DDT and urogenital malformations in newborn boys in a malarial area

BJU International

Volumn 106, Issue 3, 2010, Pages 405-411

  Bornman, Riana ^a   De Jager, Christiaan ^a   Worku, Zeleke ^b   Farias, Paulina ^c   Reif, Simon ^a  

^a UNIVERSITY OF PRETORIA   (South Africa)

^b UNIVERSITY OF SOUTH AFRICA   (South Africa)

^c INSTITUTO NACIONAL DE SALUD PÚBLICA   (Mexico)

Author keywords

DDT; Epidemiology; Indoor residual spraying; Malaria; Newborns; Testicular dysgenesis syndrome

Indexed keywords

1,1,1 TRICHLORO 2 (2 CHLOROPHENYL) 2 (4 CHLOROPHENYL)ETHANE;

ADOLESCENT; ADULT; ARTICLE; CONFIDENCE INTERVAL; CROSS-SECTIONAL STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALARIA; MALE; METABOLITE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NEWBORN; PATHOGENESIS; PESTICIDE SPRAYING; PRIORITY JOURNAL; UROGENITAL TRACT MALFORMATION;

EID: 77955754998     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2009.09003.x     Document Type: Article

References (39)

1. Skakkebæk NE, Rajpert-De Meyts E, Main KM. Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod 2001 16 : 972 978 (Pubitemid 32451837)
2. Aitken RJ, Koopman P, Lewis SEM. Seeds of concern. Nature 2004 432 : 48 52
3. Sharpe RM, Skakkebæk NE. Are estrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 1993 341 : 1392 1395
4. Fisher JS. Environmental anti-androgens and male reproductive health: focus on phthalates and testicular dysgenesis syndrome. Reproduction 2004 127 : 305 315
5. Virtanen HE, Rajpert-De Meyts E, Main KM, Skakkebæk NE, Toppari J. Testicular dysgenesis syndrome and the development and occurrence of male reproductive disorders. Toxicol Appl Pharm 2005 207 : S501 5
6. Bouwman H. South Africa and the Stockholm convention on persistent organic pollutants. S Afr J Sci 2004 100 : 323 328
7. Gerritsen AM, Kruger P, Schim van der Loeff MF, Grobusch MP. Malaria incidence in Limpopo Province, South Africa, 1998-2007. Malar J 2008 7 : 162
8. Bouwman H, Sereda B, Meinhardt HM. Simultaneous presence of DDT and pyrethroid residues in human breast milk from a malaria endemic area in South Africa. Environ Pollut 2006 144 : 902 917
9. Metcalf RL. Insect control technology. In Kroschwitz J, Howe-Grant M, Kirk-Othmer Encyclopedia of Chemical Technology, Vol. 14. New York : John Wiley and Sons, Inc, 1995 : 524 602
10. Smith AG. Chlorinated hydrocarbons. In Hayes WJ Edwards RL Jr eds, Handbook of Pesticide Toxicology, Vol. 2. New York : Academic Press, 1991 : 731 790
11. Spear R. Recognized and possible exposure to pesticides. In Hayes WJ Edwards RL Jr eds, Handbook of Pesticide Toxicology, Vol. 1. New York : Academic Press, 1999 : 245 274
12. Bouwman H, Becker PJ, Schutte CH. Malaria control and longitudinal changes in levels of DDT and its metabolites in human serum from KwaZulu. Bull World Health Organ 1994 72 : 921 930
13. World Health Organization. Environmental Health Criteria No. 9. DDT and Its Derivatives. Geneva : UNEP, WHO, 1979
14. Kelce WR, Stone CR, Laws SC, Gray LE, Kemppainen JA, Wilson EM. Persistent DDT metabolite p,p′-DDE is a potent androgen receptor antagonist. Nature 1995 375 : 581 585
15. Danzo B. Environmental xenobiotics may disrupt normal endocrine function by interfering with the binding of physiological ligands to steroid receptors and binding proteins. Environ Health Perspect 1997 105 : 294 301
16. Turusov V, Rakitsky V, Toamtis L. Dichlorodiphenyltrichloroethane (DDT): ubiquity, persistence, and risks. Environ Health Perspect 2002 110 : 125 128
17. Hunter OJ, Hankinson SE, Latten F et al. Plasma organochlorine levels and the risk of breast cancer. N Engl J Med 1997 337 : 12573 12581
18. Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for DDT, DDE, DDD. Atlanta, GA : U.S. Department of Health and Human Services, Public Health Service, 2002. Available at: http://www.atsdr.cdc.gov/ toxprofiles/tp35.html. Accessed October 2008
19. Fry DM, Toone CK. DDT-induced feminization of gull embryos. Science 1981 213 : 93 5
20. Guillette LJ Jr, Woodward AR, Crain DA, Pickford DB, Rooney AA, Percival HF. Plasma steroid concentrations and male phallus size in juvenile alligators from seven Florida Lakes. Gen Comp Endocrinol 1999 116 : 356 372
21. Gray LE Jr, Ostby LE, Furr J et al. Effects of environmental antiandrogens on reproductive development in experimental animals. Hum Reprod Update 2001 7 : 248 264 (Pubitemid 32440287)
22. De Jager C, Farias P, Barazza-Villarreal A et al. Breakthroughs in Andrology: reduced seminal parameters associated with environmental DDT exposure and p,p'-DDE concentrations in men in Chiapas, Mexico: a Cross-Sectional Study. J Androl 2006 27 : 16 27
23. Aneck-Hahn NH, Schulenburg GW, Bornman MS, Farias P, de Jager C. Impaired semen quality associated with environmental DDT exposure in young men living in a malaria area in the Limpopo Province, South Africa. J Androl 2007 28 : 423 434
24. Medical Research Council of South Africa. Malaria in Southern Africa. Malaria Risk in Southern Africa. January 2007. Information provided by the Malaria Research Programme of the Medical Research Council, South Africa. Available at: http://www.malaria.org.za/Malaria-Risk/Risk-Maps/risk-maps.html. Accessed December 2008
25. Jordan GH, Schlossberg SM. Surgery of the penis and uethra. In Wein AJ, Campbell-Walsh Urology, 9th edn. Philadelphia : WB Saunders, Elsevier, 2007 : 1089
26. Elder JS. Abnormalities of the genitalia in boys and their surgical management. In Wein AJ, Campbell-Walsh Urology, 9th edn. Philadelphia : Saunders, Elsevier 2007 : 3754 3760
27. Longnecker MP, Klebanoff MA, Brock JW et al. Maternal serum level of 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene and risk of cryptorchidism, hypospadias, and polythelia among male offspring. Am J Epidemiol 2002 155 : 313 322
28. Damstra T, Barlow S, Bergman A, Kavlock R, Van Der Kraak G eds. Global Assessment of the State of the Science of Endocrine Disruptors. International Programme on Chemical Safety. Geneva, Switzerland : World Health Organization, 2004. Available at: http://www.who.int/ipcs/publications/new-issues/endocrine- disruptors/en/. Accessed July 2008
29. Longnecker MP, Klebanoff MA, Dunson DB, Guo X, Zhou H, Brock JW. Maternal serum level of the DDT metabolite DDE in relation to fetal loss in previous pregnancies. Environ Res 2005 97 : 127 133
30. Eskenazi B, Marks AR, Bradman A et al. In utero exposure to dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) and neurodevelopment among young Mexican American children. Pediatrics 2006 118 : 233 241
31. Retik AB, Borer JG. Hypospadias. In Walsh PC, Retik AB, Vaughan ED Wein AJ, Campbell's Urology, 8th edn. Philadelphia : WB Saunders, 2002 : 2284 2333
32. Toppari J, Larsen JC, Christiansen P et al. Male reproductive health and environmental xenoestrogens. Environ Health Perspect 1996 104 (Suppl. 4 741 803
33. Delport SD, Christianson AL, van den Berg HJ, Wolmarans L, Gericke GS. Congenital anomalies in black South African liveborn neonates at an urban academic hospital. S Afr Med J 1995 85 : 11 5
34. Venter PA, Christianson AL, Hutamo CM, Makhura MP, Gericke GS. Congenital anomalies in rural black South African neonates - a silent epidemic? S Afr Med J 1995 85 : 15 20
35. Hammond-Tooke D. Transformations on a theme. In Hammond-Tooke D, The Roots of Black South Africa. Johannesburg : Jonathan Ball Publishers, 1993 : 1121
36. Consanguinity. Consanguineous marriage in Africa. Available at: http://www.consang.net/images/c/c8/Africa.pdf. Accessed December 2008
37. Longnecker MP, Gladen BC, Cupul-Uicab LE et al. In utero exposure to the antiandrogen 1,1-dichloro-2,2-bis (pchlorophenyl) ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, México. Am J Epidemiol 2007 165 : 1015 1022
38. Sharp B, Kleinschmidt I, Streat E et al. Seven years of regional malaria control collaboration - Mozambique, South Africa, and Swaziland. Am J Trop Med Hyg 2007 76 : 42 7
39. Van den Berg H. Global status of DDT and its alternatives for use in vector control to prevent disease. Stockholm Convention on Persistent Organic Pollutants. Stakeholders' Meeting to review the interim report for the establishment of a global partnership to develop alternatives to DDT. UNEP/POPS/DDTBP 23 October 2008; 1/2: 2008 Available at: http://chm.pops.int/ Programmes/DDT/Meetings/BusinessPlan/tabid/418/language/en-US/Default.aspx. Accessed October 2008