메뉴 건너뛰기




Volumn 123, Issue 3, 1998, Pages 534-539

Metabolism of 4-hydroxynonenal, a cytotoxic lipid peroxidation product, in thymocytes as an effective secondary antioxidative defense mechanism

Author keywords

4 hydroxynonenal (HNE); Aldehydes; Antioxidants; Antioxidative defense; Lipid peroxidation; Mouse thymocytes

Indexed keywords

4 HYDROXYNONENAL; ANTIOXIDANT; GLUTATHIONE; LIPID; PROTEIN;

EID: 0031891221     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a021969     Document Type: Article
Times cited : (29)

References (54)
  • 1
    • 0025814980 scopus 로고
    • Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde and related aldehydes
    • Esterbauer, H., Schaur, R.J., and Zollner, H. (1991) Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde and related aldehydes. Free Radical Biol. Med. 11, 81-128
    • (1991) Free Radical Biol. Med. , vol.11 , pp. 81-128
    • Esterbauer, H.1    Schaur, R.J.2    Zollner, H.3
  • 2
    • 0024468045 scopus 로고
    • Methods of determination of aldehydic lipid peroxidation products
    • Esterbauer, H., and Zollner, H. (1993) Methods of determination of aldehydic lipid peroxidation products. Free Radical Biol. Med. 7, 197-203
    • (1993) Free Radical Biol. Med. , vol.7 , pp. 197-203
    • Esterbauer, H.1    Zollner, H.2
  • 3
    • 0002218482 scopus 로고
    • Aldehydic products of lipid peroxidation
    • McBrien, D.C. and Slater, T.F., eds. Academic Press, New York
    • Esterbauer, H. (1982) Aldehydic products of lipid peroxidation in Free Radicals, Lipid Peroxidation and Cancer (McBrien, D.C. and Slater, T.F., eds.) pp. 101-128, Academic Press, New York
    • (1982) Free Radicals, Lipid Peroxidation and Cancer , pp. 101-128
    • Esterbauer, H.1
  • 4
    • 0022553765 scopus 로고
    • Resistance to oxidative stress by hyperplastic and neoplastic rat liver tissue monitored in terms of production of unpolar and medium polar carbonyls
    • Poli, G., Cecchini, G., Biasi, F., Chiarpotto, E., Canuto, R.A., Biocca, M.E., Muzio, G., Esterbauer, H., and Dianzani, M.U. (1986) Resistance to oxidative stress by hyperplastic and neoplastic rat liver tissue monitored in terms of production of unpolar and medium polar carbonyls. Biochim. Biophys. Acta 883, 207-214
    • (1986) Biochim. Biophys. Acta , vol.883 , pp. 207-214
    • Poli, G.1    Cecchini, G.2    Biasi, F.3    Chiarpotto, E.4    Canuto, R.A.5    Biocca, M.E.6    Muzio, G.7    Esterbauer, H.8    Dianzani, M.U.9
  • 6
    • 0028447354 scopus 로고
    • The lipid peroxidation product 4-hydroxynonenal is formed by - and is able to attract - Rat neutrophils in vivo
    • Schaur, R.J., Dussing, G., Kink, E., Schauenstein, E., Posch, W., Kukovetz, E., and Egger, G. (1994) The lipid peroxidation product 4-hydroxynonenal is formed by - and is able to attract - rat neutrophils in vivo. Free Radical Res. 20, 365-373
    • (1994) Free Radical Res. , vol.20 , pp. 365-373
    • Schaur, R.J.1    Dussing, G.2    Kink, E.3    Schauenstein, E.4    Posch, W.5    Kukovetz, E.6    Egger, G.7
  • 7
    • 0027959220 scopus 로고
    • Postischemic accumulation of the lipid peroxidation product 4-hydroxynonenal in rat small intestine
    • Grune, T., Siems, W.G., Kowalewski, J., and Esterbauer, H. (1994) Postischemic accumulation of the lipid peroxidation product 4-hydroxynonenal in rat small intestine. Life Sci. 55, 693-699
    • (1994) Life Sci. , vol.55 , pp. 693-699
    • Grune, T.1    Siems, W.G.2    Kowalewski, J.3    Esterbauer, H.4
  • 8
    • 0029153274 scopus 로고
    • 4-Hydroxynonenal formation during ischemia and reperfusion of rat small intestine
    • Siems, W.G., Grune, T., and Esterbauer, H. (1995) 4-Hydroxynonenal formation during ischemia and reperfusion of rat small intestine. Life Sci. 57, 785-789
    • (1995) Life Sci. , vol.57 , pp. 785-789
    • Siems, W.G.1    Grune, T.2    Esterbauer, H.3
  • 9
    • 0001964867 scopus 로고
    • Formation and metabolism of the lipid peroxidation product 4-hydroxynonenal in liver and small intestine
    • Poli, G., Albano, E., and Dianzani, M.U., eds. Birkhäuser Verlag, Basel/ Switzerland
    • Siems, W.G., Grune, T., Zollner, H., and Esterbauer, H. (1993) Formation and metabolism of the lipid peroxidation product 4-hydroxynonenal in liver and small intestine in Free Radicals: From Basic Science to Medicine (Poli, G., Albano, E., and Dianzani, M.U., eds.) pp. 89-101, Birkhäuser Verlag, Basel/ Switzerland
    • (1993) Free Radicals: From Basic Science to Medicine , pp. 89-101
    • Siems, W.G.1    Grune, T.2    Zollner, H.3    Esterbauer, H.4
  • 10
    • 0027201746 scopus 로고
    • Accumulation of aldehydic lipid peroxidation products during postanoxic reoxygenation of isolated rat hepatocytes
    • Grune, T., Siems, W., and Schneider, W. (1993) Accumulation of aldehydic lipid peroxidation products during postanoxic reoxygenation of isolated rat hepatocytes. Free Radical Biol. Med. 15, 125-132
    • (1993) Free Radical Biol. Med. , vol.15 , pp. 125-132
    • Grune, T.1    Siems, W.2    Schneider, W.3
  • 11
    • 0029092913 scopus 로고
    • 4-Hydroxynonenal, a novel indicator of lipid peroxidation for reperfusion injury of the myocardium
    • Heart Circ. Physiol. 38
    • Blasig, I.E., Grune, T., Schönheit, K., Rohde, E., Jakstadt, M., Haseloff, R.F., and Siems, W.G. (1995) 4-Hydroxynonenal, a novel indicator of lipid peroxidation for reperfusion injury of the myocardium. Am. J. Physiol. 269 (Heart Circ. Physiol. 38), H14-H22
    • (1995) Am. J. Physiol. , vol.269
    • Blasig, I.E.1    Grune, T.2    Schönheit, K.3    Rohde, E.4    Jakstadt, M.5    Haseloff, R.F.6    Siems, W.G.7
  • 12
    • 0029976764 scopus 로고    scopus 로고
    • Increased levels of lipid peroxidation products malondialdehyde and 4-hydroxynonenal after perinatal hypoxia
    • Schmidt, H., Grune, T., Müller, R., and Siems, W.G. (1996) Increased levels of lipid peroxidation products malondialdehyde and 4-hydroxynonenal after perinatal hypoxia. Pediatr. Res. 40, 15-20
    • (1996) Pediatr. Res. , vol.40 , pp. 15-20
    • Schmidt, H.1    Grune, T.2    Müller, R.3    Siems, W.G.4
  • 14
    • 0025736918 scopus 로고
    • Antiretinal antibodies in serum of patients with age-related macula degeneration
    • Gurne, D.H., Tso, M.O.M., Edward, D.P., and Ripps, H. (1991) Antiretinal antibodies in serum of patients with age-related macula degeneration. Ophthalmology 98, 602-607
    • (1991) Ophthalmology , vol.98 , pp. 602-607
    • Gurne, D.H.1    Tso, M.O.M.2    Edward, D.P.3    Ripps, H.4
  • 15
    • 0026482622 scopus 로고
    • Lipoate prevents glucose-induced protein modifications
    • Suzuki, Y.J., Tsuchiya, M., and Packer, L. (1992) Lipoate prevents glucose-induced protein modifications. Free Radical Res. Commun. 17, 211-217
    • (1992) Free Radical Res. Commun. , vol.17 , pp. 211-217
    • Suzuki, Y.J.1    Tsuchiya, M.2    Packer, L.3
  • 16
    • 0023612470 scopus 로고
    • Gene induction by gamma-irradiation leads to DNA fragmentation in thymocytes
    • Sellins, K.S. and Cohen, J.J. (1987) Gene induction by gamma-irradiation leads to DNA fragmentation in thymocytes. J. Immunol. 139, 3199-3206
    • (1987) J. Immunol. , vol.139 , pp. 3199-3206
    • Sellins, K.S.1    Cohen, J.J.2
  • 17
    • 0029891162 scopus 로고    scopus 로고
    • Apoptosis - Molecular mechanisms and biomedical implications
    • McConkey, D.J., Zhivotovsky, B., and Orrenius, S. (1996) Apoptosis - Molecular mechanisms and biomedical implications. Mol. Aspects Med. 17, 1-110
    • (1996) Mol. Aspects Med. , vol.17 , pp. 1-110
    • McConkey, D.J.1    Zhivotovsky, B.2    Orrenius, S.3
  • 18
    • 0029007485 scopus 로고
    • Intrathymic and extrathymic clonal deletion of T cells
    • Sprent, J. and Webb, S.R. (1995) Intrathymic and extrathymic clonal deletion of T cells. Curr. Opon. Immunol. 7, 196-205
    • (1995) Curr. Opon. Immunol. , vol.7 , pp. 196-205
    • Sprent, J.1    Webb, S.R.2
  • 19
    • 0029082906 scopus 로고
    • Antioxidant inhibition of thymocyte apoptosis by dihydro-lipoic acid
    • Bustamante, J., Slater, A.F.G., and Orrenius, S. (1995) Antioxidant inhibition of thymocyte apoptosis by dihydro-lipoic acid. Free Radical Biol. Med. 19, 339-347
    • (1995) Free Radical Biol. Med. , vol.19 , pp. 339-347
    • Bustamante, J.1    Slater, A.F.G.2    Orrenius, S.3
  • 20
    • 0027480753 scopus 로고
    • Covalent attachment of 4-hydroxynonenal to glyceraldehyde-3-phosphate dehydrogenase
    • Uchida, K. and Stadtman, E.R. (1993) Covalent attachment of 4-hydroxynonenal to glyceraldehyde-3-phosphate dehydrogenase. J. Biol. Chem. 268, 6388-6393
    • (1993) J. Biol. Chem. , vol.268 , pp. 6388-6393
    • Uchida, K.1    Stadtman, E.R.2
  • 21
    • 0027946778 scopus 로고
    • Michael addition-type 4-hydroxy-2-nonenal adducts in modified low-density lipoproteins: Markers for atherosclerosis
    • Uchida, K., Toyokuni, S., Nishikawa, K., Kawakishi, S., Oda, H., Hiai, H., and Stadtman, E.R. (1994) Michael addition-type 4-hydroxy-2-nonenal adducts in modified low-density lipoproteins: Markers for atherosclerosis. Biochemistry 33, 12487-12494
    • (1994) Biochemistry , vol.33 , pp. 12487-12494
    • Uchida, K.1    Toyokuni, S.2    Nishikawa, K.3    Kawakishi, S.4    Oda, H.5    Hiai, H.6    Stadtman, E.R.7
  • 22
    • 0027990369 scopus 로고
    • Modification of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal
    • Friguet, B., Stadtman, E.R., and Szweda, L.I. (1994) Modification of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. J. Biol. Chem. 269, 21639-21643
    • (1994) J. Biol. Chem. , vol.269 , pp. 21639-21643
    • Friguet, B.1    Stadtman, E.R.2    Szweda, L.I.3
  • 24
    • 0026769469 scopus 로고
    • Selective cleavage of thioether linkage in proteins modified with 4-hydroxynonenal
    • Uchida, K. and Stadtman, E.R. (1992) Selective cleavage of thioether linkage in proteins modified with 4-hydroxynonenal. Proc. Natl. Acad. Sci. USA 89, 5611-5615
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 5611-5615
    • Uchida, K.1    Stadtman, E.R.2
  • 25
    • 0027326559 scopus 로고
    • Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes
    • Uchida, K., Szweda, L.K., Chae, H.-H., and Stadtman, E.R. (1993) Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes. Proc. Natl. Acad. Sci. USA 90, 8742-8746
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 8742-8746
    • Uchida, K.1    Szweda, L.K.2    Chae, H.-H.3    Stadtman, E.R.4
  • 26
    • 0026606054 scopus 로고
    • Modification of histidine residues in proteins by reaction with 4-hydroxynonenal
    • Uchida, K. and Stadtman, E.R. (1992) Modification of histidine residues in proteins by reaction with 4-hydroxynonenal. Proc. Natl. Acad. Sci. USA 89, 4544-4548
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 4544-4548
    • Uchida, K.1    Stadtman, E.R.2
  • 27
    • 0026316248 scopus 로고
    • Identification of metabolic pathways of the lipid peroxidation product 4-hydroxynonenal by enterocytes of rat small intestine
    • Grune, T., Siems, W., Kowalewski, J., Zollner, H., and Esterbauer, H. (1991) Identification of metabolic pathways of the lipid peroxidation product 4-hydroxynonenal by enterocytes of rat small intestine. Biochem. Int. 25, 963-971
    • (1991) Biochem. Int. , vol.25 , pp. 963-971
    • Grune, T.1    Siems, W.2    Kowalewski, J.3    Zollner, H.4    Esterbauer, H.5
  • 28
    • 0028089905 scopus 로고
    • Metabolism of 4-hydroxynonenal, a cytotoxic lipid peroxidation product, in Ehrlich mouse ascites cells at different proliferation stages
    • Grune, T., Siems, W.G., Zollner, H., and Esterbauer, H. (1994) Metabolism of 4-hydroxynonenal, a cytotoxic lipid peroxidation product, in Ehrlich mouse ascites cells at different proliferation stages. Cancer Res. 54, 5231-5235
    • (1994) Cancer Res. , vol.54 , pp. 5231-5235
    • Grune, T.1    Siems, W.G.2    Zollner, H.3    Esterbauer, H.4
  • 29
    • 0028107892 scopus 로고
    • Identification of metabolic pathways of the lipid peroxidation product 4-hydroxynonenal by mitochondria isolated from rat kidney cortex
    • Ullrich, O., Grune, T., Henke, W., Esterbauer, H., and Siems, W.G. (1994) Identification of metabolic pathways of the lipid peroxidation product 4-hydroxynonenal by mitochondria isolated from rat kidney cortex. FEBS Lett. 352, 84-86
    • (1994) FEBS Lett. , vol.352 , pp. 84-86
    • Ullrich, O.1    Grune, T.2    Henke, W.3    Esterbauer, H.4    Siems, W.G.5
  • 30
    • 0029131006 scopus 로고
    • 4-Hydroxynonenal is degraded to mercapturic acid conjugate in rat kidney
    • Petras, T., Siems, W.G., and Grune, T. (1995) 4-Hydroxynonenal is degraded to mercapturic acid conjugate in rat kidney. Free Radical Biol. Med. 19: 685-688
    • (1995) Free Radical Biol. Med. , vol.19 , pp. 685-688
    • Petras, T.1    Siems, W.G.2    Grune, T.3
  • 31
    • 0028797410 scopus 로고
    • Mercapturic acid conjugates as urinary end metabolites of the lipid peroxidation product 4-hydroxy-2-nonenal in the rat
    • Alary, J., Bravais, F., Cravedi, J.-P., Debrauwer, L., Rao, D., and Bories, G. (1995) Mercapturic acid conjugates as urinary end metabolites of the lipid peroxidation product 4-hydroxy-2-nonenal in the rat. Chem. Res. Toxicol. 8, 34-39
    • (1995) Chem. Res. Toxicol. , vol.8 , pp. 34-39
    • Alary, J.1    Bravais, F.2    Cravedi, J.-P.3    Debrauwer, L.4    Rao, D.5    Bories, G.6
  • 33
    • 0008168916 scopus 로고
    • Qualitative and quantitative determination of metabolites of the lipid peroxidation product 4-hydroxynonenal from hepatocytes, enterocytes and tumor cells
    • Siems, W.G., Zollner, H., Grune, T., and Esterbauer, H. (1992) Qualitative and quantitative determination of metabolites of the lipid peroxidation product 4-hydroxynonenal from hepatocytes, enterocytes and tumor cells. Fresenius J. Anal. Chem. 343, 75-76
    • (1992) Fresenius J. Anal. Chem. , vol.343 , pp. 75-76
    • Siems, W.G.1    Zollner, H.2    Grune, T.3    Esterbauer, H.4
  • 34
    • 0028894538 scopus 로고
    • Human renal tubular cells: Increased postanoxic formation of aldehydic lipid peroxidation products
    • Grune, T., Sommerburg, O., Petras, T., and Siems, W. (1995) Human renal tubular cells: Increased postanoxic formation of aldehydic lipid peroxidation products. Free Radical Biol. Med. 18, 21-27
    • (1995) Free Radical Biol. Med. , vol.18 , pp. 21-27
    • Grune, T.1    Sommerburg, O.2    Petras, T.3    Siems, W.4
  • 35
    • 0022973331 scopus 로고
    • Role of cardiac glutathione transferase and of the glutathione S-conjugate export system in biotransformation of 4-hydroxynonenal in the heart
    • Ishikawa, T., Esterbauer, H., and Sies, H. (1986) Role of cardiac glutathione transferase and of the glutathione S-conjugate export system in biotransformation of 4-hydroxynonenal in the heart. J. Biol. Chem. 261, 1576-1586
    • (1986) J. Biol. Chem. , vol.261 , pp. 1576-1586
    • Ishikawa, T.1    Esterbauer, H.2    Sies, H.3
  • 36
    • 0028230943 scopus 로고
    • Reduced 4-hydroxynonenal degradation in hearts of spontaneous hypertensive rats during normoxia and postischemic reperfusion
    • Grune, T., Schönheit, K., Blasig, I., and Siems, W. (1994) Reduced 4-hydroxynonenal degradation in hearts of spontaneous hypertensive rats during normoxia and postischemic reperfusion. Cell Biochem. Funct. 12, 143-147
    • (1994) Cell Biochem. Funct. , vol.12 , pp. 143-147
    • Grune, T.1    Schönheit, K.2    Blasig, I.3    Siems, W.4
  • 37
    • 0027262395 scopus 로고
    • Relative susceptibility of the thymus and thymocytes to lipid peroxidation
    • Cabrini, L., Galli, M.C., Sechi, A.M., and Landi, L. (1993) Relative susceptibility of the thymus and thymocytes to lipid peroxidation. Biochem. Mol. Biol. Int. 29, 839-847
    • (1993) Biochem. Mol. Biol. Int. , vol.29 , pp. 839-847
    • Cabrini, L.1    Galli, M.C.2    Sechi, A.M.3    Landi, L.4
  • 40
    • 0024415274 scopus 로고
    • Lipid peroxidation and cancer: A critical reconsideration
    • Dianzani, M.U. (1989) Lipid peroxidation and cancer: a critical reconsideration. Tumori 75, 351-357
    • (1989) Tumori , vol.75 , pp. 351-357
    • Dianzani, M.U.1
  • 42
    • 0022555361 scopus 로고
    • Simultaneous separation of ribonucleotides, nucleosides and nitrogen bases by ion-pair reversed phase high performance liquid chromatography on columns with radial compression
    • Pimenov, A.M., Tikhonov, Y.V., Meisner, I.S., and Toguzov, R.T. (1985) Simultaneous separation of ribonucleotides, nucleosides and nitrogen bases by ion-pair reversed phase high performance liquid chromatography on columns with radial compression. J. Chromatogr. 365, 221-227
    • (1985) J. Chromatogr. , vol.365 , pp. 221-227
    • Pimenov, A.M.1    Tikhonov, Y.V.2    Meisner, I.S.3    Toguzov, R.T.4
  • 43
    • 0021689920 scopus 로고
    • Lipid peroxidation and lipid antioxidants in normal and tumor cells
    • Cheeseman, K.H., Burton, G.W., Ingold, K.U., and Slater, T.F. (1984) Lipid peroxidation and lipid antioxidants in normal and tumor cells. Toxicol. Pathol. 12, 235-239
    • (1984) Toxicol. Pathol. , vol.12 , pp. 235-239
    • Cheeseman, K.H.1    Burton, G.W.2    Ingold, K.U.3    Slater, T.F.4
  • 44
    • 0027247729 scopus 로고
    • The control of apoptosis in mammalian cells
    • Collins, M.K.L. and Lopez Rivas, A. (1983) The control of apoptosis in mammalian cells. Trends Biochem. Sci. 18, 307-309
    • (1983) Trends Biochem. Sci. , vol.18 , pp. 307-309
    • Collins, M.K.L.1    Lopez Rivas, A.2
  • 45
    • 0023419505 scopus 로고
    • Role of cellular calcium homeostasis in toxic liver injury induced by the pyrrolizidine alkaloid senecionine and in the alkenal trans-4-OH-2-hexenal
    • Griffin, D.A. and Segall, H.J. (1987) Role of cellular calcium homeostasis in toxic liver injury induced by the pyrrolizidine alkaloid senecionine and in the alkenal trans-4-OH-2-hexenal. J. Biochem. Toxicol. 2, 155-167
    • (1987) J. Biochem. Toxicol. , vol.2 , pp. 155-167
    • Griffin, D.A.1    Segall, H.J.2
  • 46
    • 0027325097 scopus 로고
    • 2+: Their relationship to apoptosis and oncogenesis
    • 2+: Their relationship to apoptosis and oncogenesis. FEBS Lett. 325, 104-107
    • (1993) FEBS Lett. , vol.325 , pp. 104-107
    • Richter, C.1
  • 48
    • 0030591436 scopus 로고    scopus 로고
    • Increased levels of 4-hydroxynonenal in human monocytes fed with malarial pigment hemozoin
    • Schwarzer, E., Müller, O., Arese, P., Siems, W.G., and Grune, T. (1996) Increased levels of 4-hydroxynonenal in human monocytes fed with malarial pigment hemozoin. FEBS Lett. 388, 119-122
    • (1996) FEBS Lett. , vol.388 , pp. 119-122
    • Schwarzer, E.1    Müller, O.2    Arese, P.3    Siems, W.G.4    Grune, T.5
  • 50
    • 0028176651 scopus 로고
    • Oxidative stress as a mediator of apoptosis
    • Buttke, T.M. and Sandstrom, P.A. (1994) Oxidative stress as a mediator of apoptosis. Immunol. Today 15, 7-10
    • (1994) Immunol. Today , vol.15 , pp. 7-10
    • Buttke, T.M.1    Sandstrom, P.A.2
  • 51
    • 0028967848 scopus 로고
    • Nitorne spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis
    • Slater, A.F.B., Nobel, C.S., Maellaro, E., Bustamante, J., Kimland, M., and Orrenius, S. (1995) Nitorne spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis. Biochem. J. 306, 771-778
    • (1995) Biochem. J. , vol.306 , pp. 771-778
    • Slater, A.F.B.1    Nobel, C.S.2    Maellaro, E.3    Bustamante, J.4    Kimland, M.5    Orrenius, S.6
  • 53
    • 0021846750 scopus 로고
    • Metabolism of the lipid peroxidation product 4-hydroxynonenal by isolated hepatocytes and by liver cytosolic fractions
    • Esterbauer, H., Zollner, H., and Lang, J. (1985) Metabolism of the lipid peroxidation product 4-hydroxynonenal by isolated hepatocytes and by liver cytosolic fractions. Biochem. J. 228, 363-373
    • (1985) Biochem. J. , vol.228 , pp. 363-373
    • Esterbauer, H.1    Zollner, H.2    Lang, J.3
  • 54
    • 0023445343 scopus 로고
    • Structure-activity relationships of 4-hydroxyalkenals in the conjugation catalyzed by mammalian glutathione transferase
    • Danielson, U.H., Esterbauer, H., and Mannervik, B. (1987) Structure-activity relationships of 4-hydroxyalkenals in the conjugation catalyzed by mammalian glutathione transferase. Biochem. J. 247, 707-713
    • (1987) Biochem. J. , vol.247 , pp. 707-713
    • Danielson, U.H.1    Esterbauer, H.2    Mannervik, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.