-
1
-
-
38349058657
-
Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock
-
Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL: Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock. Intensive Care Med 2008; 34: 17-60.
-
(2008)
Intensive Care Med
, vol.34
, pp. 17-60
-
-
Dellinger, R.P.1
Levy, M.M.2
Carlet, J.M.3
Bion, J.4
Parker, M.M.5
Jaeschke, R.6
Reinhart, K.7
Angus, D.C.8
Brun-Buisson, C.9
Beale, R.10
Calandra, T.11
Dhainaut, J.F.12
Gerlach, H.13
Harvey, M.14
Marini, J.J.15
Marshall, J.16
Ranieri, M.17
Ramsay, G.18
Sevransky, J.19
Thompson, B.T.20
Townsend, S.21
Vender, J.S.22
Zimmerman, J.L.23
Vincent, J.L.24
more..
-
2
-
-
0019446122
-
Neutrophil dysfunction in sepsis. II. Evidence for the role of complement activation products in cellular deactivation
-
Solomkin JS, Jenkins MK, Nelson RD, Chenoweth D, Simmons RL: Neutrophil dysfunction in sepsis. II. Evidence for the role of complement activation products in cellular deactivation. Surgery 1981; 90: 319-327.
-
(1981)
Surgery
, vol.90
, pp. 319-327
-
-
Solomkin, J.S.1
Jenkins, M.K.2
Nelson, R.D.3
Chenoweth, D.4
Simmons, R.L.5
-
3
-
-
0028082347
-
Immunologic assessment of host defense impairment in patients with septic multiple organ failure: Relationship between complement activation and changes in neutrophil function
-
Goya T, Morisaki T, Torisu M: Immunologic assessment of host defense impairment in patients with septic multiple organ failure: relationship between complement activation and changes in neutrophil function. Surgery 1994; 115: 145-155.
-
(1994)
Surgery
, vol.115
, pp. 145-155
-
-
Goya, T.1
Morisaki, T.2
Torisu, M.3
-
4
-
-
0037105426
-
Complement-induced impairment of innate immunity during sepsis
-
Huber-Lang MS, Younkin EM, Sarma JV, McGuire SR, Lu KT, Guo RF, Padgaonkar VA, Curnutte JT, Erickson R, Ward PA: Complement-induced impairment of innate immunity during sepsis. J Immunol 2002; 169: 3223-3231.
-
(2002)
J Immunol
, vol.169
, pp. 3223-3231
-
-
Huber-Lang, M.S.1
Younkin, E.M.2
Sarma, J.V.3
McGuire, S.R.4
Lu, K.T.5
Guo, R.F.6
Padgaonkar, V.A.7
Curnutte, J.T.8
Erickson, R.9
Ward, P.A.10
-
5
-
-
0024598582
-
Complement levels in septic primates treated with anti-C5a antibodies
-
Hangen DH, Stevens JH, Satoh PS, Hall EW, O'Hanley PT, Raffin TA: Complement levels in septic primates treated with anti-C5a antibodies. J Surg Res 1989; 46: 195-199.
-
(1989)
J Surg Res
, vol.46
, pp. 195-199
-
-
Hangen, D.H.1
Stevens, J.H.2
Satoh, P.S.3
Hall, E.W.4
O'Hanley, P.T.5
Raffin, T.A.6
-
6
-
-
0022453148
-
Effects of anti-C5a antibodies on the adult respiratory distress syndrome in septic primates
-
Stevens JH, O'Hanley P, Shapiro JM, Mihm FG, Satoh PS, Collins JA, Raffin TA: Effects of anti-C5a antibodies on the adult respiratory distress syndrome in septic primates. J Clin Invest 1986; 77: 1812-1816.
-
(1986)
J Clin Invest
, vol.77
, pp. 1812-1816
-
-
Stevens, J.H.1
O'Hanley, P.2
Shapiro, J.M.3
Mihm, F.G.4
Satoh, P.S.5
Collins, J.A.6
Raffin, T.A.7
-
7
-
-
61449154547
-
Immunodesign of experimental sepsis by cecal ligation and puncture
-
Rittirsch D, Huber-Lang M, Flierl M, Ward PA: Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc 2009; 4: 31-36.
-
(2009)
Nat Protoc
, vol.4
, pp. 31-36
-
-
Rittirsch, D.1
Huber-Lang, M.2
Flierl, M.3
Ward, P.A.4
-
8
-
-
0033052453
-
Protective effects of C5a blockade in sepsis
-
Czermak BJ, Sarma V, Pierson CL, Warner RL, Huber-Lang M, Bless NM, Schmal H, Friedl HP, Ward PA: Protective effects of C5a blockade in sepsis. Nat Med 1999; 5: 788-792.
-
(1999)
Nat Med
, vol.5
, pp. 788-792
-
-
Czermak, B.J.1
Sarma, V.2
Pierson, C.L.3
Warner, R.L.4
Huber-Lang, M.5
Bless, N.M.6
Schmal, H.7
Friedl, H.P.8
Ward, P.A.9
-
9
-
-
0035286776
-
Protective effects of anti-C5a peptide antibodies in experimental sepsis
-
Huber-Lang MS, Sarma JV, McGuire SR, Lu KT, Guo RF, Padgaonkar VA, Younkin EM, Laudes IJ, Riedemann NC, Younger JG, Ward PA: Protective effects of anti-C5a peptide antibodies in experimental sepsis. FASEB J 2001; 15: 568-570.
-
(2001)
FASEB J
, vol.15
, pp. 568-570
-
-
Huber-Lang, M.S.1
Sarma, J.V.2
McGuire, S.R.3
Lu, K.T.4
Guo, R.F.5
Padgaonkar, V.A.6
Younkin, E.M.7
Laudes, I.J.8
Riedemann, N.C.9
Younger, J.G.10
Ward, P.A.11
-
10
-
-
0035863922
-
Role of C5a in multiorgan failure during sepsis
-
Huber-Lang M, Sarma VJ, Lu KT, McGuire SR, Padgaonkar VA, Guo RF, Younkin EM, Kunkel RG, Ding J, Erickson R, Curnutte JT, Ward PA: Role of C5a in multiorgan failure during sepsis. J Immunol 2001; 166: 1193-1199.
-
(2001)
J Immunol
, vol.166
, pp. 1193-1199
-
-
Huber-Lang, M.1
Sarma, V.J.2
Lu, K.T.3
McGuire, S.R.4
Padgaonkar, V.A.5
Guo, R.F.6
Younkin, E.M.7
Kunkel, R.G.8
Ding, J.9
Erickson, R.10
Curnutte, J.T.11
Ward, P.A.12
-
11
-
-
0038280149
-
Structure-function relationships of human C5a and C5aR
-
Huber-Lang MS, Sarma JV, McGuire SR, Lu KT, Padgaonkar VA, Younkin EM, Guo RF, Weber CH, Zuiderweg RR, Zetoune FS, Ward PA: Structure-function relationships of human C5a and C5aR. J Immunol 2003; 170: 6115-6124.
-
(2003)
J Immunol
, vol.170
, pp. 6115-6124
-
-
Huber-Lang, M.S.1
Sarma, J.V.2
McGuire, S.R.3
Lu, K.T.4
Padgaonkar, V.A.5
Younkin, E.M.6
Guo, R.F.7
Weber, C.H.8
Zuiderweg, R.R.9
Zetoune, F.S.10
Ward, P.A.11
-
12
-
-
0033519733
-
Lowmolecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a
-
Finch AM, Wong AK, Paczkowski NJ, Wadi SK, Craik DJ, Fairlie DP, Taylor SM: Lowmolecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a. J Med Chem 1999; 42: 1965-1974.
-
(1999)
J Med Chem
, vol.42
, pp. 1965-1974
-
-
Finch, A.M.1
Wong, A.K.2
Paczkowski, N.J.3
Wadi, S.K.4
Craik, D.J.5
Fairlie, D.P.6
Taylor, S.M.7
-
13
-
-
0036793526
-
Protection of innate immunity by C5aR antagonist in septic mice
-
Huber-Lang MS, Riedeman NC, Sarma JV, Younkin EM, McGuire SR, Laudes IJ, Lu KT, Guo RF, Neff TA, Padgaonkar VA, Lambris JD, Spruce L, Mastellos D, Zetoune FS, Ward PA: Protection of innate immunity by C5aR antagonist in septic mice. FASEB J 2002; 16: 1567-1574.
-
(2002)
FASEB J
, vol.16
, pp. 1567-1574
-
-
Huber-Lang, M.S.1
Riedeman, N.C.2
Sarma, J.V.3
Younkin, E.M.4
McGuire, S.R.5
Laudes, I.J.6
Lu, K.T.7
Guo, R.F.8
Neff, T.A.9
Padgaonkar, V.A.10
Lambris, J.D.11
Spruce, L.12
Mastellos, D.13
Zetoune, F.S.14
Ward, P.A.15
-
14
-
-
0036092494
-
Anti-c5a ameliorates coagulation/fibrinolytic protein changes in a rat model of sepsis
-
Laudes IJ, Chu JC, Sikranth S, Huber-Lang M, Guo RF, Riedemann N, Sarma JV, Schmaier AH, Ward PA: Anti-c5a ameliorates coagulation/fibrinolytic protein changes in a rat model of sepsis. Am J Pathol 2002; 160: 1867-1875.
-
(2002)
Am J Pathol
, vol.160
, pp. 1867-1875
-
-
Laudes, I.J.1
Chu, J.C.2
Sikranth, S.3
Huber-Lang, M.4
Guo, R.F.5
Riedemann, N.6
Sarma, J.V.7
Schmaier, A.H.8
Ward, P.A.9
-
15
-
-
39749127834
-
Receptors for complement C5a. The importance of C5aR and the enigmatic role of C5L2
-
Lee H, Whitfeld PL, Mackay CR: Receptors for complement C5a. The importance of C5aR and the enigmatic role of C5L2. Immunol Cell Biol 2008; 86: 153-160.
-
(2008)
Immunol Cell Biol
, vol.86
, pp. 153-160
-
-
Lee, H.1
Whitfeld, P.L.2
MacKay, C.R.3
-
16
-
-
0041571471
-
C5L2, a nonsignaling C5a binding protein
-
Okinaga S, Slattery D, Humbles A, Zsengeller Z, Morteau O, Kinrade MB, Brodbeck RM, Krause JE, Choe HR, Gerard NP, Gerard C: C5L2, a nonsignaling C5a binding protein. Biochemistry 2003; 42: 9406-9415.
-
(2003)
Biochemistry
, vol.42
, pp. 9406-9415
-
-
Okinaga, S.1
Slattery, D.2
Humbles, A.3
Zsengeller, Z.4
Morteau, O.5
Kinrade, M.B.6
Brodbeck, R.M.7
Krause, J.E.8
Choe, H.R.9
Gerard, N.P.10
Gerard, C.11
-
17
-
-
0038662716
-
The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein
-
Kalant D, Cain SA, Maslowska M, Sniderman AD, Cianflone K, Monk PN: The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation- stimulating protein. J Biol Chem 2003; 278: 11123-11129.
-
(2003)
J Biol Chem
, vol.278
, pp. 11123-11129
-
-
Kalant, D.1
Cain, S.A.2
Maslowska, M.3
Sniderman, A.D.4
Cianflone, K.5
Monk, P.N.6
-
18
-
-
21244438039
-
C5L2 is a functional receptor for acylation-stimulating protein
-
Kalant D, MacLaren R, Cui W, Samanta R, Monk PN, Laporte SA, Cianflone K: C5L2 is a functional receptor for acylation-stimulating protein. J Biol Chem 2005; 280: 23936-23944.
-
(2005)
J Biol Chem
, vol.280
, pp. 23936-23944
-
-
Kalant, D.1
MacLaren, R.2
Cui, W.3
Samanta, R.4
Monk, P.N.5
Laporte, S.A.6
Cianflone, K.7
-
19
-
-
0036510770
-
The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74)
-
Cain SA, Monk PN: The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74). J Biol Chem 2002; 277: 7165-7169.
-
(2002)
J Biol Chem
, vol.277
, pp. 7165-7169
-
-
Cain, S.A.1
Monk, P.N.2
-
20
-
-
77951250395
-
The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction
-
Bamberg CE, Mackay CR, Lee H, Zahra D, Jackson J, Lim YS, Whitfeld PL, Craig S, Corsini E, Lu B, Gerard C, Gerard NP: The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction. J Biol Chem 2010; 285: 7633-7644.
-
(2010)
J Biol Chem
, vol.285
, pp. 7633-7644
-
-
Bamberg, C.E.1
MacKay, C.R.2
Lee, H.3
Zahra, D.4
Jackson, J.5
Lim, Y.S.6
Whitfeld, P.L.7
Craig, S.8
Corsini, E.9
Lu, B.10
Gerard, C.11
Gerard, N.P.12
-
21
-
-
60949109793
-
The human complement fragment receptor, C5L2, is a recycling decoy receptor
-
Scola AM, Johswich KO, Morgan BP, Klos A, Monk PN: The human complement fragment receptor, C5L2, is a recycling decoy receptor. Mol Immunol 2009; 46: 1149-1162.
-
(2009)
Mol Immunol
, vol.46
, pp. 1149-1162
-
-
Scola, A.M.1
Johswich, K.O.2
Morgan, B.P.3
Klos, A.4
Monk, P.N.5
-
22
-
-
1442290129
-
Regulatory role of C5a in LPS-induced IL-6 production by neutrophils during sepsis
-
Riedemann NC, Guo RF, Hollmann TJ, Gao H, Neff TA, Reuben JS, Speyer CL, Sarma JV, Wetsel RA, Zetoune FS, Ward PA: Regulatory role of C5a in LPS-induced IL-6 production by neutrophils during sepsis. FASEB J 2004; 18: 370-372.
-
(2004)
FASEB J
, vol.18
, pp. 370-372
-
-
Riedemann, N.C.1
Guo, R.F.2
Hollmann, T.J.3
Gao, H.4
Neff, T.A.5
Reuben, J.S.6
Speyer, C.L.7
Sarma, J.V.8
Wetsel, R.A.9
Zetoune, F.S.10
Ward, P.A.11
-
23
-
-
33947110020
-
C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a
-
Chen NJ, Mirtsos C, Suh D, Lu YC, Lin WJ, McKerlie C, Lee T, Baribault H, Tian H, Yeh WC: C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a. Nature 2007; 446: 203-207.
-
(2007)
Nature
, vol.446
, pp. 203-207
-
-
Chen, N.J.1
Mirtsos, C.2
Suh, D.3
Lu, Y.C.4
Lin, W.J.5
McKerlie, C.6
Lee, T.7
Baribault, H.8
Tian, H.9
Yeh, W.C.10
-
24
-
-
43249098418
-
Functional roles for C5a receptors in sepsis
-
Rittirsch D, Flierl MA, Nadeau BA, Day DE, Hoesel LM, Zetoune FS, MacKay CR, Cianflone K, Gerard NP, Huber-Lang MS, Köhl J, Gerard C, Sarma JV, Ward PA: Functional roles for C5a receptors in sepsis. Nat Med 2008; 14: 551-557.
-
(2008)
Nat Med
, vol.14
, pp. 551-557
-
-
Rittirsch, D.1
Flierl, M.A.2
Nadeau, B.A.3
Day, D.E.4
Hoesel, L.M.5
Zetoune, F.S.6
MacKay, C.R.7
Cianflone, K.8
Gerard, N.P.9
Huber-Lang, M.S.10
Köhl, J.11
Gerard, C.12
Sarma, J.V.13
Ward, P.A.14
-
25
-
-
20444460795
-
Evidence for a functional role of the second C5a receptor, C5L2
-
Gao H, Neff TA, Guo RF, Speyer CL, Sarma JV, Tomlins S, Man Y, Riedemann NC, Hoesel LM, Younkin EM, Zetoune FS, Ward PA: Evidence for a functional role of the second C5a receptor, C5L2. FASEB J 2005; 19: 1003-1005.
-
(2005)
FASEB J
, vol.19
, pp. 1003-1005
-
-
Gao, H.1
Neff, T.A.2
Guo, R.F.3
Speyer, C.L.4
Sarma, J.V.5
Tomlins, S.6
Man, Y.7
Riedemann, N.C.8
Hoesel, L.M.9
Younkin, E.M.10
Zetoune, F.S.11
Ward, P.A.12
-
26
-
-
0033538467
-
HMG-1 as a late mediator of endotoxin lethality in mice
-
Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, Che J, Frazier A, Yang H, Ivanova S, Borovikova L, Manogue KR, Faist E, Abraham E, Andersson J, Andersson U, Molina PE, Abumrad NN, Sama A, Tracey KJ: HMG-1 as a late mediator of endotoxin lethality in mice. Science 1999; 285: 248-251.
-
(1999)
Science
, vol.285
, pp. 248-251
-
-
Wang, H.1
Bloom, O.2
Zhang, M.3
Vishnubhakat, J.M.4
Ombrellino, M.5
Che, J.6
Frazier, A.7
Yang, H.8
Ivanova, S.9
Borovikova, L.10
Manogue, K.R.11
Faist, E.12
Abraham, E.13
Andersson, J.14
Andersson, U.15
Molina, P.E.16
Abumrad, N.N.17
Sama, A.18
Tracey, K.J.19
-
27
-
-
9644308097
-
Novel chemokine responsiveness and mobilization of neutrophils during sepsis
-
Speyer CL, Gao H, Rancilio NJ, Neff TA, Huffnagle GB, Sarma JV, Ward PA: Novel chemokine responsiveness and mobilization of neutrophils during sepsis. Am J Pathol 2004; 165: 2187-2196.
-
(2004)
Am J Pathol
, vol.165
, pp. 2187-2196
-
-
Speyer, C.L.1
Gao, H.2
Rancilio, N.J.3
Neff, T.A.4
Huffnagle, G.B.5
Sarma, J.V.6
Ward, P.A.7
-
28
-
-
0036644054
-
Altered neutrophil trafficking during sepsis
-
Guo RF, Riedemann NC, Laudes IJ, Sarma VJ, Kunkel RG, Dilley KA, Paulauskis JD, Ward PA: Altered neutrophil trafficking during sepsis. J Immunol 2002; 169: 307-314.
-
(2002)
J Immunol
, vol.169
, pp. 307-314
-
-
Guo, R.F.1
Riedemann, N.C.2
Laudes, I.J.3
Sarma, V.J.4
Kunkel, R.G.5
Dilley, K.A.6
Paulauskis, J.D.7
Ward, P.A.8
-
29
-
-
1642323504
-
Disturbed homeostasis of lung intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 during sepsis
-
Laudes IJ, Guo RF, Riedemann NC, Speyer C, Craig R, Sarma JV, Ward PA: Disturbed homeostasis of lung intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 during sepsis. Am J Pathol 2004; 164: 1435-1445.
-
(2004)
Am J Pathol
, vol.164
, pp. 1435-1445
-
-
Laudes, I.J.1
Guo, R.F.2
Riedemann, N.C.3
Speyer, C.4
Craig, R.5
Sarma, J.V.6
Ward, P.A.7
-
30
-
-
0036615932
-
C5a receptor and thymocyte apoptosis in sepsis
-
Riedemann NC, Guo RF, Laudes IJ, Keller K, Sarma VJ, Padgaonkar V, Zetoune FS, Ward PA: C5a receptor and thymocyte apoptosis in sepsis. FASEB J 2002; 16: 887-888.
-
(2002)
FASEB J
, vol.16
, pp. 887-888
-
-
Riedemann, N.C.1
Guo, R.F.2
Laudes, I.J.3
Keller, K.4
Sarma, V.J.5
Padgaonkar, V.6
Zetoune, F.S.7
Ward, P.A.8
-
31
-
-
0035338993
-
Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans
-
Hotchkiss RS, Tinsley KW, Swanson PE, Schmieg RE Jr, Hui JJ, Chang KC, Osborne DF, Freeman BD, Cobb JP, Buchman TG, Karl IE: Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans. J Immunol 2001; 166: 6952-6963.
-
(2001)
J Immunol
, vol.166
, pp. 6952-6963
-
-
Hotchkiss, R.S.1
Tinsley, K.W.2
Swanson, P.E.3
Schmieg Jr., R.E.4
Hui, J.J.5
Chang, K.C.6
Osborne, D.F.7
Freeman, B.D.8
Cobb, J.P.9
Buchman, T.G.10
Karl, I.E.11
-
32
-
-
33744987414
-
Generation of C5a in the absence of C3: A new complement activation pathway
-
Huber-Lang M, Sarma JV, Zetoune FS, Rittirsch D, Neff TA, McGuire SR, Lambris JD, Warner RL, Flierl MA, Hoesel LM, Gebhard F, Younger JG, Drouin SM, Wetsel RA, Ward PA: Generation of C5a in the absence of C3: a new complement activation pathway. Nat Med 2006; 12: 682-687.
-
(2006)
Nat Med
, vol.12
, pp. 682-687
-
-
Huber-Lang, M.1
Sarma, J.V.2
Zetoune, F.S.3
Rittirsch, D.4
Neff, T.A.5
McGuire, S.R.6
Lambris, J.D.7
Warner, R.L.8
Flierl, M.A.9
Hoesel, L.M.10
Gebhard, F.11
Younger, J.G.12
Drouin, S.M.13
Wetsel, R.A.14
Ward, P.A.15
-
33
-
-
54049102451
-
Functions of the complement components C3 and C5 during sepsis
-
Flierl MA, Rittirsch D, Nadeau BA, Day DE, Zetoune FS, Sarma JV, Huber-Lang MS, Ward PA: Functions of the complement components C3 and C5 during sepsis. FASEB J 2008; 22: 3483-3490.
-
(2008)
FASEB J
, vol.22
, pp. 3483-3490
-
-
Flierl, M.A.1
Rittirsch, D.2
Nadeau, B.A.3
Day, D.E.4
Zetoune, F.S.5
Sarma, J.V.6
Huber-Lang, M.S.7
Ward, P.A.8
|