N-n-alkylnicotinium analogs, a novel class of nicotinic receptor antagonist: Inhibition of S(-)-nicotine-evoked [3H]dopamine overflow from superfused rat striatal slices

Journal of Pharmacology and Experimental Therapeutics

Volumn 301, Issue 3, 2002, Pages 1088-1096

  Wilkins Jr , Lincoln H ^a   Haubner, Aaron ^a   Ayers, Joshua T ^a   Crooks, Peter A ^a   Dwoskin, Linda P ^a  

^a University of Kentucky   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINERGIC RECEPTOR BLOCKING AGENT; DIHYDRO BETA ERYTHROIODINE; DOPAMINE; N DODECYLNICOTINIUM IODIDE; N HEPTYLNICOTINIUM IODIDE; N HEXYLNICOTINIUM IODIDE; N OCTYLNICOTINIUM IODIDE; NICOTINE DERIVATIVE; NICOTINIC RECEPTOR BLOCKING AGENT; PYRIDINE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN SLICE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE RELEASE; DOPAMINERGIC TRANSMISSION; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; IC 50; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING;

ALKYLATION; ANIMALS; CORPUS STRIATUM; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; NICOTINE; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; PERFUSION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC; STEREOISOMERISM;

EID: 0036264529     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.301.3.1088     Document Type: Article

References (42)

1. Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structure
2. Ultrastructural localization of the α4-subunit of the neuronal acetylcholine nicotinic receptor in the rat substantia nigra
3. A new α-conotoxin which targets α3β2 nicotinic acetylcholine receptors
4. Nicotinic acetylcholine subunit mRNA expression in dopaminergic neurons of the rat substantia nigra and ventral tegmental area
5. Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors hα2β2, hα2β4, hα3β2, hα3α4, hα4β2, hα4β4 and hα7 expressed in Xenopus oocytes
6. The α5 gene product assembles with multiple acetylcholine receptor subunits to form distinctive receptor subtypes in brain
7. 3H]dopamine release by pyridino N-substituted nicotine analogs: A new class of nicotinic antagonist
8. β3: A new member of nicotinic acetylcholine receptor gene family is expressed in brain
9. Pharmacological and functional diversity of neuronal nicotinic acetylcholine receptors
10. Gene transcripts for the nicotinic acetylcholine receptor subunit, Beta4, are distributed in multiple areas of the rat central nervous system
11. Competitive neuronal nicotinic receptor antagonists: A new direction for drug discovery
12. Recent developments in neuronal nicotinic acetycholine receptor antagonists
13. 3H]dopamine release from rat striatal slices by D-2 dopamine receptors
14. Blockade of nicotinic receptor-mediated release of dopamine from striatal synaptosomes by chlorisondamine and other nicotinic antagonists administered in vitro
15. A subtype of nicotinic cholinergic receptor in rat brain is composed of α4 and β2 subunits and is up-regulated by chronic nicotine treatment
16. Formation of oligomers containing the β3 and β4 subunits of the rat nicotinic receptor
17. Immunohistochemical localization of the nicotinic acetylcholine receptor subunit α6 to dopaminergic neurons in the substantia nigra and ventral tegmental area
18. 3H]dopamine release from synaptosomes prepared from mouse striatum
19. Hippocampal synaptic transmission enhanced by low concentrations of nicotine
20. 3H]dopamine release in rat striatal slices via glutamate release
21. 3H]dopamine release from rat striatal synaptosomes and slices
22. α·conotoxin-MII blocks nicotine-stimulated dopamine release in rat striatal synaptosomes
23. Neuronal nicotinic receptor α6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain
24. Mapping of ligand binding sites of neuronal nicotinic acetylcholine receptors using chimeric a subunits
25. Neurotoxins distinguish between different neuronal nicotinic acetylcholine receptor subunit combinations
26. International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits
27. Nicotinic enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors
28. Physiological diversity of nicotinic acetylcholine receptors expressed by vertebrate neurons
29. Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine
30. Heterogeneity of nicotinic receptor class and subunit mRNA expression among individual parasympathetic neurons from rat intracardiac ganglia
31. 3H]dopamine from rat striatal synaptosomes
32. Pharmacological characterization of neuronal acetylcholine gated ion channel receptor-mediated hippocampal norepinephrine and striatal dopamine release from rat brain slices
33. Brain α-bungarotoxin binding protein cDNAs and MAbs reveal subtypes of this branch of the ligand-gated ion channel gene superfamily
34. Neuronal bungarotoxin blocks the nicotinic stimulation of endogenous dopamine release from rat striatum
35. UB-165: A novel nicotinic agonist with subtype selectivity implicates the α4β2* subtype in the modulation of dopamine release from rat striatal synaptosomes
36. The ensemble approach to distance geometry: Application to the nicotinic pharmacophore
37. The selectivity of the N′-alkylation of nicotine
38. 3H]-dopamine
39. Distribution of alpha2, alpha3, alpha4, and beta2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: A hybridization histochemical study in the rat
40. 3H-dopamine from rat brain slices
41. Presynaptic nicotinic ACh receptors
42. Presynaptic nicotinic receptors modulating dopamine release in the rat striatum