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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 8, 2011, Pages 2505-2509

Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors - Implications for early Myasthenia gravis treatment

(7) Komloova, Marketa a Musilek, Kamil b,c,d Horova, Anna b Holas, Ondrej a Dohnal, Vlastimil c Gunn Moore, Frank e Kuca, Kamil c,d,f

a Charles University in Prague Faculty of Pharmacy (Czech Republic)

b UNIVERSITY OF DEFENCE (Czech Republic)

c University of Jan Evangelista Purkynje (Czech Republic)

d UNIVERSITY HOSPITAL HRADEC KRALOVE (Czech Republic)

e UNIVERSITY OF ST ANDREWS (United Kingdom)

f UNIVERSITY OF DEFENCE (Czech Republic)

Author keywords

Cholinesterase; In vitro; Inhibitor; Molecular modelling; Myasthenia gravis; Quaternary

Indexed keywords

1,5 BIS(4 ALLYLDIMETHYLAMMONIUMPHENYL)PENTAN 3 ONE DIBROMIDE; ACETYLCHOLINESTERASE; AMBENONIUM; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; EDROPHONIUM; ETHOPROP; QUINOLINE DERIVATIVE;

ARTICLE; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; IC 50; IN VITRO STUDY; KINETICS; MOLECULAR INTERACTION; MOLECULAR MODEL; MYASTHENIA GRAVIS;

ACETYLCHOLINESTERASE; AMBENONIUM CHLORIDE; BENZENAMINIUM, 4,4'-(3-OXO-1,5-PENTANEDIYL)BIS(N,N-DIMETHYL-N-2-PROPENYL-), DIBROMIDE; BINDING SITES; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; EDROPHONIUM; HUMANS; KINETICS; MOLECULAR DYNAMICS SIMULATION; MYASTHENIA GRAVIS; PROTEIN BINDING; QUINOLINIUM COMPOUNDS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79953288102 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2011.02.047 Document Type: Article

Times cited : (28)

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