Global gene expression profiling of endothelium exposed to heme reveals an organ-specific induction of cytoprotective enzymes in sickle cell disease

PLoS ONE

Volumn 6, Issue 3, 2011, Pages

  Ghosh, Samit ^a   Tan, Fang ^a   Yu, Tianwei ^a   Li, Yuhua ^a   Adisa, Olufolake ^a   Mosunjac, Mario ^a   Ofori Acquah, Solomon F ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Children's Healthcare of Atlanta   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEME OXYGENASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE QUINONE OXIDOREDUCTASE 1; UNCLASSIFIED DRUG; HEME; NQO1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ANALYSIS; ENZYME INDUCTION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; HUMAN TISSUE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN FUNCTION; RNA ISOLATION; SICKLE CELL ANEMIA; UNINDEXED SEQUENCE; ANIMAL; CELL CULTURE; DNA MICROARRAY; DRUG EFFECT; ENDOTHELIUM; GENETICS; HEART MUSCLE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LUNG; METABOLISM; METHODOLOGY; POLYMERASE CHAIN REACTION;

MUS MUSCULUS;

ANEMIA, SICKLE CELL; ANIMALS; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM; GENE EXPRESSION PROFILING; HEME; HEME OXYGENASE-1; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LUNG; MICE; MYOCARDIUM; NAD(P)H DEHYDROGENASE (QUINONE); OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION;

EID: 79953665391     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018399     Document Type: Article

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