Genotoxic effect of chronic exposure to DDT on lymphocytes, oral mucosa and breast cells of female rats

International Journal of Environmental Research and Public Health

Volumn 8, Issue 2, 2011, Pages 540-553

  Canales Aguirre, Alejandro ^a   Padilla Camberos, Eduardo ^a   Gómez Pinedo, Ulises ^b   Salado Ponce, Hugo ^a   Feria Velasco, Alfredo ^c,d   de Celis, Ruth ^d,e  

^a CENTRO DE INVESTIGACIÓN Y ASISTENCIA EN TECNOLOGÍA Y DISEÑO DEL ESTADO DE JALISCO   (Mexico)

^b HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^c UNIVERSITY OF GUADALAJARA   (Mexico)

^d BiosMedica Cancer Research Institute   (Mexico)

^e Institute for Social Security   (Mexico)

Author keywords

Comet assay; Genetic damage; Lipid peroxidation; Micronuclei (MN); Xenohormones

Indexed keywords

CHLORPHENOTANE; OXYGEN RADICAL;

ADULT ANIMAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BREAST CELL; BREAST EPITHELIUM; COMET ASSAY; CONTROLLED STUDY; CYTOTOXICITY TEST; FEMALE; GENOTOXICITY; LIPID PEROXIDATION; LONG TERM EXPOSURE; LYMPHOCYTOTOXICITY; MICRONUCLEUS TEST; MOUTH MUCOSA; MUCOSA CELL; NONHUMAN; OXIDATIVE STRESS; PERIPHERAL LYMPHOCYTE; RAT;

RATTUS; RATTUS NORVEGICUS;

EID: 79953278976     PISSN: None     EISSN: 16604601     Source Type: Journal    
DOI: 10.3390/ijerph8020540     Document Type: Article

References (56)

1. Kristensen, V.N.; Kure, E.H.; Erikstein, B.; Harada, N.; Borresen-Dale, A. Genetic susceptibility and environmental estrogen-like compounds. Mutat. Res. 2001, 482, 77-82.
2. Pacakova, V.; Loukotkova, L.; Bosakova, Z.; Stulik, K. Analysis for estrogens as environmental pollutants-A review. J. Sep. Sci. 2009, 32, 867-882.
3. Canales-Aguirre, A.; De Celis, R.; Salado Ponce, H.; Feria-Velasco, A. Xenoestrógenos: Función y efectos. e-Gnosis 2003, 1, 1-11.
4. Dees, C.; Askari, M.; Garrett, S.; Gehrs, K.; Henley, D.; Ardies, C.M. Estrogenic and DNA-damaging activity of Red No. 3 in human breast cancer cells. Environ. Health Perspect. 1997, 105, 625-632.
5. Rowe, L.A.; Degtyareva, N.; Doetsch, P.W. DNA damage-induced reactive oxygen species (ROS) stress response in Saccharomyces cerevisiae. Free Radic. Biol. Med. 2008, 45, 1167-1177.
6. De Celis, R.; Pedron-Nuevo, N.; Feria-Velasco, A. Toxicology of male reproduction in animals and humans. Arch. Androl. 1996, 37, 201-218.
7. Tucker, J.D.; Preston, R.J. Chromosome aberrations, micronuclei, aneuploidy, sister chromatid exchanges, and cancer risk assessment. Mutat. Res. 1996, 365, 147-159.
8. Clavel, J. Progress in the epidemiological understanding of gene-environment interactions in major diseases: Cancer. C. R. Biol. 2007, 330, 306-317.
9. Linet, M.S. Evolution of cancer epidemiology. Epidemiol. Rev. 2000, 22, 35-56.
10. Hartmann, A.; Fender, H.; Speit, G. Comparative biomonitoring study of workers at a waste disposal site using cytogenetic tests and the comet (single-cell gel) assay. Environ. Mol. Mutagen. 1998, 32, 17-24.
11. Kim, B.S.; Park, J.J.; Edler, L.; Von Fournier, D.; Haase, W.; Sautter-Bihl, M.L.; Gotzes, F.; Thielmann, H.W. New measure of DNA repair in the single-cell gel electrophoresis (comet) assay. Environ. Mol. Mutagen. 2002, 40, 50-56.
12. Padilla-Camberos, E.; Feria-Velasco, A. Prueba de Ames, usos e importancia en detección de agentes genotóxicos. In Genética Ambiente y Salud; Alvarez-Moya, C., Ed.; Universidad de Guadalajara: Guadalajara, Mexico, 2001; pp. 117-126.
13. Fenech, M. The micronucleus assay determination of chromosomal level DNA damage. Methods Mol. Biol. 2008, 410, 185-216.
14. Hallare, A.V.; Gervasio, M.K.; Gervasio, P.L.; Acacio-Claro, P.J. Monitoring genotoxicity among gasoline station attendants and traffic enforcers in the city of Manila using the micronucleus assay with exfoliated epithelial cells. Environ. Monit. Assess. 2009, 156, 331-341.
15. Majer, B.J.; Laky, B.; Knasmuller, S.; Kassie, F. Use of the micronucleus assay with exfoliated epithelial cells as a biomarker for monitoring individuals at elevated risk of genetic damage and in chemoprevention trials. Mutat. Res. 2001, 489, 147-172.
16. Dhawan, A.; Bajpayee, M.; Parmar, D. Comet assay: A reliable tool for the assessment of DNA damage in different models. Cell Biol. Toxicol. 2009, 25, 5-32.
17. Binelli, A.; Riva, C.; Cogni, D.; Provini, A. Genotoxic effects of p, p'-DDT (1,1,1-trichloro-2,2-bis-(chlorophenyl) ethane) and its metabolites in Zebra mussel (D. polymorpha) by SCGE assay and micronucleus test. Environ. Mol. Mutagen. 2008, 49, 406-415.
18. Wojewodzka, M.; Buraczewska, I.; Kruszewski, M. A modified neutral comet assay: Elimination of lysis at high temperature and validation of the assay with anti-single-stranded DNA antibody. Mutat. Res. 2002, 518, 9-20.
19. Mandelker, L. Oxidative stress: The role of mitochondria, free radicals, and antioxidants. Vet. Clin. North Am. Small Anim. Pract. 2008, 38, ix-xi.
20. Huang, Y.L.; Sheu, J.Y.; Lin, T.H. Association between oxidative stress and changes of trace elements in patients with breast cancer. Clin. Biochem. 1999, 32, 131-136.
21. Burton, A. Pesticides: Toward DDT-free malaria control. Environ. Health Perspect. 2009, 117, A344-A347.
22. Bornman, R.; De Jager, C.; Worku, Z.; Farias, P.; Reif, S. DDT and urogenital malformations in newborn boys in a malarial area. BJU Int. 2009, 106, 405-411.
23. Wrobel, M.; Mlynarczuk, J.; Kotwica, J. The adverse effect of dichlorodiphenyltrichloroethane (DDT) and its metabolite (DDE) on the secretion of prostaglandins and oxytocin in bovine cultured ovarian and endometrial cells. Reprod. Toxicol. 2009, 27, 72-78.
24. Tarone, R.E. DDT and breast cancer trends. Environ. Health Perspect. 2008, 116, A374-A377.
25. Snedeker, S.M. Pesticides and breast cancer risk: A review of DDT, DDE, and dieldrin. Environ. Health Perspect. 2001, 109, 35-47.
26. Rehwagen, C. WHO recommends DDT to control malaria. BMJ 2006, 333, 622-646.
27. WHO gives indoor use of DDT a clean bill of health for controlling malaria. Indian J. Med. Sci. 2006, 60, 439-441.
28. Torres-Bugarin, O.; De Anda-Casillas, A.; Ramirez-Munoz, M.P.; Sanchez-Corona, J.; Cantu, J.M.; Zuniga, G. Determination of diesel genotoxicity in firebreathers by micronuclei and nuclear abnormalities in buccal mucosa. Mutat. Res. 1998, 413, 277-281.
29. Singh, N.P.; McCoy, M.T.; Tice, R.R.; Schneider, E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 1988, 175, 184-191.
30. Helma, C.; Uhl, M. A public domain image-analysis program for the single-cell gel-electrophoresis (comet) assay. Mutat. Res. 2000, 466, 9-15.
31. Colorimetric Assay for Lipid Peroxidation; Product No. FR 12; Oxford Biomedical Research: Oxford, MI, USA, 2003.
32. Bradford, M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72, 248-254.
33. Hemnani, T.; Parihar, M.S. Reactive oxygen species and oxidative DNA damage. Indian J. Physiol. Pharmacol. 1998, 42, 440-452.
34. Epe, B. Role of endogenous oxidative DNA damage in carcinogenesis: What can we learn from repair-deficient mice? Biol. Chem. 2002, 383, 467-475.
35. Bolognesi, C. Genotoxicity of pesticides: A review of human biomonitoring studies. Mutat. Res. 2003, 543, 251-272.
36. De Ferrari, M.; Artuso, M.; Bonassi, S.; Bonatti, S.; Cavalieri, Z.; Pescatore, D.; Marchini, E.; Pisano, V.; Abbondandolo, A. Cytogenetic biomonitoring of an Italian population exposed to pesticides: Chromosome aberration and sister-chromatid exchange analysis in peripheral blood lymphocytes. Mutat. Res. 1991, 260, 105-113.
37. Gauthier, J.M.; Dubeau, H.; Rassart, E. Induction of micronuclei in vitro by organochlorine compounds in beluga whale skin fibroblasts. Mutat. Res. 1999, 439, 87-95.
38. Carrano, A.V.; Natarajan, A.T. International commission for protection against environmental mutagens and carcinogens. ICPEMC publication No. 14. Considerations for population monitoring using cytogenetic techniques. Mutat. Res. 1988, 204, 379-406.
39. Anderson, D.; Plewa, M.J. The international comet assay workshop. Mutagenesis 1998, 13, 67-73.
40. Fairbairn, D.W.; Olive, P.L.; O'Neill, K.L. The comet assay: A comprehensive review. Mutat. Res. 1995, 339, 37-59.
41. Gonzalez-Mille, D.J.; Ilizaliturri-Hernández, C.; Espinosa-Reyes, G.; Costilla-Salazar, R.; Díaz-Barriga, F.; Ize-Lema, I.; Mejía-Saavedra, J. Exposure to persistent organic pollutants (POPs) and DNA damage as an indicador of environmental stress in fish of different feeding habits of Coatzacoalcos, Veracruz, Mexico. Ecotoxicology 2010, 19, 1238-1248.
42. Dhawan, A.; Bajpayee, M.; Parmar, D. Comet assay: A reliable tool for the assessment of DNA damage in different models. Cell Biol. Toxicol. 2009, 25, 5-32.
43. Sekihashi, K.; Yamamoto, A.; Matsumura, Y.; Ueno, S.; Watanabe-Akanuma, M.; Kassie, F.; Knasmüller, S.; Tsuda, S.; Sasaki, Y.F. Comparative investigation of multiple organs of mice and rats in the comet assay. Mutat. Res. 2002, 517, 53-75.
44. Vaghef, H.; Nygren, P.; Edling, C.; Bergh, J.; Hellman, B. Alkaline single-cell gel electrophoresis and human biomonitoring for genotoxicity: A pilot study on breast cancer patients undergoing chemotherapy including cyclophosphamide. Mutat. Res. 1997, 395, 127-138.
45. Pfohl-Leszkowicz, A.; Weber-Lotfi, F.; Masfaraud, J.F.; Devaux, A.; Laouedj, A.; Guillemaut, P.; Malaveille, C.; Rether, B.; Monod, G.; Dirheimer, G. DNA adduct detection: Some applications in monitoring exposure to environmental genotoxic chemicals. IARC Sci. Publ. 1993, 124, 373-378.
46. Karuzina, I.I.; Archakov, A.I. The oxidative inactivation of cytochrome P450 in monooxygenase reactions. Free Radic. Biol. Med. 1994, 16, 73-97.
47. Freeman, B.A. Oxygen: The air-borne nutrient that both sustains and threatens life. Nutrition 2000, 16, 478-480.
48. Barreto, G.; Madureira, D.; Capani, F.; Aon-Bertolino, L.; Saraceno, E.; Alvarez-Giraldez, L.D. The role of catechols and free radicals in benzene toxicity: An oxidative DNA damage pathway. Environ. Mol. Mutagen. 2009, 50, 771-780.
49. Siems, W.G.; Pimenov, A.M.; Esterbauer, H.; Grune, T. Metabolism of 4-hydroxynonenal, a cytotoxic lipid peroxidation product, in thymocytes as an effective secondary antioxidative defense mechanism. J. Biochem. 1998, 123, 534-539.
50. Esterbauer, H.; Schaur, R.J.; Zollner, H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic. Biol. Med. 1991, 11, 81-128.
51. Bagchi, D.; Bagchi, M.; Hassoun, E.A.; Stohs, S.J. In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticides. Toxicology 1995, 104, 129-140.
52. Nath, R.G.; Ocando, J.E.; Chung, F.L. Detection of 1, N2-propanodeoxyguanosine adducts as potential endogenous DNA lesions in rodent and human tissues. Cancer Res. 1996, 56, 452-456.
53. Wang, M.; Dhingra, K.; Hittelman, W.N.; Liehr, J.G.; de Andrade, M.; Li, D. Lipid peroxidation-induced putative malondialdehyde-DNA adducts in human breast tissues. Cancer Epidemiol. Biomarkers Prev. 1996, 5, 705-710.
54. Perez-Maldonado, I.N.; Herrera, C.; Batres, L.E.; Gonzalez-Amaro, R.; Diaz-Barriga, F.; Yanez. L. DDT-induced oxidative damage in human blood mononuclear cells. Environ. Res. 2005, 98, 177-184.
55. Olinski, R.; Jurgowiak, M. The role of reactive oxygen species in mutagenesis and carcinogenesis processes. Postepy. Biochem. 1999, 45, 50-58.
56. Panayiotidis, M. Reactive oxygen species (ROS) in multistage carcinogenesis. Cancer Lett. 2008, 266, 3-5.