Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells

Biological Chemistry

Volumn 388, Issue 5, 2007, Pages 457-465

  Sirchia, Rosalia ^a   Luparello, Claudio ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

Breast cancer; Differential display; Gene expression; PCR; PTHrP

Indexed keywords

A4 DIFFERENTIATION PROTEIN; PARATHYROID HORMONE RELATED PROTEIN; PARATHYROID HORMONE RELATED PROTEIN[39-94]; PROTEIN; TRANSCRIPTION FACTOR MSX1; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CONTROLLED STUDY; COX6C GENE; CYTOTOXICITY; DIFFERENTIAL DISPLAY; DOWN REGULATION; FDZ6 GENE; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; MULTIPLEX POLYMERASE CHAIN REACTION; NUCLEOTIDE SEQUENCE; OXR1 GENE; PRIORITY JOURNAL; PROTEIN ANALYSIS; TMCO4 GENE; TUMOR CELL; UPREGULATION;

BIOLOGICAL MARKERS; BREAST NEOPLASMS; CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 8; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MOLECULAR SEQUENCE DATA; PARATHYROID HORMONE-RELATED PROTEIN;

EID: 34249076577     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2007.059     Document Type: Article

References (46)

1. Aarts, M.M., Rix, A., Guo, J., Bringhurst, R., and Henderson, J.E. (1999). The nucleolar targeting signal (NTS) of parathyroid hormone related protein mediates endocytosis and nucleolar translocation. J. Bone Miner. Res. 14, 1493-1503.
2. Altschul, S.F., Madden, T.L., Schaffer, A.A., Zhang, J., Zhang, Z., Miller, W., and Lipman, D.J. (1997). Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25, 3389-3402.
3. Breitwieser, G.E., McLenithan, J.C., Cortese, J.F., Shields, J.M., Oliva, M.M., Majewski, J.L., Machamer, C.E., and Yang, V.W. (1997). Colonic epithelium-enriched protein A4 is a proteolipid that exhibits ion channel characteristics. Am. J. Physiol. 272, C957-C965.
4. Clemens, T.L., Cormier, S., Eichinger, A., Endlich K, Fiaschi-Taesch, N., Fischer, E., Friedman, P.A., Karaplis, A.C., Massfelder, T., Rossert, J., et al. (2001). Parathyroid hormone-related protein and its receptors: nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and the pancreatic islets. Br. J. Pharmacol. 134, 1113-1116.
5. De Miguel, F., Fiaschi-Taesch, N., Lopez-Talaverna, J.C., Tarane, K.K., Massfelder, T., Helwig, J.J., and Stewart, A.F. (2001). The C-terminal region of PTHrP, in addition to the nuclear localization signal, is essential for the intracrine stimulation of proliferation in vascular smooth muscle cell. Endocrinology 142, 4096-4105.
6. Dias Neto, E., Correa, R.G., Verjovski-Almeida, S., Briones, M.R., Nagai, M.A., da Silva, W. Jr., Zago, M.A., Bordin, S., Costa, F.F., Goldman, G.H., et al. (2000). Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. Proc. Natl. Acad. Sci. USA 97, 3491-3496.
7. Dittmer, A., Vetter, M., Schunke, D., Span, P.N., Sweep, F., Thomssen, C., and Dittmer, J. (2006). Parathyroid hormone-related protein regulates tumor-relevant genes in breast cancer cells. J. Biol. Chem. 281, 14563-14572.
8. Divieti, P., Geller, A.I., Suliman, G., Juppner, H., and Bringhurst, F.R. (2005). Receptors specific for the carboxyl-terminal region of parathyroid hormone on bone-derived cells: determinants of ligand binding and bioactivity. Endocrinology 146, 1863-1870.
9. Dunbar, M.E., Dann, P.R., Robinson, G.W., Henninghausen, L., Zhang, J.P., and Wysolmerski, J.J. (1999). Parathyroid hormone-related protein signaling is necessary for sexual dimorphism during embryonic mammary development. Development 126, 3485-3493.
10. Elliott, N. and Volkert, M.R. (2004). Stress induction and mitochondrial localization of Oxr1 proteins in yeast and humans. Mol. Cell. Biol. 24, 3180-3187.
11. Fiaschi-Taesch, N.M. and Stewart, A.F. (2003). Minireview: parathyroid hormone-related protein as an intracrine factor: trafficking mechanisms and functional consequences. Endocrinology 144, 407-411.
12. Foley, J., Dann, P., Hong, J., Cosgrove, J., Dreyer, B., Rimm, D., Dunbar, M., Philbrick, W., and Wysolmerski, J. (2001). Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development. Development 128, 513-525.
13. Golan, T., Yaniv, A., Bafico, A., Liu, G., and Gazit, A. (2004). The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt β-catenin signaling cascade. J. Biol. Chem. 279, 14879-14888.
14. Guise, T.A., Yin, J.J., Taylor, S.D., Kumagai, Y., Dallas, M., Boyce, B.F., Yoneda, T., and Mundy, G.R. (1996). Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. J. Clin. Invest. 98, 1544-1549.
15. Hoey, R.P., Sanderson, C., Iddon, J., Brady, G., Bundred, N.J., and Anderson, N.G. (2003). The parathyroid hormone-related protein receptor is expressed in breast cancer bone metastases and promotes autocrine proliferation in breast carcinoma cells. Br. J. Cancer 88, 567-573.
16. Hofmann, W., Royer, H.D., Drechsler, M., Schneider, S., and Royer-Pokora, B. (1993). Characterization of the transcriptional regulatory region of the human WT1 gene. Oncogene 8, 3123-3132.
17. Hoogendam, J., Farih-Sips, H., van Beek, E., Lowik, C.W., Wit, J.M., and Karperien, M. (2006a). Novel late response genes of PTHrP in chondrocytes. Horm. Res. 67, 159-170.
18. Hoogendam, J., Parlevliet, E., Miclea, R., Lowik, C.W., Wit, J.M., and Karperien, M. (2006b). Novel early target genes of parathyroid hormone-related peptide in chondrocytes. Endocrinology 147, 3141-3152.
19. Iwamoto, K., Bundo, M., Yamamoto, M., Ozawa, H., Saito, T., and Kato, T. (2004). Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. Neurosci. Res. 49, 379-385.
20. Lee, S.M., Shin, H., Jang, S.W., Shim, J.J., Song, I.S., Son, K.N., Hwang, J., Shin, Y.H., Kim, H.H., Lee, C.K., et al. (2004). PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells. Biochem. Biophys. Res. Commun. 324, 768-772.
21. Leist, M. and Jäättelä, M. (2001). Four deaths and a funeral: from caspases to alternative mechanisms. Nat. Rev. Mol. Cell. Biol. 2, 589-598.
22. Lenka, N., Vijayasarathy, C., Mullick, J., and Avadhani, N.G. (1998). Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex. Prog. Nucleic Acid Res. Mol. Biol. 61, 309-344.
23. Luparello, C. and Sirchia, R. (2005). Type V collagen regulates the expression of apoptotic and stress response genes by breast cancer cells. J. Cell. Physiol. 202, 411-421.
24. Luparello, C., Burtis, W.J., Raue, F., Birch, M.A., and Gallagher, J.A. (1995). Parathyroid hormone-related peptide and 8701-BC breast cancer cell growth and invasion in vitro. Evidence for growth-inhibiting and invasion-promoting effect. Mol. Cell. Endocrinol. 111, 225-232.
25. Luparello, C., Birch, M.A., Gallagher, J.A., and Burtis, W.J. (1997a). Clonal heterogeneity of the growth and invasive response of a human breast carcinoma cell line to parathyroid hormone-related peptide fragments. Carcinogenesis. 18, 23-29.
26. Luparello, C., Noël, A., and Pucci-Minafra, I. (1997b). Intratumoral heterogeneity for hsp90β mRNA levels in a breast cancer cell line. DNA Cell Biol. 16, 1231-1236.
27. Luparello, C., Schilling, T., Cirincione, R., and Pucci-Minafra, I. (1999). Extracellular matrix regulation of PTHrP and PTH/PTHrP receptor in a human breast cancer cell line. FEBS Lett. 463, 265-269.
28. ++] and hormones in the breast cancer cell line 8701-BC. Biol. Chem. 381, 303-308.
29. Luparello, C., Romanotto, R., Tipa, A., Sirchia, R., Olmo, N., Lopez de Silanes, I., Turnay, J., Lizarbe, M.A., and Stewart, A.F. (2001). Mid-region parathyroid hormone-related protein inhibits growth and invasion 'in vitro' and tumorigenesis 'in vivo' of human breast cancer cells. J. Bone Miner. Res. 16, 2173-2181.
30. Luparello, C., Sirchia, R., and Pupello, D. (2003). PTHrP (67-86) regulates the expression of stress proteins in breast cancer cells inducing modifications in urokinase-plasminogen activator and MMP-1 expression. J. Cell Sci. 116, 2421-2430.
31. Massfelder, T., Dann, P., Wu, T.L., Vasavada, R., Helwig, J.J., and Stewart, A.F. (1997). Opposing mitogenic and anti-mitogenic actions of parathyroid hormone-related protein in vascular smooth muscle cells: a critical role for nuclear targeting. Proc. Natl. Acad. Sci. USA 94, 13630-13635.
32. Oliva, M.M., Wu, T.C., and Yang, V.W. (1993). Isolation and characterization of a differentiation-dependent gene in the human colonic cell line HT29-18. Arch. Biochem. Biophys. 302, 183-192.
33. Orloff, J.J., Ganz, M.B., Ribaudo, A.E., Burtis, W.J., Reiss, M., Milstone, L.M., and Stewart, A.F. (1992). Analysis of PTHRP binding and signal transduction mechanisms in benign and malignant squamous cells. Am. J. Physiol. 262, E599-607.
34. Pearson, W.R., and Lipman, D.J. (1988). Improved tools for biological sequence comparison. Proc. Natl. Acad. Sci. USA 85, 2444-2448.
35. Satoh, K., Ginsburg, E., and Vonderhaar, B.K. (2004). Msx-1 and Msx-2 in mammary gland development. J. Mammary Gland Biol. Neoplasia 9, 195-205.
36. Shen, R., Chen, Y., Huang, L., Vitale, E., and Solurs, M. (1994). Characterization of the human MSX-1 promoter and an enhancer responsible for retinoic acid induction. Cell. Mol. Biol. Res. 40, 297-312.
37. Sirchia, R., Ciacciofera, V., and Luparello, C. (2003). Tumor cell-collagen interactions: identification and semi-quantitative evaluation of selectively expressed genes by combination of differential display- and multiplex-PCR. Biol. Proc. Online 5, 222-227.
38. Sirchia, R., Priulla, M., Sciandrello, G., Caradonna, F., Barbata, G., and Luparello, C. (2007a). Mid-region parathyroid hormone-related protein (PTHrP) binds chromatin of MDAMB231 breast cancer cells and isolated oligonucleotides 'in vitro'. Breast Cancer Res. Treat. DOI 10.1007/s10549-006-9437-z.
39. Sirchia, R., Gullo, A., and Luparello, C. (2007b). Aspects of the cytotoxic activity of PTHrP [38-94]-amide on human breast cancer cells. In: Novel Aspects of PTHrP Physiopathology, C. Luparello, ed. (Happauge, NJ, USA: Nova Science).
40. Soifer, N.E., Dee, K.E., Burtis, W.J., Matovcik, L.M., Wu, T.L., Milstone, L.M., Broadus, A.E., Philbrick, W.M., and Stewart, A.F. (1992). Secretion of novel mid-region fragment of parathyroid hormone-related protein by three different cell lines in culture. J. Biol. Chem. 267, 18236-18243.
41. Sokolov, B.P. and Prockop, D.J. (1994). A rapid and simple PCR-based method for isolation of cDNAs from differentially expressed genes. Nucleic Acids Res. 22, 4009-4015.
42. Stewart, A.F., Wu,.T, Burtis, W.J., Weir, E.C., Broadus, A.E., and Insogna, K.L. (1987). The relative potency of a human tumor-derived PTH-like adenylate cyclase-stimulating preparation in three bioassays. J. Bone Miner. Res. 2, 37-43.
43. Strid, H., Care, A., Jansson, T., and Powell, T. (2002). Parathyroid hormone-related peptide (38-94) amide stimulates ATP dependent calcium transport in the basal plasma membrane of the human syncytiotrophoblast. J. Endocrinol. 175, 517-524.
44. Wu, T.L., Vasavada, R.C., Yang, K., Massfelder, T., Ganz, M., Abbas, S.K., Care, A.D., and Stewart, A.F. (1996). Structural and physiologic characterization of the mid-region secretory species of parathyroid hormone-related protein. J. Biol. Chem. 271, 24372-24381.
45. Wysolmerski, J.J. and Stewart, A.F. (1998). The physiology of parathyroid hormone-related protein: an emerging role as a developmental factor. Annu. Rev. Physiol. 60, 431-460.
46. Yang, K.H., de Papp, A.E., Soifer, N.E., Dreyer, B.E., Wu, T.L., Porter, S.E., Bellantoni, M., Burtis, W.J., Insogna, K.L., and Broadus, A.E. (1994). Parathyroid hormone-related protein: evidence for isoform- and tissue-specific posttranslational processing. Biochemistry 33, 7460-7469.