Miltefosine-Induced Apoptotic Cell Death on Leishmania major and L. tropica Strains

Korean Journal of Parasitology

Volumn 49, Issue 1, 2011, Pages 17-23

  Khademvatan, Shahram ^a   Gharavi, Mohammad Javad ^b   Rahim, Fakher ^a   Saki, Jasem ^a  

^a AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Apoptosis; ED50; IC50; Leishmania major; Leishmania tropica; Miltefosine

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; GENOMIC DNA; LIPOCORTIN 5; MILTEFOSINE; PHOSPHATIDYLSERINE;

AGAR GEL ELECTROPHORESIS; AMASTIGOTE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRUCTURE; COLORIMETRY; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DOSE RESPONSE; DRUG ACTIVITY; FLUORESCENCE ACTIVATED CELL SORTING; IC 50; IN VITRO STUDY; INCUBATION TIME; LEISHMANIA MAJOR; LEISHMANIA TROPICA; LEISHMANIASIS; MICROSCOPY; NONHUMAN; PROMASTIGOTE; QUALITATIVE ANALYSIS; STRAIN IDENTIFICATION;

ANIMALS; APOPTOSIS; CELL CYCLE; CELL LINE; DNA FRAGMENTATION; HUMANS; LEISHMANIA MAJOR; LEISHMANIA TROPICA; LEISHMANIASIS, CUTANEOUS; MICE; PHOSPHORYLCHOLINE;

LEISHMANIA MAJOR; LEISHMANIA TROPICA;

EID: 79953284018     PISSN: 00234001     EISSN: 17380006     Source Type: Journal    
DOI: 10.3347/kjp.2011.49.1.17     Document Type: Article

References (27)

1. Ellis RE, Yuan JY, Horvitz HR. Mechanisms and functions of cell death. Ann Rev Cell Biol 1991; 7: 663-698.
2. Raff MC. Social controls on cell survival and cell death. Nature 1992; 356(6368): 397-400.
3. Vaux DL. Toward an understanding of the molecular mechanisms of physiological cell death. Proc Natl Acad Sci USA 1993; 90: 786-789.
4. Steller H. Mechanisms and genes of cellular suicide. Science 1995; 267(5203): 1445-1449.
5. Heussler VT, Küenzi P, Rottenberg S. Inhibition of apoptosis by intracellular protozoan parasites. Int J Parasitol 2001; 31: 1166-1176.
6. McConkey DJ, Zhivotovsky B, Orrenius S. Apoptosis--molecular mechanisms and biomedical implications. Mol Aspects Med 1996; 17: 1-110.
7. Hamann A, Brust D, Osiewacz HD. Apoptosis pathways in fungal growth, development and ageing. Trends Microbiol 2008; 16: 276-283.
8. Wanderley JL, Benjamin A, Real F, Bonomo A, Moreira ME, Barcinski MA. Apoptotic mimicry: an altruistic behavior in host/Leishmania interplay. Braz J Med Biol Res 2005; 38: 807-812.
9. Guerin PJ, Olliaro P, Sundar S, Boelaert M, Croft SL, Desjeux P, Wasunna MK, Bryceson AD. Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda. Lancet Infect Dis 2002; 2: 494-501.
10. Mohebali M, Javadian E, Yaghoobi-Ershadi MR, Akhavan AA, Hajjaran H, Abaei MR. Characterization of Leishmania infection in rodents from endemic areas of the Islamic Republic of Iran. East Mediterr Health J 2004; 10: 591-599.
11. Mohebali M, Edrissian GH, Nadim A, Hajjaran H, Akhoundi B, Hooshmand B, Zarei Z, Arshi A, Mirsamadi N, Naeini KM, Mamishi S, Sanati AA, Moshfe AA, Charehdar S, Fakhar M. Application of direct agglutination test (DAT) for the diagnosis and seroepidemiological studies of visceral leishmaniasis in the Islamic Republic of Iran. Iran J Parasitol 2006; 1: 15-25.
12. Momeni AZ, Aminjavaheri M. Successful treatment of non-healing cases of cutaneous leishmaniasis, using a combination of meglumine antimoniate plus allopurinol. Eur J Dermatol 2003; 13: 40-43.
13. Hadighi R, Mohebali M, Boucher P, Hajjaran H, Khamesipour A, Ouellette M. Unresponsiveness to Glucantime treatment in Iranian cutaneous leishmaniasis due to drug-resistant Leishmania tropica parasites. PLoS Med 2006; 3: e162.
14. Mishra BB, Kale RR, Singh RK, Tiwari VK. Alkaloids: future prospective to combat leishmaniasis. Fitoterapia 2009; 80: 81-90.
15. Richard JV, Werbovetz KA. New antileishmanial candidates and lead compounds. Curr Opin Chem Biol 2010; 14: 447-455.
16. Mohebali M, Fotouhi A, Hooshmand B, Zarei Z, Akhoundi B, Rahnema A, Razaghian AR, Kabir MJ, Nadim A. Comparison of miltefosime and meglumine antimoniate for the treatment of zoonotic cutaneous leishmaniasis (ZCL) by a randomized clinical trial in Iran. Acta Trop 2007; 103: 33-40.
17. Verma NK, Dey CS. Possible mechanism of miltefosine-mediated death of Leishmania donovani. Antimicrob Agents Chemother 2004; 48: 3010-3015.
18. Wortmann G, Hochberg L, Houng HH, Sweeney C, Zapor M, Aronson N, Weina P, Ockenhouse CF. Rapid identification of Leishmania complexes by a real-time PCR assay. Am J Trop Med Hyg 2005; 73: 999-1004.
19. Ameen M. Cutaneous and mucocutaneous leishmaniasis: emerging therapies and progress in disease management. Expert Opin Pharmacother 2010; 11: 557-569.
20. Hadighi R, Boucher P, Khamesipour A, Meamar AR, Roy G, Ouellette M, Mohebali M. Glucantime-resistant Leishmania tropica isolated from Iranian patients with cutaneous leishmaniasis are sensitive to alternative antileishmania drugs. Parasitol Res 2007; 101: 1319-1322.
21. Esmaeili J, Mohebali M, Edrissian GH, Rezayat SM, Ghazi-Khansari M, Charehdar S. Evaluation of miltefosine against L. major (mrho/ir/75/er): in vitro and in vivo studies. Acta Med Iran 2008; 4: 191-196.
22. Arnoult D, Akarid K, Grodet A, Petit PX, Estaquier J, Ameisen JC. On the evolution of programmed cell death: apoptosis of the unicellular eukaryote Leishmania major involves cysteine proteinase activation and mitochondrion permeabilization. Cell Death Differ 2002; 9: 65-81.
23. Paris C, Loiseau PM, Bories C, Bréard J. Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes. Antimicrob Agents Chemother 2004; 48: 852-859.
24. Wanderley JL, Barcinski MA. Apoptosis and apoptotic mimicry: the Leishmania connection. Cell Mol Life Sci 2010; 67: 1653-1659.
25. Khademvatan S, Gharavi MJ, Akhlaghi L, Samadikuchaksaraei A, Oormazdi H, Mousavizadeh K, Hadighi R, Saki J. Induction of apoptosis by miltefosine in Iranian strain of Leishmania infantum promastigotes. Iranian J Parasitol 2009; 4: 23-31.
26. Lee N, Bertholet S, Debrabant A, Muller J, Duncan R, Nakhasi HL. Programmed cell death in the unicellular protozoan parasite Leishmania. Cell Death Differ 2002; 9: 53-64.
27. 2+ levels through the activation of non-selective cation channels induced by oxidative stress causes mitochondrial depolarization leading to apoptosis-like death in Leishmania donovani promastigotes. J Biol Chem 2002; 277: 24717-24727.