Nucleotide binding switches the information flow in RAS GTPases

PLoS Computational Biology

Volumn 7, Issue 3, 2011, Pages

  Raimondi, Francesco ^a   Portella, Guillem ^b   Orozco, Modesto ^b,c   Fanelli, Francesca ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b BARCELONA SUPERCOMPUTING CENTER   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING ENERGY; HYDROLYSIS; MOLECULAR DYNAMICS; POSITIVE IONS; PROTEINS; SIGNAL TRANSDUCTION; SOLVENTS;

AMINO-ACIDS; EXCHANGE FACTORS; G PROTEIN; GTPASES; GUANINE; GUANINE NUCLEOTIDE-BINDING PROTEINS; INFORMATION FLOWS; NUCLEOTIDE BINDING; SMALL G PROTEINS; SOLVENT EXPOSURE;

NUCLEOTIDES;

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR 1; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; RAS PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TRANSDUCIN;

ALLOSTERISM; ARTICLE; CONTROLLED STUDY; COUPLING FACTOR; GENE SWITCHING; HYDROLYSIS; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; NUCLEOTIDE BINDING SITE; PHYSIOLOGICAL PROCESS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; BINDING SITE; BIOLOGY; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; PLIABILITY; PRINCIPAL COMPONENT ANALYSIS; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; BINDING SITES; COMPUTATIONAL BIOLOGY; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PLIABILITY; PRINCIPAL COMPONENT ANALYSIS; PROTEIN STRUCTURE, TERTIARY; RAS PROTEINS; SEQUENCE ALIGNMENT;

EID: 79953648564     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1001098     Document Type: Article

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