Beneficial effects of IKKε-deficiency on body weight and insulin sensitivity are lost in high fat diet-induced obesity in mice

Biochemical and Biophysical Research Communications

Volumn 407, Issue 2, 2011, Pages 288-294

  Scheja, Ludger ^a   Heese, Barbara ^a,b   Seedorf, Klaus ^a,c  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^c INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

Inhibitor of kB kinase epsilon; Insulin resistance; Nuclear factor B; Obesity

Indexed keywords

I KAPPA B KINASE EPSILON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LEPTIN; TUMOR NECROSIS FACTOR ALPHA;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; LIVER; MALE; MOUSE; NONHUMAN; OBESITY; PLASMA; PRIORITY JOURNAL;

ANIMALS; BIOLOGICAL MARKERS; BODY WEIGHT; DIETARY FATS; I-KAPPA B KINASE; INFLAMMATION MEDIATORS; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, KNOCKOUT; NF-KAPPA B; OBESITY;

MUS;

EID: 79953684623     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.02.137     Document Type: Article

References (29)

1. Hotamisligil G.S. Inflammation and metabolic disorders. Nature 2006, 444:860-867.
2. Shoelson S.E., Herrero L., Naaz A. Obesity, inflammation, and insulin resistance. Gastroenterology 2007, 132:2169-2180.
3. Herschkovitz A., Liu Y.F., Ilan E., et al. Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance. J. Biol. Chem. 2007, 282:18018-18027.
4. Taniguchi C.M., Emanuelli B., Kahn C.R. Critical nodes in signalling pathways: insights into insulin action. Nature Rev. Mol. Cell Biol. 2006, 7:85-96.
5. Nakagawa Y., Shimano H., Yoshikawa T., et al. TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes. Nature Med. 2006, 12:107-113.
6. Hirashima Y., Tsuruzoe K., Kodama S. Et al., Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway. J. Endocrinol. 2003, 179:253-266.
7. Rui L., Yuan M., Frantz D., et al. SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. J. Biol. Chem. 2002, 277:42394-42398.
8. Uysal K.T., Wiesbrock S.M., Marino M.W. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 1997, 389:610-614.
9. Ventre J., Doebber T., Wu M., et al. Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice. Diabetes 1997, 46:1526-1531.
10. Yuan M., Konstantopoulos N., Lee J., et al. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 2001, 293:1673-1677.
11. Baker R.G., Hayden M.S., Ghosh S. NF-κB, inflammation, and metabolic disease. Cell Metab. 2011, 13:11-22.
12. Ghosh S., Hayden M.S. New regulators of NF-kappaB in inflammation. Nature Rev. Immunol. 2008, 8:837-848.
13. Arkan M.C., Hevener A.L., Greten F.R., et al. IKK-beta links inflammation to obesity-induced insulin resistance. Nature Med. 2005, 11:191-198.
14. Cai D., Yuan M., Frantz D.F., et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nature Med. 2005, 11:183-190.
15. Shimada T., Kawai T., Takeda K., et al. IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. Internat. Immunol. 1999, 11:1357-1362.
16. Peters R.T., Liao S.M., Maniatis T. IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex. Mol. Cell 2000, 5:513-522.
17. Traenckner E.B., Pahl H.L., Henkel T., et al. Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli. EMBO J. 1995, 14:2876-2883.
18. Kravchenko V.V., Mathison J.C., Schwamborn K., et al. IKKi/IKKepsilon plays a key role in integrating signals induced by pro-inflammatory stimuli. J. Biol. Chem. 2003, 278:26612-26619.
19. Clark K., Peggie M., Plater L., et al. Novel cross-talk within the IKK family controls innate immunity. Biochem. J. 2011, 434:93-104.
20. Eddy S.F., Guo S., Demicco E.G., et al. Inducible IkappaB kinase/IkappaB kinase epsilon expression is induced by CK2 and promotes aberrant nuclear factor-kappaB activation in breast cancer cells. Cancer Res. 2005, 65:11375-11383.
21. Boehm J.S., Zhao J.J., Yao J., et al. Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell 2007, 129:1065-1079.
22. Chiang S.H., Bazuine M., Lumeng C.N., et al. The protein kinase IKKepsilon regulates energy balance in obese mice. Cell 2009, 138:961-975.
23. Matthews D.R., Hosker J.P., Rudenski A.S., et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28:412-419.
24. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25:402-408.
25. Xu H., Barnes G.T., Yang Q., et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 2003, 112:1821-1830.
26. Weisberg S.P., McCann D., Desai M., et al. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 2003, 112:1796-1808.
27. Blackwell T.S., Christman J.W. The role of nuclear factorkB in cytokine gene regulation. Am. J. Resp. Cell. Mol. Biol. 1997, 17:3-9.
28. Nomura F., Kawai T., Nakanishi K., et al. NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation. Genes Cells 2000, 5:191-202.
29. Wietek C., Cleaver C.S., Ludbrook V., et al. kappaB kinase epsilon interacts with p52 and promotes transactivation via p65. J. Biol. Chem. 2006, 281:34973-34981.