Discovery of non-peptide, small molecule antagonists of α9α10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 8, 2011, Pages 2476-2479

  Zheng, Guangrong ^a   Zhang, Zhenfa ^a   Dowell, Cheryl ^b   Wala, Elzbieta ^c   Dwoskin, Linda P ^a   Holtman, Joseph R ^d   McIntosh, J Michael ^b,e   Crooks, Peter A ^a  

^a University of Kentucky   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

^d LOYOLA UNIVERSITY CHICAGO   (United States)

^e UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

9 10 nAChR; Analgesic; Pain; SAR

Indexed keywords

AMMONIUM DERIVATIVE; ANALGESIC AGENT; NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA9ALPHA10; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; INFLAMMATION; NEUROPATHIC PAIN; STRUCTURE ACTIVITY RELATION;

ANALGESICS; ANIMALS; DRUG EVALUATION, PRECLINICAL; NICOTINIC ANTAGONISTS; PAIN; QUATERNARY AMMONIUM COMPOUNDS; RATS; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79953288241     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.02.043     Document Type: Article

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