Deteriorating effect of fluvastatin on the cholestatic liver injury induced by bile duct ligation in rats

General Physiology and Biophysics

Volumn 30, Issue 1, 2011, Pages 66-74

  Lotková, Halka ^a   Staňková, Pavla ^a   Roušar, Tomáš ^a   Kučera, Otto ^a   Kohoutek, Lukáš ^b   Mičuda, Stanislav ^a   Brčáková, Eva ^a,c   Kolouchová, Gabriela ^a   Červinková, Zuzana ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b UNIVERSITY OF PARDUBICE   (Czech Republic)

^c Charles University in Prague Faculty of Pharmacy   (Czech Republic)

Author keywords

Bile duct ligation; Cholestasis; Statin

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; FLUINDOSTATIN; GLUTATHIONE; INTERLEUKIN 6; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; DETERIORATION; HISTOPATHOLOGY; INTRAHEPATIC CHOLESTASIS; MALE; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT;

ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BILIRUBIN; CHOLESTASIS, INTRAHEPATIC; FATTY ACIDS, MONOUNSATURATED; GAMMA-GLUTAMYLTRANSFERASE; GLUCURONOSYLTRANSFERASE; GLUTATHIONE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INDOLES; INTERLEUKIN-6; LIGATION; LIVER; MALE; RATS; RATS, WISTAR; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA;

RATTUS; RATTUS NORVEGICUS;

EID: 79953678645     PISSN: 02315882     EISSN: None     Source Type: Journal    
DOI: 10.4149/gpb_2011_01_66     Document Type: Article

References (51)

1. Arnaud C., Burger F., Steffens S., Veillard N. R., Nguyen T. H., Trono D., Mach F. (2005): Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: New evidence for direct antiinflammatory effects of statins. Arterioscler. Tromb. Vasc. Biol. 25, 1231-1236 doi:10.1161/01.ATV.0000163840. 63685.0c
2. Awad A. S., Kamel R. (2010): Effect of rosuvastatin on cholestasis-induced hepatic injury in rat livers. J. Biochem. Mol. Toxicol. 24, 89-94
3. Barón V., Muriel P. (1999): Role of glutathione, lipd peroxidation and antioxidants on acute bile-duct obstruction in the rat. Biochim. Biophys. Acta 1472, 173-180
4. Bohan A., Chen W. S., Denson L. A., Held M. A., Boyer J. L. (2003): Tumor necrosis factor alpha-dependent up-regulation of Lrh-1 and Mrp3 (Abcc3) reduces liver injury in obstructive cholestasis. J. Biol. Chem. 278, 36688-36698 doi:10.1074/jbc.M304011200
5. Brcakova E., Fuksa L., Cermanova J., Kolouchova G., Hroch M., Hirsova P., Martinkova J., Staud F. Micuda S. (2009): Alteration of methotrexate biliary and renal elimination during extrahepatic and intrahepatic cholestasis in rats. Biol. Pharm. Bull. 32, 1978-1985 doi:10.1248/bpb.32.1978
6. Bustamante E., Soper J. W., Pedersen P. L. (1977): A high-yield preparative method for isolation of rat liver mitochondria. Anal. Biochem. 80, 401-408 doi:10.1016/0003-2697(77)90661-3
7. Czaja M. J., Weiner F. R., Flanders K. C., Giambrone M. A., Wind R., Biempica L., Zern M. A. (1989): In vitro and in vivo association of transforming growth factor-beta 1 with hepatic fibrosis. J. Cell. Biol. 108, 2477-2482 doi:10.1083/jcb.108.6.2477
8. Demirbilek S., Akin M., Gurunluoglu K., Aydin N. E., Emre M. H., Taş E., Aksoy R. T., Ay S. (2006): The NF-kappaB inhibitors attenuate hepatic injury in bile duct ligated rats. Pediatr. Surg. Int. 22, 655-663 doi:10.1007/s00383-006-1721-9
9. Demirbilek S., Tas E., Gurunluoglu K., Akin M., Aksoy R. T., Emre M. H., Aydin N. E., Ay S., Ozatay N. (2007): Fluvastastin reduced liver injury in rat model of extrahepatic cholestasis. Pediatr. Surg. Int. 23, 155-162 doi:10.1007/s00383-006-1829-y
10. Dold S., Laschke M. W., Lavasani S., Menger M. D., Jeppsson B., Thorlacius H. (2009): Simvastatin protects against cholestasis-induced liver injury. Br. J. Pharmacol. 156, 466-474 doi:10.1111/j.1476-5381.2008.00043.x
11. Eken H., Ozturk H., Ozturk H., Buyukbayram H. (2006): Dose-related effects of dexamethasone on liver damage due to bile duct ligation in rats. World J. Gastroenterol. 12, 5379-5383
12. Fernández-Martínez E., Pérez-Alvarez V., Tsutsumi V., Shibayama M., Muriel P. (2006): Chronic bile duct obstruction induces changes in plasma and hepatic levels of cytokines and nitric oxide in the rat. Exp. Toxicol. Pathol. 58, 49-58 doi:10.1016/j.etp.2006.03.002
13. Fujiwara Y., Shimada M., Yamashita Y., Adachi E., Shirabe K., Takenaka K., Sugimachi K. (2001): Cytokine characteristics of jaundice in mouse liver. Cytokine 13, 188-191 doi:10.1006/cyto.2000.0781 (Pubitemid 32579310)
14. Gores G. J., Miyoshi H., Botla R., Aguilar H. I., Bronk S. E (1998): Induction of the mitochondrial permeability transition as a mechanism of liver injury during cholestasis: a potential role for mitochondrial proteases. Biochim. Biophys. Acta 1366, 167-175 doi:10.1016/S0005-2728(98)00111-X
15. Hattori T., Saito K., Takemura M., Ho H., Ohta H., Wada H., Sei Y., Kawamura M., Seishima M. (2009): Statin-induced Ca2+ release was increased in B lymphocytes in patients who showed elevated serum creatine kinase during statin treatment. J. Atheroscler. Thromb. 16, 870-877
16. Hissin P. J., Hilf R. (1976): A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal. Biochem. 74, 214-226 doi:10.1016/0003-2697(76)90326-2
17. Hogeboom G. H., Schneider W. C. (1951): Proteins of liver and hepatoma mitochondria. Science 113, 355-358 doi:10.1126/science.113.2935.355
18. Kand'ár R., Záková P., Lotková H., Kucera O., Cervinková Z. (2007): Determination of reduced and oxidized glutathione in biological samples using liquid chromatography with fluorimetric detection. J. Pharm. Biomed. Anal. 43, 1382-1387 doi:10.1016/j.jpba.2006.11.028
19. Karaman A., Iraz M., Kirimlioglu H., Karadag N., Tas E., Fadillioglu E. (2006): Hepatic damage in biliary-obstructed rats is ameliorated by leflunomide treatment. Pediatr. Surg. Int. 22, 701-708 doi:10.1007/s00383-006-1744-2
20. Kennedy J. A., Clements W. D., Kirk S. J., McCaigue M. D., Campbell G. R., Erwin P. J., Halliday M. I., Rowlands B. J. (1999): Characterization of the Kupffer cell response to exogenous endotoxin in a rodent model of obstructive jaundice. Br. J. Surg. 86, 628-633 doi:10.1046/j.1365-2168.1999.01114.x
21. Koeppel T. A., Trauner M., Baas J. C., Thies J. C., Schlosser S. F., Post S., Gebhard M. M., Herfarth C., Boyer J. L., Otto G. (1997): Extrahepatic biliary obstruction impairs microvascular perfusion and increases leukocyte adhesion in rat liver. Hepatology 26, 1085-1091 (Pubitemid 27509287)
22. Krähenbühl S., Talos Ch., Lauterburg B. H., Reichen J. (1995): Reduced antioxidative capacity in liver mitochondria from bile duct ligated rats. Hepatology 22, 607-612
23. Lacour S., Gautier J. C., Pallardy M., Roberts R. (2005): Cytokines as a potential biomarkers of liver toxicity. Cancer Biomark. 1, 29-39
24. Lázár G. Jr., Paszt A., Kaszaki J., Duda E., Szakács J., Tiszlavicz L., Boros M., Balogh A., Lázár G. (2002): Kupffer cell phagocytosis blockade decreases morbidity in endotoxemic rats with obstructive jaundice. Inflamm. Res. 51, 511-518 doi:10.1007/PL00012421
25. Lee J., Azzaroli F., Wang L., Soroka C. J., Gigliozzi A., Setchell K. D., Kramer W., Boyer J. L. (2001): Adaptive regulation of bile salt transporters in kidney and liver in obstructive cholestasis in the rat. Gastroenterology 121, 1473-1484 doi:10.1053/gast.2001.29608 (Pubitemid 33140464)
26. Lee S. K., Kim Y. C., Song S. B., Kim Y. S. (2010): Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis. Biochem. Biophys. Res. Commun. 391, 1592-1597 doi:10.1016/j.bbrc.2009.12.077
27. Liu T. Z., Lee K. T., Chern C. L., Cheng J. T., Stern A., Tsai L. Y. (2001): Free radical-triggered hepatic injury of experimental obstructive jaundice of rats involves overproduction of proinflammatory cytokines and enhanced activation of nuclear factor κB. Ann. Clin. Lab. Sci. 31, 383-390
28. Liu R. M., Gaston Pravia K. A. (2010): Oxidative stres and glutathione in TGF-β-mediated fibrogenesis. Free Radic. Biol. Med. 48, 1-15 doi:10.1016/j.freeradbiomed.2009.09.026
29. McRae M. P., Brouwer K. L., Kashuba A. D. (2003): Cytokine regulation of P-glycoprotein. Drug Metab. Rev. 35, 19-33 doi:10.1081/DMR-120018247
30. Lu S. C. (2009): Regulation of glutathione synthesis. Mol. Asp. Med. 30, 42-59 doi:10.1016/j.mam.2008.05.005
31. Muriel P., Suarez O. R. (1994): Role of lipid peroxidation in biliary obstruction in rat. J. Appl. Toxicol. 14, 423-426 doi:10.1002/jat.2550140607
32. Nadanaciva S., Dykens J. A., Bernal A., Capaldi R. A., Will Y. (2007): Mitochondrial impairement by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration. Toxicol. Appl. Pharmacol. 223, 277-287 doi:10.1016/j.taap.2007.06.003
33. Ogawa K., Suzuki H., Hirohashi T., Ishikawa T., Meier P. J., Hirose K., Akizawa T., Yoshioka M., Sugiyama Y. (2000): Characterization of inducible nature of MRP3 in rat liver. Am. J. Physiol. 278, G 438-446
34. Paumgartner G. (2006): Medical treatment of cholestatic liver diseases: From pathobiology to pharmacological targets. World Gastroenterol. 28, 4445-4451
35. Plebani M., Panozzo M. P., Basso D., De Paoli M., Biasin R., Infantolino D. (1999): Cytokines and the progression of liver damage in experimental bile duct ligation. Clin. Exp. Pharmacol. Physiol. 26, 358-363 doi:10.1046/j.1440- 1681.1999.03042.x
36. Purucker E., Winograd R., Roeb E., Matern S. (1998): Glutathione status in liver and plasma during development of biliary cirrhosis after bile duct ligation. Res. Exp. Med. (Berl.) 198, 167-174 doi:10.1007/s004330050100
37. Radilova H., Libra A., Holasova S., Safarova M., Viskova A., Kunc F., Buncek M. (2009): COX-1 is coupled with mPGES-1 and ABCC4 in human cervix cancer cells. Mol. Cell. Biochem. 330, 131-140 doi:10.1007/s11010-009-0126-1
38. Rolo A. P., Oliveira P. J., Moreno A. J., Palmeira C. M. (2001): Chenodeoxycholate is a potent inducer of the paermeability transition pore in rat liver mitochondria. Biosc. Rep. 21, 73-80 doi:10.1023/A:1010438202519
39. Rolo A. P., Oliveira P. J., Seiça R., Santos M. S., Moreno A. J., Palmeira C. M. (2002): Disruption of mitochondrial calcium homeostasis after chronic alpha-naphthylisothiocyanate administration: relevance for cholestasis. J. Invest. Med. 50, 193-200 doi:10.2310/6650.2002.33433
40. Saito J. M, Maher J. (2000): Bile duct ligation in rats induces biliary expression of cytokine-induced neutrophil chemoattractant. Gastroenterology 118, 1157-1168 doi:10.1016/S0016-5085(00)70369-6 (Pubitemid 30346993)
41. Soylu A. R., Aydogdu N., Basaran U. N., Altaner S., Tarcin O., Gedik N., Umit H., Tezel A., Dokmeci G., Baloglu H., Ture M., Kutlu K., Kaymak K. (2006): Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats. World J. Gastroenterol. 12, 6835-6841
42. Tahan G., Tarcin O., Tahan V., Eren F., Gedik N., Sahan E., Biberoglu N., Guzel S., Bozbas A., Tozun N., Yucel O. (2007): The effects of N-acetylcysteine on bile duct ligation-induced liver fibrosis in rats. Dig. Dis. Sci. 52, 3348-3354 doi:10.1007/s10620-006-9717-9
43. Tilg H., Wilmer A., Vogel W., Herold M., Nölchen B., Judmaier G., Huber C. (1992): Serum levels of cytokines in chronic liver diseases. Gastroenterology 103, 264-274
44. Tiitto L. H., Peltoniemi M. J., Kaarteenaho-Wiik R. L., Soini Y. M. Paakko, P. K., Sormunen R. T., Kinnula V. I. (2004): Cell-specific regulation of gamma-glutamylcysteine synthetase in human intersticial lung diseases. Hum. Pathol. 35, 832-839 doi:10.1016/j.humpath.2004.03.010
45. Vandesompele J., De Preter K., Pattyn F., Poppe B., Van Roy N., De Paepe A., Speleman F. (2002): Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 3: Research 0034
46. Velho J. A., Okanobo H., Degasperi G. R., Matsumoto M. Y., Alberici L. C., Cosso R. G., Oliveira H. C., Vercesi A. E. (2006): Statins induce calcium-dependent mitochondrial permeability transition. Toxicology 219, 124-132 doi:10.1016/j.tox.2005.11.007
47. Vendemiale G., Grattagliano I., Altomare E., Serviddio G., Portincasa P., Prigigallo F., Palasciano G. (2001): Mitochondrial oxidative damage and myocardial fibrosis in rats chronically intoxicated with moderate doses of ethanol. Toxicol. Lett. 123, 209-216 doi:10.1016/S0378-4274(01)00401-5
48. Yang H., Ramani K., Xia M., Ko K. S., Li T. W., Oh P., Li J., Lu S. C. (2009): Dysregulation of glutathione synthesis during cholestasis in mice: molecular mechanisms and therapeutic implications. Hepatology 49, 1982-1991 doi:10.1002/hep.22908
49. Yilmaz M., Ara C., Isik B., Karadag N., Yilmaz S., Polat A., Coban S., Duzova H. (2007): The effect of aminoguanidine against cholestatic liver injury in rats. Cell Biochem. Funct. 25, 625-632 doi:10.1002/cbf.1359
50. Younes R. N., Poggetti R. S., Fontes B., Itinoshe M. M., Yoshida V. M., Carvalho M. E., Birolini D. (2007): Obstructive jaundice induces early depression of mitochondrial respiration in rat hepatocytes. Acta Cir. Brasil. 22, 251-254 doi:10.1590/S0102-86502007000400004
51. Zollner G., Trauner M. (2006): Molecular mechanisms of cholestasis. Wien Med. Wochenschr. 156, 380-385 doi:10.1007/s10354-006-0312-7