Kupffer cell phagocytosis blockade decreases morbidity in endotoxemic rats with obstructive jaundice

Inflammation Research

Volumn 51, Issue 10, 2002, Pages 511-518

  Lazar Jr G ^a   Paszt, A ^a   Kaszaki, J ^a   Duda, E ^c   Szakacs J ^b   Tiszlavicz, L ^b   Boros, M ^a   Balogh, A ^a   Lazar G ^b  

^a UNIVERSITY OF SZEGED   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

^c INSTITUTE OF BIOCHEMISTRY   (Hungary)

Author keywords

Biliary obstruction; Gadolinium chloride; Jaundice; Macrophage; Sepsis

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; ENDOTOXIN; GADOLINIUM CHLORIDE; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; GADOLINIUM; PEROXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENDOTOXEMIA; HISTOLOGY; KUPFFER CELL; LETHALITY; LUNG INJURY; MACROPHAGE; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OBSTRUCTIVE JAUNDICE; PHAGOCYTOSIS; RAT; ANIMAL; BIOSYNTHESIS; BLOOD; CHOLESTASIS; DRUG EFFECT; IMMUNOLOGY; LIVER; LIVER FUNCTION TEST; LUNG; METABOLISM; PATHOLOGY; SURVIVAL; WISTAR RAT;

ADENOSINE TRIPHOSPHATE; ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CHOLESTASIS; CYTOKINES; ENDOTOXEMIA; GADOLINIUM; INTERLEUKIN-6; KUPFFER CELLS; LIVER; LIVER FUNCTION TESTS; LUNG; MALE; PEROXIDASE; PHAGOCYTOSIS; RATS; RATS, WISTAR; SURVIVAL ANALYSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036812062     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/pl00012421     Document Type: Article

References (43)

1. Pain JA, Cahill CJ, Bailey ME. Perioperative complications in obstructive jaundice: Therapeutic considerations. Br J Surg 1985; 72: 942-5.
2. Kocsár L, Bertók L, Verteresz V. Effect of bile acids on the intestinal absorption of endotoxin in rats. J Bacteriol 1969; 100: 220-8.
3. Bailey ME. Endotoxin bile salts, and renal function in obstructive jaundice. Br J Surg 1976; 63: 774-8.
4. Katz S, Gross K, Plager D, Cikrit D, Rosenthal R, Grosfeld JL et al. Adverse effect of endotoxin on hepatic bacterial clearance. Gastroenterology 1983; 84: 1378-81.
5. Van Bossuyt H, Desmaretz G, Gaeta GB, Wisse E. The role of bile acids in the development of endotoxaemia during obstructive jaundice in the rat. J Hepatol 1990; 10: 274-9.
6. Crofton RW, Martino MC, Diesselhof-den Dulk MMC, Van Furth R. The origin, kinetics and characteristic of the Kupffer cells in the normal steady state. J Exp Med 1978; 148: 1-17.
7. Mathison JC, Ulevits R. The clearance, tissue distribution and cellular localization of intravenously injected lipopolisacharide in rabbits. J Immunol 1979; 123: 2133-243.
8. Border JR. Hypothesis: Sepsis, multiple organ failure, and the macrophage. Arch Surg 1986; 123: 285-6.
9. Scott-Conner CEH, Grogan JB. The pathophysiology of biliary obstruction and its effect on phagocytic and immune function. J Surg Res 1994; 57: 316-36.
10. Kirton OC, Jones R, Zapol WM, Reid L. The development of a model subacute lung injury after intra-abdominal infection. Surgery 1984; 96: 384-94.
11. Lázár G. The reticuloendothelial-blocking effect of rare earth metals in rats. J Reticuloendothelial Soc 1973; 13: 231-7.
12. Husztik E, Lázár G, Párducz A. Electron microscopic study of Kupffer-cell phagocytosis blockade induced by gadolinium chloride. Brit J Exp Pathol 1980; 61: 624-30.
13. Barriault C, Audet M, Yousef IM, Tuchweber B. Effect of agents which modify reticuloendothelial system function on acute phalloidin-induced lethality and hepatotoxicity in mice. Toxicol Appl Pharmacol 1995; 131: 206-15.
14. Suzika S, Toledo-Pereyra LH, Ridriguez F, Lopez F. Role of Kupffer cells in neutrophil activation and infiltration following total hepatic ischaemia and reperfusion. Circ Shock 1994; 42: 204-9.
15. Lázár G, Husztik E, Lázár G. Effects of endotoxin and gadolinium chloride in acute septic peritonitis end septic shock in rats. Prog Clin Biol Res 1986; 236B: 323-8.
16. Aggarwal BB, Kohr WJ, Hass PE. Human tumor necrosis factor production, purification, and characterization. J Biol Chem 1985; 260: 2345-54.
17. Kuebler WM, Abels C, Schuerer L, Goetz AE. Measurement of neutrophil content in brain and lung tissue by a modified myeloperoxidase assay. Int J Microcirc 1996; 16: 89-97.
18. Lamprecht W, Trautschold I. Adenosine 5′-triphophate determination with hexokinase and glucose 6-phosphate dehydrogenase. In: Bergmeyer HU. editor. Methods of Enzymatic Analysis. Verlag Chemie, Weinheim and Academic Press, New York, 1976: 2101-9.
19. Diamond T, Dolan S, Thompson RLE, Rowlands BJ. Development and reversal of endotoxaemia and ETX related death in obstructive jaundice. Surgery 1990; 108: 370-5.
20. Grey JD, Krukowski ZH, Matheson NA. Surgical morbidity and mortality in one hundred and twenty patients with obstructive jaundice. Br J Surg 1988; 75: 16-9.
21. Clements WDB, Halliday MI, McCaigue MD, Barclay RG, Rowlands BJ. Effects of extrahepatic obstructive jaundice on Kupffer cell clearance capacity. Arch Surg 1993; 128: 200-5.
22. Clements WDB, Erwin P, McCaigue MD, Halliday I., Barclay GR, Rowlands BJ. Conclusive evidence of endotoxaemia in biliary obstruction. Gut 1998; 42: 293-9.
23. Hoffmann R, Grewe M, Estler HC, Schulze-Specking A, Decker K. Regulation of tumor necrosis factor-alpha-mRNA synthesis and distribution of tumor necrosis factor-alpha-mRNA synthesizing cells in rat liver during experimental endotoxaemia. J Hepatol 1994; 20: 122-8.
24. Bemelmans MHA, Gouma DJ, Greve JW, Buurman WA. Cytokines tumor necrosis factor and interleukin-6 in experimental biliary obstruction in mice. Hepatology 1992; 15: 1132-6.
25. Puntis MCA, Jiang WG. Plasma cytokine levels and monocyte activation in patients with obstructive jaundice. J Gastroenterol Hepatol 1996; 11: 7-13.
26. O'Neil S, Hunt J, Filkins J, Gamelli R. Obstructive jaundice in rats results in exaggerated hepatic production of tumor necrosis factor-alpha and systemic and tissue tumor necrosis factor-alpha levels after endotoxin. Surgery 1997; 122: 7281-6.
27. Decker K. Biologically active products of stimulated liver macrophages (Kupffer cells). Eur J Biochem 1990; 192: 196-261.
28. Ito Y, Machen NW, Urbaschek R, McCuskey RS. Biliary obstruction exacerbates the hepatic microvascular inflammatory response to edotoxin. Shock 2000; 14: 599-604.
29. Koeppel TA, Trauner M, Baas JC, Thies JC, Schlosser SF, Post S et al. Extrahepatic biliary obstruction impairs microvascular perfusion and increases leukocyte adhesion in rat liver. Hepatology 1997; 26: 1085-91.
30. Chang S, O'Hara N. Chronic biliary obstruction induces pulmonary intravascular phagocytosis and endotoxin sensitivity in rats. J Clin Invest 1994; 94: 2009-19.
31. Spivey JR, Bronk SF, Gores GJ. Glycochenodeoxycholate-induced lethal cell injury in rat hepatocytes. J Clin Invest 1993; 92: 17-24.
32. Krahenbuhl S, Talos C, Fischer S, Rechen J. Toxicity of bile acids on the electron transport chain of isolated rat liver mitochondria. Hepatology 1994; 19: 471-9.
33. Jaeschke H, Farhood A. Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver. Am J Physiol 1991; 260: G355-62.
34. Shiraton Y, Tanaka M, Hai K, Kawase T, Shiina S, Sugimoto T. Role of edotoxin-responsive macrophages in hepatic injury. Hepatology 1990; 11: 183-92.
35. Tóth CA, Thomas P. Liver endocytosis and Kupffer cells. Hepatology 1992; 16: 255-66.
36. Vollmar B, Rüttinger D, Wanner GA, Leiderer R, Menger MD. Modulation of Kupffer cell activity by gadolinium chloride in endotoxemic rats. Shock 1996; 6: 434-41.
37. Schauer RJ, Bilzer M, Kalmuk S, Gerbes AL, Leiderer R, Schildberg FW, Messmer K. Microcirculatory failure after rat liver transplantation is related to Kupffer cell-derived oxidant stress but not involved in early graft dysfunction. Transplantation 2001; 72: 1692-9.
38. Yamaga M, Evans CH. Suppression of mitogen-antigen induced lymphocyte proliferation by lanthanides. Experientia 1989; 45: 1129-36.
39. Lázár G Jr, Lázár G, Kaszaki J, Oláh J, Kiss I, Husztik E. Inhibition of anaphylactic shock by gadolinium chloride-induced Kupffer cell blockade. Agents Actions 1994; 41: C97-8.
40. Iimuro Y, Yamamoto M, Kohno H, Itakura J, Fujii H, Matsumoto Y. Blockade of liver macrophage by gadolinium blockade reduces lethality in endotoxic rats: Analysis of mechanism of lethality in endotoxemia. J Leukocyte Biol 1994; 55: 723-31.
41. Jenei B, Lázár G, Bartha K, Medgyesi GA. Hypotensive action of IgG preparations containing aggregates is suppressed by PAF-receptor antagonist BN 52021 and gadolinium chloride (an agent blocking Kupffer cell function). Agents Actions 1991; 32: 333-5.
42. Lázár G Jr, Farkas Gy, Csanádi J, Lázár G. Gadolinium chloride-induced macrophage blockade prevents rejection of human insulinoma cell xenograft in rats. Transplantation 1997; 63: 729-32.
43. Jorgensen PF, Götzinger P, Scholz T, Gundersen Y, Sautner T, Függer R et al. The role of Kupffer cell inhibition in porcine endotoxemia. Shock 2001; 16: 466-72.