Inhibition of gamma interferon decreases bacterial load in peritonitis by accelerating peritoneal fibrin deposition and tissue repair

Infection and Immunity

Volumn 71, Issue 5, 2003, Pages 2766-2774

  Qiu, Gang ^a   Gribbin, Elizabeth ^a   Harrison, Kathryn ^a   Sinha, Neil ^a   Yin, Kingsley ^a  

^a UMDNJ School of Osteopathic Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRIN; GAMMA INTERFERON; GAMMA INTERFERON ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIAL PERITONITIS; BLOOD CLOTTING DISORDER; CECUM; CONTROLLED STUDY; CYTOKINE PRODUCTION; FIBRIN DEPOSITION; INFLAMMATION; MALE; NONHUMAN; PERITONEUM ADHESION; PRIORITY JOURNAL; RAT; TISSUE REPAIR;

ANIMALS; BACTERIA; BLOTTING, WESTERN; FIBRIN; FIBRINOGEN; INTERFERON TYPE II; INTERLEUKIN-6; MALE; PERITONITIS; PLASMINOGEN ACTIVATOR INHIBITOR 1; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0037408295     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.71.5.2766-2774.2003     Document Type: Article

References (32)

1. Car, B. D., V. M. Eng, B. Schnyder, L. Ozmen, S. Huang, P. Gallay, D. Heumann, M. Aguet, and B. Ryffel. 1994. Interferon-gamma receptor deficient mice are resistant to endotoxic shock. J. Exp. Med. 179:1437-1444.
2. Chaudry, I. H., K. A. Wichterman, and A. E. Baue. 1979. Effect of sepsis on tissue adenine nucleotide levels. Surgery. 85:205-211.
3. Chegini, N., H. Rong, B. Bennett, and K. I. Stone. 1999. Peritoneal fluid cytokine and eicosanoid levels and their relation to the incidence of peritoneal adhesion. J. Soc. Gynecol. Investig. 6:153-157.
4. Docke, W. D., F. Randow, U. Syrbe, D. Krausch, K. Asadullah, P. Reinke, H. D. Volk, and W. Kox. 1997. Monocyte deactivation in septic patients: restoration by IFN-γ treatment. Nat. Med. 3:678-681.
5. Doherty, G. M., J. R. Lange, H. N. Langstein, H. R. Alexander, C. M. Buresh, and J. A. Norton. 1992. Evidence for IFN-γ as a mediator of the lethality of endotoxin and tumor necrosis factor-alpha. J. Immunol. 149:1666-1670.
6. Ebong, S. J., D. R. Call, G. Bolgos, D. E. Newcomb, J. I. Granger, M. O'Reilly, and D. G. Remick. 1999. Immunopathologic responses to nonlethal sepsis. Shock 12:118-126.
7. Echtenacher, B., K. Weigl, N. Lehn, and D. N. Mannel. 2001. Tumor necrosis factor-dependent adhesions as a major protective mechanism early in septic peritonitis in mice. Infect. Immun. 69:3550-3555.
8. Ghellai, A. M., A. F. Stucchi, D. J. Lynch, K. C. Skinner, M. J. Colt, and J. M. Becker. 2000. Role of hyaluronate-based membrane in the prevention of peritonitis-induced adhesions. J. Gastrointest. Surg. 4:310-315.
9. Gurujeyalakshmi, G., and S. N. Giri. 1995. Molecular mechanisms of antifibrotic effect of interferon-γ in bleomycin-mouse model of lung fibrosis: downregulation of TGF-β and procollagen I and III gene expression. Exp. Lung Res. 21:791-794.
10. Hellebrekers, B. W. J., T. C. M. Trimbos-Kemper, J. B. M. Z. Trimbos, J. J. Emeis, and T. Kooistra. 2000. Use of fibrinolytic agents in the prevention of post-operative adhesion formation. Fertil. Steril. 74(2):203-212.
11. Kaidi, A. A., M. Nazzal, T. Gurchumelidze, M. A. Ali, E. J. Dawe, and Y. J. Silva. 1995. Preoperative administration of antibodies against tumor necrosis factor-alpha (TNF-α) and interleukin-1 (IL-1) and their impact on peritoneal adhesion formation. Am. Surg. 61:569-572.
12. Keller, R., P. Joller, R. Keist, H. Binz, and P. H. van der Meide. 1988. Modulation of major histocompatibilty complex (MHC) expression by interferons and microbial agents. Scand. J. Immunol. 28:113-121.
13. Kohler, J., D. Heumann, G. Garotta, D. LeRoy, S. Bailat, C. Barras, J.-D. Baumgartner, and M. P. Glauser. 1993. IFN-γ involvement in the severity of gram-negative infections in mice. J. Immunol. 151:916-921.
14. Kumar, A., V. Thota, L. Dee, J. Olson, E. Uretz, and J. E. Parillo. 1996. Tumor necrosis factor-α and IL-1β are responsible for the in vitro myocardial cell depression induced by human septic shock serum. J. Exp. Med. 183: 949-958.
15. Meldrum, D. R. 1998. Tumor necrosis factor in the heart. Am. J. Physiol. 274:R577-R595.
16. Mercer-Jones, M. A., M. Heinzelmann, J. C. Peyton, D. J. Wickel, M. Cook, and W. G. Cheadle. 1997. The pulmonary inflammatory response to experimental fecal peritonitis: relative roles of tumor necrosis factor-α and endotoxin. Inflammation 21:401-417.
17. Miles, R. H., T. P. Paxton, D. J. Dries, and R. L. Gamelli. 1994. Interferongamma increases mortality following cecal ligation and puncture. J. Trauma 36:607-611.
18. Miles, R. H., T. P. Paxton, D. Zacheis, D. J. Dries, and R. L. Gamelli. 1994. Systemic administration of interferon-γ impairs wound healing. J. Surg. Res. 56:288-294.
19. Mulligan, M. S., R. L. Warner, J. L. Foreback, T. P. Shanley, and P. A. Ward. 1997. Protective effects of IL-4, IL-10, IL-12 and IL-13 in IgG immune complex-induced lung injury: role of endogenous IL-12. J. Immunol. 159: 3483-3489.
20. Nathan, C. F., H. W. Murray, M. E. Wiebe, and B. Y. Rubin. 1983. Identification of interferon-γ as the lymphokine that activates human macrophage oxidative metabolism and anti-microbial activity. J. Exp. Med. 158:670-689.
21. Oberholzer, A., C. Oberholzer, and L. L. Moldawer. 2001. Sepsis syndromes: understanding the role of innate and acquired immunity. Shock 16:83-96.
22. O'Suilleabhain, C., S. T. O'Sullivan, J. L. Kelly, J. Lederer, J. A. Mannick, and M. L. Rodrick. 1996. Interleukin-12 treatment restores normal resistance to bacterial challenge after burn injury. Surgery 120:290-292.
23. Qiu, G., C. Wang, R. Smith, K. Harrison, and K. Yin. 2001. Role of IFN-γ in bacterial containment in a model of intra-abdominal sepsis. Shock 16: 425-429.
24. Remick, D. G., G. R. Bolgos, J. Siddiqui, J. Shin, and J. A. Nemzek. 2002. Six at six: interleukin-6 measured 6h after the initiation of sepsis predicts mortality over 3 days. Shock 17:463-467.
25. Salgado, A., J. L. Boveda, J. Monasterio, R. M. Segura, M. Mourelle, J. Gomez-Jimenez, and R. Peracaula. 1994. Inflammatory mediators and their influence on hemostasis. Haemostasis 24(2):132-138.
26. Seki, S., S.-I. Osada, S. Ono, S. Aosasa, Y. Habu, T. Nishikage, H. Mochizuki, and H. Hiraide. 1998. Role of liver NK cells and peritoneal macrophages in gamma interferon and interleukin-10 production in experimental bacterial peritonitis in mice. Infect. Immun. 66:5286-5294.
27. Silva, A. T., and J. Cohen. 1992. Role of interferon-γ in experimental gramnegative sepsis. J. Infect. Dis. 166:331-335.
28. Steinhauser, M. L., C. M. Hogaboam, N. W. Lukacs, R. M. Strieter, and S. L. Kunkel. 1999. Multiple roles for IL-12 in a model of acute septic peritonitis. J. Immunol. 162:5437-5443.
29. Tapper, H., and H. Herwald. 2000. Modulation of hemostatic mechanisms in bacterial infectious diseases. Blood 96:2329-2337.
30. Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen specific adaptive immunity. Annu. Rev. Immunol. 13:251-276.
31. Young, H. A., and K. J. Hardy. 1990. Interferon-γ: producer cells, activation stimuli, and molecular genetic regulation. Pharmacol. Ther. 45:137-151.
32. Zantl, N., A. Uebe, B. Neumann, H. Wagner, J. R. Siewert, B. Holzmann, C. D. Heidecke, and K. Pfeffer. 1998. Essential role of gamma interferon in survival of colon ascendens stent peritonitis, a novel murine model of abdominal sepsis. Infect. Immun. 66:2300-2309.