Astrocyte elevated gene-1 and breast cancer (Review)

Oncology Letters

Volumn 2, Issue 3, 2011, Pages 399-405

  Wang, Chuan ^a   Yang, Qifeng ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Angiogenesis; Astrocyte elevated gene 1; Breast cancer; Metastasis; Prognosis

Indexed keywords

ANGIOGENESIS; ASTROCYTE ELEVATED GENE 1; BREAST CANCER; CANCER GROWTH; CANCER INVASION; CELLULAR DISTRIBUTION; CHEMICAL STRUCTURE; GENE; GENE ACTIVITY; GENE LOCATION; HUMAN; METASTASIS; NONHUMAN; PROGNOSIS; REVIEW;

EID: 79953284599     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2011.268     Document Type: Review

References (54)

1. Krcova Z, Ehrmann J, Krejci V, Eliopoulos A and Kolar Z: Tpl-2/Cot and COX-2 in breast cancer. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 152: 21-25, 2008.
2. Jezierska A and Motyl T: Matrix metalloproteinase-2 involvement in breast cancer progression: a mini-review. Med Sci Monit 15: RA32-RA40, 2009.
3. Gasparini G: Therapy of breast cancer with molecular targeting agents. Ann Oncol 16: iv28-iv36, 2005.
4. Osborne C, Wilson P and Tripathy D: Oncogenes and tumor suppressor genes in breast cancer: potential diagnostic and therapeutic applications. Oncologist 9: 361-377, 2004.
5. Su ZZ, Kang DC, Chen YM, et al: Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH. Oncogene 21: 3592-3602, 2002.
6. Hu G, Wei Y and Kang Y: The multifaceted role of MTDH/AEG-1 in cancer progression. Clin Cancer Res 15: 5615-5620, 2009.
7. Li J, Zhang N, Song LB, et al: Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival. Clin Cancer Res 14: 3319-3326, 2008.
8. Kang D, Su Z, Sarkar D, Emdad L, Volsky D and Fisher P: Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. Gene 353: 8-15, 2005.
9. Brown DM and Ruoslahti E: Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. Cancer Cell 5: 365-374, 2004.
10. Hu G, Chong R, Yang Q, et al: MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell 15: 9-20, 2009.
11. Su Z: Customized rapid subtraction hybridization (RaSH) gene microarrays identify overlapping expression changes in human fetal astrocytes resulting from human immunodeficiency virus-1 infection or tumor necrosis factor-α treatment. Gene 306: 67-78, 2003.
12. Emdad L: Activation of the nuclear factor κB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis. Cancer Res 66: 1509-1516, 2006.
13. Thirkettle HJ, Girling J, Warren AY, et al: LYRIC/AEG-1 is targeted to different subcellular compartments by ubiquitinylation and intrinsic nuclear localization signals. Clin Cancer Res 15: 3003-3013, 2009.
14. Wu RC, Qin J, Hashimoto Y, et al: Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) coactivator activity by IκB kinase. Mol Cell Biol 22: 3549-3561, 2002.
15. Lee SG, Su ZZ, Emdad L, Sarkar D and Fisher PB: Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc. Proc Natl Acad Sci USA 103: 17390-17395, 2006.
16. Lee SG, Jeon HY, Su ZZ, et al: Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma. Oncogene 28: 2476-2484, 2009.
17. Thirkettle HJ, Mills IG, Whitaker HC and Neal DE: Nuclear LYRIC/AEG-1 interacts with PLZF and relieves PLZF-mediated repression. Oncogene 28: 3663-3670, 2009.
18. Sarkar D, Park ES, Emdad L, Lee SG, Su ZZ and Fisher PB: Molecular basis of nuclear factor-κB activation by astrocyte elevated gene-1. Cancer Res 68: 1478-1484, 2008.
19. Yoo BK, Emdad L, Su ZZ, et al: Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression. J Clin Invest 119: 465-477, 2009.
20. Kikuno N, Shiina H, Urakami S, et al: Knockdown of astrocyte-elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity. Oncogene 26: 7647-7655, 2007.
21. Khuda II, Koide N, Noman AS, et al: Astrocyte elevated gene-1 (AEG-1) is induced by lipopolysaccharide as toll-like receptor 4 (TLR4) ligand and regulates TLR4 signalling. Immunology 128: e700-e706, 2009.
22. Lee SG, Su ZZ, Emdad L, Sarkar D, Franke TF and Fisher PB: Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling. Oncogene 27: 1114-1121, 2007.
23. Yu C, Chen K, Zheng H, et al: Overexpression of astrocyte elevated gene-1 (AEG-1) is associated with esophageal squamous cell carcinoma (ESCC) progression and pathogenesis. Carcinogenesis 30: 894-901, 2009.
24. Emdad L, Lee SG, Su ZZ, et al: Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis. Proc Natl Acad Sci USA 106: 21300-21305, 2009.
25. Doerfler W Hohlwey U, Müller K, Remus R, Heller H and Hertz J: Foreign DNA integration perturbations of the genome oncogenesis. Ann NY Acad Sci 945: 276-288, 2001.
26. Li J, Yang L, Song L, et al: Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1. Oncogene 28: 3188-3196, 2009.
27. Liu JM, Yuan Y, Huan J and Shen ZY: Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2. Oncogene 20: 336-345, 2001.
28. Meng XB, Lu HM and Shen ZY: BCCIP functions through p53 to regulate the expression of p21Waf1/Cip1. Cell Cycle 3: 1457-1462, 2004.
29. Ash S, Yang D and Britt D: LYRIC/AEG-1 overexpression modulates BCCIPα protein levels in prostate tumor cells. Biochem Biophys Res Commun 371: 333-338, 2008.
30. Meng X, Fan J and Shen Z: Roles of BCCIP in chromosome stability and cytokinesis. Oncogene 26: 6253-6260, 2007.
31. Emdad L, Sarkar D, Su Z, et al: Astrocyte elevated gene-1: recent insights into a novel gene involved in tumor progression, metastasis and neurodegeneration. Pharmacol Ther 114: 155-170, 2007.
32. Kunnumakkara A, Anand P and Aggarwal B: Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett 269: 199-225, 2008.
33. Qiao M, Sheng SJ and Pardee AB: Metastasis and Akt activation. Cell Cycle 7: 2991-2996, 2008.
34. Cao Y: Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis. Nat Rev Cancer 5: 735-743, 2005.
35. Liu L, Wu J, Ying Z, et al: Astrocyte elevated gene-1 upregulates matrix metalloproteinase-9 and induces human glioma invasion. Cancer Res 70: 3750-3759, 2010.
36. Hanahan D and Weinberg RA: The hallmarks of cancer. Cell 100: 57-70, 2000.
37. Matsuo Y, Ochi N, Sawai H, et al: CXCL8/IL-8 and CXCL12/SDF-1α co-operatively promote invasiveness and angiogenesis in pancreatic cancer. Int J Cancer 124: 853-861, 2009.
38. Kuwano T: Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis. FASEB J 18: 300-310, 2004.
39. Marrogi A, Travis W, Welsh J, et al: Nitric oxide synthase, cyclooxygenase 2, and vascular endothelial growth factor in the angiogenesis of non-small cell lung carcinoma. Clin Cancer Res 6: 4739-4744, 2000.
40. Liu H, Song X, Liu C, Xie L, Wei L and Sun R: Knockdown of astrocyte elevated gene-1 inhibits proliferation and enhancing chemo-sensitivity to cisplatin or doxorubicin in neuroblastoma cells. J Exp Clin Cancer Res 28: 19, 2009.
41. Lerebours F, Vacher S, Andrieu C, et al: NF-kappa B genes have a major role in inflammatory breast cancer. BMC Cancer 8: 41, 2008.
42. Yoo BK, Gredler R, Vozhilla N, et al: Identification of genes conferring resistance to 5-fluorouracil. Proc Natl Acad Sci USA 106: 12938-12943, 2009.
43. Yoo BK, Chen D, Su ZZ, et al: Molecular mechanism of chemoresistance by astrocyte elevated gene-1. Cancer Res 70: 3249-3258, 2010.
44. Kim DH, Mohapatra G, Bollen A, Waldman FM and Feuerstein BG: Chromosomal abnormalities in glioblastoma multiforme tumors and glioma cell lines detected by comparative genomic hybridization. Int J Cancer 60: 812-819, 1995.
45. Ried T JK, Holtgreve-Grez H, et al: Comparative genomic hybridization of formalin-fixed, paraffin-embedded breast tumors reveals different patterns of chromosomal gains and losses in fibroadenomas and diploid and aneuploid carcinomas. Cancer Res 55: 5415-5423, 1995.
46. Bergamaschi A, Kim YH, Wang P, et al: Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer. Genes Chromosomes Cancer 45: 1033-1040, 2006.
47. Warr T Ward S, Burrows J, et al: Identification of extensive genomic loss and gain by comparative genomic hybridisation in malignant astrocytoma in children and young adults. Genes Chromosomes Cancer 31: 15-22, 2001.
48. Sarkar D, Emdad L, Lee SG, Yoo BK, Su ZZ and Fisher PB: Astrocyte elevated gene-1: far more than just a gene regulated in astrocytes. Cancer Res 69: 8529-8535, 2009.
49. Micalizzi DS, Farabaugh SM and Ford HL: Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression. J Mammary Gland Biol Neoplasia 15: 117-134, 2010.
50. Trimboli AJ, Fukino K, de Bruin A, et al: Direct evidence for epithelial-mesenchymal transitions in breast cancer. Cancer Res 68: 937-945, 2008.
51. Radisky ES and Radisky DC: Matrix metalloproteinase-induced epithelial-mesenchymal transition in breast cancer. J Mammary Gland Biol Neoplasia 15: 201-212, 2010.
52. Britt D, Yang D, Flanagan D, et al: Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells. Exp Cell Res 300: 134-148, 2004.
53. Itoh M and Bissell MJ: The organization of tight junctions in epithelia: implications for mammary gland biology and breast tumorigenesis. J Mammary Gland Biol Neoplasia 8: 449-462, 2003.
54. Ikenouchi J: Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail. J Cell Sci 116: 1959-1967, 2003.