Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling. Neurosci. Lett. 412, 211-216. (Pubitemid 46109146)
31. Sato, N., Meijer, L., Skaltsounis, L., et al. (2004). Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat. Med. 10, 55-63. (Pubitemid 38524699)
32. Shi, Y., Desponts, C., Do, J.T., et al. (2008). Induction of plurip-otent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 3, 568-574.
33. Smith, J., Ladi, E., Mayer-Proschel, M., et al. (2000). Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell. Proc. Natl. Acad. Sci. USA 97, 10032-10037.
34. Sperger, J.M., Chen, X., Draper, J.S., et al. (2003). Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors. Proc. Natl. Acad. Sci. USA 100, 13350-13355. (Pubitemid 37444745)
35. Stadtfeld, M., Maherali, N., Breault, D.T., et al. (2008a). Defining molecular cornerstones during fibroblast to iPS cell repro-gramming in mouse. Cell Stem Cell 2, 230-240.
36. Stadtfeld, M., Nagaya, M., Utikal, J., et al. (2008b). Induced pluripotent stem cells generated without viral integration. Science 322, 945-949.
37. Stadtfeld, M., Apostolou, E., Akutsu, H., et al. (2010). Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature doi:10.1038/nat-ure09017.
38. Takahashi, K., and Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676. (Pubitemid 44233629)
39. Tobimatsu, T., Kaji, H., Sowa, H., et al. (2006). Parathyroid hormone increases beta-catenin levels through Smad3 in mouse osteoblastic cells. Endocrinology 147, 2583-2590.
40. Wernig, M., Lengner, C.J., Hanna, J., et al. (2008a). A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat. Biotechnol. 26, 916-24.
41. Wernig, M., Zhao, J.P., Pruszak, J., et al. (2008b). Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc. Natl. Acad. Sci. USA 105, 5856-5861. (Pubitemid 351758462)
42. Wood, S.A., Allen, N.D., Rossant, J., et al. (1993). Non-injection methods for the production of embryonic stem cell-embryo chimaeras. Nature 365, 87-89.
43. Zhang, H., Guo, D., Wang, L., et al. (2005). Effect of nicotine on Oct-4 and Rex-1 expression of mouse embryonic stem cells. Reprod. Toxicol. 19, 473-478. (Pubitemid 40313601)
44. Zhou, H., Wu, S., Joo, J.Y., et al. (2009). Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell 4, 381-384.