Genetic variants in telomere-maintaining genes and skin cancer risk

Human Genetics

Volumn 129, Issue 3, 2011, Pages 247-253

  Nan, Hongmei ^a,b   Qureshi, Abrar A ^b   Prescott, Jennifer ^a,b   De Vivo, Immaculata ^a,b   Han, Jiali ^a,b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTECTION OF TELOMERE 1; TANKYRASE; TELOMERASE REVERSE TRANSCRIPTASE; TELOMERE BINDING PROTEIN; TELOMERIC REPEAT BINDING FACTOR 1; TELOMERIC REPEAT BINDING FACTOR 2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BASAL CELL CARCINOMA; CANCER RISK; CANCER SUSCEPTIBILITY; CAUCASIAN; CLPTM1L GENE; CONTROLLED STUDY; FEMALE; GENE; GENE LOCUS; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MELANOMA; NURSE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SKIN CANCER; SQUAMOUS CELL CARCINOMA; TELOMERE;

COHORT STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MELANOMA; NEOPLASMS, BASAL CELL; NEOPLASMS, SQUAMOUS CELL; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; RISK; SKIN NEOPLASMS; TELOMERASE; TELOMERE; TELOMERIC REPEAT BINDING PROTEIN 1;

EID: 79953733129     PISSN: 03406717     EISSN: 14321203     Source Type: Journal    
DOI: 10.1007/s00439-010-0921-5     Document Type: Article

References (24)

1. Bataille V, Kato BS, Falchi M, Gardner J, Kimura M, Lens M, Perks U, Valdes AM, Bennett DC, Aviv A, Spector TD (2007) Nevus size and number are associated with telomere length and represent potential markers of a decreased senescence in vivo. Cancer Epidemiol Biomarkers Prev 16:1499-1502 (Pubitemid 47076885)
2. Baumann P, Cech TR (2001) Pot1, the putative telomere end-binding protein in fission yeast and humans. Science 292:1171-1175 (Pubitemid 32440940)
3. Blasco MA (2003) Mammalian telomeres and telomerase: why they matter for cancer and aging. Eur J Cell Biol 82:441-446
4. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay JW, Lichtsteiner S, Wright WE (1998) Extension of life-span by introduction of telomerase into normal human cells. Science 279:349-352
5. Broccoli D, Smogorzewska A, Chong L, de Lange T (1997) Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat Genet 17:231-235
6. Campisi J, Kim SH, Lim CS, Rubio M (2001) Cellular senescence, cancer and aging: the telomere connection. Exp Gerontol 36:1619-1637 (Pubitemid 32982869)
7. Chang E, Harley CB (1995) Telomere length and replicative aging in human vascular tissues. Proc Natl Acad Sci USA 92:11190-11194
8. Chong L, van Steensel B, Broccoli D, Erdjument-Bromage H, Hanish J, Tempst P, de Lange T (1995) A human telomeric protein. Science 270:1663-1667 (Pubitemid 26002442)
9. Gilchrest BA, Eller MS, Geller AC, Yaar M (1999) The pathogenesis of melanoma induced by ultraviolet radiation. N Engl J Med 340:1341-1348 (Pubitemid 29196597)
10. Greider CW (1999) Telomeres do D-loop-T-loop. Cell 97:419-422
11. Haiman CA, Stram DO (2008) Utilizing HapMap and tagging SNPs. Methods Mol Med 141:37-54
12. Han J, Colditz GA, Hunter DJ (2006) Risk factors for skin cancers: a nested case-control study within the Nurses' Health Study. Int J Epidemiol 35:1514-1521 (Pubitemid 46178928)
13. Han J, Qureshi AA, Prescott J, Guo Q, Ye L, Hunter DJ, De Vivo I (2009) A prospective study of telomere length and the risk of skin cancer. J Invest Dermatol 129:415-421
14. Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T (1999) p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283:1321-1325
15. Kruk PA, Rampino NJ, Bohr VA (1995) DNA damage and repair in telomeres: relation to aging. Proc Natl Acad Sci USA 92:258-262
16. Lundblad V, Szostak JW (1989) A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 57:633-643
17. McGrath M, Lee IM, Buring J, Hunter DJ, De Vivo I (2008) Novel breast cancer risk alleles and endometrial cancer risk. Int J Cancer 123:2961-2964
18. Mooi WJ, Peeper DS (2006) Oncogene-induced cell senescence-halting on the road to cancer. N Engl J Med 355:1037-1046 (Pubitemid 44343547)
19. Nemes Z, Steinert PM (1999) Bricks and mortar of the epidermal barrier. Exp Mol Med 31:5-19 (Pubitemid 29164098)
20. Pooley KA, Tyrer J, Shah M, Driver KE, Leyland J, Brown J, Audley T, McGuffog L, Ponder BA, Pharoah PD, Easton DF, Dunning AM (2010) No association between TERT-CLPTM1L single nucleotide polymorphism rs401681 and mean telomere length or cancer risk. Cancer Epidemiol Biomarkers Prev 19:1862-1865
21. Rafnar T, Sulem P, Stacey SN, Geller F, Gudmundsson J, Sigurdsson A, Jakobsdottir M, Helgadottir H, Thorlacius S, Aben KK, Blondal T, Thorgeirsson TE, Thorleifsson G, Kristjansson K, Thorisdottir K, Ragnarsson R, Sigurgeirsson B, Skuladottir H, Gudbjartsson T, Isaksson HJ, Einarsson GV, Benediktsdottir KR, Agnarsson BA, Olafsson K, Salvarsdottir A, Bjarnason H, Asgeirsdottir M, Kristinsson KT, Matthiasdottir S, Sveinsdottir SG, Polidoro S, Hoiom V, Botella-Estrada R, Hemminki K, Rudnai P, Bishop DT, Campagna M, Kellen E, Zeegers MP, de Verdier P, Ferrer A, Isla D, Vidal MJ, Andres R, Saez B, Juberias P, Banzo J, Navarrete S, Tres A, Kan D, Lindblom A, Gurzau E, Koppova K, de Vegt F, Schalken JA, van der Heijden HF, Smit HJ, Termeer RA, Oosterwijk E, van Hooij O, Nagore E, Porru S, Steineck G, Hansson J, Buntinx F, Catalona WJ, Matullo G, Vineis P, Kiltie AE, Mayordomo JI, Kumar R, Kiemeney LA, Frigge ML, Jonsson T, Saemundsson H, Barkardottir RB, Jonsson E, Jonsson S, Olafsson JH, Gulcher JR, Masson G, Gudbjartsson DF, Kong A, Thorsteinsdottir U, Stefansson K (2009) Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nat Genet 41:221-227
22. Smith S, de Lange T (2000) Tankyrase promotes telomere elongation in human cells. Curr Biol 10:1299-1302
23. van Steensel B, Smogorzewska A, de Lange T (1998) TRF2 protects human telomeres from end-to-end fusions. Cell 92:401-413 (Pubitemid 28093017)
24. Wai LK (2004) Telomeres, telomerase, and tumorigenesis-a review. Med Gen Med 6:19