Dopamine D4 receptor oligomerization - Contribution to receptor biogenesis

FEBS Journal

Volumn 278, Issue 8, 2011, Pages 1333-1344

  Van Craenenbroeck, Kathleen ^a,e   Borroto Escuela, Dasiel O ^b   Romero Fernandez, Wilber ^b   Skieterska, Kamila ^a   Rondou, Pieter ^a   Lintermans, Béatrice ^a   Vanhoenacker, Peter ^a,d   Fuxe, Kjell ^b   Ciruela, Francisco ^c   Haegeman, Guy ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF BARCELONA   (Spain)

^d ActoGeniX NV   (Belgium)

^e GHENT UNIVERSITY   (Belgium)

Author keywords

bioluminescence resonance energy transfer; dimerization; dopamine D 4 receptor; G protein coupled receptors; receptor biogenesis

Indexed keywords

DIMER; DOPAMINE 4 RECEPTOR; POLYMER;

ARTICLE; BINDING AFFINITY; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CELL STRAIN HEK293; CELL SURFACE; CHO CELL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; MOLECULAR WEIGHT; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN POLYMORPHISM; PROTEIN SYNTHESIS; PROTEIN TARGETING; PROTEIN TRANSPORT; QUALITY CONTROL; WESTERN BLOTTING; WILD TYPE; CHEMISTRY; DIMERIZATION; LUMINESCENCE; METABOLISM;

DIMERIZATION; ENDOPLASMIC RETICULUM; HEK293 CELLS; HUMANS; LUMINESCENT MEASUREMENTS; PROTEIN FOLDING; RECEPTORS, DOPAMINE D4;

EID: 79953675996     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2011.08052.x     Document Type: Article

References (38)

1. Milligan G, (2009) G protein-coupled receptor hetero-dimerization: contribution to pharmacology and function. Br J Pharmacol 158, 5-14.
2. Galvez T, Duthey B, Kniazeff J, Blahos J, Rovelli G, Bettler B, Prezeau L, &, Pin JP, (2001) Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function. EMBO J 20, 2152-2159. (Pubitemid 32410585)
3. Margeta-Mitrovic M, Jan YN, &, Jan LY, (2000) A trafficking checkpoint controls GABA(B) receptor heterodimerization. Neuron 27, 97-106.
4. Salahpour A, Angers S, Mercier JF, Lagace M, Marullo S, &, Bouvier M, (2004) Homodimerization of the beta2-adrenergic receptor as a prerequisite for cell surface targeting. J Biol Chem 279, 33390-33397. (Pubitemid 39062987)
5. Schmauss C, Haroutunian V, Davis KL, &, Davidson M, (1993) Selective loss of dopamine D3-type receptor mRNA expression in parietal and motor cortices of patients with chronic schizophrenia. Proc Natl Acad Sci USA 90, 8942-8946. (Pubitemid 23306427)
6. Karpa KD, Lin R, Kabbani N, &, Levenson R, (2000) The dopamine D3 receptor interacts with itself and the truncated D3 splice variant d3nf: D3-D3nf interaction causes mislocalization of D3 receptors. Mol Pharmacol 58, 677-683.
7. Callier S, Snapyan M, Le Crom S, Prou D, Vincent JD, &, Vernier P, (2003) Evolution and cell biology of dopamine receptors in vertebrates. Biol Cell 95, 489-502. (Pubitemid 37441640)
8. Zawarynski P, Tallerico T, Seeman P, Lee SP, O'Dowd BF, &, George SR, (1998) Dopamine D2 receptor dimers in human and rat brain. FEBS Lett 441, 383-386. (Pubitemid 29065320)
9. Wang M, Pei L, Fletcher PJ, Kapur S, Seeman P, &, Liu F, (2010) Schizophrenia, amphetamine-induced sensitized state and acute amphetamine exposure all show a common alteration: increased dopamine D2 receptor dimerization. Mol Brain 3, 25.
10. Strange PG, (2005) Oligomers of D2 dopamine receptors: evidence from ligand binding. J Mol Neurosci 26, 155-160.
11. Scarselli M, Novi F, Schallmach E, Lin R, Baragli A, Colzi A, Griffon N, Corsini GU, Sokoloff P, Levenson R, et al. (2001) D2/D3 dopamine receptor heterodimers exhibit unique functional properties. J Biol Chem 276, 30308-30314.
12. Maggio R, &, Millan MJ, (2010) Dopamine D2-D3 receptor heteromers: pharmacological properties and therapeutic significance. Curr Opin Pharmacol 10, 100-107.
13. Aizman O, Brismar H, Uhlen P, Zettergren E, Levey AI, Forssberg H, Greengard P, &, Aperia A, (2000) Anatomical and physiological evidence for D1 and D2 dopamine receptor colocalization in neostriatal neurons. Nat Neurosci 3, 226-230. (Pubitemid 30140783)
14. George SR, &, O'Dowd BF, (2007) A novel dopamine receptor signaling unit in brain: heterooligomers of D1 and D2 dopamine receptors. ScientificWorldJournal 7, 58-63.
15. Rashid AJ, So CH, Kong MM, Furtak T, El-Ghundi M, Cheng R, O'Dowd BF, &, George SR, (2007) D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum. Proc Natl Acad Sci USA 104, 654-659. (Pubitemid 46123080)
16. So CH, et al. (2005) D1 and D2 dopamine receptors form heterooligomers and cointernalize after selective activation of either receptor. Mol Pharmacol 68, 568-578. (Pubitemid 41206010)
17. Fiorentini C, Busi C, Gorruso E, Gotti C, Spano P, &, Missale C, (2008) Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization. Mol Pharmacol 74, 59-69. (Pubitemid 351872159)
18. Marcellino D, et al. (2008) Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum. J Biol Chem 283, 26016-26025.
19. Canals M, et al. (2003) Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer. J Biol Chem 278, 46741-46749. (Pubitemid 37452253)
20. Hillion J, et al. (2002) Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors. J Biol Chem 277, 18091-18097. (Pubitemid 34967623)
21. Kearn CS, Blake-Palmer K, Daniel E, Mackie K, &, Glass M, (2005) Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: a mechanism for receptor cross-talk? Mol Pharmacol 67, 1697-1704. (Pubitemid 40594170)
22. Marcellino D, et al. (2008) Antagonistic cannabinoid CB1/dopamine D2 receptor interactions in striatal CB1/D2 heteromers. A combined neurochemical and behavioral analysis. Neuropharmacology 54, 815-823.
23. Navarro G, et al. (2008) Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer. ScientificWorldJournal 8, 1088-1097.
24. Carriba P, et al. (2008) Detection of heteromerization of more than two proteins by sequential BRET-FRET. Nat Methods 5, 727-733.
25. Cabello N, et al. (2009) Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher-order oligomers in living cells. J Neurochem 109, 1497-1507.
26. Baragli A, Alturaihi H, Watt HL, Abdallah A, &, Kumar U, (2007) Heterooligomerization of human dopamine receptor 2 and somatostatin receptor 2 Co-immunoprecipitation and fluorescence resonance energy transfer analysis. Cell Signal 19, 2304-2316. (Pubitemid 47361686)
27. Rocheville M, Lange DC, Kumar U, Patel SC, Patel RC, &, Patel YC, (2000) Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity. Science 288, 154-157. (Pubitemid 30203051)
28. Rondou P, Haegeman G, &, Van Craenenbroeck K, (2010) The dopamine D4 receptor: biochemical and signalling properties. Cell Mol Life Sci 67, 1971-1986.
29. Van Craenenbroeck K, Clark SD, Cox MJ, Oak JN, Liu F, &, Van Tol HH, (2005) Folding efficiency is rate-limiting in dopamine D4 receptor biogenesis. J Biol Chem 280, 19350-19357. (Pubitemid 41379642)
30. Van Craenenbroeck K, Gellynck E, Lintermans B, Leysen JE, Van Tol HH, Haegeman G, &, Vanhoenacker P, (2006) Influence of the antipsychotic drug pipamperone on the expression of the dopamine D4 receptor. Life Sci 80, 74-81. (Pubitemid 44809299)
31. Rondou P, Haegeman G, Vanhoenacker P, &, Van Craenenbroeck K, (2008) BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase. J Biol Chem 283, 11083-11096.
32. Han Y, Moreira IS, Urizar E, Weinstein H, &, Javitch JA, (2009) Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation. Nat Chem Biol 5, 688-695.
33. Van Craenenbroeck K, Vanhoenacker P, Leysen JE, &, Haegeman G, (2001) Evaluation of the tetracycline- and ecdysone-inducible systems for expression of neurotransmitter receptors in mammalian cells. Eur J Neurosci 14, 968-976. (Pubitemid 35463770)
34. Mercier JF, Salahpour A, Angers S, Breit A, &, Bouvier M, (2002) Quantitative assessment of beta 1- and beta 2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer. J Biol Chem 277, 44925-44931. (Pubitemid 36159089)
35. Fonseca JM, &, Lambert NA, (2009) Instability of a class a G protein-coupled receptor oligomer interface. Mol Pharmacol 75, 1296-1299.
36. Dorsch S, Klotz KN, Engelhardt S, Lohse MJ, &, Bunemann M, (2009) Analysis of receptor oligomerization by FRAP microscopy. Nat Methods 6, 225-230.
37. Spooren A, et al. (2010) Resistance of the dopamine D4 receptor to agonist-induced internalization and degradation. Cell Signal 22, 600-609.
38. Borroto-Escuela DO, Garcia-Negredo G, Garriga P, Fuxe K, &, Ciruela F, (2010) The M(5) muscarinic acetylcholine receptor third intracellular loop regulates receptor function and oligomerization. Biochim Biophys Acta 1803, 813-825.