A unique P-glycoprotein interacting agent displays anticancer activity against hepatocellular carcinoma through inhibition of GRP78 and mTOR pathways

Biochemical Pharmacology

Volumn 81, Issue 9, 2011, Pages 1136-1144

  Kuo, Ting Chun ^a   Chiang, Po Cheng ^b   Yu, Chia Chun ^a   Nakagawa Goto, Kyoko ^c   Bastow, Kenneth F ^c   Lee, Kuo Hsiung ^c   Guh, Jih Hwa ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^c University of North Carolina   (United States)

Author keywords

ATPase activity; GRP78; mTOR pathways; Multidrug resistance; P glycoprotein

Indexed keywords

GENISTEIN; GLUCOSE REGULATED PROTEIN 78; GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; KNG I 322; MAMMALIAN TARGET OF RAPAMYCIN; S6 KINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VERAPAMIL;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ANTINEOPLASTIC AGENTS; BASE SEQUENCE; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DNA PRIMERS; DRUG SCREENING ASSAYS, ANTITUMOR; FLAVONES; HEAT-SHOCK PROTEINS; HUMANS; LIVER NEOPLASMS; P-GLYCOPROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TOR SERINE-THREONINE KINASES;

EID: 79953725972     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.02.013     Document Type: Article

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