메뉴 건너뛰기




Volumn 3, Issue 1, 2011, Pages 396-407

Parathyroid hormone-related protein (PTHrP): A key regulator of life/death decisions by tumor cells with potential clinical applications

Author keywords

Apoptosis; Cell proliferation; PTHrP; Tumor cells

Indexed keywords

HEAT SHOCK PROTEIN 90; HEAT SHOCK TRANSCRIPTION FACTOR 1; PARATHYROID HORMONE RELATED PROTEIN;

EID: 79953715662     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers3010396     Document Type: Review
Times cited : (20)

References (52)
  • 1
    • 57349106908 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein (PTHrP): An ancient string of cytokines with many known and still unknown functions
    • In Luparello, C., Ed.; Nova Science Publishers: New York, NY, USA
    • Whitfield, J.F. Parathyroid hormone-related protein (PTHrP): an ancient string of cytokines with many known and still unknown functions. In Novel Aspects of PTHrP Physiopathology; Luparello, C., Ed.; Nova Science Publishers: New York, NY, USA, 2007; pp. 1-25.
    • (2007) Novel Aspects of PTHrP Physiopathology , pp. 1-25
    • Whitfield, J.F.1
  • 2
    • 77955873729 scopus 로고    scopus 로고
    • Midregion PTHrP and human breast cancer cells
    • Luparello, C. Midregion PTHrP and human breast cancer cells. Sci. World J. 2010, 10, 1016-1028.
    • (2010) Sci. World J. , vol.10 , pp. 1016-1028
    • Luparello, C.1
  • 4
    • 0037205449 scopus 로고    scopus 로고
    • Parathyroid hormone and parathyroid hormone-related protein exert both pro-and anti-apoptotic effects in mesenchymal cells
    • Chen, H.L.; Demiralp, B.; Schneider, A.; Koh, A.J.; Silve, C.; Wang, C.Y.; McCauley, L.K.; Parathyroid hormone and parathyroid hormone-related protein exert both pro-and anti-apoptotic effects in mesenchymal cells. J. Biol. Chem. 2002, 277, 19374-19381.
    • (2002) J. Biol. Chem. , vol.277 , pp. 19374-19381
    • Chen, H.L.1    Demiralp, B.2    Schneider, A.3    Koh, A.J.4    Silve, C.5    Wang, C.Y.6    McCauley, L.K.7
  • 6
    • 54049099247 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein (107-139) increases human osteoblastic cell survival by activation of vascular endothelial growth factor receptor-2
    • Alonso, V.; de Gortázar, A.R.; Ardura, J.A.; Andrade-Zapata, I.; Alvarez-Arroyo, M.V.; Esbrit, P. Parathyroid hormone-related protein (107-139) increases human osteoblastic cell survival by activation of vascular endothelial growth factor receptor-2. J. Cell. Physiol. 2008, 217, 717-727.
    • (2008) J. Cell. Physiol. , vol.217 , pp. 717-727
    • Alonso, V.1    de Gortázar, A.R.2    Ardura, J.A.3    Andrade-Zapata, I.4    Alvarez-Arroyo, M.V.5    Esbrit, P.6
  • 8
    • 0023281621 scopus 로고
    • The relative potency of a human tumor-derived PTH-like adenylate cyclase-stimulating preparation in three bioassays
    • Stewart, A.F.; Wu, T.; Burtis, W.J.; Weir, E.C.; Broadus, A.E.; Insogna, K.L. The relative potency of a human tumor-derived PTH-like adenylate cyclase-stimulating preparation in three bioassays. J. Bone Miner. Res. 1987, 2, 37-43.
    • (1987) J. Bone Miner. Res. , vol.2 , pp. 37-43
    • Stewart, A.F.1    Wu, T.2    Burtis, W.J.3    Weir, E.C.4    Broadus, A.E.5    Insogna, K.L.6
  • 9
    • 0023879546 scopus 로고
    • Identification of transcripts encoding a parathyroid hormone-like peptide in messenger RNAs from a variety of human and animal tumors associated with humoral hypercalcemia of malignancy
    • Ikeda, K.; Mangin, M.; Dreyer, B.E.; Webb, A.C.; Posillico, J.T.; Stewart, A.F.; Bander, N.H.; Weir, E.C.; Insogna, K.L.; Broadus, A.E. Identification of transcripts encoding a parathyroid hormone-like peptide in messenger RNAs from a variety of human and animal tumors associated with humoral hypercalcemia of malignancy. J. Clin. Invest. 1988, 81, 2010-2014.
    • (1988) J. Clin. Invest. , vol.81 , pp. 2010-2014
    • Ikeda, K.1    Mangin, M.2    Dreyer, B.E.3    Webb, A.C.4    Posillico, J.T.5    Stewart, A.F.6    Bander, N.H.7    Weir, E.C.8    Insogna, K.L.9    Broadus, A.E.10
  • 10
    • 77953434436 scopus 로고    scopus 로고
    • Molecular signalling of PTHrP in tumor
    • In Luparello, C. Ed.; Nova Science Publishers: New York, NY, USA
    • Alokail, M. S. Molecular signalling of PTHrP in tumor. In Novel Aspects of PTHrP Physiopathology; Luparello, C. Ed.; Nova Science Publishers: New York, NY, USA, 2007; pp. 191-233.
    • (2007) Novel Aspects of PTHrP Physiopathology , pp. 191-233
    • Alokail, M.S.1
  • 11
    • 79953723886 scopus 로고    scopus 로고
    • PTHrP/PTH1R: A complex crosstalk among diffrent signalling pathways
    • In Luparello, C., Ed.; Nova Science Publishers: New York, NY, USA
    • Maioli, E.; Fortino, V.; Torricelli, C. PTHrP/PTH1R: A complex crosstalk among diffrent signalling pathways. In Novel Aspects of PTHrP Physiopathology; Luparello, C., Ed.; Nova Science Publishers: New York, NY, USA, 2007; pp. 143-164.
    • (2007) Novel Aspects of PTHrP Physiopathology , pp. 143-164
    • Maioli, E.1    Fortino, V.2    Torricelli, C.3
  • 12
    • 1842372716 scopus 로고    scopus 로고
    • Antiproliferative effect of the C-terminal fragments of parathyroid hormone-related protein, PTHrP-(107-111) and (107-139), on osteoblastic osteosarcoma cells
    • Valín, A.; García-Ocaña, A.; De Miguel, F.; Sarasa, J.L.; Esbrit, P. Antiproliferative effect of the C-terminal fragments of parathyroid hormone-related protein, PTHrP-(107-111) and (107-139), on osteoblastic osteosarcoma cells. J. Cell. Physiol. 1997, 170, 209-215.
    • (1997) J. Cell. Physiol. , vol.170 , pp. 209-215
    • Valín, A.1    García-Ocaña, A.2    De Miguel, F.3    Sarasa, J.L.4    Esbrit, P.5
  • 14
    • 0034985016 scopus 로고    scopus 로고
    • C-terminal parathyroid hormone-related protein (PTHrP) (107-139) stimulates intracellular Ca(2+) through a receptor different from the type 1 PTH/PTHrP receptor in osteoblastic osteosarcoma UMR 106 cells
    • Valín, A.; Guillén, C.; Esbrit, P. C-terminal parathyroid hormone-related protein (PTHrP) (107-139) stimulates intracellular Ca(2+) through a receptor different from the type 1 PTH/PTHrP receptor in osteoblastic osteosarcoma UMR 106 cells. Endocrinology 2001, 142, 2752-2759.
    • (2001) Endocrinology , vol.142 , pp. 2752-2759
    • Valín, A.1    Guillén, C.2    Esbrit, P.3
  • 15
    • 0029006719 scopus 로고
    • Parathyroid hormone-related peptide and 8701-BC breast cancer cell growth and invasion in vitro: Evidence for growth-inhibiting and invasion-promoting effects
    • Luparello, C.; Burtis, W.J.; Raue, F.; Birch, M.A.; Gallagher, J.A. Parathyroid hormone-related peptide and 8701-BC breast cancer cell growth and invasion in vitro: Evidence for growth-inhibiting and invasion-promoting effects. Mol. Cell. Endocrinol. 1995, 111, 225-232.
    • (1995) Mol. Cell. Endocrinol. , vol.111 , pp. 225-232
    • Luparello, C.1    Burtis, W.J.2    Raue, F.3    Birch, M.A.4    Gallagher, J.A.5
  • 17
    • 0031419422 scopus 로고    scopus 로고
    • Clonal heterogeneity of the growth and invasive response of a human breast carcinoma cell line to parathyroid hormone-related peptide fragments
    • Luparello, C.; Birch, M.A.; Gallagher, J.A.; Burtis, W.J. Clonal heterogeneity of the growth and invasive response of a human breast carcinoma cell line to parathyroid hormone-related peptide fragments. Carcinogenesis 1997, 18, 23-29.
    • (1997) Carcinogenesis , vol.18 , pp. 23-29
    • Luparello, C.1    Birch, M.A.2    Gallagher, J.A.3    Burtis, W.J.4
  • 18
    • 0038497892 scopus 로고    scopus 로고
    • PTHrP [67-86] regulates the expression of stress proteins in breast cancer cells inducing modifications in urokinase-plasminogen activator and MMP-1 expression
    • Luparello, C.; Sirchia, R.; Pupello, D. PTHrP [67-86] regulates the expression of stress proteins in breast cancer cells inducing modifications in urokinase-plasminogen activator and MMP-1 expression. J. Cell Sci. 2003, 116, 2421-2430.
    • (2003) J. Cell Sci. , vol.116 , pp. 2421-2430
    • Luparello, C.1    Sirchia, R.2    Pupello, D.3
  • 20
    • 34548036706 scopus 로고    scopus 로고
    • Mid-region parathyroid hormone-related protein (PTHrP) binds chromatin of MDA-MB23 1 breast cancer cells and isolated oligonucleotides "in vitro"
    • Sirchia, R.; Priulla, M.; Sciandrello, G.; Caradonna, F.; Barbata, G.; Luparello, C. Mid-region parathyroid hormone-related protein (PTHrP) binds chromatin of MDA-MB23 1 breast cancer cells and isolated oligonucleotides "in vitro". Breast Cancer Res. Treat. 2007, 105, 105-116.
    • (2007) Breast Cancer Res. Treat. , vol.105 , pp. 105-116
    • Sirchia, R.1    Priulla, M.2    Sciandrello, G.3    Caradonna, F.4    Barbata, G.5    Luparello, C.6
  • 21
    • 34249076577 scopus 로고    scopus 로고
    • Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells
    • Sirchia, R.; Luparello, C. Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells. Biol. Chem. 2007, 388, 457-465.
    • (2007) Biol. Chem. , vol.388 , pp. 457-465
    • Sirchia, R.1    Luparello, C.2
  • 22
    • 51649109922 scopus 로고    scopus 로고
    • Midregion PTHrP regulates Rip1 and caspase expression in MDA-MB231 breast cancer cells
    • Luparello, C.; Sirchia, R.; Lo Sasso, B. Midregion PTHrP regulates Rip1 and caspase expression in MDA-MB231 breast cancer cells. Breast Cancer Res. Treat. 2008, 111, 461-474.
    • (2008) Breast Cancer Res. Treat. , vol.111 , pp. 461-474
    • Luparello, C.1    Sirchia, R.2    Lo Sasso, B.3
  • 23
    • 77953407641 scopus 로고    scopus 로고
    • The role of PTHrP in mitogenic signaling via EGFR-dependent pathways in breast cancer cells
    • Alokail, M.S. The role of PTHrP in mitogenic signaling via EGFR-dependent pathways in breast cancer cells. Mol. Cell. Pharmacol. 2009, 1, 278-289.
    • (2009) Mol. Cell. Pharmacol. , vol.1 , pp. 278-289
    • Alokail, M.S.1
  • 24
    • 0025324407 scopus 로고
    • Parathyroid hormone related peptide can function as an autocrine growth factor in human renal cell carcinoma
    • Burton, P.B.; Moniz, C.; Knight, D.E. Parathyroid hormone related peptide can function as an autocrine growth factor in human renal cell carcinoma. Biochem. Biophys. Res. Commun. 1990, 167, 1134-1138.
    • (1990) Biochem. Biophys. Res. Commun. , vol.167 , pp. 1134-1138
    • Burton, P.B.1    Moniz, C.2    Knight, D.E.3
  • 25
    • 0035883426 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein regulates the growth of orthotopic human lung tumors in athymic mice
    • Hastings, R.H.; Burton, D.W.; Quintana, R.A.; Biederman, E.; Gujral, A.; Deftos, L.J. Parathyroid hormone-related protein regulates the growth of orthotopic human lung tumors in athymic mice. Cancer 2001, 92, 1402-1410.
    • (2001) Cancer , vol.92 , pp. 1402-1410
    • Hastings, R.H.1    Burton, D.W.2    Quintana, R.A.3    Biederman, E.4    Gujral, A.5    Deftos, L.J.6
  • 27
    • 78549293136 scopus 로고    scopus 로고
    • Combinatorial library discovery of small molecule inhibitors of lung cancer proliferation and parathyroid hormone-related protein expression
    • Hastings, R.H.; Burton, D.W.; Nefzi, A.; Montgrain, P.R.; Quintana, R.; Deftos, L.J. Combinatorial library discovery of small molecule inhibitors of lung cancer proliferation and parathyroid hormone-related protein expression. Cancer Biol. Ther. 2010, 10, 1067-1075.
    • (2010) Cancer Biol. Ther. , vol.10 , pp. 1067-1075
    • Hastings, R.H.1    Burton, D.W.2    Nefzi, A.3    Montgrain, P.R.4    Quintana, R.5    Deftos, L.J.6
  • 28
    • 31544447243 scopus 로고    scopus 로고
    • Sex-specific survival advantage with parathyroid hormone-related protein in non-small cell lung carcinoma patients
    • Hastings, R.H.; Laux, A.M.; Casillas, A.; Xu, R.; Lukas, Z.; Ernstrom, K.; Deftos, L.J. Sex-specific survival advantage with parathyroid hormone-related protein in non-small cell lung carcinoma patients. Clin. Cancer Res. 2006, 12, 499-506.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 499-506
    • Hastings, R.H.1    Laux, A.M.2    Casillas, A.3    Xu, R.4    Lukas, Z.5    Ernstrom, K.6    Deftos, L.J.7
  • 29
    • 77950841746 scopus 로고    scopus 로고
    • Parathyroid hormone-related peptide and parathyroid hormone-related peptide receptor type 1 expression in human lung adenocarcinoma
    • Monego, G.; Lauriola, L.; Ramella, S.; D'Angelillo, R.M.; Lanza, P.; Granone, P.; Ranelletti, F.O. Parathyroid hormone-related peptide and parathyroid hormone-related peptide receptor type 1 expression in human lung adenocarcinoma. Chest 2010, 137, 898-908.
    • (2010) Chest , vol.137 , pp. 898-908
    • Monego, G.1    Lauriola, L.2    Ramella, S.3    D'Angelillo, R.M.4    Lanza, P.5    Granone, P.6    Ranelletti, F.O.7
  • 31
    • 0028892749 scopus 로고
    • Regulation in vivo of the growth of Leydig cell tumors by antisense ribonucleic acid for parathyroid hormone-related peptide
    • Rabbani, S.A.; Gladu, J.; Liu, B.; Goltzman, D. Regulation in vivo of the growth of Leydig cell tumors by antisense ribonucleic acid for parathyroid hormone-related peptide. Endocrinology 1995, 136, 5416-5422.
    • (1995) Endocrinology , vol.136 , pp. 5416-5422
    • Rabbani, S.A.1    Gladu, J.2    Liu, B.3    Goltzman, D.4
  • 33
    • 0034456253 scopus 로고    scopus 로고
    • Enhanced growth of MCF-7 breast cancer cells overexpressing parathyroid hormone-related peptide
    • Falzon, M.; Du, P. Enhanced growth of MCF-7 breast cancer cells overexpressing parathyroid hormone-related peptide. Endocrinology 2000, 141, 1882-1892.
    • (2000) Endocrinology , vol.141 , pp. 1882-1892
    • Falzon, M.1    Du, P.2
  • 34
    • 0036155912 scopus 로고    scopus 로고
    • Intracrine PTHrP protects against serum starvation-induced apoptosis and regulates the cell cycle in MCF-7 breast cancer cells
    • Tovar Sepulveda, V.A.; Shen, X.; Falzon, M. Intracrine PTHrP protects against serum starvation-induced apoptosis and regulates the cell cycle in MCF-7 breast cancer cells. Endocrinology 2002, 143, 596-606.
    • (2002) Endocrinology , vol.143 , pp. 596-606
    • Tovar Sepulveda, V.A.1    Shen, X.2    Falzon, M.3
  • 36
    • 26244468709 scopus 로고    scopus 로고
    • Modulation of parathyroid hormone-related protein levels (PTHrP) in anaplastic thyroid cancer
    • Dackiw, A.; Pan, J.; Xu, G.; Yeung, S.C. Modulation of parathyroid hormone-related protein levels (PTHrP) in anaplastic thyroid cancer. Surgery 2005, 138, 456-463.
    • (2005) Surgery , vol.138 , pp. 456-463
    • Dackiw, A.1    Pan, J.2    Xu, G.3    Yeung, S.C.4
  • 37
    • 34547114754 scopus 로고    scopus 로고
    • Human parathyroid hormone-related protein and human parathyroid hormone receptor type 1 are expressed in human medulloblastomas and regulate cell proliferation and apoptosis in medulloblastoma-derived cell lines
    • Gessi, M; Monego, G; Calviello, G; Lanza, P; Giangaspero, F; Silvestrini, A; Lauriola, L; Ranelletti FO. Human parathyroid hormone-related protein and human parathyroid hormone receptor type 1 are expressed in human medulloblastomas and regulate cell proliferation and apoptosis in medulloblastoma-derived cell lines. Acta Neuropathol. 2007, 114, 135-145.
    • (2007) Acta Neuropathol. , vol.114 , pp. 135-145
    • Gessi, M.1    Monego, G.2    Calviello, G.3    Lanza, P.4    Giangaspero, F.5    Silvestrini, A.6    Lauriola, L.7    Ranelletti, F.O.8
  • 40
    • 9144230617 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein is an essential growth factor for human clear cell renal carcinoma and a target for the von Hippel-Lindau tumor suppressor gene
    • Massfelder, T.; Lang, H.; Schordan, E.; Lindner, V.; Rothhut, S.; Welsch, S.; Simon-Assmann, P.; Barthelmebs, M.; Jacqmin, D.; Helwig, J.J. Parathyroid hormone-related protein is an essential growth factor for human clear cell renal carcinoma and a target for the von Hippel-Lindau tumor suppressor gene. Cancer Res. 2004, 64, 180-188.
    • (2004) Cancer Res. , vol.64 , pp. 180-188
    • Massfelder, T.1    Lang, H.2    Schordan, E.3    Lindner, V.4    Rothhut, S.5    Welsch, S.6    Simon-Assmann, P.7    Barthelmebs, M.8    Jacqmin, D.9    Helwig, J.J.10
  • 42
    • 62349134194 scopus 로고    scopus 로고
    • Von Hippel-Lindau tumor suppressor gene-dependent mRNA stabilization of the survival factor parathyroid hormone-related protein in human renal cell carcinoma by the RNA-binding protein HuR
    • Danilin, S.; Sourbier, C.; Thomas, L.; Rothhut, S.; Lindner, V.; Helwig, J.J.; Jacqmin, D.; Lang, H.; Massfelder, T. von Hippel-Lindau tumor suppressor gene-dependent mRNA stabilization of the survival factor parathyroid hormone-related protein in human renal cell carcinoma by the RNA-binding protein HuR. Carcinogenesis 2009, 30, 387-396.
    • (2009) Carcinogenesis , vol.30 , pp. 387-396
    • Danilin, S.1    Sourbier, C.2    Thomas, L.3    Rothhut, S.4    Lindner, V.5    Helwig, J.J.6    Jacqmin, D.7    Lang, H.8    Massfelder, T.9
  • 43
    • 34848886113 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein induces cell survival in human renal cell carcinoma through the PI3K Akt pathway: Evidence for a critical role for integrin-linked kinase and nuclear factor kappa B
    • Agouni, A.; Sourbier, C.; Danilin, S.; Rothhut, S.; Lindner, V.; Jacqmin, D.; Helwig, J.J.; Lang, H.; Massfelder, T. Parathyroid hormone-related protein induces cell survival in human renal cell carcinoma through the PI3K Akt pathway: evidence for a critical role for integrin-linked kinase and nuclear factor kappa B. Carcinogenesis 2007, 28, 1893-1901.
    • (2007) Carcinogenesis , vol.28 , pp. 1893-1901
    • Agouni, A.1    Sourbier, C.2    Danilin, S.3    Rothhut, S.4    Lindner, V.5    Jacqmin, D.6    Helwig, J.J.7    Lang, H.8    Massfelder, T.9
  • 44
    • 67651149656 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein regulates cell survival pathways via integrin alpha6beta4-mediated activation of phosphatidylinositol 3-kinase/Akt signaling
    • Bhatia, V.; Mula, R.V.; Weigel, N.L.; Falzon, M. Parathyroid hormone-related protein regulates cell survival pathways via integrin alpha6beta4-mediated activation of phosphatidylinositol 3-kinase/Akt signaling. Mol. Cancer Res. 2009, 7, 1119-1131.
    • (2009) Mol. Cancer Res. , vol.7 , pp. 1119-1131
    • Bhatia, V.1    Mula, R.V.2    Weigel, N.L.3    Falzon, M.4
  • 45
    • 0031807008 scopus 로고
    • Characterization of the cell-specific expression of parathyroid hormone-related protein in normal and neoplastic prostate tissue
    • Wu, G.; Iwamura, M.; di Sant'Agnese, P.A.; Deftos, L.J.; Cockett, A.T.K.; Gershagen, S. Characterization of the cell-specific expression of parathyroid hormone-related protein in normal and neoplastic prostate tissue. Urology 1995, 51, 110-120.
    • (1995) Urology , vol.51 , pp. 110-120
    • Wu, G.1    Iwamura, M.2    di Sant'Agnese, P.A.3    Deftos, L.J.4    Cockett, A.T.K.5    Gershagen, S.6
  • 46
    • 70349754434 scopus 로고    scopus 로고
    • The neuroendocrine-derived peptide parathyroid hormone-related protein promotes prostate cancer cell growth by stabilizing the androgen receptor
    • DaSilva, J.; Gioeli, D.; Weber, M.J.; Parsons, S.J. The neuroendocrine-derived peptide parathyroid hormone-related protein promotes prostate cancer cell growth by stabilizing the androgen receptor. Cancer Res. 2009, 69, 7402-7411.
    • (2009) Cancer Res. , vol.69 , pp. 7402-7411
    • DaSilva, J.1    Gioeli, D.2    Weber, M.J.3    Parsons, S.J.4
  • 47
    • 78751645271 scopus 로고    scopus 로고
    • E1A oncogene expression inhibits PTHrP P3 promoter activity and sensitizes human prostate cancer cells to TNF-induced apoptosis
    • Asadi, F.K.; Kukreja, S.C.; Boyer, B.; Valess, A.M.; Cook, J.L. E1A oncogene expression inhibits PTHrP P3 promoter activity and sensitizes human prostate cancer cells to TNF-induced apoptosis. Int. Urol. Nephrol. 2010, 42, 971-978.
    • (2010) Int. Urol. Nephrol. , vol.42 , pp. 971-978
    • Asadi, F.K.1    Kukreja, S.C.2    Boyer, B.3    Valess, A.M.4    Cook, J.L.5
  • 48
    • 77956459044 scopus 로고    scopus 로고
    • Rac and Rho GTPases in cancer cell motility control
    • Parri, M.; Chiarugi, P. Rac and Rho GTPases in cancer cell motility control. Cell Commun. Signal. 2010, 8, 23.
    • (2010) Cell Commun. Signal. , vol.8 , pp. 23
    • Parri, M.1    Chiarugi, P.2
  • 49
    • 33947601561 scopus 로고    scopus 로고
    • Increased cell survival, migration, invasion, and Akt expression in PTHrP-overexpressing LoVo colon cancer cell lines
    • Shen, X.; Mula, R.V.; Evers, B.M.; Falzon, M. Increased cell survival, migration, invasion, and Akt expression in PTHrP-overexpressing LoVo colon cancer cell lines. Regul. Pept. 2007, 141, 61-72.
    • (2007) Regul. Pept. , vol.141 , pp. 61-72
    • Shen, X.1    Mula, R.V.2    Evers, B.M.3    Falzon, M.4
  • 50
    • 36049009987 scopus 로고    scopus 로고
    • PTHrP increases xenograft growth and promotes integrin alpha6beta4 expression and Akt activation in colon cancer
    • Shen, X.; Rychahou, P.G.; Evers, B.M.; Falzon, M. PTHrP increases xenograft growth and promotes integrin alpha6beta4 expression and Akt activation in colon cancer. Cancer Lett. 2007, 258, 241-252.
    • (2007) Cancer Lett. , vol.258 , pp. 241-252
    • Shen, X.1    Rychahou, P.G.2    Evers, B.M.3    Falzon, M.4
  • 51
    • 70349752918 scopus 로고    scopus 로고
    • Nuclear PTHrP targeting regulates PTHrP secretion and enhances LoVo cell growth and survival
    • Bhatia, V; Saini, M.K.; Falzon, M. Nuclear PTHrP targeting regulates PTHrP secretion and enhances LoVo cell growth and survival. Regul. Pept. 2009, 158, 149-155.
    • (2009) Regul. Pept. , vol.158 , pp. 149-155
    • Bhatia, V.1    Saini, M.K.2    Falzon, M.3
  • 52
    • 77956912825 scopus 로고    scopus 로고
    • PTHrP promotes colon cancer cell migration and invasion in an integrin α6β4-dependent manner through activation of Rac1
    • Mula, R.V.; Bhatia, V.; Falzon, M. PTHrP promotes colon cancer cell migration and invasion in an integrin α6β4-dependent manner through activation of Rac1. Cancer Lett. 2010, 298, 119-127.
    • (2010) Cancer Lett. , vol.298 , pp. 119-127
    • Mula, R.V.1    Bhatia, V.2    Falzon, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.