메뉴 건너뛰기




Volumn 89, Issue 4, 2011, Pages 499-506

IL-7-dependent STAT-5 activation and CD8+ T cell proliferation are impaired in HIV infection

Author keywords

Bcl 2; CD127

Indexed keywords

CD8 ANTIGEN; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR; INTERLEUKIN 7 RECEPTOR ALPHA; PROTEIN BCL 2; STAT5 PROTEIN;

EID: 79953682517     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0710430     Document Type: Article
Times cited : (25)

References (53)
  • 2
    • 0023777814 scopus 로고
    • Cytotoxic T cells clear virus but augment lung pathology in mice infected with respiratory syncytial virus
    • Cannon, M. J., Openshaw, P. J., Askonas, B. A. (1988) Cytotoxic T cells clear virus but augment lung pathology in mice infected with respiratory syncytial virus. J. Exp. Med. 168, 1163-1168.
    • (1988) J. Exp. Med. , vol.168 , pp. 1163-1168
    • Cannon, M.J.1    Openshaw, P.J.2    Askonas, B.A.3
  • 3
    • 0028820386 scopus 로고
    • Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor
    • Walter, E. A., Greenberg, P. D., Gilbert, M. J., Finch, R. J., Watanabe, K. S., Thomas, E. D., Riddell, S. R. (1995) Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N. Engl. J. Med. 333, 1038-1044.
    • (1995) N. Engl. J. Med. , vol.333 , pp. 1038-1044
    • Walter, E.A.1    Greenberg, P.D.2    Gilbert, M.J.3    Finch, R.J.4    Watanabe, K.S.5    Thomas, E.D.6    Riddell, S.R.7
  • 4
    • 0030961152 scopus 로고    scopus 로고
    • Severe genital herpes infections in HIV-infected individuals with impaired herpes simplex virus-specific CD8+ cytotoxic T lymphocyte responses
    • Posavad, C. M., Koelle, D. M., Shaughnessy, M. F., Corey, L. (1997) Severe genital herpes infections in HIV-infected individuals with impaired herpes simplex virus-specific CD8+ cytotoxic T lymphocyte responses. Proc. Natl. Acad. Sci. USA 94, 10289-10294.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10289-10294
    • Posavad, C.M.1    Koelle, D.M.2    Shaughnessy, M.F.3    Corey, L.4
  • 6
    • 0033198537 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1-specific cytotoxic T lymphocyte activity is inversely correlated with HIV type 1 viral load in HIV type 1-infected long-term survivors
    • Betts, M. R., Krowka, J. F., Kepler, T. B., Davidian, M., Christopherson, C., Kwok, S., Louie, L., Eron, J., Sheppard, H., Frelinger, J. A. (1999) Human immunodeficiency virus type 1-specific cytotoxic T lymphocyte activity is inversely correlated with HIV type 1 viral load in HIV type 1-infected long-term survivors. AIDS Res. Hum. Retroviruses 15, 1219-1228.
    • (1999) AIDS Res. Hum. Retroviruses , vol.15 , pp. 1219-1228
    • Betts, M.R.1    Krowka, J.F.2    Kepler, T.B.3    Davidian, M.4    Christopherson, C.5    Kwok, S.6    Louie, L.7    Eron, J.8    Sheppard, H.9    Frelinger, J.A.10
  • 7
    • 17144445832 scopus 로고    scopus 로고
    • Human immunodeficiency virus type1-and cytomegalovirus-specific cytotoxic T lymphocytes can persist at high frequency for prolonged periods in the absence of circulating peripheral CD4(+) T cells
    • Spiegel, H. M., Ogg, G. S., DeFalcon, E., Sheehy, M. E., Monard, S., Haslett, P. A., Gillespie, G., Donahoe, S. M., Pollack, H., Borkowsky, W., Mc-Michael, A. J., Nixon, D. F. (2000) Human immunodeficiency virus type1-and cytomegalovirus-specific cytotoxic T lymphocytes can persist at high frequency for prolonged periods in the absence of circulating peripheral CD4(+) T cells. J. Virol. 74, 1018-1022.
    • (2000) J. Virol. , vol.74 , pp. 1018-1022
    • Spiegel, H.M.1    Ogg, G.S.2    DeFalcon, E.3    Sheehy, M.E.4    Monard, S.5    Haslett, P.A.6    Gillespie, G.7    Donahoe, S.M.8    Pollack, H.9    Borkowsky, W.10    McMichael, A.J.11    Nixon, D.F.12
  • 8
    • 0031973577 scopus 로고    scopus 로고
    • Circulating CD8 T lymphocytes in human immunodeficiency virus-infected individuals have impaired function and downmodulate CD3 ζ, the signaling chain of the T-cell receptor complex
    • Trimble, L. A., Lieberman, J. (1998) Circulating CD8 T lymphocytes in human immunodeficiency virus-infected individuals have impaired function and downmodulate CD3 ζ, the signaling chain of the T-cell receptor complex. Blood 91, 585-594.
    • (1998) Blood , vol.91 , pp. 585-594
    • Trimble, L.A.1    Lieberman, J.2
  • 10
    • 0032842111 scopus 로고    scopus 로고
    • Perforin is not co-expressed with granzyme A within cytotoxic granules in CD8 T lymphocytes present in lymphoid tissue during chronic HIV infection
    • Andersson, J., Behbahani, H., Lieberman, J., Connick, E., Landay, A., Patterson, B., Sonnerborg, A., Lore, K., Uccini, S., Fehniger, T. E. (1999) Perforin is not co-expressed with granzyme A within cytotoxic granules in CD8 T lymphocytes present in lymphoid tissue during chronic HIV infection. AIDS 13, 1295-1303.
    • (1999) AIDS , vol.13 , pp. 1295-1303
    • Andersson, J.1    Behbahani, H.2    Lieberman, J.3    Connick, E.4    Landay, A.5    Patterson, B.6    Sonnerborg, A.7    Lore, K.8    Uccini, S.9    Fehniger, T.E.10
  • 11
    • 0036530017 scopus 로고    scopus 로고
    • Persistent numbers of tetramer+ CD8(+) T cells, but loss of interferon-γ+ HIV-specific T cells during progression to AIDS
    • Kostense, S., Vandenberghe, K., Joling, J., Van Baarle, D., Nanlohy, N., Manting, E., Miedema, F. (2002) Persistent numbers of tetramer+ CD8(+) T cells, but loss of interferon-γ+ HIV-specific T cells during progression to AIDS. Blood 99, 2505-2511.
    • (2002) Blood , vol.99 , pp. 2505-2511
    • Kostense, S.1    Vandenberghe, K.2    Joling, J.3    Van Baarle, D.4    Nanlohy, N.5    Manting, E.6    Miedema, F.7
  • 12
    • 0035885920 scopus 로고    scopus 로고
    • Dressed to kill? A review of why antiviral CD8 T lymphocytes fail to prevent progressive immunodeficiency in HIV-1 infection
    • Lieberman, J., Shankar, P., Manjunath, N., Andersson, J. (2001) Dressed to kill? A review of why antiviral CD8 T lymphocytes fail to prevent progressive immunodeficiency in HIV-1 infection. Blood 98, 1667-1677.
    • (2001) Blood , vol.98 , pp. 1667-1677
    • Lieberman, J.1    Shankar, P.2    Manjunath, N.3    Andersson, J.4
  • 14
    • 33846632842 scopus 로고    scopus 로고
    • Interleukin-7 receptor expression: Intelligent design
    • Mazzucchelli, R., Durum, S. K. (2007) Interleukin-7 receptor expression: intelligent design. Nat. Rev. Immunol. 7, 144-154.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 144-154
    • Mazzucchelli, R.1    Durum, S.K.2
  • 15
    • 0347382593 scopus 로고    scopus 로고
    • Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    • Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D., Ahmed, R. (2003) Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 4, 1191-1198.
    • (2003) Nat. Immunol. , vol.4 , pp. 1191-1198
    • Kaech, S.M.1    Tan, J.T.2    Wherry, E.J.3    Konieczny, B.T.4    Surh, C.D.5    Ahmed, R.6
  • 16
    • 0034332403 scopus 로고    scopus 로고
    • Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo
    • Schluns, K. S., Kieper, W. C., Jameson, S. C., Lefrancois, L. (2000) Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat. Immunol. 1, 426-432.
    • (2000) Nat. Immunol. , vol.1 , pp. 426-432
    • Schluns, K.S.1    Kieper, W.C.2    Jameson, S.C.3    Lefrancois, L.4
  • 17
    • 0038655228 scopus 로고    scopus 로고
    • Cytokine control of memory T-cell development and survival
    • Schluns, K. S., Lefrancois, L. (2003) Cytokine control of memory T-cell development and survival. Nat. Rev. Immunol. 3, 269-279.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 269-279
    • Schluns, K.S.1    Lefrancois, L.2
  • 18
    • 0026048392 scopus 로고
    • IL-7 regulation of cytotoxic lymphocytes: Pore-forming protein gene expression, interferon-γ production, and cytotoxicity of human peripheral blood lymphocytes subsets
    • Smyth, M. J., Norihisa, Y., Gerard, J. R., Young, H. A., Ortaldo, J. R. (1991) IL-7 regulation of cytotoxic lymphocytes: pore-forming protein gene expression, interferon-γ production, and cytotoxicity of human peripheral blood lymphocytes subsets. Cell. Immunol. 138, 390-403.
    • (1991) Cell. Immunol. , vol.138 , pp. 390-403
    • Smyth, M.J.1    Norihisa, Y.2    Gerard, J.R.3    Young, H.A.4    Ortaldo, J.R.5
  • 19
    • 0025101928 scopus 로고
    • Interleukin 7 enhances cytolytic T lymphocyte generation and induces lymphokineactivated killer cells from human peripheral blood
    • Alderson, M. R., Sassenfeld, H. M., Widmer, M. B. (1990) Interleukin 7 enhances cytolytic T lymphocyte generation and induces lymphokineactivated killer cells from human peripheral blood. J. Exp. Med. 172, 577-587.
    • (1990) J. Exp. Med. , vol.172 , pp. 577-587
    • Alderson, M.R.1    Sassenfeld, H.M.2    Widmer, M.B.3
  • 22
    • 0029146183 scopus 로고
    • Elevated circulating interleukin-7 levels in patients with systemic juvenile rheumatoid arthritis
    • De Benedetti, F., Massa, M., Pignatti, P., Kelley, M., Faltynek, C. R., Martini, A. (1995) Elevated circulating interleukin-7 levels in patients with systemic juvenile rheumatoid arthritis. J. Rheumatol. 22, 1581-1585.
    • (1995) J. Rheumatol. , vol.22 , pp. 1581-1585
    • de Benedetti, F.1    Massa, M.2    Pignatti, P.3    Kelley, M.4    Faltynek, C.R.5    Martini, A.6
  • 23
  • 24
    • 34548291989 scopus 로고    scopus 로고
    • Reduced numbers of IL-7 receptor (CD127) expressing immune cells and IL-7-signaling defects in peripheral blood from patients with breast cancer
    • Vudattu, N. K., Magalhaes, I., Schmidt, M., Seyfert-Margolis, V., Maeurer, M. J. (2007) Reduced numbers of IL-7 receptor (CD127) expressing immune cells and IL-7-signaling defects in peripheral blood from patients with breast cancer. Int. J. Cancer 121, 1512-1519.
    • (2007) Int. J. Cancer , vol.121 , pp. 1512-1519
    • Vudattu, N.K.1    Magalhaes, I.2    Schmidt, M.3    Seyfert-Margolis, V.4    Maeurer, M.J.5
  • 25
    • 0035894221 scopus 로고    scopus 로고
    • Interleukin-7 receptor expression on CD8(+) T cells is reduced in HIV infection and partially restored with effective antiretroviral therapy
    • MacPherson, P. A., Fex, C., Sanchez-Dardon, J., Hawley-Foss, N., Angel, J. B. (2001) Interleukin-7 receptor expression on CD8(+) T cells is reduced in HIV infection and partially restored with effective antiretroviral therapy. J. Acquir. Immune Defic. Syndr. 28, 454-457.
    • (2001) J. Acquir. Immune Defic. Syndr. , vol.28 , pp. 454-457
    • McPherson, P.A.1    Fex, C.2    Sanchez-Dardon, J.3    Hawley-Foss, N.4    Angel, J.B.5
  • 26
    • 33645072224 scopus 로고    scopus 로고
    • CD127 expression and regulation are altered in the memory CD8 T cells of HIV-infected patients-reversal by highly active anti-retroviral therapy (HAART)
    • Colle, J. H., Moreau, J. L., Fontanet, A., Lambotte, O., Joussemet, M., Delfraissy, J. F., Theze, J. (2006) CD127 expression and regulation are altered in the memory CD8 T cells of HIV-infected patients-reversal by highly active anti-retroviral therapy (HAART). Clin. Exp. Immunol. 143, 398-403.
    • (2006) Clin. Exp. Immunol. , vol.143 , pp. 398-403
    • Colle, J.H.1    Moreau, J.L.2    Fontanet, A.3    Lambotte, O.4    Joussemet, M.5    Delfraissy, J.F.6    Theze, J.7
  • 29
    • 0038784460 scopus 로고    scopus 로고
    • Effects of IL-7 on early human thymocyte progenitor cells in vitro and in SCID-hu Thy/Liv mice
    • Napolitano, L. A., Stoddart, C. A., Hanley, M. B., Wieder, E., McCune, J. M. (2003) Effects of IL-7 on early human thymocyte progenitor cells in vitro and in SCID-hu Thy/Liv mice. J. Immunol. 171, 645-654.
    • (2003) J. Immunol. , vol.171 , pp. 645-654
    • Napolitano, L.A.1    Stoddart, C.A.2    Hanley, M.B.3    Wieder, E.4    McCune, J.M.5
  • 30
  • 31
    • 32944455546 scopus 로고    scopus 로고
    • IL-7Rα expression on CD4(+) T lymphocytes decreases with HIV disease progression and inversely correlates with immune activation
    • Koesters, S. A., Alimonti, J. B., Wachihi, C., Matu, L., Anzala, O., Kimani, J., Embree, J. E., Plummer, F. A., Fowke, K. R. (2006) IL-7Rα expression on CD4(+) T lymphocytes decreases with HIV disease progression and inversely correlates with immune activation. Eur. J. Immunol. 36, 336-344.
    • (2006) Eur. J. Immunol. , vol.36 , pp. 336-344
    • Koesters, S.A.1    Alimonti, J.B.2    Wachihi, C.3    Matu, L.4    Anzala, O.5    Kimani, J.6    Embree, J.E.7    Plummer, F.A.8    Fowke, K.R.9
  • 32
    • 33845481806 scopus 로고    scopus 로고
    • The correlation between levels of IL-7Rα expression and responsiveness to IL-7 is lost in CD4 lymphocytes from HIV-infected patients
    • Colle, J. H., Moreau, J. L., Fontanet, A., Lambotte, O., Delfraissy, J. F., Theze, J. (2007) The correlation between levels of IL-7Rα expression and responsiveness to IL-7 is lost in CD4 lymphocytes from HIV-infected patients. AIDS 21, 101-103.
    • (2007) AIDS , vol.21 , pp. 101-103
    • Colle, J.H.1    Moreau, J.L.2    Fontanet, A.3    Lambotte, O.4    Delfraissy, J.F.5    Theze, J.6
  • 33
    • 58049198420 scopus 로고    scopus 로고
    • IL-2 receptor γ chain cytokines differentially regulate human CD8+CD127+ and CD8+CD127-T cell division and susceptibility to apoptosis
    • Crawley, A. M., Katz, T., Parato, K., Angel, J. B. (2009) IL-2 receptor γ chain cytokines differentially regulate human CD8+CD127+ and CD8+CD127-T cell division and susceptibility to apoptosis. Int. Immunol. 21, 29-42.
    • (2009) Int. Immunol. , vol.21 , pp. 29-42
    • Crawley, A.M.1    Katz, T.2    Parato, K.3    Angel, J.B.4
  • 34
    • 33751572484 scopus 로고    scopus 로고
    • Generation and growth of CD28nullCD8+ memory T cells mediated by IL-15 and its induced cytokines
    • Chiu, W. K., Fann, M., Weng, N. P. (2006) Generation and growth of CD28nullCD8+ memory T cells mediated by IL-15 and its induced cytokines. J. Immunol. 177, 7802-7810.
    • (2006) J. Immunol. , vol.177 , pp. 7802-7810
    • Chiu, W.K.1    Fann, M.2    Weng, N.P.3
  • 37
    • 0030067103 scopus 로고    scopus 로고
    • Interleukin-2 receptor common γ-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: Selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) gene expression
    • Akbar, A. N., Borthwick, N. J., Wickremasinghe, R. G., Panayoitidis, P., Pilling, D., Bofill, M., Krajewski, S., Reed, J. C., Salmon, M. (1996) Interleukin-2 receptor common γ-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) gene expression. Eur. J. Immunol. 26, 294-299.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 294-299
    • Akbar, A.N.1    Borthwick, N.J.2    Wickremasinghe, R.G.3    Panayoitidis, P.4    Pilling, D.5    Bofill, M.6    Krajewski, S.7    Reed, J.C.8    Salmon, M.9
  • 38
    • 67649982105 scopus 로고    scopus 로고
    • Progressive CD127 down-regulation correlates with increased apoptosis of CD8 T cells during chronic HIV-1 infection
    • Zhang, S. Y., Zhang, Z., Fu, J. L., Kang, F. B., Xu, X. S., Nie, W. M., Zhou, C. B., Zhao, M., Wang, F. S. (2009) Progressive CD127 down-regulation correlates with increased apoptosis of CD8 T cells during chronic HIV-1 infection. Eur. J. Immunol. 39, 1425-1434.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 1425-1434
    • Zhang, S.Y.1    Zhang, Z.2    Fu, J.L.3    Kang, F.B.4    Xu, X.S.5    Nie, W.M.6    Zhou, C.B.7    Zhao, M.8    Wang, F.S.9
  • 39
  • 40
    • 67650458437 scopus 로고    scopus 로고
    • Responsiveness of T cells to interleukin-7 is associated with higher CD4(+) T cell counts in HIV-1-positive individuals with highly active antiretroviral therapy-induced viral load suppression
    • Camargo, J. F., Kulkarni, H., Agan, B. K., Gaitan, A. A., Beachy, L. A., Srinivas, S., He, W., Anderson, S., Marconi, V. C., Dolan, M. J., Ahuja, S. K. (2009) Responsiveness of T cells to interleukin-7 is associated with higher CD4(+) T cell counts in HIV-1-positive individuals with highly active antiretroviral therapy-induced viral load suppression. J. Infect. Dis. 199, 1872-1882.
    • (2009) J. Infect. Dis. , vol.199 , pp. 1872-1882
    • Camargo, J.F.1    Kulkarni, H.2    Agan, B.K.3    Gaitan, A.A.4    Beachy, L.A.5    Srinivas, S.6    He, W.7    Anderson, S.8    Marconi, V.C.9    Dolan, M.J.10    Ahuja, S.K.11
  • 42
    • 12144290424 scopus 로고    scopus 로고
    • Defective interleukin-2-dependent STAT5 signalling in CD8 T lymphocytes from HIV-positive patients: Restoration by antiretroviral therapy
    • Kryworuchko, M., Pasquier, V., Keller, H., David, D., Goujard, C., Gilquin, J., Viard, J. P., Joussemet, M., Delfraissy, J. F., Theze, J. (2004) Defective interleukin-2-dependent STAT5 signalling in CD8 T lymphocytes from HIV-positive patients: restoration by antiretroviral therapy. AIDS 18, 421-426.
    • (2004) AIDS , vol.18 , pp. 421-426
    • Kryworuchko, M.1    Pasquier, V.2    Keller, H.3    David, D.4    Goujard, C.5    Gilquin, J.6    Viard, J.P.7    Joussemet, M.8    Delfraissy, J.F.9    Theze, J.10
  • 43
    • 0037340455 scopus 로고    scopus 로고
    • Human immunodeficiency virus-1 envelope glycoproteins and anti-CD4 antibodies inhibit interleukin-2-induced Jak/STAT signalling in human CD4 T lymphocytes
    • Kryworuchko, M., Pasquier, V., Theze, J. (2003) Human immunodeficiency virus-1 envelope glycoproteins and anti-CD4 antibodies inhibit interleukin-2-induced Jak/STAT signalling in human CD4 T lymphocytes. Clin. Exp. Immunol. 131, 422-427.
    • (2003) Clin. Exp. Immunol. , vol.131 , pp. 422-427
    • Kryworuchko, M.1    Pasquier, V.2    Theze, J.3
  • 44
    • 78149397413 scopus 로고    scopus 로고
    • Interleukin-7 enhances memory CD8 T-cell recall responses in health but its activity is impaired in human immunodeficiency virus infection
    • O'Connor, A. M., Crawley, A. M., Angel, J. B. (2010) Interleukin-7 enhances memory CD8 T-cell recall responses in health but its activity is impaired in human immunodeficiency virus infection. Immunology 131, 525-536.
    • (2010) Immunology , vol.131 , pp. 525-536
    • O'Connor, A.M.1    Crawley, A.M.2    Angel, J.B.3
  • 45
    • 41349093966 scopus 로고    scopus 로고
    • IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival
    • Wofford, J. A., Wieman, H. L., Jacobs, S. R., Zhao, Y., Rathmell, J. C. (2008) IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. Blood 111, 2101-2111.
    • (2008) Blood , vol.111 , pp. 2101-2111
    • Wofford, J.A.1    Wieman, H.L.2    Jacobs, S.R.3    Zhao, Y.4    Rathmell, J.C.5
  • 46
    • 33846861326 scopus 로고    scopus 로고
    • IL-7-induced proliferation of recent thymic emigrants requires activation of the PI3K pathway
    • Swainson, L., Kinet, S., Mongellaz, C., Sourisseau, M., Henriques, T., Taylor, N. (2007) IL-7-induced proliferation of recent thymic emigrants requires activation of the PI3K pathway. Blood 109, 1034-1042.
    • (2007) Blood , vol.109 , pp. 1034-1042
    • Swainson, L.1    Kinet, S.2    Mongellaz, C.3    Sourisseau, M.4    Henriques, T.5    Taylor, N.6
  • 48
    • 4544331713 scopus 로고    scopus 로고
    • Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells
    • Barata, J. T., Silva, A., Brandao, J. G., Nadler, L. M., Cardoso, A. A., Boussiotis, V. A. (2004) Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells. J. Exp. Med. 200, 659-669.
    • (2004) J. Exp. Med. , vol.200 , pp. 659-669
    • Barata, J.T.1    Silva, A.2    Brandao, J.G.3    Nadler, L.M.4    Cardoso, A.A.5    Boussiotis, V.A.6
  • 50
    • 72849135730 scopus 로고    scopus 로고
    • Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: Decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway
    • Juffroy, O., Bugault, F., Lambotte, O., Landires, I., Viard, J. P., Niel, L., Fontanet, A., Delfraissy, J. F., Theze, J., Chakrabarti, L. A. (2010) Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway. J. Virol. 84, 96-108.
    • (2010) J. Virol. , vol.84 , pp. 96-108
    • Juffroy, O.1    Bugault, F.2    Lambotte, O.3    Landires, I.4    Viard, J.P.5    Niel, L.6    Fontanet, A.7    Delfraissy, J.F.8    Theze, J.9    Chakrabarti, L.A.10
  • 51
    • 0029980469 scopus 로고    scopus 로고
    • Apoptosis associated with ex vivo down-regulation of Bcl-2 and up-regulation of Fas in potential cytotoxic CD8+ T lymphocytes during HIV infection
    • Boudet, F., Lecoeur, H., Gougeon, M. L. (1996) Apoptosis associated with ex vivo down-regulation of Bcl-2 and up-regulation of Fas in potential cytotoxic CD8+ T lymphocytes during HIV infection. J. Immunol. 156, 2282-2293.
    • (1996) J. Immunol. , vol.156 , pp. 2282-2293
    • Boudet, F.1    Lecoeur, H.2    Gougeon, M.L.3
  • 53
    • 0031924699 scopus 로고    scopus 로고
    • Altered receptor expression and decreased sensitivity of T-cells to the stimulatory cytokines IL-2, IL-7 and IL-12 in HIV infection
    • Vingerhoets, J., Bisalinkumi, E., Penne, G., Colebunders, R., Bosmans, E., Kestens, L., Vanham, G. (1998) Altered receptor expression and decreased sensitivity of T-cells to the stimulatory cytokines IL-2, IL-7 and IL-12 in HIV infection. Immunol. Lett. 61, 53-61.
    • (1998) Immunol. Lett. , vol.61 , pp. 53-61
    • Vingerhoets, J.1    Bisalinkumi, E.2    Penne, G.3    Colebunders, R.4    Bosmans, E.5    Kestens, L.6    Vanham, G.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.