Hepatic damage in biliary-obstructed rats is ameliorated by leflunomide treatment

Pediatric Surgery International

Volumn 22, Issue 9, 2006, Pages 701-708

  Karaman, Abdurrahman ^a   Iraz, Mustafa ^a   Kirimlioglu, Hale ^a   Karadag, Nese ^a   Tas, Erkan ^a   Fadillioglu, Ersin ^b  

^a INONU UNIVERSITY   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Bile duct ligation; Extrahepatic cholestasis; Impaired bile flow; Leflunomide; Lipid peroxidation; Oxidative stress

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIINFLAMMATORY AGENT; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CARBONYL DERIVATIVE; CATALASE; HYDROXYPROLINE; IMMUNOSUPPRESSIVE AGENT; LEFLUNOMIDE; MALONALDEHYDE; MYELOPEROXIDASE; NITRIC OXIDE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; BILE DUCT OBSTRUCTION; CHOLESTASIS; CONTROLLED STUDY; DISEASE SEVERITY; DRUG INHIBITION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FEMALE; HISTOPATHOLOGY; LEUKOCYTE ACTIVATION; LIVER FIBROSIS; LIVER INJURY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANALYSIS OF VARIANCE; ANIMALS; CHOLESTASIS, EXTRAHEPATIC; FEMALE; IMMUNOSUPPRESSIVE AGENTS; ISOXAZOLES; LIPID PEROXIDATION; OXIDATIVE STRESS; RATS; RATS, WISTAR;

EID: 33748421528     PISSN: 01790358     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00383-006-1744-2     Document Type: Article

References (44)

1. Hagymasi K, Kocsis I, Lugasi A, Feher J, Blazovics A (2002) Extrahepatic biliary obstruction: can silymarin protect liver function? Phytother Res 16:78-80
2. Nobili V, Marcellini M, Giovannelli L et al (2004) Association of serum interleukin-8 levels with the degree of fibrosis in infants with chronic liver disease. J Pediatr Gastroenterol Nutr 39:540-544
3. Shinkai M, Shinkai T, Puri P, Stringer MD (2006) Elevated expression of IL2 is associated with increased infiltration of CD8+ T cells in biliary atresia. J Pediatr Surg 41:300-305
4. Harty MW, Huddleston HM, Papa EF et al (2005) Repair after cholestatic liver injury correlates with neutrophil infiltration and matrix metalloproteinase 8 activity. Surgery 138:313-320
5. Saito JM, Maher JJ (2000) Bile duct ligation in rats induces biliary expression of cytokine-induced neutrophil chemoattractant. Gastroenterology 118:1157-1168
6. Kullak-Ublick GA, Meier PJ (2000) Mechanisms of cholestasis. Clin Liver Dis 4:357-385
7. Gedik N, Kabasakal L, Sehirli O et al (2005) Long-term administration of aqueous garlic extract (AGE) alleviates liver fibrosis and oxidative damage induced by biliary obstruction in rats. Life Sci 76:2593-2606
8. Muriel P, Moreno MG et al (2004) Effects of silymarin and vitamins E and C on liver damage induced by prolonged biliary obstruction in the rat. Basic Clin Pharmacol Toxicol 94:99-104
9. Sokol RJ, Winklhofer-Roob BM, Devereaux MW, McKim JM Jr (1995) Generation of hydroperoxides in isolated rat hepatocytes and hepatic mitochondria exposed to hydrophobic bile acids. Gastroenterology 109:1249-1256
10. Pastor A, Collado PS, Almar M, Gonzales-Gallego J (1997) Antioxidant enzyme status in biliary obstructed rats: effects of N-acetylcysteine. J Hepatol 27:363-370
11. Karaman A, Demirbilek S, Sezgin N et al (2003) Protective effect of polyunsaturated phosphatidylcholine on liver damage induced by biliary obstruction in rats. J Pediatr Surg 38:1341-1347
12. Karaman A, Fadillioglu E, Turkmen E et al (2006) Protective effects of leflunomide against ischemia-reperfusion injury of the rat liver. Pediatr Surg Int 22:428-434
13. Imose M, Nagaki M, Kimura K et al (2004) Leflunomide protects from T-cell-mediated liver injury in mice through inhibition of nuclear factor kappaB. Hepatology 40:1160-1169
14. Bartlett RR, Anagnostopulos H, Zielinski T, Mattar T, Schleyerbach R (1993) Effects of leflunomide on immune responses and models of inflammation. Springer Semin Immunopathol 14:381-394
15. Silverman E, Spiegel L, Hawkins D et al (2005) Long-term open-label preliminary study of the safety and efficacy of leflunomide in patients with polyarticular-course juvenile rheumatoid arthritis. Arthritis Rheum 52:554-562
16. 4 in rats. Acta Pharmacol Sin 25:915-920
17. Elkayam O, Yaron I, Shirazi I et al (2003) Active leflunomide metabolite inhibits interleukin 1b, tumour necrosis factor a, nitric oxide, and metalloproteinase-3 production in activated human synovial tissue cultures. Ann Rheum Dis 62:440-443
18. Irmak MK, Koltuksuz U, Kutlu NO et al (2001) The effect of caffeic acid phenethyl ester on ischemia-reperfusion injury in comparison with alpha-tocopherol in rat kidneys. Urol Res 29:190-193
19. Lowry O, Rosenbraugh N, Farr L, Rondall R (1951) Protein measurement with the folin-phenol reagent. J Biol Chem 183:265-275
20. Sun Y, Oberley LW, Li Y (1988) A simple method for clinical assay of superoxide dismutase. Clin Chem 34:497-500
21. Aebi H (1974) Catalase. In: Bergmeyer HU (ed) Methods of enzymatic analysis. Academic, New York, pp 673-677
22. Cortas NK, Wakid NW (1990) Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method. Clin Chem 36:1440-1443
23. Wei H, Frenkel K (1993) Relationship of oxidative events and DNA oxidation in SENCAR mice to in vivo promoting activity of phorbol ester-type tumor promoters. Carcinogenesis 14:1195-1201
24. Esterbauer H, Cheeseman KH (1990) Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. In: Packer L, Glazer AN (eds) Methods in enzymology. Oxygen radicals in biological systems, vol 186. Academic, California, pp 407-421
25. Levine RL, Garland D, Oliver CN, Amici A et al (1990) Determination of carbonyl content in oxidatively modified proteins. In: Packer L, Glazer AN (eds) Methods in enzymology. Oxygen radicals in biological systems, vol 186. Academic, California, pp 464-478
26. Woessner JB (1961) The determination of hydroxyproline in tissue and protein samples containing small proportions of this amino acid. Arch Biochem Biophys 93:440-447
27. Ishak K, Baptista A, Bianchi L et al (1995) Histological grading and staging of chronic hepatitis. J Hepatol 22:696-699
28. Tracy TF Jr, Dillon P, Fox ES et al (1996) The inflammatory response in pediatric biliary disease: macrophage phenotype and distribution. J Pediatr Surg 31:121-126
29. Rodriguez-Garay EA (2003) Cholestasis: human disease and experimental animal models. Ann Hepatol 2:150-158
30. Strazzabosco M, Fabris L, Spirli C (2005) Pathophysiology of cholangiopathies. J Clin Gastroenterol 39:90-102
31. Lazaridis KN, Strazzabosco M, LaRusso NF (2004) Pathophysiology of cholangiopathies. Gastroenterology 127:1565-1577
32. Yao HW, Li J, Jin Y (2003) Effect of leflunomide on immunological liver injury in mice. World J Gastroenterol 9:320-323
33. Manna SK, Aggarwal BB (1999) Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-κB activation and gene expression. J Immunol 162:2095-2102
34. Dahm IJ, Hewett JA, Rooth RA (1998) Bile and bile salts potentiate superoxide anion released from activated rat peritoneal neutrophils. Toxicol Appl Pharmacol 95:82-92
35. Krahenbuhl S, Talos Ch, Lauterburg BH, Reichen J (1995) Reduced antioxidative capacity in liver mitochondria from bile duct ligated rats. Hepatology 22:607-612
36. Roeb E, Purucker E, Gartung C et al (2003) Effect of glutathione depletion and hydrophilic bile acids on hepatic acute phase reaction in rats with extrahepatic cholestasis. Scand J Gastroenterol 38:878-885
37. Mayoral P, Criado M, Hidalgo F et al (1999) Effects of chronic nitric oxide activation or inhibition on early hepatic fibrosis in rats with bile duct ligation. Clin Sci (Lond) 96:297-305
38. Nussler AK, Di Silvio M, Liu ZZ et al (1995) Further characterization and comparison of inducible nitric oxide synthase in mouse, rat, and human hepatocytes. Hepatology 21:1552-1560
39. Laszlo F, Whittle BJ, Evans SM, Moncada S (1995) Association of microvascular leakage with induction of nitric oxide synthase: effects of nitric oxide synthase inhibitors in various organs. Eur J Pharmacol 283:47-53
40. Marley R, Holt S, Fernando B et al (1999) Lipoic acid prevents development of the hyperdynamic circulation in anesthetized rats with biliary cirrhosis. Hepatology 29:1358-1363
41. Jankovic V, Samardzic T, Stosic GS et al (2000) Cell-specific inhibition of inducible nitric oxide synthase activation by leflunomide. Cell Immunol 199:73-80
42. Miljkovic D, Samardzic T, Stojkovic MM et al (2001) Leflunomide inhibits activation of inducible nitric oxide synthase in rat astrocytes. Brain Res 889:331-338
43. Lang A, Schoonhoven R, Tuvia S et al (2000) Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells. J Hepatol 33:49-58
44. Chojkier M, Houglum K, Lee KS, Buck M (1998) Long and short-term D-a-tocopherol supplementation inhibits liver collagen a1(I) gene expression. Am J Physiol 275:1480-1485