Dynamic changes in Th1, Th17, and FoxP3+ T cells in patients with acute cellular rejection after cardiac transplantation

Clinical Transplantation

Volumn 25, Issue 2, 2011, Pages

  Wang, Sihua ^a   Li, Jun ^a   Xie, Aini ^a   Wang, Guohua ^a   Xia, Ni ^b   Ye, Ping ^a   Rui, Lu ^c   Xia, Jiahong ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c FUWAI HOSPITAL   (China)

Author keywords

Acute cellular rejection; Cardiac transplantation; Cytokine; Th1; Th17

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 23; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR T BET;

ACUTE GRAFT REJECTION; ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; FEMALE; GRAFT RECIPIENT; HEART TRANSPLANTATION; HUMAN; MALE; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; TH1 CELL; TH17 CELL;

BLOTTING, WESTERN; CD4-POSITIVE T-LYMPHOCYTES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; IMMUNOENZYME TECHNIQUES; INTERFERON-GAMMA; INTERLEUKIN-17; INTERLEUKIN-23; MYOCARDIUM; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTE SUBSETS; TH1 CELLS;

EID: 79953312645     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/j.1399-0012.2010.01362.x     Document Type: Article

References (40)

1. Deuse T, Haddad F, Pham M et al. Twenty-year survivors of heart transplantation at Stanford University. Am J Transplant 2008: 8: 1769.
2. Afzali B, Lombardi G, Lechler RI, Lord GM. The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin Exp Immunol 2007: 148: 32.
3. Saleem S, Konieczny BT, Lowry RP, Baddoura FK, Lakkis FG. Acute rejection of vascularized heart allografts in the absence of IFNgamma. Transplantation 1996: 62: 1908.
4. Yuan X, Paez-Cortez J, Schmitt-Knosalla I et al. A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy. J Exp Med 2008: 205: 3133.
5. Loong CC, Hsieh HG, Lui WY, Chen A, Lin CY. Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejection. J Pathol 2002: 197: 322.
6. Vanaudenaerde BM, Dupont LJ, Wuyts WA et al. The role of interleukin-17 during acute rejection after lung transplantation. Eur Respir J 2006: 27: 779.
7. Langrish CL, Chen Y, Blumenschein WM et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 2005: 201: 233.
8. Korn T, Bettelli E, Gao W et al. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 2007: 448: 484.
9. Van Kooten C, Boonstra JG, Paape ME et al. Interleukin-17 activates human renal epithelial cells in vitro and is expressed during renal allograft rejection. J Am Soc Nephrol 1998: 9: 1526.
10. Fujino S, Andoh A, Bamba S et al. Increased expression of interleukin 17 in inflammatory bowel disease. Gut 2003: 52: 65.
11. Zheng Y, Danilenko DM, Valdez P et al. Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 2007: 445: 648.
12. Amadi-Obi A, Yu CR, Liu X et al. TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat Med 2007: 13: 711.
13. Annunziato F, Cosmi L, Santarlasci V et al. Phenotypic and functional features of human Th17 cells. J Exp Med 2007: 204: 1849.
14. Kryczek I, Bruce AT, Gudjonsson JE et al. Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis. J Immunol 2008: 181: 4733.
15. Kryczek I, Banerjee M, Cheng P et al. Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments. Blood 2009: 114: 1141.
16. VanBuskirk AM, Wakely ME, Orosz CG. Transfusion of polarized TH2-like cell populations into SCID mouse cardiac allograft recipients results in acute allograft rejection. Transplantation 1996: 62: 229.
17. Csencsits K, Wood SC, Lu G et al. Graft rejection mediated by CD4+ T cells via indirect recognition of alloantigen is associated with a dominant Th2 response. Eur J Immunol 2005: 35: 843.
18. Keane MP, Gomperts BN, Weigt S et al. IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome. J Immunol 2007: 178: 511.
19. Gavin MA, Torgerson TR, Houston E et al. Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc Natl Acad Sci USA 2006: 103: 6659.
20. Long E, Wood KJ. Understanding FOXP3: progress towards achieving transplantation tolerance. Transplantation 2007: 84: 459.
21. Stewart S, Winters GL, Fishbein MC et al. Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant 2005: 24: 1710.
22. Ocana E, Perez-Requena J, Bohorquez JC, Brieva JA, Rodriguez C. Chemokine receptor expression on infiltrating lymphocytes from abdominal aortic aneurysms: role of CXCR4-CXCL12 in lymphoid recruitment. Atherosclerosis 2008: 200: 264.
23. Dijke IE, Caliskan K, Korevaar SS et al. FOXP3 mRNA expression analysis in the peripheral blood and allograft of heart transplant patients. Transpl Immunol 2008: 18: 250.
24. Atalar K, Afzali B, Lord G, Lombardi G. Relative roles of Th1 and Th17 effector cells in allograft rejection. Curr Opin Organ Transplant 2009: 14: 23.
25. Eberl G, Marmon S, Sunshine MJ, Rennert PD, Choi Y, Littman DR. An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat Immun 2004: 5: 64.
26. Cupedo T, Crellin NK, Papazian N et al. Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells. Nat Immun 2009: 10: 66.
27. Faust SM, Lu G, Marini BL et al. Role of T cell TGFbeta signaling and IL-17 in allograft acceptance and fibrosis associated with chronic rejection. J Immunol 2009: 183: 7297.
28. Fabrega E, Lopez-Hoyos M, San Segundo D, Casafont F, Pons-Romero F. Changes in the serum levels of interleukin-17/interleukin-23 during acute rejection in liver transplantation. Liver Transpl 2009: 15: 629.
29. Vanaudenaerde BM, De Vleeschauwer SI, Vos R et al. The role of the IL23/IL17 axis in bronchiolitis obliterans syndrome after lung transplantation. Am J Transplant 2008: 8: 1911.
30. Weaver CT, Hatton RD, Mangan PR, Harrington LE. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 2007: 25: 821.
31. Burlingham WJ, Love RB, Jankowska-Gan E et al. IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants. J Clin Invest 2007: 117: 3498.
32. Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006: 24: 179.
33. D'Elios MM, Josien R, Manghetti M et al. Predominant Th1 cell infiltration in acute rejection episodes of human kidney grafts. Kidney Int 1997: 51: 1876.
34. Homs S, Mansour H, Desvaux D et al. Predominant Th1 and cytotoxic phenotype in biopsies from renal transplant recipients with transplant glomerulopathy. Am J Transplant 2009: 9: 1230.
35. Hoffmann SC, Hale DA, Kleiner DE et al. Functionally significant renal allograft rejection is defined by transcriptional criteria. Am J Transplant 2005: 5: 573.
36. Rangachari M, Mauermann N, Marty RR et al. T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17. J Exp Med 2006: 203: 2009.
37. Korn T, Reddy J, Gao W et al. Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med 2007: 13: 423.
38. Min SI, Ha J, Park CG et al. Sequential evolution of IL-17 responses in the early period of allograft rejection. Exp Mol Med 2009: 41: 707.
39. Boros P, Bromberg JS. New cellular and molecular immune pathways in ischemia/reperfusion injury. Am J Transplant 2006: 6: 652.
40. Tay SS, Plain KM, Bishop GA. Role of IL-4 and Th2 responses in allograft rejection and tolerance. Curr Opin Organ Transplant 2009: 14: 16.