Good COP1 or bad COP1? In vivo veritas

Journal of Clinical Investigation

Volumn 121, Issue 4, 2011, Pages 1263-1265

  Wei, Wenyi ^a   Kaelin Jr , William G ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ACTIVATING TRANSCRIPTION FACTOR; BINDING PROTEIN; CULLIN; CULLIN 4; DNA DAMAGE BINDING PROTEIN 1; MEMBRANE PROTEIN; MESSENGER RNA; METASTASIS ASSOCIATED PROTEIN 1; MYC PROTEIN; PROTEIN C FOS; PROTEIN C JUN; PROTEIN P53; PROTEIN RBX1; PROTEIN TORC2; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR JUNB; TRANSCRIPTION FACTOR JUND; TRANSCRIPTION FACTOR PEA3; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE COP1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARABIDOPSIS; CARBOXY TERMINAL SEQUENCE; CELL CYCLE PROGRESSION; CELL FUNCTION; CELL GROWTH; CELL PROLIFERATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; GENE AMPLIFICATION; HUMAN; MISSENSE MUTATION; NONHUMAN; NOTE; PHOTOMORPHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

ANIMALS; ENZYME STABILITY; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MICE, MUTANT STRAINS; MODELS, BIOLOGICAL; NEOPLASMS; NUCLEAR PROTEINS; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES;

EID: 79953320003     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI57080     Document Type: Note

References (20)

1. Deshaies RJ, Joazeiro CA. RING domain E3 ubiquitin ligases. Annu Rev Biochem. 2009;78:399-434.
2. Schwechheimer C, Deng XW. The COP/DET/FUS proteins-regulators of eukaryotic growth and development. Semin Cell Dev Biol. 2000;11(6):495-503. (Pubitemid 32118755)
3. Osterlund MT, Hardtke CS, Wei N, Deng XW. Targeted destabilization of HY5 during light-regulated development of Arabidopsis. Nature. 2000;405(6785):462- 466. (Pubitemid 30367423)
4. Yi C, Deng XW. COP1 - from plant photomorphogenesis to mammalian tumorigenesis. Trends Cell Biol. 2005;15(11):618-625. (Pubitemid 41619426)
5. Dornan D, et al. The ubiquitin ligase COP1 is a critical negative regulator of p53. Nature. 2004;429(6987):86-92. (Pubitemid 38620556)
6. Wertz IE, et al. Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science. 2004;303(5662):1371-1374. (Pubitemid 38269430)
7. Savio MG, Rotondo G, Maglie S, Rossetti G, Bender JR, Pardi R. COP1D, an alternatively spliced constitutive photomorphogenic-1 (COP1) product, stabilizes UV stress-induced c-Jun through inhibition of fulllength COP1. Oncogene. 2008;27(17):2401-2411. (Pubitemid 351521098)
8. Qi L, et al. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science. 2006;312(5781):1763-1766. (Pubitemid 43962887)
9. Li DQ, et al. E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1. Proc Natl Acad Sci U S A. 2009;106(41):17493-17498.
10. Kato S, Ding J, Pisck E, Jhala US, Du K. COP1 functions as a FoxO1 ubiquitin E3 ligase to regulate FoxO1-mediated gene expression. J Biol Chem. 2008;283(51):35464-35473.
11. Dentin R, et al. Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Nature. 2007;449(7160):366-369. (Pubitemid 47443476)
12. Baert JL, Monte D, Verreman K, Degerny C, Coutte L, de Launoit Y. The E3 ubiquitin ligase complex component COP1 regulates PEA3 group member stability and transcriptional activity. Oncogene. 2010; 29(12):1810-1820.
13. Migliorini D, et al. Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice. J Clin Invest. 2011;121(4):1329-1343.
14. Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol. 2002;4(5):E131-E136. (Pubitemid 34521026)
15. Jariel-Encontre I, et al. Complex mechanisms for c-fos and c-jun degradation. Mol Biol Rep. 1997;24(1-2):51-56. (Pubitemid 27269426)
16. Westermarck J. Regulation of transcription factor function by targeted protein degradation: an overview focusing on p53, c-Myc, and c-Jun. Methods Mol Biol. 2010;647:31-36.
17. Wei W, Jin J, Schlisio S, Harper JW, Kaelin WG Jr. The v-Jun point mutation allows c-Jun to escape GSK3- dependent recognition and destruction by the Fbw7 ubiquitin ligase. Cancer Cell. 2005;8(1):25-33. (Pubitemid 40991812)
18. Gao M, et al. Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch. Science. 2004;306(5694):271-275. (Pubitemid 39336871)
19. Mariani O, et al. JUN oncogene amplification and overexpression block adipocytic differentiation in highly aggressive sarcomas. Cancer Cell. 2007;11(4):361-374. (Pubitemid 46518313)
20. Dornan D, et al. ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage. Science. 2006;313(5790):1122-1126. (Pubitemid 44300238)