Acacetin inhibits the invasion and migration of human non-small cell lung cancer A549 cells by suppressing the p38α MAPK signaling pathway

Molecular and Cellular Biochemistry

Volumn 350, Issue 1-2, 2011, Pages 135-148

  Chien, Shang Tao ^a   Lin, Su Shun ^a   Wang, Cheng Kun ^b,c   Lee, Yuan Bin ^d   Chen, Kun Shiang ^c   Fong, Yao ^e   Shih, Yuan Wei ^c  

^a KAOHSIUNG ARMED FORCES GENERAL HOSPITAL   (Taiwan)

^b E Chyun Dermatology Clinic   (Taiwan)

^c CHUNG HWA UNIVERSITY OF MEDICAL TECHNOLOGY   (Taiwan)

^d Yongkang Veterans Hospital   (Taiwan)

^e NONE

Author keywords

Acacetin; Invasion; Migration; MMP 2; MMP 9; p38a MAPK; u PA

Indexed keywords

ACACETIN; GELATINASE A; GELATINASE B; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE 6; MIXED LINEAGE KINASE 3; PROTEIN C FOS; PROTEIN C JUN; PROUROKINASE;

ARTICLE; CANCER CELL; CELL ADHESION; CELL INVASION; CELL MIGRATION; CELL STRUCTURE; CONTROLLED STUDY; CYTOSKELETON; CYTOTOXICITY; DOWN REGULATION; DRUG EFFECT; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; NUCLEOTIDE SEQUENCE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL MOVEMENT; DOWN-REGULATION; DRUG EVALUATION, PRECLINICAL; FLAVONES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MITOGEN-ACTIVATED PROTEIN KINASE 14; MODELS, BIOLOGICAL; NEOPLASM INVASIVENESS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 79953727528     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-010-0692-2     Document Type: Article

References (49)

1. Surh YJ (2003) Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3:768-780
2. Sporn MB, Suh N (2000) Chemoprevention of cancer. Carcinogenesis 21:525-530
3. Lippman SM, Hong WK (2002) Cancer prevention science and practice. Cancer Res 62:5119-5125
4. Clinton SK, Giovannucci E (1998) Diet, nutrition, and prostate cancer. Annu Rev Nutr 18:413-440
5. Kraft C, Jenett-Siems K, Siems K, Jakupovic J, Mavi S, Bienzle U, Eich E (2003) In vitro antiplasmodial evaluation of medicinal plants from Zimbabwe. Phytother Res 17:123-128
6. Pan MH, Lai CS, Wang YJ, Ho CT (2006) Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice. Biochem Pharmacol 72:1293-1303
7. Yin Y, Gong FY, Wu XX, Sun Y, Li YH, Chen T, Xu Q (2008) Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita. J Ethnopharmacol 120:1-6
8. Hsu YL, Kuo PL, Lin CC (2004) Acacetin inhibits the proliferation of HepG2 by blocking cell cycle progression and inducing apoptosis. Biochem Pharmacol 67:823-829
9. Hsu YL, Kuo PL, Liu CF, Lin CC (2004) Acacetin-induced cell cycle arrest and apoptosis in human non-small cell lung cancer A549 cells. Cancer Lett 212:53-60
10. Pan MH, Lai CS, Hsu PC, Wang YJ (2005) Acacetin induces apoptosis in human gastric carcinoma cells accompanied by activation of caspase cascades and production of reactive oxygen species. J Agric Food Chem 53:620-630
11. Shim HY, Park JH, Paik HD, Nah SY, Kim DS, Han YS (2007) Acacetin-induced apoptosis of human breast cancer MCF-7 cells involves caspase cascade, mitochondria-mediated death signaling and SAPK/JNK1/2-c-Jun activation. Mol Cells 24:95-104
12. Singh RP, Agrawal P, Yim D, Agarwal C, Agarwal R (2005) Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: structure-activity relationship with linarin and linarin acetate. Carcinogenesis 26:845-854
13. Zhang K, Yang EB, Tang Wong KP, Mack P (1997) Inhibition of glutathione reductase by plant polyphenols. Biochem Pharmacol 54:1047-1053
14. Doostdar H, Burke MD, Mayer RT (2000) Bioflavonoids: selective substrates and inhibitors for cytochrome P450 CYP1A and CYP1B1. Toxicology 144:31-38
15. Boege F, Straub T, Kehr A, Boesenberg C, Christiansen K, Andersen A, Jakob F, Köhrle J (1996) Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I. J Biol Chem 271:2262-2270
16. Bernhard EJ, Gruber SB, Muschel RJ (1994) Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells. Proc Natl Acad Sci USA 91:4293-4297
17. Duffy MJ, Duggan C (2004) The urokinase plasminogen activator system: a rich source of tumour markers for the individualized management of patients with cancer. Clin Biochem 37:541-548
18. Itoh Y, Nagase H (2002) Matrix metalloproteinases in cancer. Essays Biochem 38:21-36
19. Weiss L (1990) Metastatic inefficiency. Adv Cancer Res 54: 159-211
20. Huang SC, Ho CT, Lin-Shiau SY, Lin JK (2005) Carnosol inhibits the invasion of B16/F10 mouse melanoma cells by suppressing metalloproteinase-9 through down-regulating nuclear factor-kappa B and c-Jun. Biochem Pharmacol 69:221-232
21. Westermarck J, Kahari VM (1999) Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J 13:781-792
22. Aguirre Ghiso JA, Alonso DF, Farias EF, Gomez DE, de Kier Joffe EB (1999) Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype. Eur J Biochem 263:295-304
23. Pearson G, Robinson F, Beers Gibson T, Xu B, Karandikar M, Berman K, Cobb MH (2001) Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 22:153-183
24. Raingeaud J, Whitmarsh AJ, Barrett T, Derijard B, Davis RJ (1996) MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen activated protein kinase signal transduction pathway. Mol Cell Biol 16:1247-1255
25. Johnson GL, Lapadat R (2002) Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298:1911-1912
26. Karin M, Ben-Neriah Y (2000) Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol 18:621-663
27. Kunnumakkara AB, Anand P, Aggarwal BB (2008) Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett 269:199-225
28. Lee SO, Jeong YJ, Im HG, Kim CH, Chang YC, Lee IS (2007) Silibinin suppresses PMA-induced MMP-9 expression by blocking the AP-1 activation via MAPK signaling pathways in MCF-7 human breast carcinoma cells. Biochem Biophys Res Commun 354:165-171
29. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63
30. Ochi Y, Atsumi S, Aoyagi T, Umezawa K (1993) Inhibition of tumor cell invasion in the Boyden chamber assay by a mannosidase inhibitor, mannostatin A. Anticancer Res 13:1421-1424
31. Chu SC, Chiou HL, Chen PN, Yang SF, Hsieh YS (2004) Silibinin inhibits the invasion of humanlung cancer cells viadecreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2. Mol Carcinog 40:143-149
32. Ito H, Duxbury M, Benoit E, Clancy TE, Zinner MJ, Ashley SW, Whang EE (2004) Prostaglandin E2 enhances pancreatic cancer invasiveness through an Ets-1-dependent induction of matrix metalloproteinase-2. Cancer Res 64:7439-7446
33. Ma W, Lim W, Gee K, Aucoin S, Nandan D, Kozlowski M, Diaz-Mitoma F, Kumar A (2001) The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide stimulated human macrophages. J Biol Chem 276:13664-13674
34. Lin HH, Chen JH, Kuo WH, Wang CJ (2007) Chemopreventive properties of Hibiscus sabdariffa L. on human gastric carcinoma cells through apoptosis induction and JNK/p38 MAPK signaling activation. Chem Biol Interact 165:59-75
35. Choudhury GG, Karamitsos C, Hernandez J, Gentilini A, Bardgette J, Abboud HE (1997) PI-3-kinase and MAPK regulate mesangial cell proliferation and migration in response to PDGF. Am J Physiol 273:F931-F938
36. Duan C, Bauchat JR, Hsieh T (2000) Phosphatidylinositol 3-kinase is required for insulin-like growth factor-I-induced vascular smooth muscle cell proliferation and migration. Circ Res 86:15-23
37. Brockman JA, Scherer DC, McKinsey TA, Hall SM, Qi X, Lee WY, Ballard DW (1995) Coupling of a signal response domain in IjBa to multiple pathways for NF-jB activation. Mol Cell Biol 15:2809-2818
38. Lee SO, Jeong YJ, Im HG, Kim CH, Chang YC, Lee IS (2007) Silibinin suppresses PMA-induced MMP-9 expression by blocking the AP-1 activation via MAPK signaling pathways in MCF-7 human breast carcinoma cells. Biophys Res Commun 354:165-171
39. Al Husaini H, Wheatley-Price P, Clemons M, Shepherd FA (2009) Prevention and management of bone metastasis in lung cancer: a review. J Thorac Oncol 4:251-259
40. Pal SK, Figlin RA, Reckamp KL (2008) The role of targeting mammalian target of rapamycin in lung cancer. Clin Lung Cancer 9:340-345
41. KimD,KimS,KohH,Yoon SO,ChungAS,ChoKS,Chung J (2001) Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production. FASEB J 15:1953-1962
42. Kleiner DE, Stetler-Stevenson WG (1999) Matrix metalloproteinases and metastasis. Cancer Chemother Pharmacol 43:S42-S51
43. Stetler-Stevenson WG, Aznavoorian S, Liotta LA (1993) Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annu Rev Cell Biol 9:541-573
44. Carter AB, Knudtson KL, Monick MM, Hunninghake GW (1999) The p38 mitogen-activated protein kinase is required for NF-kappaB-dependent gene expression. The role of TATA-binding protein (TBP). J Biol Chem 274:30858-30863
45. Lasa M, Brook M, Saklatvala J, Clark AR (2001) Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogen-activated protein kinase p38. Mol Cell Biol 21:771-780
46. Johansson N, Ala-aho R, Uitto V, Grénman R, Fusenig NE, López-Otín C, Kähäri VM (2000) Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinase. J Cell Sci 113:227-235
47. Nagase H, Woessner JF Jr (1999) Matrix metalloproteinases. J Biol Chem 274:21491-21494
48. Rothhammer T, Hahne JC, Florin A, Poser I, Soncin F, Wernert N, Bosserhoff AK (2004) The Ets-1 transcription factor is involved in the development and invasion of malignant melanoma. Cell Mol Life Sci 61:118-128
49. Sliva D (2004) Signaling pathways responsible for cancer cell invasion as targets for cancer therapy. Curr Cancer Drug Targets 4:327-336