tris-Azaaromatic quaternary ammonium salts: Novel templates as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 24, 2007, Pages 6701-6706

  Zheng, Guangrong ^a   Sumithran, Sangeetha P ^a   Deaciuc, Agripina G ^a   Dwoskin, Linda P ^a   Crooks, Peter A ^a  

^a University of Kentucky   (United States)

Author keywords

Dopamine release; Nicotine; Nicotinic acetylcholine receptor; tris Azaaromatic quaternary ammonium

Indexed keywords

1,3,5 TRIS[[1 (3 PICOLINIUM)]PENT 1 YNYL]BENZENE; DOPAMINE; HETEROCYCLIC COMPOUND; METHYLLYCACONITINE; NICOTINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; PICOLINE DERIVATIVE; QUATERNARY AMMONIUM DERIVATIVE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CORPUS STRIATUM; DOPAMINE RELEASE; DRUG BINDING SITE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; NONHUMAN; RAT;

ANIMALS; AZA COMPOUNDS; BRAIN; DOPAMINE; MOLECULAR STRUCTURE; NICOTINE; NICOTINIC ANTAGONISTS; QUATERNARY AMMONIUM COMPOUNDS; RATS; RECEPTORS, NICOTINIC; SALTS; STRUCTURE-ACTIVITY RELATIONSHIP; TROMETHAMINE;

RATTUS;

EID: 35848943867     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.10.062     Document Type: Article

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