5-HT and depression: Is the glass half-full?

Current Opinion in Pharmacology

Volumn 11, Issue 1, 2011, Pages 45-51

  Sharp, Trevor ^a   Cowen, Philip J ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b WARNEFORD HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CITALOPRAM; PSILOCYBINE; RISPERIDONE; SB 207145; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 4 AGONIST; SEROTONIN 4 RECEPTOR; SEROTONIN 6 AGONIST; SEROTONIN 6 RECEPTOR; SEROTONIN AGONIST; SEROTONIN UPTAKE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DEPRESSION; DNA POLYMORPHISM; GENE; GENETIC PREDISPOSITION; HUMAN; MAJOR DEPRESSION; NERVE CELL PLASTICITY; NEUROENDOCRINE SYSTEM; NEUROPSYCHOLOGY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SLC6A4 GENE;

EID: 79953721439     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2011.02.003     Document Type: Review

References (67)

1. W.H. Organisation The global burden of disease: 2004 update 2008 Part 4: 51
2. A.J. Rush, M.H. Trivedi, S.R. Wisniewski, A.A. Nierenberg, J.W. Stewart, D. Warden, G. Niederehe, M.E. Thase, P.W. Lavori, and B.D. Lebowitz Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report Am J Psychiatry 163 2006 1905 1917 (Pubitemid 44807782)
3. P. Blier The well of novel antidepressants: running dry J Psychiatry Neurosci 35 2010 219 220
4. J. Andersen, L. Olsen, K.B. Hansen, O. Taboureau, F.S. Jorgensen, A.M. Jorgensen, B. Bang-Andersen, J. Egebjerg, K. Stromgaard, and A.S. Kristensen Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter J Biol Chem 285 2010 2051 2063
5. P.J. Cowen Serotonin and depression: pathophysiological mechanism or marketing myth? Trends Pharmacol Sci 29 2008 433 436 A critical account of the role of 5-HT in the symptoms of depression.
6. Z. Bhagwagar, R. Whale, and P.J. Cowen State and trait abnormalities in serotonin function in major depression Br J Psychiatry 180 2002 24 28 (Pubitemid 34093621)
7. K.P. Lesch, D. Bengel, A. Heils, S.Z. Sabol, B.D. Greenberg, S. Petri, J. Benjamin, C.R. Muller, D.H. Hamer, and D.L. Murphy Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region Science 274 1996 1527 1531 (Pubitemid 26403928)
8. P.A. Sargent, K.H. Kjaer, C.J. Bench, E.A. Rabiner, C. Messa, J. Meyer, R.N. Gunn, P.M. Grasby, and P.J. Cowen Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment Arch Gen Psychiatry 57 2000 174 180 (Pubitemid 30075269)
9. W.C. Drevets, M.E. Thase, E.L. Moses-Kolko, J. Price, E. Frank, D.J. Kupfer, and C. Mathis Serotonin-1A receptor imaging in recurrent depression: replication and literature review Nucl Med Biol 34 2007 865 877 (Pubitemid 47505401)
10. J.H. Meyer, A.A. Wilson, P. Rusjan, M. Clark, S. Houle, S. Woodside, J. Arrowood, K. Martin, and M. Colleton Serotonin2A receptor binding potential in people with aggressive and violent behaviour J Psychiatry Neurosci 33 2008 499 508
11. Z. Bhagwagar, R. Hinz, M. Taylor, S. Fancy, P. Cowen, and P. Grasby Increased 5-HT(2A) receptor binding in euthymic, medication-free patients recovered from depression: a positron emission study with [(11)C]MDL 100,907 Am J Psychiatry 163 2006 1580 1587 (Pubitemid 44465759)
12. S. Selvaraj, N. Venkatesha Murthy, Z. Bhagwagar, S.K. Bose, R. Hinz, P.M. Grasby, and P.J. Cowen Diminished brain 5-HT transporter binding in major depression: a positron emission tomography study with [(11)C]DASB Psychopharmacology (Berl) 213 2011 555 562
13. Z. Bhagwagar, N. Murthy, S. Selvaraj, R. Hinz, M. Taylor, S. Fancy, P. Grasby, and P. Cowen 5-HTT binding in recovered depressed patients and healthy volunteers: a positron emission tomography study using [11C]DASB Am J Psychiatry 164 2007 1858 1865 (Pubitemid 351739239)
14. P.J. Cowen, M. Parry-Billings, and E.A. Newsholme Decreased plasma tryptophan levels in major depression J Affect Disord 16 1989 27 31 (Pubitemid 19020852)
15. Maes M, Leonard BE, Myint AM, Kubera M, Verkerk R: The new '5-HT' hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression. Prog Neuropsychopharmacol Biol Psychiatry, in press.
16. H.G. Ruhe, N.S. Mason, and A.H. Schene Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies Mol Psychiatry 12 2007 331 359 A thorough analysis of studies investigating the influence of monoamine depletion in drug-free healthy controls and patients with depression or at risk. (Pubitemid 46496835)
17. Y. Temel, L.J. Boothman, A. Blokland, P.J. Magill, H.W. Steinbusch, V. Visser-Vandewalle, and T. Sharp Inhibition of 5-HT neuron activity and induction of depressive-like behavior by high-frequency stimulation of the subthalamic nucleus Proc Natl Acad Sci U S A 104 2007 17087 17092 (Pubitemid 350210996)
18. Tan SKH, Hartung H, Sharp T, Temel Y: Serotonin-dependent depression in Parkinson's disease: a role for the subthalamic nucleus? Neuropharmacology, in press.
19. M. Laruelle Imaging synaptic neurotransmission with in vivo binding competition techniques: a critical review J Cereb Blood Flow Metab 20 2000 423 451 (Pubitemid 30164887)
20. L.M. Paterson, R.J. Tyacke, D.J. Nutt, and G.M. Knudsen Measuring endogenous 5-HT release by emission tomography: promises and pitfalls J Cereb Blood Flow Metab 30 2010 1682 1706 An up-to-date account of progress in the application of PET radiotracers to detect 5-HT release.
21. L. Marner, N. Gillings, K. Madsen, D. Erritzoe, W.F. Baare, C. Svarer, S.G. Hasselbalch, and G.M. Knudsen Brain imaging of serotonin 4 receptors in humans with [11C]SB207145-PET Neuroimage 50 2010 855 861
22. C.L. Licht, A.B. Marcussen, G. Wegener, D.H. Overstreet, S. Aznar, and G.M. Knudsen The brain 5-HT4 receptor binding is down-regulated in the Flinders Sensitive Line depression model and in response to paroxetine administration J Neurochem 109 2009 1363 1374
23. R. Vidal, E.M. Valdizan, R. Mostany, A. Pazos, and E. Castro Long-term treatment with fluoxetine induces desensitization of 5-HT4 receptor-dependent signalling and functionality in rat brain J Neurochem 110 2009 1120 1127
24. J. Lundberg, C. Halldin, and L. Farde Measurement of serotonin transporter binding with PET and [11C]MADAM: a test-retest reproducibility study Synapse 60 2006 256 263 (Pubitemid 44036720)
25. D.L. Murphy, and K.P. Lesch Targeting the murine serotonin transporter: insights into human neurobiology Nat Rev Neurosci 9 2008 85 96 A comprehensive review of the 5-HT transporter gene and the impact of variation of this gene in humans and animal models. (Pubitemid 351164876)
26. E.A. Ehli, Y. Hu, T. Lengyel-Nelson, J.J. Hudziak, and G.E. Davies Identification and functional characterization of three novel alleles for the serotonin transporter-linked polymorphic region Mol Psychiatry 2011
27. L. Pezawas, A. Meyer-Lindenberg, E.M. Drabant, B.A. Verchinski, K.E. Munoz, B.S. Kolachana, M.F. Egan, V.S. Mattay, A.R. Hariri, and D.R. Weinberger 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression Nat Neurosci 8 2005 828 834 (Pubitemid 43085851)
28. A. Caspi, K. Sugden, T.E. Moffitt, A. Taylor, I.W. Craig, H. Harrington, J. McClay, J. Mill, J. Martin, and A. Braithwaite Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene Science 301 2003 386 389 One of the first studies reporting the impact of 5-HT transporter gene x environment interactions on depression risk. (Pubitemid 36877077)
29. A. Caspi, A.R. Hariri, A. Holmes, R. Uher, and T.E. Moffitt Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits Am J Psychiatry 167 2010 509 527 A critical analysis of human 5-HT transporter gene-phenotype associations.
30. N. Risch, R. Herrell, T. Lehner, K.Y. Liang, L. Eaves, J. Hoh, A. Griem, M. Kovacs, J. Ott, and K.R. Merikangas Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis JAMA 301 2009 2462 2471
31. R. Uher, and P. McGuffin The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update Mol Psychiatry 15 2010 18 22 A critical analysis of human 5-HT transporter gene-phenotype associations to compliment the above review by Caspi et al.
32. J. Flint, and M.R. Munafo The endophenotype concept in psychiatric genetics Psychol Med 37 2007 163 180 (Pubitemid 46158160)
33. N.V. Murthy, S. Selvaraj, P.J. Cowen, Z. Bhagwagar, W.J. Riedel, P. Peers, J.L. Kennedy, B.J. Sahakian, M.A. Laruelle, and E.A. Rabiner Serotonin transporter polymorphisms (SLC6A4 insertion/deletion and rs25531) do not affect the availability of 5-HTT to [11C] DASB binding in the living human brain Neuroimage 52 2010 50 54
34. S.J. Line, C. Barkus, C. Coyle, K.A. Jennings, R.M. Deacon, K.P. Lesch, T. Sharp, and D.M. Bannerman Opposing alterations in anxiety and species-typical behaviours in serotonin transporter overexpressor and knockout mice Eur Neuropsychopharmacol 21 2011 108 116
35. A. Bartolomucci, V. Carola, T. Pascucci, S. Puglisi-Allegra, S. Cabib, K.P. Lesch, S. Parmigiani, P. Palanza, and C. Gross Increased vulnerability to psychosocial stress in heterozygous serotonin transporter knockout mice Dis Model Mech 3 2010 459 470
36. V. Carola, G. Frazzetto, T. Pascucci, E. Audero, S. Puglisi-Allegra, S. Cabib, K.P. Lesch, and C. Gross Identifying molecular substrates in a mouse model of the serotonin transporter × environment risk factor for anxiety and depression Biol Psychiatry 63 2008 840 846 (Pubitemid 351458447)
37. M.S. Ansorge, R. Hen, and J.A. Gingrich Neurodevelopmental origins of depressive disorders Curr Opin Pharmacol 7 2007 8 17 An interesting account of how deficits in the maturation of brain circuits might impact on emotional function to increase the risk for depression later in life. (Pubitemid 46238045)
38. I.M.H. van, K. Caspers, M.J. Bakermans-Kranenburg, S.R. Beach, and R. Philibert Methylation matters: interaction between methylation density and serotonin transporter genotype predicts unresolved loss or trauma Biol Psychiatry 68 2010 405 407 One of the first studies reporting an association between adverse life events and methylation status of the 5-HT transporter gene.
39. E.L. Kinnally, J.P. Capitanio, R. Leibel, L. Deng, C. LeDuc, F. Haghighi, and J.J. Mann Epigenetic regulation of serotonin transporter expression and behavior in infant rhesus macaques Genes Brain Behav 9 2010 575 582
40. 1A receptor gene, on antidepressant mechanisms.
41. 1A risk allele on stress vulnerability and antidepressant response.
42. J.H. Meyer, A.A. Wilson, S. Sagrati, D. Hussey, A. Carella, W.Z. Potter, N. Ginovart, E.P. Spencer, A. Cheok, and S. Houle Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study Am J Psychiatry 161 2004 826 835 (Pubitemid 38625335)
43. P. Blier, and C. de Montigny Current advances and trends in the treatment of depression Trends Pharmacol Sci 15 1994 220 226 (Pubitemid 24210726)
44. T. Sharp, L. Boothman, J. Raley, and P. Queree Important messages in the 'post': recent discoveries in 5-HT neurone feedback control Trends Pharmacol Sci 28 2007 629 636 A review of current knowledge of the pharmacology and physiology of 5-HT feedback mechanisms. (Pubitemid 350166575)
45. M.J. Millan Dual- and triple-acting agents for treating core and co-morbid symptoms of major depression: novel concepts, new drugs Neurotherapeutics 6 2009 53 77
46. R. Whale, T. Terao, P. Cowen, N. Freemantle, and J. Geddes Pindolol augmentation of serotonin reuptake inhibitors for the treatment of depressive disorder: a systematic review J Psychopharmacol 24 2010 513 520
47. J.C. Nelson, and G.I. Papakostas Atypical antipsychotic augmentation in major depressive disorder: a meta-analysis of placebo-controlled randomized trials Am J Psychiatry 166 2009 980 991
48. V. Krishnan, and E.J. Nestler The molecular neurobiology of depression Nature 455 2008 894 902 An interesting review of the neurobiology of depression that combines insights from clinical studies and animal models.
49. I. Sillaber, M. Panhuysen, M.S. Henniger, F. Ohl, C. Kuhne, B. Putz, T. Pohl, J.M. Deussing, M. Paez-Pereda, and F. Holsboer Profiling of behavioral changes and hippocampal gene expression in mice chronically treated with the SSRI paroxetine Psychopharmacology (Berl) 200 2008 557 572
50. E. Castren Is mood chemistry? Nat Rev Neurosci 6 2005 241 246 An lucid account of the neural plasticity hypothesis of depression and antidepressant action. (Pubitemid 40342418)
51. E. Castren, and T. Rantamaki The role of BDNF and its receptors in depression and antidepressant drug action: reactivation of developmental plasticity Dev Neurobiol 70 2010 289 297
52. J.O. Groves Is it time to reassess the BDNF hypothesis of depression? Mol Psychiatry 12 2007 1079 1088 An important critical analysis of the role of BDNF in the cause and treatment of depression. (Pubitemid 350191365)
53. L. Santarelli, M. Saxe, C. Gross, A. Surget, F. Battaglia, S. Dulawa, N. Weisstaub, J. Lee, R. Duman, and O. Arancio Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants Science 301 2003 805 809 This study provided some of the first evidence that an increase in neurogenesis in hippocampus mediates behavioural effects SSRI administration. (Pubitemid 36962615)
54. D.J. David, B.A. Samuels, Q. Rainer, J.W. Wang, D. Marsteller, I. Mendez, M. Drew, D.A. Craig, B.P. Guiard, and J.P. Guilloux Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression Neuron 62 2009 479 493
55. K.Q. Tanis, and R.S. Duman Intracellular signaling pathways pave roads to recovery for mood disorders Ann Med 39 2007 531 544 (Pubitemid 350035570)
56. V. Duric, M. Banasr, P. Licznerski, H.D. Schmidt, C.A. Stockmeier, A.A. Simen, S.S. Newton, and R.S. Duman A negative regulator of MAP kinase causes depressive behavior Nat Med 16 2010 1328 1332
57. T.M. Eriksson, P. Delagrange, M. Spedding, M. Popoli, A.A. Mathe, S.O. Ogren, and P. Svenningsson Emotional memory impairments in a genetic rat model of depression: involvement of 5-HT/MEK/Arc signaling in restoration Mol Psychiatry 2011 In press
58. G. Lucas, V.V. Rymar, J. Du, O. Mnie-Filali, C. Bisgaard, S. Manta, L. Lambas-Senas, O. Wiborg, N. Haddjeri, and G. Pineyro Serotonin(4) (5-HT(4)) receptor agonists are putative antidepressants with a rapid onset of action Neuron 55 2007 712 725 (Pubitemid 47334877)
59. P. Svenningsson, E.T. Tzavara, H. Qi, R. Carruthers, J.M. Witkin, G.G. Nomikos, and P. Greengard Biochemical and behavioral evidence for antidepressant-like effects of 5-HT6 receptor stimulation J Neurosci 27 2007 4201 4209 (Pubitemid 46597167)
60. F.X. Vollenweider, and M. Kometer The neurobiology of psychedelic drugs: implications for the treatment of mood disorders Nat Rev Neurosci 11 2010 642 651 An interesting account of recent behavioural and neuroimaging studies showing that psychedelic drugs modulate neural circuits implicated in depression and anxiety disorders, and may reduce the symptoms of these disorders.
61. G. Hayward, G.M. Goodwin, P.J. Cowen, and C.J. Harmer Low-dose tryptophan depletion in recovered depressed patients induces changes in cognitive processing without depressive symptoms Biol Psychiatry 57 2005 517 524 (Pubitemid 40311987)
62. C.J. Harmer, N.C. Shelley, P.J. Cowen, and G.M. Goodwin Increased positive versus negative affective perception and memory in healthy volunteers following selective serotonin and norepinephrine reuptake inhibition Am J Psychiatry 161 2004 1256 1263 (Pubitemid 38859176)
63. C.J. Harmer, G.M. Goodwin, and P.J. Cowen Why do antidepressants take so long to work? A cognitive neuropsychological model of antidepressant drug action Br J Psychiatry 195 2009 102 108 An important account of how antidepressants might elevate mood by acting on negative emotional processing to bring about cognitive and psychological relearning.
64. Pringle A, Browning M, Cowen PJ, Harmer CJ: A cognitive neuropsychological model of antidepressant drug action. Prog Neuropsychopharmacol Biol Psychiatry, in press.
65. M. Browning, C. Reid, P.J. Cowen, G.M. Goodwin, and C.J. Harmer A single dose of citalopram increases fear recognition in healthy subjects J Psychopharmacol 21 2007 684 690 (Pubitemid 47437913)
66. J.F. Maya Vetencourt, A. Sale, A. Viegi, L. Baroncelli, R. De Pasquale, O.F. O'Leary, E. Castren, and L. Maffei The antidepressant fluoxetine restores plasticity in the adult visual cortex Science 320 2008 385 388 An important study reporting that SSRI administration reinstates ocular dominance plasticity in adulthood via a BDNF-dependent mechanism. (Pubitemid 351555663)
67. T. Enkel, D. Gholizadeh, O. von Bohlen Und Halbach, C. Sanchis-Segura, R. Hurlemann, R. Spanagel, P. Gass, and B. Vollmayr Ambiguous-cue interpretation is biased under stress- and depression-like states in rats Neuropsychopharmacology 35 2009 1008 1015 An interesting model of negative cognitive bias in rodents.